DE69527947T2 - Cyanidfreies reagens und verfahren zur bestimmung von hämoglobin - Google Patents

Cyanidfreies reagens und verfahren zur bestimmung von hämoglobin

Info

Publication number: DE69527947T2
Authority: DE; Germany
Prior art keywords: reagent; cyanide; blood sample; group; free
Prior art date: 1994-03-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69527947T

Other languages

English (en)

Other versions

DE69527947D1 (de

Inventor

Ran Kim

D Stroupe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Laboratories

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-11

Filing date

1995-03-06

Publication date

2003-05-28

1995-03-06 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

2002-10-02 Publication of DE69527947D1 publication Critical patent/DE69527947D1/de

2003-05-28 Application granted granted Critical

2003-05-28 Publication of DE69527947T2 publication Critical patent/DE69527947T2/de

2015-03-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000003153 chemical reaction reagent Substances 0.000 title abstract 5
102000001554 Hemoglobins Human genes 0.000 title abstract 2
108010054147 Hemoglobins Proteins 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
239000008280 blood Substances 0.000 abstract 2
210000004369 blood Anatomy 0.000 abstract 2
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
238000002835 absorbance Methods 0.000 abstract 1
RRUDCFGSUDOHDG-UHFFFAOYSA-N acetohydroxamic acid Chemical compound CC(O)=NO RRUDCFGSUDOHDG-UHFFFAOYSA-N 0.000 abstract 1
229960001171 acetohydroxamic acid Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 abstract 1
230000001545 erythrolytic effect Effects 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

DE69527947T 1994-03-11 1995-03-06 Cyanidfreies reagens und verfahren zur bestimmung von hämoglobin Expired - Lifetime DE69527947T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21262694A	1994-03-11	1994-03-11
PCT/US1995/002897 WO1995024651A1 (en)	1994-03-11	1995-03-06	Cyanide-free reagent and method for the determination of hemoglobin

Publications (2)

Publication Number	Publication Date
DE69527947D1 DE69527947D1 (de)	2002-10-02
DE69527947T2 true DE69527947T2 (de)	2003-05-28

Family

ID=22791814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69527947T Expired - Lifetime DE69527947T2 (de)	1994-03-11	1995-03-06	Cyanidfreies reagens und verfahren zur bestimmung von hämoglobin

Country Status (9)

Country	Link
US (2)	US5612223A (de)
EP (1)	EP0749583B1 (de)
JP (1)	JP3523878B2 (de)
AT (1)	ATE223059T1 (de)
AU (1)	AU1984295A (de)
CA (1)	CA2183558C (de)
DE (1)	DE69527947T2 (de)
ES (1)	ES2184795T3 (de)
WO (1)	WO1995024651A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0770216A1 (de) *	1994-07-14	1997-05-02	Abbott Laboratories	Verfahren und reagenzien zur cyanidfreien bestimmung von hämoglobin und leukocyten in vollblut
US5834315A (en) *	1994-12-23	1998-11-10	Coulter Corporation	Cyanide-free reagent and method for hemoglobin determination and leukocyte differentitation
US5763280A (en) *	1997-01-21	1998-06-09	Coulter International Corp.	Cyanide-free lytic reagent composition and method for hemoglobin and cell analysis
US5882934A (en) *	1997-01-21	1999-03-16	Coulter International Corp.	Composition and method for hemoglobin and cell analysis
US5858794A (en) *	1997-05-13	1999-01-12	Bayer Corporation	Cyanide-containing hemoglobin reagent composition and method providing acceptable precision, accuracy and freedom from white cell interference on automated hematology analyzers
US5935857A (en) *	1997-08-01	1999-08-10	Coulter International Corp.	Blood diluent
US6074881A (en) *	1998-08-03	2000-06-13	Bayer Corporation	Method for the prevention of hemoglobin interference in reagent systems for measuring peroxidase activity
DE19835243A1 (de) *	1998-08-04	2000-02-24	Lmb Technologie Gmbh	Vorrichtung und Verfahren zum Bestimmen eines Hämoglobinwerts von Blut
AU2001282550A1 (en) *	2000-09-07	2002-03-22	Wako Pure Chemical Industries, Ltd.	Method of quantifying total hemoglobin and glycohemoglobin
GB0110053D0 (en) *	2001-04-24	2001-06-13	Axis Shield Asa	Assay
US6916658B2 (en)	2001-07-27	2005-07-12	Beckman Coulter, Inc.	Method for measurement of immature granulocytes
US6573102B2 (en)	2001-07-27	2003-06-03	Coulter International Corp.	Lytic reagent composition for determination of nucleated blood cells
JP2005506525A (ja) *	2001-07-27	2005-03-03	ベックマンコールター，インコーポレーテッド	有核赤血球の計測法の方法
US6410330B1 (en)	2001-07-27	2002-06-25	Coulter International Corp.	Method for measurement of nucleated red blood cells
US6890756B2 (en) *	2002-04-05	2005-05-10	Streck Laboratories, Inc.	Method of using cyanide-free lyse solution to emulate a cyanide-containing lyse solution in the measurement of hemoglobin
IES20020936A2 (en) *	2002-12-03	2003-11-26	Trinity Res Ltd	A cyanide-free reagent for measuring haemoglobin in blood, and a method for measuring haemoglobin
WO2006042555A2 (en) *	2004-10-20	2006-04-27	Chempaq A/S	Lysing reagent for simultaneous enumeration of different types of blood cells in a blood sample
US7235404B2 (en)	2005-05-04	2007-06-26	Beckman Coulter, Inc.	Cyanide-free lytic reagent composition and method of use for hemoglobin and white blood cell measurement
DE102005060993A1 (de) *	2005-12-20	2007-06-28	Medisynthana Diagnostics Gmbh & Co. Kg	Konversionsreagenz sowie Verfahren und Kit zur Bestimmung des Hämoglobins
US7361510B2 (en) *	2006-01-20	2008-04-22	Beckman Coulter, Inc.	Methods of detection of iron deficiency
GB2445442A (en) *	2006-09-26	2008-07-09	Ge Healthcare Bio Sciences	Nucleic acid purification using anion exchange
GB2445441B (en) *	2006-09-26	2010-06-30	Ge Healthcare Bio Sciences	Nucleic acid purification method
GB2443505B (en) *	2006-09-26	2008-12-31	Ge Healthcare Bio Sciences	Nucleic acid purification method
US8067580B2 (en) *	2008-02-07	2011-11-29	Ge Healthcare Bio-Sciences Corp.	Isolation of DNA, RNA and protein from a single sample
CN102282467B (zh)	2008-11-13	2014-08-13	贝克曼考尔特公司	对血红蛋白测量的颗粒干扰的校正的方法
US8614066B2 (en)	2009-08-26	2013-12-24	Abbott Laboratories	Method of using ligand-free lysing agent in hemoglobin analysis
US8603309B2 (en)	2011-09-12	2013-12-10	Nova Biomedical Corporation	Disposable sensor for electrochemical detection of hemoglobin
US10502666B2 (en)	2013-02-06	2019-12-10	Alentic Microscience Inc.	Sample processing improvements for quantitative microscopy
CA2953620C (en)	2013-06-26	2020-08-25	Alentic Microscience Inc.	Sample processing improvements for microscopy
CN103698501B (zh) *	2013-12-23	2015-07-29	深圳开立生物医疗科技股份有限公司	一种无氰化物溶血剂
GB201716136D0 (en) *	2017-10-03	2017-11-15	Cyanoguard Ag	Process
CN107907690B (zh) *	2017-11-15	2020-07-10	南通伊仕生物技术股份有限公司	一种超敏c反应蛋白检测试剂盒及其使用方法
WO2020054572A1 (ja) *	2018-09-12	2020-03-19	積水メディカル株式会社	ヘモグロビン類測定用試薬及びヘモグロビン類の測定方法
JP2023027418A (ja) *	2019-12-12	2023-03-02	Ｐｈｃホールディングス株式会社	糖化ヘモグロビンの電気化学測定方法およびそれに用いる測定キット

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4200435A (en) *	1978-12-26	1980-04-29	Abbott Laboratories	Determination of glycosylated hemoglobin in blood
US4255385A (en) *	1979-10-23	1981-03-10	Abbott Laboratories	Reagent and test kit for determining glycosylated hemoglobin
US4274978A (en) *	1979-12-07	1981-06-23	Abbott Laboratories	Standards for determining glycosylated hemoglobin
JPS61148369A (ja) *	1984-12-06	1986-07-07	テクニコン・インストウルメンツ・コーポレイシヨン	シアニドを含まないヘモグロビン試薬
US4853338A (en) *	1987-05-20	1989-08-01	Technicon Instruments Corporation	Cyanide-free hemoglobin reagent
JP2619900B2 (ja) *	1988-01-27	1997-06-11	東亜医用電子株式会社	血液中の白血球およびヘモグロビンの測定用試薬および方法
JP2836865B2 (ja) *	1989-10-23	1998-12-14	東亜医用電子株式会社	血液中の白血球およびヘモグロビンの測定用試薬
US5242832A (en) *	1990-03-01	1993-09-07	Toa Medical Electronics Co., Ltd.	Reagent for measurement of leukocytes and hemoglobin in blood
GB9024771D0 (en) *	1990-11-14	1991-01-02	Axis Research	Assay

1995
- 1995-03-06 JP JP52362295A patent/JP3523878B2/ja not_active Expired - Fee Related
- 1995-03-06 ES ES95912800T patent/ES2184795T3/es not_active Expired - Lifetime
- 1995-03-06 AU AU19842/95A patent/AU1984295A/en not_active Abandoned
- 1995-03-06 WO PCT/US1995/002897 patent/WO1995024651A1/en active IP Right Grant
- 1995-03-06 DE DE69527947T patent/DE69527947T2/de not_active Expired - Lifetime
- 1995-03-06 CA CA002183558A patent/CA2183558C/en not_active Expired - Fee Related
- 1995-03-06 AT AT95912800T patent/ATE223059T1/de not_active IP Right Cessation
- 1995-03-06 EP EP95912800A patent/EP0749583B1/de not_active Expired - Lifetime
- 1995-08-31 US US08/524,128 patent/US5612223A/en not_active Expired - Lifetime
1996
- 1996-10-15 US US08/730,193 patent/US5866428A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE223059T1 (de)	2002-09-15
JP3523878B2 (ja)	2004-04-26
EP0749583B1 (de)	2002-08-28
US5866428A (en)	1999-02-02
AU1984295A (en)	1995-09-25
CA2183558A1 (en)	1995-09-14
US5612223A (en)	1997-03-18
CA2183558C (en)	2006-01-24
EP0749583A1 (de)	1996-12-27
DE69527947D1 (de)	2002-10-02
ES2184795T3 (es)	2003-04-16
JPH09511575A (ja)	1997-11-18
WO1995024651A1 (en)	1995-09-14

Legal Events

Date	Code	Title	Description
2003-09-25	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE69527947T2 (de)	2003-05-28	Cyanidfreies reagens und verfahren zur bestimmung von hämoglobin
DE3853671T2 (de)	1995-10-19	Reagens und Verfahren zur Messung von Leukozyten und Hämoglobin im Blut.
ATE223044T1 (de)	2002-09-15	Nachweis von retikulozyten mit coriphosphin o
ATE117803T1 (de)	1995-02-15	Reagenz und verfahren zur verwendung desselben in der automatischen durchflusszytometrischen bestimmung von mindestens einer leukocyten- subpopulation aus vollblut.
DE69623174D1 (de)	2002-10-02	Verfahren und Reagenszusammensetzung zur Durchführung von differenzierenden Leukocytzählungen in frischen und gealteren Vollblutproben, auf der Grundlage der bereitsvorhandenen Peroxidaseaktivität der Leukocyten
IL103056A (en)	1997-04-15	Method for sphering of red blood cells
DE69411928T2 (de)	1999-02-18	Verfahren, reagenz und testsatz zum nachweis von okkultem blut in stuhl
DE69941044D1 (de)	2009-08-13	Methoden, Apparat und Computerprogramm zur quantitativen Bestimmung von Nukleinsäurensequenzen in Proben unter Verwendung von Standardkurven und Abschätzungen von Amplifikationsverhältnissen
ATE360090T1 (de)	2007-05-15	Vorrichtung und verfahren zum bestimmen der koagulation in flüssigproben
DE69213315D1 (de)	1996-10-10	Reagenzien und Verfahren zur Zellanalyse im Harn
DE59007613D1 (de)	1994-12-08	Verfahren zum Nachweis und zur Bestimmung von Humanserumalbumin in biologischen Flüssigkeiten mit Hilfe fluorogener Cyanin-Farbstoffe.
DE68917613D1 (de)	1994-09-29	Natriumdecylsulfat enthaltende Waschlösung, Testsatz und Verfahren zur Bestimmung eines immunologischen Liganden.
ATE74211T1 (de)	1992-04-15	Verfahren zum nachweis eines analyten sowie hierfuer geeignetes mittel.
ATE218166T1 (de)	2002-06-15	Verfahren zur reduzierung der beeinflussung von diagnostischen tests durch heparin unter verwendung von metallsalzen und diagnostisches reagenz für diagnostische tests zur bestimmung der gerinnungsfähigkeit des blutes enthaltend metallsalze
ATE97501T1 (de)	1993-12-15	Reagens und verfahren zur bestimmung von haemoglobin im blut.
DE69124030D1 (de)	1997-02-20	Testverfahren, die ein lösliches fibrinähnliches Monomer nutzen
DE69430410D1 (de)	2002-05-23	Methode zum Nachweis von Fructosamin
DE69832090D1 (de)	2005-12-01	Verfahren zur bestimmung der konzentration eines analyten unter verwendung eines bioelementes und einen transduzer, und eine vorrichtung mit einem kleinen volumen zur verwendung im verfahren
EP0747944A3 (de)	1998-03-04	Potentiometrische Messung der Substratoxidation und Überzugsporosität
DE69922213D1 (de)	2004-12-30	Verfahren und testsatz zur bestimmung der analytkonzentration im blut
DE69909238D1 (de)	2003-08-07	Verfahren und Reagens zur Bestimmung von Bilirubinen
EP0285603A3 (de)	1990-02-28	Verfahren zur Bestimmung von Cyclosporin-A im Blut
ATE417262T1 (de)	2008-12-15	Messvorrichtung und verfahren zur bestimmung von teilchenkonzentrationen in einer flüssigkeit
WO2004016802A3 (en)	2004-08-12	Methods and apparatus for preparing and assaying biological samples to determine protein concentration
DE58909122D1 (de)	1995-04-20	Verfahren zum nachweis der funktionsfähigkeit der nierentubuli.