DE69435150D1 - Systeme zur intrapulmonaren Verabreichung von wässrigen Lösungen - Google Patents

Systeme zur intrapulmonaren Verabreichung von wässrigen Lösungen

Info

Publication number
DE69435150D1
DE69435150D1 DE69435150T DE69435150T DE69435150D1 DE 69435150 D1 DE69435150 D1 DE 69435150D1 DE 69435150 T DE69435150 T DE 69435150T DE 69435150 T DE69435150 T DE 69435150T DE 69435150 D1 DE69435150 D1 DE 69435150D1
Authority
DE
Germany
Prior art keywords
systems
aqueous solutions
intrapulmonary administration
intrapulmonary
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69435150T
Other languages
English (en)
Inventor
Lester John Lloyd
Peter M Lloyd
Reid M Rubsamen
Jeffrey Arthur Schuster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Aradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/065,660 external-priority patent/US5709202A/en
Application filed by Aradigm Corp filed Critical Aradigm Corp
Application granted granted Critical
Publication of DE69435150D1 publication Critical patent/DE69435150D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/001—Details of inhalators; Constructional features thereof with means for agitating the medicament using ultrasonic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1418—Threaded type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0418—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with electronic history memory
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
DE69435150T 1993-05-21 1994-05-20 Systeme zur intrapulmonaren Verabreichung von wässrigen Lösungen Expired - Fee Related DE69435150D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/065,660 US5709202A (en) 1993-05-21 1993-05-21 Intrapulmonary delivery of aerosolized formulations
US08/166,972 US5497763A (en) 1993-05-21 1993-12-14 Disposable package for intrapulmonary delivery of aerosolized formulations

Publications (1)

Publication Number Publication Date
DE69435150D1 true DE69435150D1 (de) 2008-11-27

Family

ID=26745835

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1994633380 Expired - Fee Related DE69433380T2 (de) 1993-05-21 1994-05-20 Systeme zur interpulmonaren verabreichung von wässrigen lösungen
DE69435150T Expired - Fee Related DE69435150D1 (de) 1993-05-21 1994-05-20 Systeme zur intrapulmonaren Verabreichung von wässrigen Lösungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1994633380 Expired - Fee Related DE69433380T2 (de) 1993-05-21 1994-05-20 Systeme zur interpulmonaren verabreichung von wässrigen lösungen

Country Status (6)

Country Link
US (7) US5497763A (de)
EP (2) EP1366778B1 (de)
JP (1) JP3375637B2 (de)
AU (1) AU690561B2 (de)
DE (2) DE69433380T2 (de)
WO (1) WO1994027653A2 (de)

Families Citing this family (366)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA26230A (uk) * 1990-03-02 1999-07-19 Глексо Груп Лімітед Іhгалятор для спільhого використаhhя з лікувальhим блоком і лікувальhий блок
US6540154B1 (en) * 1991-04-24 2003-04-01 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US9215979B2 (en) * 1992-11-17 2015-12-22 Robert Bosch Healthcare Systems, Inc. Multi-user remote health monitoring system
US7624028B1 (en) 1992-11-17 2009-11-24 Health Hero Network, Inc. Remote health monitoring and maintenance system
US6968375B1 (en) * 1997-03-28 2005-11-22 Health Hero Network, Inc. Networked system for interactive communication and remote monitoring of individuals
US5307263A (en) 1992-11-17 1994-04-26 Raya Systems, Inc. Modular microprocessor-based health monitoring system
US20010011224A1 (en) 1995-06-07 2001-08-02 Stephen James Brown Modular microprocessor-based health monitoring system
WO2001037174A1 (en) 1992-11-17 2001-05-25 Health Hero Network, Inc. Method and system for improving adherence with a diet program or other medical regimen
SE9203570D0 (sv) * 1992-11-27 1992-11-27 Astra Ab Inhaler for multiple use
US5970973A (en) * 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US6024090A (en) * 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5724957A (en) * 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5507277A (en) 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5873358A (en) * 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
AUPM411494A0 (en) * 1994-02-25 1994-03-24 Central Sydney Area Health Service Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
CA2202884C (en) 1994-10-28 2009-01-06 Lester J. Lloyd Device and method of creating aerosolized mist of respiratory drug
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6782886B2 (en) 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US5622166A (en) * 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
US5829436A (en) * 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
US5753302A (en) * 1996-04-09 1998-05-19 David Sarnoff Research Center, Inc. Acoustic dispenser
US5968913A (en) * 1996-07-03 1999-10-19 Inspire Pharmaceuticals, Inc. Pharmaceutical compositions of uridine triphosphate
US5770152A (en) * 1996-11-18 1998-06-23 Aradigm Corporation Collapsible container for measuring particles in a sample fluid
US6694975B2 (en) 1996-11-21 2004-02-24 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5906202A (en) * 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US6131570A (en) * 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
SE9700424D0 (sv) 1997-02-07 1997-02-07 Astra Ab Powder inhaler
US6192882B1 (en) 1997-02-24 2001-02-27 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US5829435A (en) * 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US5855564A (en) * 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
NL1006813C1 (nl) * 1997-08-20 1998-01-21 Sipke Wadman Verpakkingen voor een vast reactie-draagmedium.
US6237590B1 (en) * 1997-09-18 2001-05-29 Delsys Pharmaceutical Corporation Dry powder delivery system apparatus
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6946117B1 (en) * 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
EP1149602B1 (de) 1997-11-19 2015-01-07 Aptar France SAS Sprühvorrichtung für einen für die Atemtherapie geeigneten Inhalator
US6116238A (en) * 1997-12-02 2000-09-12 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
US6158431A (en) * 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US7244714B1 (en) * 1998-06-12 2007-07-17 Aradigm Corporation Methods of delivering aerosolized polynucleotides to the respiratory tract
WO1999064094A1 (en) * 1998-06-12 1999-12-16 Aradigm Corporation Methods of delivering aerosolized polynucleotides to the respiratory tract
US6260549B1 (en) 1998-06-18 2001-07-17 Clavius Devices, Inc. Breath-activated metered-dose inhaler
BR9912672A (pt) 1998-08-18 2002-06-11 Univ California Prevenção de produção de muco no trato respiratório por administração de antagonistas de egf-r
FR2783431B1 (fr) * 1998-09-23 2001-02-02 System Assistance Medical Nebuliseur permettant de delivrer un brouillard a un patient et procede de fonctionnement d'un tel nebuliseur
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6354516B1 (en) 1999-11-02 2002-03-12 Aradigm Corporation Pore structures for reduced pressure aerosolization
US6070575A (en) * 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
WO2000029167A1 (en) * 1998-11-16 2000-05-25 Aradigm Corporation Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs
ES2149748T3 (es) 1998-12-01 2007-06-16 Microflow Engineering Sa Inhalador con nebulizador de ondas ultrasonicas que presenta unas aberturas de boquilla superpuestas sobre las crestas de un patron de onda estacionaria.
GB0114272D0 (en) * 2001-06-12 2001-08-01 Optinose As Nasal delivery device
US6223744B1 (en) 1999-03-16 2001-05-01 Multi-Vet Ltd. Wearable aerosol delivery apparatus
AU4979700A (en) 1999-05-03 2000-11-17 Battelle Memorial Institute Compositions for aerosolization and inhalation
US7258850B2 (en) * 1999-05-04 2007-08-21 Aradigm Corporation Methods and compositions for treating erectile dysfunction
US7148960B2 (en) * 1999-06-10 2006-12-12 Aradigm Corporation Method and device for non-destructive analysis of perforations in a material
US7301621B2 (en) * 1999-06-10 2007-11-27 Aradigm Corporation Method and device for non-destructive analysis of perforations in a material
US6624885B1 (en) 1999-06-10 2003-09-23 Aradigm Corporation Method and device for non-destructive analysis of perforation in a material
US6606992B1 (en) * 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US20080138294A1 (en) * 1999-07-16 2008-06-12 Igor Gonda Systems and methods for effecting cessation of tobacco use
US20080138398A1 (en) * 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
WO2001005459A1 (en) * 1999-07-16 2001-01-25 Aradigm Corporation System for effecting smoke cessation
US20080138399A1 (en) * 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
US8256433B2 (en) * 1999-07-16 2012-09-04 Aradigm Corporation Systems and methods for effecting cessation of tobacco use
US6730066B1 (en) * 1999-08-03 2004-05-04 Pharmacia Ab Liquid delivery container
GB9920839D0 (en) * 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
TR200200645T2 (tr) * 1999-09-13 2002-07-22 Sheffield Pharmaceuticals, Inc. Akış kontrolü ve filtre yöntemi ve aygıtı.
AU781452B2 (en) 1999-09-15 2005-05-26 Aradigm Corporation Pore structures for reduced pressure aerosolization
EP1747816A3 (de) * 1999-09-15 2007-02-14 Aradigm Corporation Poren Struktur zur Niederdruckzerstäubung
US6547468B2 (en) 2001-06-22 2003-04-15 The Procter & Gamble Company Dosing reservoir
US6679256B2 (en) * 1999-12-17 2004-01-20 Nektar Therapeutics Systems and methods for extracting powders from receptacles
US6295986B1 (en) 2000-01-12 2001-10-02 Aradigm Corporation Reactive ion etching method of fabricating nozzles for aerosolized delivery of therapeutic or diagnostic agents
US7171965B2 (en) * 2000-02-01 2007-02-06 Valois S.A.S. Breath actuated dry powder inhaler and tape dose strip
WO2001072605A1 (en) * 2000-03-27 2001-10-04 Dura Pharmaceuticals, Inc. Containers for individual doses of an inhalable pharmaceutical
EP1280576B1 (de) * 2000-04-03 2010-05-05 Battelle Memorial Institute Ausgabevorrichtungen und flüssigformulierungen
US6948491B2 (en) * 2001-03-20 2005-09-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7600511B2 (en) * 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
MXPA02010884A (es) * 2000-05-05 2003-03-27 Aerogen Ireland Ltd Aparato y metodo para el suministro de medicamentos al sistema respiratorio.
US7971588B2 (en) * 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8336545B2 (en) * 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US8404217B2 (en) * 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
AU6124601A (en) 2000-05-10 2001-11-20 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7080644B2 (en) * 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US6543443B1 (en) 2000-07-12 2003-04-08 Aerogen, Inc. Methods and devices for nebulizing fluids
EP1301230A1 (de) * 2000-07-15 2003-04-16 Glaxo Group Limited Medikamentenspender
US20020106368A1 (en) * 2000-07-28 2002-08-08 Adrian Bot Novel methods and compositions to upregulate, redirect or limit immune responses to peptides, proteins and other bioactive compounds and vectors expressing the same
AUPR020400A0 (en) * 2000-09-19 2000-10-12 Glaxo Wellcome Australia Ltd Inhalation device
CA2425214A1 (en) * 2000-10-09 2003-04-08 Siemens Aktiengesellschaft Medicament dispenser
EP1343521A2 (de) * 2000-12-01 2003-09-17 Battelle Memorial Institute Verfahren zur stabilisierung von biomolekülen (z.b. insulin) in flüssigen formulierungen
US6482863B2 (en) 2000-12-15 2002-11-19 S. C. Johnson & Son, Inc. Insect repellant formulation deliverable by piezoelectric device
US7121275B2 (en) * 2000-12-18 2006-10-17 Xerox Corporation Method of using focused acoustic waves to deliver a pharmaceutical product
US8122880B2 (en) * 2000-12-18 2012-02-28 Palo Alto Research Center Incorporated Inhaler that uses focused acoustic waves to deliver a pharmaceutical product
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
US7225807B2 (en) 2001-03-15 2007-06-05 Creare Incorporated Systems and methods for aerosol delivery of agents
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US6732943B2 (en) * 2001-04-05 2004-05-11 Aradigm Corporation Method of generating uniform pores in thin polymer films
SE0101233L (sv) * 2001-04-05 2002-10-01 Microdrug Ag Förfarande och anordning för frigörande av pulver och inhalatoranordning för administrering av medicinskt pulver
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
US6554201B2 (en) 2001-05-02 2003-04-29 Aerogen, Inc. Insert molded aerosol generator and methods
US6732944B2 (en) * 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US20070122353A1 (en) * 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US6759029B2 (en) * 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
EP1392258B1 (de) 2001-05-24 2008-11-26 Alexza Pharmaceuticals, Inc. Verabreichung von alprazolam, estazolam, midazolam oder triazolam durch inhalation
US6805853B2 (en) 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
GB0125134D0 (en) * 2001-10-19 2001-12-12 Glaxo Group Ltd Medicament dispenser
EP1455875A2 (de) * 2001-11-21 2004-09-15 Alexza Molecular Delivery Corporation Offenzellige substrate für zur arzneimittelverabreichung
AU2002363947A1 (en) 2001-11-21 2003-07-24 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US20030168057A1 (en) * 2001-12-14 2003-09-11 Inhale Therapeutic Systems, Inc. Electronically controllable aerosol delivery
EP1455784A1 (de) * 2001-12-17 2004-09-15 Aryx Therapeutics Schmerzmittelabgabesystem und verfahren zur verwendung desselbigen
WO2003051367A1 (en) * 2001-12-18 2003-06-26 Alexza Molecular Delivery Corporation Parental analgesic formulations comprising fentanyl and a cannabinoid receptor agonist
JP2005514393A (ja) * 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US20050205089A1 (en) * 2002-01-07 2005-09-22 Aerogen, Inc. Methods and devices for aerosolizing medicament
WO2003057291A1 (en) * 2002-01-07 2003-07-17 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US7677467B2 (en) * 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
WO2003059424A1 (en) 2002-01-15 2003-07-24 Aerogen, Inc. Methods and systems for operating an aerosol generator
AU2003209475A1 (en) * 2002-03-07 2003-09-16 Vectura Limited Fast melt multiparticulate formulations for oral delivery
GB0209526D0 (en) * 2002-04-26 2002-06-05 Glaxo Group Ltd Medicament dispenser
EP1499276A2 (de) * 2002-04-29 2005-01-26 Glaxo Group Limited Warnsystem
GB0209783D0 (en) * 2002-04-29 2002-06-05 Glaxo Group Ltd Medicament dispenser
US7118010B2 (en) * 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6889690B2 (en) 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US6985798B2 (en) * 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
WO2003094900A1 (en) 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US6915962B2 (en) * 2002-05-20 2005-07-12 Aerogen, Inc. Apparatus for providing aerosol for medical treatment and methods
US20070044792A1 (en) * 2005-08-30 2007-03-01 Aerogen, Inc. Aerosol generators with enhanced corrosion resistance
WO2004002395A2 (en) * 2002-06-27 2004-01-08 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluating non-pharmaceutical dry powders
US7025754B2 (en) * 2002-07-01 2006-04-11 Ventaira Pharmaceuticals, Inc. Drug containment system
US20040055595A1 (en) * 2002-09-19 2004-03-25 Noymer Peter D. Aerosol drug delivery system employing formulation pre-heating
US6962266B2 (en) * 2002-10-04 2005-11-08 Ecolab Inc. Method and apparatus for using a unit dose dispenser
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US7185650B2 (en) * 2002-12-19 2007-03-06 Arie Huber Systems and methods for determining a minimum effective dose of an inhaled drug for an individual patient at a given time
WO2004066705A2 (en) * 2003-01-24 2004-08-12 University Of Virginia Patent Foundation Non-invasive drug self-administration system for animals
US6933026B2 (en) * 2003-02-06 2005-08-23 Aradgim Corporation Method to reduce damage caused by irradiation of halogenated polymers
GB2398254B (en) * 2003-02-11 2005-12-07 Bespak Plc Dispensing Apparatus
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
GB0303870D0 (en) * 2003-02-20 2003-03-26 Norton Healthcare Ltd Pre-metered dose magazine for breath-actuated dry powder inhaler
GB0308771D0 (en) * 2003-04-16 2003-05-21 Univ Loughborough Pulmonary drug delivery
DE10319646B3 (de) * 2003-05-02 2004-09-02 Hilti Ag Treibmittelbehälter für Setzgeräte und brennkraftbetriebenes Setzgerät
US7726308B1 (en) * 2003-05-09 2010-06-01 Maurino Flora Apparatus and method for respiratory drug delivery
US6971385B1 (en) * 2003-05-09 2005-12-06 Maurino Flora Apparatus and method for respiratory drug delivery
AU2004240629B2 (en) * 2003-05-16 2010-02-25 Arriva Pharmaceuticals, Inc. Treatment of respiratory disease by inhalation of synthetic matrix metalloprotease inhibitors
GB0311461D0 (en) 2003-05-19 2003-06-25 Glaxo Group Ltd Display system
WO2004104490A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
US8616195B2 (en) * 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7451761B2 (en) 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7877268B2 (en) * 2003-11-13 2011-01-25 Avinash Uttamrao Kulkarni Intelligent pill box
EP1711220A1 (de) * 2004-01-16 2006-10-18 Biodel, Inc. Sublinguale arzneimittelabgabevorrichtung
US7607435B2 (en) * 2004-01-21 2009-10-27 Battelle Memorial Institute Gas or liquid flow sensor
CA2554068A1 (en) * 2004-02-06 2005-08-25 Microdose Technologies, Inc. A blister pack for use with an inhalation device
CA2554136C (en) * 2004-02-24 2013-05-28 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
IN2014DN01746A (de) * 2004-04-02 2015-07-10 Government Of The Us Secretary Of The Dept Of Health And Human Services Ct S For Disease Control And
CA2561403C (en) * 2004-04-20 2015-12-01 Aerogen, Inc. Aerosol delivery apparatus for pressure assisted breathing
US7290541B2 (en) * 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7267121B2 (en) * 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
CA2563365A1 (en) * 2004-04-23 2005-11-03 Mystic Pharmaceuticals, Inc. Multiple unit dose drug delivery system
DE102004025136A1 (de) * 2004-05-17 2005-12-15 Körber Ag Spendervorrichtung, Produktträger sowie Packungseinheit aus Produktträger und Spendervorrichtung
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
FR2872798B1 (fr) * 2004-07-09 2007-10-05 Valois Sas Ensemble de blisters pour dispositif d'inhalation
EP1785155A1 (de) * 2004-08-02 2007-05-16 Canon Kabushiki Kaisha Chemische flüssigkeitskartusche und diese verwendendes inhalationsgerät
US7581540B2 (en) * 2004-08-12 2009-09-01 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
GB0418738D0 (en) * 2004-08-23 2004-09-22 3M Innovative Properties Co Medicinal aerosol formulation receptacle and production thereof
US8210171B2 (en) * 2004-09-13 2012-07-03 Oriel Therapeutics, Inc. Tubular dry powder drug containment systems, associated inhalers and methods
WO2006037636A2 (en) * 2004-10-06 2006-04-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing powder
GB0422413D0 (en) * 2004-10-08 2004-11-10 Breath Ltd High efficiency nebulisation
WO2006047663A2 (en) * 2004-10-26 2006-05-04 The University Of North Carolina At Chapel Hill Aerosol generation of therapeutic agents
GB0428169D0 (en) * 2004-12-23 2005-01-26 3M Innovative Properties Co Pressurized inhalation devices
US20060173267A1 (en) * 2004-12-27 2006-08-03 Aprius Medical Service, Inc. Method and device for administering health care remotely
FR2881119B1 (fr) * 2005-01-25 2010-07-30 Valois Sas Dispositif de distribution de produit fluide.
GB2423199B (en) * 2005-02-11 2009-05-13 Pa Consulting Services Power supply systems for electrical devices
EA012656B1 (ru) * 2005-05-25 2009-12-30 Аэроджен, Инк. Вибрационные системы и их применение
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
US20070012316A1 (en) * 2005-07-14 2007-01-18 Joann Truza Disposable compact rescue inhaler
EP1934805A4 (de) * 2005-08-25 2017-01-11 Oriel Therapeutics, Inc. Medikamentenbehältersysteme mit sticks, diesbezügliche kits, trockenpulver-inhalierer und verfahren
EP1931495A4 (de) * 2005-10-03 2009-08-26 Aradigm Corp Verfahren und system zur laserbearbeitung
PL1962805T3 (pl) 2005-12-08 2017-01-31 Insmed Incorporated Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych
US7958887B2 (en) 2006-03-10 2011-06-14 Aradigm Corporation Nozzle pore configuration for intrapulmonary delivery of aerosolized formulations
US20070221065A1 (en) * 2006-03-23 2007-09-27 Adisorn Aroonwilas Heat recovery gas absorption process
EP1844807A1 (de) 2006-04-13 2007-10-17 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Medikamentenmagazin, sowie Vorrichtung und Verfahren zum Öffnen desselben; Mehrdosispulverinhalator
US9539303B2 (en) * 2006-04-24 2017-01-10 Celgene Corporation Treatment of Ras-expressing tumors
ES2707548T3 (es) 2006-05-15 2019-04-04 United Therapeutics Corp Administración de treprostinil utilizando un inhalador de dosis medida
DE102006026786A1 (de) 2006-06-07 2007-12-13 Joachim Kern Dosierinhalator
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド スマートな非経口送達システム
CA2657435A1 (en) 2006-07-10 2008-07-03 Medipacs, Inc. Super elastic epoxy hydrogel
US20080025871A1 (en) * 2006-07-27 2008-01-31 The Regents Of The University Of California Low-loss storage system for liquid slurries of small particles
KR20090077914A (ko) 2006-09-11 2009-07-16 쿠리스 인코퍼레이션 항증식제로서의 다작용성 소분자
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8071127B2 (en) * 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
FR2909644B1 (fr) * 2006-12-11 2011-03-04 Valois Sas Dispositif de distribution de produit fluide
FR2909643B1 (fr) * 2006-12-11 2011-03-04 Valois Sas Dispositif de distribution de produit fluide
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
JP2010515541A (ja) 2007-01-09 2010-05-13 ミスティック ファーマシューティカルズ， インコーポレイテッド 経鼻カートリッジデバイス
EP2121088B1 (de) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung
GB0708758D0 (en) 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
DE102007023012A1 (de) * 2007-05-15 2008-11-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber und Filter
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US9248076B2 (en) 2007-05-16 2016-02-02 Mystic Pharmaceuticals, Inc. Dose dispensing containers
CA2688689C (en) 2007-05-16 2015-06-30 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
EP2157992B1 (de) 2007-06-15 2016-12-14 iDTx Systems, Inc. Arzneimittelabgabe- und überwachungssystem für einen ventilator
GB0713876D0 (en) * 2007-07-18 2007-08-29 3M Innovative Properties Co Manufacture of components for medicinal dispensers
CN103707452B (zh) 2007-09-14 2017-05-03 神秘制药公司 深冲压容器形成方法
EP2042208A1 (de) * 2007-09-25 2009-04-01 Boehringer Ingelheim Pharma GmbH & Co. KG Abgabevorrichtung
EP2207890A4 (de) * 2007-10-05 2010-12-15 Barofold Inc Hochdruckbehandlung aggregierter interferone
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
WO2009073734A2 (en) 2007-12-03 2009-06-11 Medipacs, Inc. Fluid metering device
DE102007063535A1 (de) * 2007-12-21 2009-06-25 Cycnad Gmbh & Co. Kg Pharmazeutische Zusammensetzung zur Prophylaxe und/oder symptomatischen Behandlung von zystischer Fibrose
EP2077132A1 (de) * 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Abgabevorrichtung, Aufbewahrungsvorrichtung und Verfahren zur Abgabe einer Formulierung
EP2257172A4 (de) * 2008-02-26 2013-07-03 Elevation Pharmaceuticals Inc Verfahren und system zur behandlung der chronisch obstruktiver lungenerkrankung durch verabreichung zerstäubter anticholinergika
US20100055045A1 (en) 2008-02-26 2010-03-04 William Gerhart Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
WO2009111612A1 (en) * 2008-03-07 2009-09-11 Novartis Ag Aerosolization device
FR2930163B1 (fr) * 2008-04-16 2010-05-21 Valois Sas Dispositif de distribution de produit fluide.
US8251876B2 (en) 2008-04-22 2012-08-28 Hill-Rom Services, Inc. Breathing exercise apparatus
WO2009131694A1 (en) * 2008-04-23 2009-10-29 Anthony Alexander Porous medical dorsal column self anchoring lead
JP5339842B2 (ja) 2008-10-06 2013-11-13 キヤノン株式会社 吐出ヘッド及び液滴吐出装置
WO2010042036A1 (en) * 2008-10-08 2010-04-15 Astrazeneca Ab Inhaler with audible indicator means
CN102405044A (zh) 2009-02-06 2012-04-04 南加利福尼亚大学 含有单萜的治疗组合物
WO2010093292A1 (en) * 2009-02-11 2010-08-19 Saab Ab Decoy material package, a dispenser and a method for dispensing decoy material
WO2010096242A1 (en) * 2009-02-18 2010-08-26 Aradigm Corporation Ph-modulated formulations for pulmonary delivery
KR101411889B1 (ko) 2009-02-27 2014-06-27 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염 바이러스 억제제
JP2010207297A (ja) * 2009-03-09 2010-09-24 Canon Inc 液体吐出装置及び液体吐出方法
WO2010105776A1 (en) * 2009-03-17 2010-09-23 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
EP3508239B1 (de) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
MY159925A (en) * 2009-05-21 2017-02-15 Microdose Therapeutx Inc Rotary cassette system for dry powder inhaler
DK2445502T4 (da) 2009-06-25 2022-11-28 Alkermes Pharma Ireland Ltd Heterocycliske forbindelser til behandling af neurologiske og psykologiske lidelser
JP2012531961A (ja) * 2009-07-01 2012-12-13 アストラゼネカ・アクチエボラーグ 粉末を気流に引き込むためのディスペンサーおよび方法
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US9180263B2 (en) * 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
WO2011008737A2 (en) 2009-07-13 2011-01-20 The University Of North Carolina At Chapel Hill Engineered aerosol particles, and associated methods
US9238102B2 (en) 2009-09-10 2016-01-19 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
EP2477642A4 (de) * 2009-09-17 2013-03-13 Mutual Pharmaceutical Co Verfahren zur behandlung von asthma mit antivirusmitteln
TR200908847A2 (tr) 2009-11-23 2011-06-21 Bi̇lgi̇ç Mahmut Kuru toz formunda ilaç taşıyan blister ambalaj.
UA107097C2 (en) 2009-11-25 2014-11-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Dispenser
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
WO2011085022A1 (en) * 2010-01-05 2011-07-14 Microdose Therapeutx, Inc. Inhalation device and method
AU2010339689B2 (en) 2010-01-07 2015-02-19 Alkermes Pharma Ireland Limited Quaternary ammonium salt prodrugs
US10857311B2 (en) 2010-01-12 2020-12-08 Omega Life Science Ltd. Method and apparatus for producing fine concentrated aerosol
US20110182831A1 (en) * 2010-01-25 2011-07-28 Aradigm Corporation Systems and methods used in conjunction with nicotine vaccines for effecting cessation of tobacco use
CN102905612A (zh) 2010-02-01 2013-01-30 普罗秋斯数字健康公司 双腕式数据采集系统
JP5841951B2 (ja) 2010-02-01 2016-01-13 プロテウス デジタル ヘルス， インコーポレイテッド データ収集システム
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
CN102892289B (zh) 2010-03-03 2015-03-25 尼昂克技术公司 包含单萜的药物组合物
US8869793B1 (en) 2010-05-18 2014-10-28 Idtx Systems, Inc. Compact self-contained automated MDI adapters or units for ventilators
EP2585151B1 (de) 2010-06-24 2018-04-04 Boehringer Ingelheim International GmbH Vernebler
CA2802733C (en) 2010-06-24 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
US20160038600A1 (en) 2012-08-03 2016-02-11 Neonc Technologies Inc. Pharmaceutical compositions comprising poh derivatives
CN103168018B (zh) 2010-08-27 2015-10-21 尼昂克技术公司 包含poh衍生物的药物组合物
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
EP2651864B1 (de) 2010-12-17 2016-07-13 Neonc Technologies Inc. Verfahren und vorrichtungen zur verwendung von isoperillylalkohol
CA2822447C (en) 2010-12-23 2018-05-01 Alkermes Pharma Ireland Limited Multi-api loading prodrugs
TWI574687B (zh) 2011-01-03 2017-03-21 古利斯股份有限公司 具有鋅結合部份之刺蝟拮抗劑
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
ES2733128T3 (es) 2011-04-01 2019-11-27 Curis Inc Inhibidor de fosfoinosítido 3-quinasa con un resto de unión a cinc
CN104053530B (zh) * 2011-04-29 2016-10-19 提克纳有限责任公司 用于浸渍纤维粗纱的具有流动扩散浇注通路的模具和方法
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US8969337B2 (en) 2011-12-15 2015-03-03 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
AU2012337241B2 (en) 2011-12-30 2016-10-13 Grifols, S.A. Alpha1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations
US9180271B2 (en) 2012-03-05 2015-11-10 Hill-Rom Services Pte. Ltd. Respiratory therapy device having standard and oscillatory PEP with nebulizer
JP2015510956A (ja) 2012-03-14 2015-04-13 メディパックス インコーポレイテッド 過剰反応性分子を含むスマートポリマー材料
US9682093B2 (en) 2012-03-30 2017-06-20 Charles R. Drew University Of Medicine And Science Compositions and methods for treating or preventing metabolic syndrome disorders
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
ES2743039T3 (es) 2012-11-29 2020-02-18 Insmed Inc Formulaciones de vancomicina estabilizada
US20150313915A1 (en) 2012-11-30 2015-11-05 The Regents Of The University Of California Anticonvulsant activity of steroids
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
WO2015018904A1 (en) 2013-08-09 2015-02-12 Boehringer Ingelheim International Gmbh Nebulizer
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
GB201316314D0 (en) * 2013-09-13 2013-10-30 The Technology Partnership Plc Fluid management for vibration perforate membrane spray systems
WO2015042412A1 (en) 2013-09-20 2015-03-26 E-Nicotine Technology. Inc. Devices and methods for modifying delivery devices
CA2924772A1 (en) 2013-10-01 2015-04-09 Novartis Ag Blister track inhaler device having a separate end path and methods of use thereof
US9987227B2 (en) 2013-10-22 2018-06-05 Aradigm Corporation Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile
US10821240B2 (en) 2014-02-11 2020-11-03 Vapor Cartridge Technology Llc Methods and drug delivery devices using cannabis
US9220294B2 (en) 2014-02-11 2015-12-29 Timothy McCullough Methods and devices using cannabis vapors
US9380813B2 (en) 2014-02-11 2016-07-05 Timothy McCullough Drug delivery system and method
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
KR20160138494A (ko) 2014-03-31 2016-12-05 데비오팜 인터네셔날 에스 에이 Fgfr 융합물
EP3129008A4 (de) 2014-04-08 2017-09-06 Aradigm Corporation Liposome, die nach dem gefrieren und auftauen arzneimittelnanokristalle bilden
US9532986B2 (en) 2014-04-08 2017-01-03 Aradigm Corporation Liposomal ciprofloxacin formulations with activity against non-tuberculous mycobacteria
US10173025B2 (en) 2014-04-21 2019-01-08 Idtx Systems, Inc. Automated drug delivery systems
KR102492824B1 (ko) 2014-05-07 2023-01-30 베링거 인겔하임 인터내셔날 게엠베하 분무기, 표시 디바이스 및 컨테이너
WO2015169430A1 (en) 2014-05-07 2015-11-12 Boehringer Ingelheim International Gmbh Nebulizer
US10238675B2 (en) 2014-05-15 2019-03-26 Insmed Incorporated Methods for treating pulmonary non-tuberculous mycobacterial infections
US10857313B2 (en) * 2014-07-01 2020-12-08 Aerami Therapeutics, Inc. Liquid nebulization systems and methods
US10065788B2 (en) * 2014-07-08 2018-09-04 Medipense Inc. Pill dispenser with cylindrical package holder for array-type packages
EP4112071A1 (de) 2014-08-26 2023-01-04 HSF Pharmaceuticals Neuartige immunisierungsmittel und verfahren zur verwendung
JP6739424B2 (ja) * 2014-10-13 2020-08-12 オメガ ライフ サイエンス リミテッド 噴霧器およびその使用
US10561814B2 (en) 2014-11-19 2020-02-18 Idtx Systems, Inc. Automated drug dispensing systems with automated HME bypass for ventilator circuits
EP3244914A4 (de) 2015-01-16 2018-08-15 The J. David Gladstone Institutes Verfahren zur behandlung von tauopathie
KR20170131405A (ko) 2015-02-12 2017-11-29 네온씨 테크놀로지스, 아이엔씨. 페릴릴 알코올 유도체를 포함하는 의약 조성물
AU2016225111B2 (en) 2015-02-27 2021-12-09 Board Of Regents, The University Of Texas System Polypeptide therapeutics and uses thereof
DK3268072T3 (da) 2015-03-11 2024-01-22 Alexza Pharmaceuticals Inc Anvendelse af antistatiske materialer i luftvejen til termisk aerosolkondensationsproces
JP6480598B2 (ja) 2015-04-02 2019-03-13 ヒル−ロム サービシーズ プライヴェート リミテッド 呼吸装置用マニホールド
US20180207390A1 (en) * 2015-07-20 2018-07-26 Medical Developments International Limited Inhaler device for inhalable liquids
KR102641177B1 (ko) * 2015-07-20 2024-02-26 펄 테라퓨틱스 인코포레이티드 에어로졸 전달 시스템 및 관련 방법
US20190046436A1 (en) * 2016-02-29 2019-02-14 Nicogen Ltd. Nicotine formulation and aerosols
US11597708B2 (en) 2016-09-16 2023-03-07 Hsf Pharmaceuticals Sa Inhibitors of heat shock factors and uses thereof
EP3297131A1 (de) 2016-09-19 2018-03-21 Siemens Aktiengesellschaft Stator für eine elektrische rotierende maschine
CA3039908A1 (en) * 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
WO2018071435A1 (en) * 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
JP7144411B2 (ja) 2016-11-30 2022-09-29 ネオンク テクノロジーズ インク． ペリリルアルコール－３－ブロモピルベート複合体及びがんの治療方法
US10799653B2 (en) 2017-01-09 2020-10-13 United Therapeutics Corporation Aerosol delivery device and method for manufacturing and operating the same
CA3067858A1 (en) 2017-06-20 2018-12-27 Respirion Pharmaceuticals Pty Ltd Method for reducing lung infection
JP2020524173A (ja) 2017-06-20 2020-08-13 レスピリオン・ファーマシューティカルズ・プロプライエタリー・リミテッド 肺炎症を低減させる方法
WO2019071008A1 (en) 2017-10-04 2019-04-11 Pneuma Respiratory, Inc. ELECTRONIC DEVICE FOR DELIVERY OF LINEAR SHAPE ADMINISTRATION OPERATED BY BREATHING AND METHODS OF USE
EP4344719A2 (de) * 2017-10-17 2024-04-03 Pneuma Respiratory, Inc. Nasale arzneimittelabgabevorrichtung und verwendungsverfahren
JP2021502178A (ja) 2017-11-08 2021-01-28 ニューマ・リスパイラトリー・インコーポレイテッド 小容積アンプルを有して呼吸により電気的に作動するインライン液滴送達装置および使用方法
CA3225993A1 (en) 2018-02-08 2019-08-15 University Of Southern California The use of monoterpene, sesquiterpene, or their derivatives to permeabilize the blood brain barrier
DE102018103937A1 (de) * 2018-02-21 2019-08-22 Fresenius Medical Care Deutschland Gmbh Vorrichtung enthaltend Dialyselösung oder Dialyselösungskonzentrat
EP3762024A1 (de) 2018-03-08 2021-01-13 HSF Pharmaceuticals Lokalisierte aktivierung herpesvirus-vektorierter impfstoffe als virusreplikationsbooster
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
EP3790527A4 (de) * 2018-05-08 2022-03-02 Omega Life Science Ltd Zerstäuber, zerstäuberkartuschen und verwendungen davon
JP2021523269A (ja) 2018-05-10 2021-09-02 シーアイエス ファーマ アクツィエンゲゼルシャフトＣＩＳ Ｐｈａｒｍａ ＡＧ 複数の活性剤分子を含む生体適合コポリマー
BR112021004404A2 (pt) 2018-09-10 2021-08-03 Lung Therapeutics, Inc. fragmentos de peptídeos modificados da proteína cav-1 e o uso destes no tratamento de fibrose
BR112021004371A2 (pt) 2018-09-11 2021-05-25 Curis Inc. terapia em combinação com um inibidor de fosfoinositídeo 3-quinase com uma porção de ligação a zinco
EP3628355A1 (de) * 2018-09-27 2020-04-01 Ttp Plc. Kartusche für ein aerosolabgabesystem
EP3628354A1 (de) * 2018-09-27 2020-04-01 Ttp Plc. Aerosolabgabesystem mit perforierter membran
EP3653716A1 (de) 2018-11-19 2020-05-20 HSF Pharmaceuticals Replikationskompetente gesteuerte alpha-herpesvirus-virusvektoren und verwendungen davon
PE20212261A1 (es) 2019-03-14 2021-11-29 Om Pharma Sa Extractos bacterianos estables como farmacos
CA3154135A1 (en) 2019-09-16 2021-03-25 Vapor Cartridge Technology Llc Drug delivery system with stackable substrates
EP4051320A1 (de) 2019-10-30 2022-09-07 CIS Pharma AG Biokompatible polymere arzneimittelträger zur abgabe von wirkstoffen
KR102199036B1 (ko) * 2020-01-13 2021-01-08 서울공간정보 주식회사 실시간 조위관측을 위한 초음파 측정기
WO2021191266A1 (en) 2020-03-25 2021-09-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Aerosolization of hdl for the treatment of lung infections
EP3892275A1 (de) 2020-04-08 2021-10-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Aerosolisierung von hcq oder dessen metaboliten zur behandlung von lungeninfektionen
AU2021255621A1 (en) 2020-04-17 2022-10-20 United Therapeutics Corporation Treprostinil for use in the treatment of intersitial lung disease
WO2021214279A1 (en) 2020-04-24 2021-10-28 Hsf Pharmaceuticals Replication-competent controlled herpesviruses expressing a sars cov-2 antigen
CN112237676B (zh) * 2020-10-16 2022-12-13 南京青龙水务有限公司 一种可规避交叉感染的外用药膏涂抹器
EP4359046A1 (de) 2021-06-22 2024-05-01 Pneuma Respiratory, Inc. Tröpfchenabgabevorrichtung mit schubausstoss
WO2023006993A1 (en) 2021-07-30 2023-02-02 Atmosr Fused amino pyridine or pyrimidine derivatives for the treatment of congenital central hypoventilation syndrome

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE530625C (de) * 1927-05-17 1931-07-30 Julius Baggesen Vorrichtung zur Abhaltung von Erschuetterungen, die vom Strassenbetrieb herruehren, an Gebaeuden
GB546607A (en) * 1940-08-14 1942-07-21 British Thomson Houston Co Ltd Improvements in and relating to air conditioning apparatus
US2598823A (en) * 1947-12-04 1952-06-03 O'grady Austin Peter Joseph Inhalant preparation
US3121021A (en) * 1960-04-18 1964-02-11 Minnesota Mining & Mfg Breathable surgical adhesive tapes
US3187748A (en) * 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
DK121618B (da) * 1965-08-13 1971-11-08 Sumitomo Chemical Co Fremgangsmåde til laminering af en folie eller film, der består af polyethylen eller -propylen, på en gaze.
US3301392A (en) * 1965-11-24 1967-01-31 Ethicon Inc Nested package
DE1575050A1 (de) * 1966-01-12 1972-04-13 Misto Gen Equipment Co Ultraschall-Nebelerzeugungsgeraet
DE1813993C3 (de) * 1968-12-11 1974-01-24 Paul Ritzau Pari-Werk Kg, 8135 Soecking Vorrichtung zum Zerstäuben und Vernebeln von flüssigen oder pulverförmigen Stoffen
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3635567A (en) * 1969-12-31 1972-01-18 Thomas F Richardson Jr Package and applicator unit
NO134730L (de) * 1971-07-19 1900-01-01
GB1413285A (en) * 1971-11-25 1975-11-12 Bespak Industries Ltd Aerosol devices
US3840009A (en) * 1971-12-27 1974-10-08 Alza Corp Self-powered vapor pressure delivery device
US3757782A (en) * 1972-06-05 1973-09-11 Vivian C Aiken Fluid pressurizable swab applicator for medicament, antiseptic or the like
US3870593A (en) * 1972-06-06 1975-03-11 Minnesota Mining & Mfg Stretch-oriented porous films and preparation and use thereof
US3812854A (en) * 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
US3903335A (en) * 1973-04-27 1975-09-02 Mardon Flexible Packaging Ltd Heat sealed package
US3888247A (en) * 1973-10-10 1975-06-10 Minnesota Mining & Mfg First aid bandage
US3991304A (en) * 1975-05-19 1976-11-09 Hillsman Dean Respiratory biofeedback and performance evaluation system
DE2537765B2 (de) * 1975-08-25 1981-04-09 Siemens AG, 1000 Berlin und 8000 München Medizinisches Inhalationsgerät zur Behandlung von Krankheiten der Atmungswege
GB1518998A (en) * 1975-08-28 1978-07-26 Gillette Co Packaging flowable materials
US4361401A (en) * 1978-05-22 1982-11-30 Instrumentation Laboratory Inc. Automatic sample deposition in flameless analysis
DE2835135C3 (de) * 1978-08-10 1982-03-04 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Wirkstoff-Speicher für ein Inhalationsgerät
DE2837040C2 (de) * 1978-08-24 1982-10-21 Siemens AG, 1000 Berlin und 8000 München Flüssigkeitstransportsystem für ein Inhalationsgerät
CA1097276A (en) * 1978-12-15 1981-03-10 Marcel J. H. Staar Package for storing and spraying small amounts of liquids
DE2854841C2 (de) * 1978-12-19 1981-03-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Flüssigkeitszerstäuber, vorzugsweise Inhalationsgerät
DE7917568U1 (de) * 1979-06-19 1979-09-20 Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart Inhalationsgeraet
JPS5623936A (en) * 1979-08-01 1981-03-06 Chest Corp Measuring apparatus of trachea hypersensitivity
CA1178191A (en) * 1980-10-06 1984-11-20 Naoyoshi Maehara Electric liquid atomizing apparatus
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
GB2104393B (en) * 1981-08-13 1984-11-07 Glaxo Group Ltd Medical inhalation devices
AU553251B2 (en) * 1981-10-15 1986-07-10 Matsushita Electric Industrial Co., Ltd. Arrangement for ejecting liquid
FR2516387A1 (fr) * 1981-11-16 1983-05-20 Fabre Sa Pierre Inhalateur liberant des quantites pre-dosees de principe actif volatil ou entrainable par un excipient volatil contenu dans des microcapsules reparties periodiquement sur un support, ainsi que ledit support et son procede de fabrication
FI79651C (fi) * 1982-10-08 1990-02-12 Glaxo Group Ltd Doseringsanordning foer medicin.
US4469255A (en) * 1982-11-19 1984-09-04 Cook International, Inc. Automatic and adjustable valving mechanism
CH662736A5 (fr) * 1983-01-14 1987-10-30 Firmenich & Cie Dispositif pour le parfumage d'air ambiant et d'enceintes fermees.
US4558820A (en) * 1983-04-25 1985-12-17 S. C. Johnson & Son, Inc. Vapor-dispensing device
US4604847A (en) * 1983-09-14 1986-08-12 Moulding Jr Thomas S Medicine package, method of opening the package, and machine for performing the method
DE3339832A1 (de) * 1983-11-01 1985-05-09 Reinhard 6361 Niddatal Napierski Elektrisches geraet zum verdampfen von wirkstoffen, insbesondere insektiziden
US4508749A (en) * 1983-12-27 1985-04-02 International Business Machines Corporation Patterning of polyimide films with ultraviolet light
EP0174033B1 (de) * 1984-09-07 1991-03-27 OMRON Corporation Schwingungserzeuger für ein Inhalationsgerät mit Ultraschallzerstäubung
NZ209900A (en) * 1984-10-16 1989-08-29 Univ Auckland Automatic inhaler
US4648393A (en) * 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
US4592348A (en) * 1984-12-17 1986-06-03 Waters Iv William C Aerosol inhaler
US4759782A (en) * 1985-07-05 1988-07-26 Pall Corporation Coalescing filter for removal of liquid aerosols from gaseous streams
US4803978A (en) * 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
NZ219021A (en) * 1986-01-27 1989-06-28 Gea Farmaceutisk Fabrik As Inhaler: medicine discharged intermittently during each inhalation
LU86368A1 (fr) * 1986-03-24 1987-11-11 Oreal Procede pour preparer et distribuer un produit comprenant au moins deux composants,et dispositif pour sa mise en oeuvre
US4790305A (en) * 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system
US4926852B1 (en) * 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
DE3627222A1 (de) * 1986-08-11 1988-02-18 Siemens Ag Ultraschall-taschenzerstaeubergeraet
ATE76311T1 (de) * 1986-08-19 1992-06-15 Genentech Inc Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen.
US4762124A (en) * 1986-10-28 1988-08-09 Kimberly-Clark Corporation Liquid dispensing pouch
US4896832A (en) * 1987-09-07 1990-01-30 Bespak Plc Dispensing apparatus for metered quantities of pressurised fluid
US4852582A (en) * 1987-09-11 1989-08-01 Pell Donald M Method and kit for measuring the effectiveness of bronchodilators
US4923169A (en) * 1987-12-23 1990-05-08 Siemens-Bendix Automotive Electronics L.P. Multi-stream thin edge orifice disks for valves
CH678151A5 (en) * 1988-07-13 1991-08-15 Heinz Hermann Weick Self-medication nasal dispenser
US4984158A (en) * 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
US5092466A (en) * 1988-10-21 1992-03-03 Large Scale Biology Corportion Apparatus and method for storing samples of protein gene products, insert-containing cells or dna
US4917301A (en) * 1988-11-15 1990-04-17 International Flavors & Fragrances, Inc. Container with microporous membrane for dispensing vapor from volatile liquid
EP0373237A1 (de) * 1988-12-13 1990-06-20 Siemens Aktiengesellschaft Inhalationsgerät, insbesondere Taschen-Inhalationsgerät
ES2087911T3 (es) * 1989-04-28 1996-08-01 Riker Laboratories Inc Dispositivo de inhalacion de polvo seco.
DK235589D0 (da) * 1989-05-12 1989-05-12 Wolff & Kaaber Fremgangsmaade og indretning til blanding af en fast og en flydende komponent
GB2236677A (en) * 1989-08-26 1991-04-17 Reckitt & Colmann Prod Ltd Device for the evaporation of volatile liquids
FR2651643B1 (fr) * 1989-09-11 1993-06-18 Rhone Poulenc Sante Systeme de liberation continue de la vitamine a dans l'eau d'alimentation.
IT1237118B (it) * 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5152456A (en) * 1989-12-12 1992-10-06 Bespak, Plc Dispensing apparatus having a perforate outlet member and a vibrating device
BE1003570A3 (fr) * 1990-01-26 1992-04-21 Dekeyser Michel Dispositif de stockage et de distribution de doses de matiere pateuse et son procede de realisation.
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
IT1243344B (it) * 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
US5115975A (en) * 1990-07-24 1992-05-26 Lynndon Shilling Dispenser device and cartridge for volatile substance with rate control for volatilization thereof
GB9016789D0 (en) * 1990-07-31 1990-09-12 Lilly Industries Ltd Medicament administering devices
DE4133274A1 (de) * 1991-08-22 1993-02-25 Boehringer Ingelheim Kg Vorrichtung zum atemzugsynchronen ausloesen eines mechanischen schaltvorganges
GB9023282D0 (en) * 1990-10-25 1990-12-05 Riker Laboratories Inc Inhalation device
GB9026025D0 (en) * 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
DE69127826T2 (de) * 1990-12-17 1998-04-09 Minnesota Mining & Mfg Inhalationsgerät
US5230867A (en) * 1991-04-05 1993-07-27 Waterbury Companies, Inc. Extended release fragrance dispensing cartridge
GB9109064D0 (en) * 1991-04-26 1991-06-12 Dunne Miller Weston Ltd Dispensing device
JPH06509958A (ja) * 1991-08-26 1994-11-10 ミネソタ　マイニング　アンド　マニュファクチャリング　カンパニー 粉末ディスペンサ
DE4128295A1 (de) * 1991-08-27 1993-03-04 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer fliessfaehige medien
DE4136826A1 (de) * 1991-11-08 1993-05-13 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
GB9123953D0 (en) * 1991-11-12 1992-01-02 Minnesota Mining & Mfg Inhalation device
GB9125699D0 (en) * 1991-12-03 1992-01-29 Glaxo Group Ltd Device
EP0558879B1 (de) * 1992-03-04 1997-05-14 Astra Aktiebolag Wegwerfinhalator
US5244482A (en) * 1992-03-26 1993-09-14 The University Of Tennessee Research Corporation Post-treatment of nonwoven webs
IL107120A (en) * 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
DE4236886C2 (de) * 1992-10-31 1997-11-20 Klocke Verpackungs Service Behälter zur Aufnahme von aromatischen Substanzen
JP3211525B2 (ja) * 1993-04-22 2001-09-25 オムロン株式会社 薄材メッシュ、その製造方法及びその製造装置
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations

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Publication number Publication date
US5823178A (en) 1998-10-20
DE69433380D1 (de) 2004-01-15
AU6956994A (en) 1994-12-20
EP0701457A4 (de) 1997-12-17
US6123068A (en) 2000-09-26
EP1366778B1 (de) 2008-10-15
US5660166A (en) 1997-08-26
WO1994027653A3 (en) 1995-02-09
US6014969A (en) 2000-01-18
EP0701457A1 (de) 1996-03-20
US5718222A (en) 1998-02-17
EP0701457B1 (de) 2003-12-03
AU690561B2 (en) 1998-04-30
EP1366778A3 (de) 2004-03-03
WO1994027653A2 (en) 1994-12-08
JP3375637B2 (ja) 2003-02-10
DE69433380T2 (de) 2004-09-16
EP1366778A2 (de) 2003-12-03
JPH09503723A (ja) 1997-04-15
US5544646A (en) 1996-08-13
US5497763A (en) 1996-03-12

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