DE69435265D1 - Phosphorizierende verbindungen zur visualisierung von gewebesauerstoff - Google Patents
Phosphorizierende verbindungen zur visualisierung von gewebesauerstoffInfo
- Publication number
- DE69435265D1 DE69435265D1 DE69435265T DE69435265T DE69435265D1 DE 69435265 D1 DE69435265 D1 DE 69435265D1 DE 69435265 T DE69435265 T DE 69435265T DE 69435265 T DE69435265 T DE 69435265T DE 69435265 D1 DE69435265 D1 DE 69435265D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- phosphorizing
- visualizing
- fuel oxygen
- energy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
- G01N31/225—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for oxygen, e.g. including dissolved oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
- A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/137,624 US6362175B1 (en) | 1991-09-20 | 1993-10-15 | Porphyrin compounds for imaging tissue oxygen |
PCT/US1994/011695 WO1995010522A1 (en) | 1993-10-15 | 1994-10-14 | Phosphorescent compounds for imaging tissue oxygen |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69435265D1 true DE69435265D1 (de) | 2010-03-04 |
Family
ID=22478306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435265T Expired - Lifetime DE69435265D1 (de) | 1993-10-15 | 1994-10-14 | Phosphorizierende verbindungen zur visualisierung von gewebesauerstoff |
Country Status (7)
Country | Link |
---|---|
US (1) | US6362175B1 (de) |
EP (1) | EP0723548B1 (de) |
AT (1) | ATE455116T1 (de) |
AU (1) | AU700941B2 (de) |
CA (1) | CA2174209C (de) |
DE (1) | DE69435265D1 (de) |
WO (1) | WO1995010522A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593899A (en) * | 1993-02-25 | 1997-01-14 | Trustees Of The University Of Pennsylvania | Device and method for measuring tissue oxygenation through the skin using oxygen dependent quenching of phosphorescence |
US5837865A (en) * | 1993-10-15 | 1998-11-17 | Trustees Of The University Of Pennsylvania | Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen |
DE19627164C2 (de) * | 1996-07-05 | 1998-09-24 | Deutsches Krebsforsch | Herstellung polyether-aufweisender Chlorine und Bakteriochlorine, solche Verbindungen und ihre Verwendung |
WO1998003512A1 (en) | 1996-07-22 | 1998-01-29 | Novartis Ag | Process for the preparation of platinum or palladium benzoporphyrins and platinum or palladium cyclohexenoporphyrins, intermediates, and an oxygen sensor comprising platinum or palladium cyclohexenoporphyrin |
US5830138A (en) * | 1996-12-16 | 1998-11-03 | Trustees Of The University Of Pennsylvania | Intravascular catheter probe for clinical oxygen, pH and CO2 measurement |
US6274086B1 (en) * | 1996-12-16 | 2001-08-14 | The Trustees Of The University Of Pennsylvania | Apparatus for non-invasive imaging oxygen distribution in multi-dimensions |
US6165741A (en) * | 1997-05-30 | 2000-12-26 | The Trustees Of The University Of Pennsylvania | Method for rapid detection of bacterial growth in cultures |
US6190612B1 (en) | 1998-01-21 | 2001-02-20 | Bayer Corporation | Oxygen sensing membranes and methods of making same |
US6306347B1 (en) | 1998-01-21 | 2001-10-23 | Bayer Corporation | Optical sensor and method of operation |
US6254831B1 (en) | 1998-01-21 | 2001-07-03 | Bayer Corporation | Optical sensors with reflective materials |
US6107083A (en) * | 1998-08-21 | 2000-08-22 | Bayer Corporation | Optical oxidative enzyme-based sensors |
JP5000050B2 (ja) * | 2001-08-31 | 2012-08-15 | 浩 前田 | 抗腫瘍剤及びその製造方法 |
WO2003083434A2 (en) * | 2002-04-02 | 2003-10-09 | Yeda Research And Development Co. Ltd. | Characterization of moving objects in a stationary background |
AU2002951886A0 (en) * | 2002-10-08 | 2002-10-24 | The Western Australian Centre For Pathology And Medical Research | A method for measuring antioxident status |
GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
JP2006522329A (ja) * | 2003-03-07 | 2006-09-28 | ラクセル・バイオサイエンシズ・リミテッド | 酸素感受性プローブ |
JP2005290282A (ja) * | 2004-04-02 | 2005-10-20 | Fuji Photo Film Co Ltd | フタロシアニンの製造方法 |
GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
JP2008539905A (ja) * | 2005-05-06 | 2008-11-20 | エダ リサーチ アンド ディベロップメント カンパニー,リミティド | 心臓周期に関連する血管における赤血球の運動の撮像および分析 |
EP1973503B1 (de) * | 2006-01-04 | 2013-09-25 | The Trustees of the University of Pennsylvania | Sauerstoffsensor zur internen überwachung von gewebesauerstoff in vivo |
US7575890B2 (en) | 2006-01-18 | 2009-08-18 | Oxygen Enterprises, Ltd. | Method for rapid detection and evaluation of cultured cell growth |
US8403862B2 (en) * | 2007-12-20 | 2013-03-26 | Yeda Research And Development Co. Ltd. | Time-based imaging |
WO2009108947A2 (en) * | 2008-02-28 | 2009-09-03 | The Trustees Of The University Of Pennsylvania | Imaging dendrimer nanoprobes and uses thereof |
US8323978B2 (en) * | 2008-11-07 | 2012-12-04 | Mocon, Inc. | Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery |
WO2010053888A1 (en) * | 2008-11-07 | 2010-05-14 | Mocon, Inc | Calibration card for oxygen optical sensors |
US8241911B2 (en) * | 2008-11-07 | 2012-08-14 | Mocon, Inc. | Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery |
US20110136247A1 (en) * | 2009-12-07 | 2011-06-09 | Dmitri Boris Papkovsky | Photoluminescent oxygen probe with reduced cross-sensitivity to humidity |
US9274060B1 (en) | 2011-01-13 | 2016-03-01 | Mocon, Inc. | Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe |
US9121827B2 (en) | 2011-06-30 | 2015-09-01 | Mocon, Inc. | Method of contemporaneously monitoring changes in analyte concentration in a plurality of samples on individual schedules |
EA201491551A1 (ru) * | 2012-02-27 | 2015-02-27 | Сергей Виноградов | Улучшенные фосфоресцентные молекулы для измерения содержания кислорода и способы визуализации |
US10493168B2 (en) * | 2012-02-27 | 2019-12-03 | Oxygen Enterprises, Ltd | Phosphorescent meso-unsubstituted metallo-porphyrin probe molecules for measuring oxygen and imaging methods |
US9057687B2 (en) | 2012-04-20 | 2015-06-16 | Mocon, Inc. | Calibration vial and technique for calibrating a fiber optic oxygen sensing needle |
WO2014011724A1 (en) | 2012-07-10 | 2014-01-16 | The General Hospital Corporation | System and method for monitoring and treating a surface of a subject |
US8658429B1 (en) | 2012-08-06 | 2014-02-25 | Mocon, Inc. | Photoluminescent oxygen probe tack |
EP3797798B1 (de) * | 2013-03-14 | 2022-09-28 | Profusa, Inc. | Sauerstoffsensoren |
JP6457998B2 (ja) | 2013-03-14 | 2019-01-23 | プロフサ,インコーポレイテッド | 光信号を補正するための方法およびデバイス |
CA2907356C (en) | 2013-03-15 | 2022-07-12 | Sherri Ann MCFARLAND | Metal-based coordination complexes as photodynamic compounds and their use |
US9420967B2 (en) | 2013-03-19 | 2016-08-23 | Surgisense Corporation | Apparatus, systems and methods for determining tissue oxygenation |
US9789206B2 (en) | 2013-07-10 | 2017-10-17 | The General Hospital Corporation | Compounds, systems, and methods for monitoring and treating a surface of a subject |
CN103788952A (zh) * | 2014-01-24 | 2014-05-14 | 中国科学院长春光学精密机械与物理研究所 | 高掺杂宽带激发稀土上转换荧光纳米材料及其制备方法 |
JP2017513664A (ja) * | 2014-04-05 | 2017-06-01 | サージセンス コーポレイション | 組織酸素化のマッピングのための装置、システム、および方法 |
CN115505280A (zh) * | 2016-12-21 | 2022-12-23 | 普罗菲尤萨股份有限公司 | 可聚合的近红外染料 |
EP3645056A4 (de) * | 2017-06-29 | 2021-03-17 | Profusa, Inc. | Multianalytmessende gewebeintegrationssensoren |
JP7245611B2 (ja) * | 2017-07-04 | 2023-03-24 | 三星電子株式会社 | 近赤外線有機光センサが組み込まれた有機発光ダイオードパネル及びこれを含む表示装置 |
US11534503B2 (en) | 2017-12-28 | 2022-12-27 | Profusa, Inc. | Oxidase-based sensors and methods of using |
CN109470666B (zh) * | 2018-11-07 | 2023-11-24 | 上海萨迦生物科技有限公司 | 一种近红外激光共聚焦生物芯片扫描仪 |
CN113968864B (zh) * | 2020-07-23 | 2023-04-07 | 浙大城市学院 | 一种基于锌卟啉轴向配位调控的Cu+荧光探针、制备方法和应用 |
US11874221B2 (en) * | 2021-01-26 | 2024-01-16 | Yokogawa Electric Corporation | Measurement of dissolved oxygen using optical radiation induced luminescence |
WO2023178034A1 (en) * | 2022-03-14 | 2023-09-21 | Hollister Incorporated | System and method for detecting oxygen for prediction, detection, mitigation and/or prevention of peristomal skin injury |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2219093A (en) | 1938-02-01 | 1940-10-22 | Lund Otto | Two-stroke internal combustion engine |
US5156840A (en) * | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
GB8805849D0 (en) | 1988-03-11 | 1988-04-13 | Efamol Holdings | Porphyrins & cancer treatment |
US4947850A (en) * | 1988-03-11 | 1990-08-14 | Trustees Of The University Of Pennsylvania | Method and apparatus for imaging an internal body portion of a host animal |
DE3809671A1 (de) | 1988-03-18 | 1989-09-28 | Schering Ag | Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5227481A (en) * | 1989-07-07 | 1993-07-13 | National Starch And Chemical Investment Holding Corporation | Cationic polysaccharides and reagents for their preparation |
US5238940A (en) * | 1990-03-22 | 1993-08-24 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
US5149801A (en) * | 1990-11-21 | 1992-09-22 | The Regents Of The University Of California | Boronated porphyrin compounds |
US5280115A (en) * | 1991-09-12 | 1994-01-18 | Sun Company, Inc. (R&M) | Nitrated metalloporphyrins as catalysts for alkane oxidation |
US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
GB9408746D0 (en) | 1994-05-03 | 1994-06-22 | Scotia Holdings Plc | Tumour locallising photosensitising compounds |
-
1993
- 1993-10-15 US US08/137,624 patent/US6362175B1/en not_active Expired - Lifetime
-
1994
- 1994-10-14 EP EP94930778A patent/EP0723548B1/de not_active Expired - Lifetime
- 1994-10-14 WO PCT/US1994/011695 patent/WO1995010522A1/en active Application Filing
- 1994-10-14 AU AU79798/94A patent/AU700941B2/en not_active Ceased
- 1994-10-14 DE DE69435265T patent/DE69435265D1/de not_active Expired - Lifetime
- 1994-10-14 CA CA002174209A patent/CA2174209C/en not_active Expired - Fee Related
- 1994-10-14 AT AT94930778T patent/ATE455116T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2174209C (en) | 2005-01-25 |
AU7979894A (en) | 1995-05-04 |
CA2174209A1 (en) | 1995-04-20 |
ATE455116T1 (de) | 2010-01-15 |
EP0723548B1 (de) | 2010-01-13 |
AU700941B2 (en) | 1999-01-14 |
US6362175B1 (en) | 2002-03-26 |
EP0723548A4 (de) | 1997-01-15 |
WO1995010522A1 (en) | 1995-04-20 |
EP0723548A1 (de) | 1996-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |