DE69434739D1 - Menschliche knochen-morphogenetische proteine zur verwendung bei neuronaler regeneration - Google Patents

Menschliche knochen-morphogenetische proteine zur verwendung bei neuronaler regeneration

Info

Publication number
DE69434739D1
DE69434739D1 DE69434739T DE69434739T DE69434739D1 DE 69434739 D1 DE69434739 D1 DE 69434739D1 DE 69434739 T DE69434739 T DE 69434739T DE 69434739 T DE69434739 T DE 69434739T DE 69434739 D1 DE69434739 D1 DE 69434739D1
Authority
DE
Germany
Prior art keywords
bone morphogenetic
human bone
morphogenetic proteins
neural
neuronal regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434739T
Other languages
English (en)
Other versions
DE69434739T2 (de
Inventor
A Wang
Alessandro S D
Dean Toriumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
University of Illinois
University of Illinois at Urbana Champaign
Original Assignee
Genetics Institute LLC
University of Illinois
University of Illinois at Urbana Champaign
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC, University of Illinois, University of Illinois at Urbana Champaign filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of DE69434739D1 publication Critical patent/DE69434739D1/de
Publication of DE69434739T2 publication Critical patent/DE69434739T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
DE69434739T 1993-08-26 1994-08-19 Menschliche Knochen-morphogenetische Proteine zur Verwendung bei neuronaler Rehgeneration Expired - Lifetime DE69434739T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11249293A 1993-08-26 1993-08-26
US112492 1993-08-26
PCT/US1994/009330 WO1995005846A1 (en) 1993-08-26 1994-08-19 Neural regeneration using human bone morphogenetic proteins

Publications (2)

Publication Number Publication Date
DE69434739D1 true DE69434739D1 (de) 2006-06-22
DE69434739T2 DE69434739T2 (de) 2007-05-10

Family

ID=22344181

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434739T Expired - Lifetime DE69434739T2 (de) 1993-08-26 1994-08-19 Menschliche Knochen-morphogenetische Proteine zur Verwendung bei neuronaler Rehgeneration

Country Status (15)

Country Link
US (1) US5756457A (de)
EP (2) EP1716864A1 (de)
JP (3) JPH09501932A (de)
KR (2) KR100328752B1 (de)
AT (1) ATE326234T1 (de)
AU (1) AU677866B2 (de)
CA (1) CA2169191C (de)
DE (1) DE69434739T2 (de)
DK (1) DK0716610T3 (de)
ES (1) ES2265146T3 (de)
FI (1) FI960809A (de)
NO (1) NO960711D0 (de)
OA (1) OA10358A (de)
PT (1) PT716610E (de)
WO (1) WO1995005846A1 (de)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US6506729B1 (en) 1991-03-11 2003-01-14 Curis, Inc. Methods and compositions for the treatment and prevention of Parkinson's disease
US6723698B2 (en) 1991-03-11 2004-04-20 Curis, Inc. Methods and compositions for the treatment of motor neuron injury and neuropathy
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US20080070842A1 (en) * 1991-11-04 2008-03-20 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
ES2213745T3 (es) * 1993-05-12 2004-09-01 Genetics Institute, Llc Composiciones de bmp-11.
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
PT733109E (pt) * 1993-12-07 2006-07-31 Genetics Inst Llc Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao
WO1996030038A1 (en) * 1995-03-29 1996-10-03 The Rockefeller University Peptide growth factor having epidermal inducing activity
US7026292B1 (en) 1995-12-12 2006-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
WO1997034618A1 (en) 1996-03-22 1997-09-25 The General Hospital Corporation Administration of polypeptide growth factors following central nervous system ischemia or trauma
US5808011A (en) * 1996-07-01 1998-09-15 Biopure Corporation Method for chromatographic removal of prions
US6037519A (en) 1997-10-20 2000-03-14 Sdgi Holdings, Inc. Ceramic fusion implants and compositions
US10028851B2 (en) 1997-04-15 2018-07-24 Advanced Cardiovascular Systems, Inc. Coatings for controlling erosion of a substrate of an implantable medical device
US8172897B2 (en) 1997-04-15 2012-05-08 Advanced Cardiovascular Systems, Inc. Polymer and metal composite implantable medical devices
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
CN1273534A (zh) * 1997-08-04 2000-11-15 加利福尼亚大学董事会 治疗神经缺损的方法
US20010007657A1 (en) * 1997-08-04 2001-07-12 Reid James Steven Compositions and methods for manipulating glial progenitor cells and treating neurological deficits
US7795202B2 (en) * 1997-08-04 2010-09-14 Neurorepair, Inc. Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a)
WO1999024057A2 (en) * 1997-11-07 1999-05-20 Genetics Inst Neuronal uses of bmp-11
US20030170213A1 (en) * 1998-01-23 2003-09-11 Marc F. Charette Methods and compositions for enhancing cognitive function using morphogenic proteins
US5984926A (en) * 1998-02-24 1999-11-16 Jones; A. Alexander M. Bone screw shimming and bone graft containment system and method
ES2389387T3 (es) 1998-03-17 2012-10-25 Genentech, Inc. Polipéptidos homólogos de VEGF y de BMP1
US6294655B1 (en) 1998-04-03 2001-09-25 Hyseq, Inc. Anti-interleukin-1 receptor antagonist antibodies and uses thereof
US6541623B1 (en) 1998-04-03 2003-04-01 Hyseq, Inc. Interleukin—1 receptor antagonist and uses thereof
US6426191B1 (en) 1998-04-03 2002-07-30 Hyseq, Inc. Assays involving an IL-1 receptor antagonist
US7147839B2 (en) * 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
CA2336220A1 (en) * 1998-07-24 2000-02-03 The Carnegie Institution Of Washington Method for maintenance and propagation of germline stem cells using members of the tgf-.beta. family of growth factors
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906172C1 (de) * 1999-02-08 2000-07-13 Ethicon Gmbh Resorbierbares Implantat
WO2000064460A2 (en) * 1999-04-23 2000-11-02 Sulzer Orthopedics Ltd. Composition for enhancing functional recovery of a mammal from central and/or peripheral nervous system injury of traumatic or pathological origin
JP4828703B2 (ja) 1999-04-28 2011-11-30 ジェネティックス インスティテュート エルエルシー ヒトｇｉｌ−１９／ａｅ２８９タンパク質、及び、同タンパク質をコードするポリヌクレオチド
DK1054018T3 (da) 1999-05-18 2009-05-18 Dyax Corp Fab-fragmentbiblioteker og fremgangsmåde til anvendelse deraf
AU7355500A (en) * 1999-09-08 2001-04-10 Genetics Institute Inc. Bmp-9 compositions and methods for inducing differentiation of cholinergic neurons
EP1762244A1 (de) * 1999-09-08 2007-03-14 Genetics Institute, LLC Bmp-9 zusammensetzungen zur differenzierung der cholinergischen neuronen
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
US6368787B1 (en) 1999-12-16 2002-04-09 Stryker Corporation Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements
US6527801B1 (en) * 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US8109994B2 (en) 2003-01-10 2012-02-07 Abbott Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US20040087016A1 (en) * 2000-05-12 2004-05-06 University Of Utah Research Foundation Compositions and methods for cell dedifferentiation and tissue regeneration
AU2001264598B2 (en) * 2000-05-12 2006-07-06 University Of Utah Research Foundation Compositions and methods for tissue dedifferentiation and regeneration
CA2648046A1 (en) 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP2275549A1 (de) 2000-06-23 2011-01-19 Genentech, Inc. Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Erkrankungen in Verbindung mit Angiogenese
CZ301649B6 (cs) * 2000-06-28 2010-05-12 Ed. Geistlich Soehne Ag Fur Chemische Industrie Incorporated Under The Laws Of Switzerland Trubice pro regeneraci nervu a zpusob jejich výroby
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
JP3871525B2 (ja) * 2001-04-26 2007-01-24 ニプロ株式会社 生体組織または器官再生用器具
DK1399023T3 (da) * 2001-06-01 2008-08-18 Wyeth Corp Sammensætninger til systemisk indgivelse af sekvenser, der koder for knoglemorfogenese-proteiner
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
IL160188A0 (en) * 2001-08-13 2004-07-25 Univ Florida Materials and methods to promote repair of nerve tissue
US7285304B1 (en) 2003-06-25 2007-10-23 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US7989018B2 (en) 2001-09-17 2011-08-02 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US6863683B2 (en) 2001-09-19 2005-03-08 Abbott Laboratoris Vascular Entities Limited Cold-molding process for loading a stent onto a stent delivery system
US7320789B2 (en) * 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
WO2003072714A2 (en) * 2002-02-21 2003-09-04 Wyeth Follistatin domain containing proteins
KR20040094709A (ko) * 2002-02-21 2004-11-10 와이어쓰 폴리스타틴 도메인을 포함하는 단백질
WO2003099992A2 (en) * 2002-05-17 2003-12-04 Wyeth Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
ES2524444T3 (es) * 2002-06-27 2014-12-09 Roberto Beretta Método para preparar una lámina de fibrina sólida
WO2004014940A2 (en) * 2002-08-13 2004-02-19 Wyeth PEPTIDES AS SOLUBILIZING EXCIPIENTS FOR TRANSFORMING GROWTH FACTOR ß PROTEINS
EP2192129A1 (de) * 2002-09-16 2010-06-02 Johns Hopkins University Metalloproteaseaktivierung von Myostatin sowie Verfahren zur Modulation der Myostatinaktivität
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
US7758881B2 (en) 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US8435550B2 (en) 2002-12-16 2013-05-07 Abbot Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
CA2526669A1 (en) 2003-06-02 2004-12-16 Wyeth Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders
ATE554108T1 (de) 2003-07-25 2012-05-15 Amgen Inc Verfahren bezüglich ldcam und crtam
ATE357244T1 (de) * 2003-09-12 2007-04-15 Wyeth Corp Injizierbare feste calciumphosphat-stäbe zur abgabe von osteogenen proteinen
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
CA2541852A1 (en) * 2003-10-07 2005-05-12 Quark Biotech, Inc. Bone morphogenetic protein (bmp) 2a and uses thereof
US20050214339A1 (en) * 2004-03-29 2005-09-29 Yiwen Tang Biologically degradable compositions for medical applications
KR100917403B1 (ko) * 2004-06-23 2009-09-14 티슈진, 인코포레이티드 신경 재생
US8568469B1 (en) 2004-06-28 2013-10-29 Advanced Cardiovascular Systems, Inc. Stent locking element and a method of securing a stent on a delivery system
US8241554B1 (en) 2004-06-29 2012-08-14 Advanced Cardiovascular Systems, Inc. Method of forming a stent pattern on a tube
US8747879B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device to reduce chance of late inflammatory response
US7731890B2 (en) 2006-06-15 2010-06-08 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US8778256B1 (en) 2004-09-30 2014-07-15 Advanced Cardiovascular Systems, Inc. Deformation of a polymer tube in the fabrication of a medical article
US8747878B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device by controlling crystalline structure
US7971333B2 (en) 2006-05-30 2011-07-05 Advanced Cardiovascular Systems, Inc. Manufacturing process for polymetric stents
EP1778275A2 (de) * 2004-08-12 2007-05-02 Wyeth Kombinationstherapie für diabetes, adipositas und herz-kreislauf-erkrankungen unter verwendung von gdf-8-hemmern
US9283099B2 (en) 2004-08-25 2016-03-15 Advanced Cardiovascular Systems, Inc. Stent-catheter assembly with a releasable connection for stent retention
US7229471B2 (en) 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
US7875233B2 (en) 2004-09-30 2011-01-25 Advanced Cardiovascular Systems, Inc. Method of fabricating a biaxially oriented implantable medical device
US8173062B1 (en) 2004-09-30 2012-05-08 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube in fabricating a medical article
US8043553B1 (en) 2004-09-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
AU2006232914A1 (en) * 2005-03-23 2006-10-12 Wyeth Detection of an immune response to GDF-8 modulating agents
US20060229715A1 (en) * 2005-03-29 2006-10-12 Sdgi Holdings, Inc. Implants incorporating nanotubes and methods for producing the same
BRPI0609504A2 (pt) * 2005-03-30 2010-04-13 Wyeth Corp métodos para estimular o crescimento capilar administrando proteìnas morfogenéticas ósseas (bmps)
US7381048B2 (en) 2005-04-12 2008-06-03 Advanced Cardiovascular Systems, Inc. Stents with profiles for gripping a balloon catheter and molds for fabricating stents
US20060292690A1 (en) * 2005-06-22 2006-12-28 Cesco Bioengineering Co., Ltd. Method of making cell growth surface
ES2562243T3 (es) * 2005-06-23 2016-03-03 Tissuegene, Inc. Compuesto neuroprotector eficaz
US7658880B2 (en) 2005-07-29 2010-02-09 Advanced Cardiovascular Systems, Inc. Polymeric stent polishing method and apparatus
US9248034B2 (en) 2005-08-23 2016-02-02 Advanced Cardiovascular Systems, Inc. Controlled disintegrating implantable medical devices
CN101351544B (zh) * 2005-08-26 2013-06-12 罗切斯特大学 胶质限制性前体衍生的星形胶质细胞移植以促进轴突生长
DE102005042455A1 (de) * 2005-09-06 2007-04-12 Medizinische Hochschule Hannover Nervenimplantat
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US20070156230A1 (en) 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US7951185B1 (en) 2006-01-06 2011-05-31 Advanced Cardiovascular Systems, Inc. Delivery of a stent at an elevated temperature
US7964210B2 (en) 2006-03-31 2011-06-21 Abbott Cardiovascular Systems Inc. Degradable polymeric implantable medical devices with a continuous phase and discrete phase
US8003156B2 (en) 2006-05-04 2011-08-23 Advanced Cardiovascular Systems, Inc. Rotatable support elements for stents
US7761968B2 (en) 2006-05-25 2010-07-27 Advanced Cardiovascular Systems, Inc. Method of crimping a polymeric stent
US7951194B2 (en) 2006-05-26 2011-05-31 Abbott Cardiovascular Sysetms Inc. Bioabsorbable stent with radiopaque coating
US8752268B2 (en) 2006-05-26 2014-06-17 Abbott Cardiovascular Systems Inc. Method of making stents with radiopaque markers
US7959940B2 (en) 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US7842737B2 (en) 2006-09-29 2010-11-30 Abbott Cardiovascular Systems Inc. Polymer blend-bioceramic composite implantable medical devices
US8343530B2 (en) 2006-05-30 2013-01-01 Abbott Cardiovascular Systems Inc. Polymer-and polymer blend-bioceramic composite implantable medical devices
US8034287B2 (en) * 2006-06-01 2011-10-11 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8486135B2 (en) 2006-06-01 2013-07-16 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from branched polymers
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
US8333000B2 (en) 2006-06-19 2012-12-18 Advanced Cardiovascular Systems, Inc. Methods for improving stent retention on a balloon catheter
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US9072820B2 (en) 2006-06-26 2015-07-07 Advanced Cardiovascular Systems, Inc. Polymer composite stent with polymer particles
US8128688B2 (en) 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US7794776B1 (en) 2006-06-29 2010-09-14 Abbott Cardiovascular Systems Inc. Modification of polymer stents with radiation
US7740791B2 (en) 2006-06-30 2010-06-22 Advanced Cardiovascular Systems, Inc. Method of fabricating a stent with features by blow molding
US7823263B2 (en) 2006-07-11 2010-11-02 Abbott Cardiovascular Systems Inc. Method of removing stent islands from a stent
US7757543B2 (en) 2006-07-13 2010-07-20 Advanced Cardiovascular Systems, Inc. Radio frequency identification monitoring of stents
US7998404B2 (en) 2006-07-13 2011-08-16 Advanced Cardiovascular Systems, Inc. Reduced temperature sterilization of stents
US7794495B2 (en) 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
US7886419B2 (en) 2006-07-18 2011-02-15 Advanced Cardiovascular Systems, Inc. Stent crimping apparatus and method
EP2046361A4 (de) 2006-07-26 2011-06-29 Univ California Osteogene verstärkerzusammensetzung
US8016879B2 (en) 2006-08-01 2011-09-13 Abbott Cardiovascular Systems Inc. Drug delivery after biodegradation of the stent scaffolding
JP4569543B2 (ja) * 2006-08-18 2010-10-27 ニプロ株式会社 膨潤可能な棒状体を備えた組織再生器具の前駆体
US9173733B1 (en) 2006-08-21 2015-11-03 Abbott Cardiovascular Systems Inc. Tracheobronchial implantable medical device and methods of use
US20090202515A1 (en) * 2006-09-08 2009-08-13 Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. Agents for suppressing neural fibrotic degeneration
US7923022B2 (en) 2006-09-13 2011-04-12 Advanced Cardiovascular Systems, Inc. Degradable polymeric implantable medical devices with continuous phase and discrete phase
EP2097117B1 (de) * 2006-12-11 2013-05-22 Medizinische Hochschule Hannover Implantat aus vernetzten spinnen-seidenfäden
US8099849B2 (en) 2006-12-13 2012-01-24 Abbott Cardiovascular Systems Inc. Optimizing fracture toughness of polymeric stent
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8262723B2 (en) 2007-04-09 2012-09-11 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polymer blends with star-block copolymers
US7829008B2 (en) 2007-05-30 2010-11-09 Abbott Cardiovascular Systems Inc. Fabricating a stent from a blow molded tube
US7959857B2 (en) 2007-06-01 2011-06-14 Abbott Cardiovascular Systems Inc. Radiation sterilization of medical devices
US8202528B2 (en) 2007-06-05 2012-06-19 Abbott Cardiovascular Systems Inc. Implantable medical devices with elastomeric block copolymer coatings
US8293260B2 (en) 2007-06-05 2012-10-23 Abbott Cardiovascular Systems Inc. Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US7901452B2 (en) 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
US7955381B1 (en) 2007-06-29 2011-06-07 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
EP2435468B1 (de) 2009-05-26 2018-11-14 The Regents of The University of California Fibromodulinpeptid
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
US8808353B2 (en) 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
US8568471B2 (en) 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
CN103080301B (zh) 2010-08-19 2016-10-19 加州大学董事会 包含血管周干细胞和nell-1蛋白的组合物
JPWO2012029148A1 (ja) * 2010-09-01 2013-10-28 株式会社オステオファーマ 組換えヒト骨形成タンパク質−２凍結乾燥製剤
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
US8726483B2 (en) 2011-07-29 2014-05-20 Abbott Cardiovascular Systems Inc. Methods for uniform crimping and deployment of a polymer scaffold
US8956394B1 (en) 2014-08-05 2015-02-17 Woven Orthopedic Technologies, Llc Woven retention devices, systems and methods
US9907593B2 (en) 2014-08-05 2018-03-06 Woven Orthopedic Technologies, Llc Woven retention devices, systems and methods
US9943351B2 (en) 2014-09-16 2018-04-17 Woven Orthopedic Technologies, Llc Woven retention devices, systems, packaging, and related methods
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
EP3271380B1 (de) * 2015-03-17 2021-08-11 ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. Verfahren zur reinigung knochenmorphogenetischer proteine
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold
US10555758B2 (en) 2015-08-05 2020-02-11 Woven Orthopedic Technologies, Llc Tapping devices, systems and methods for use in bone tissue
EP3551105A4 (de) 2016-12-09 2020-07-29 Woven Orthopedic Technologies, LLC Rückhaltevorrichtungen, gitter und zugehörige systeme und verfahren
US11116876B2 (en) 2018-02-20 2021-09-14 Shu-Tung And Alice Li Foundation Inc. Methods and devices for repair of severed peripheral nerves with erythropoietin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868161A (en) * 1984-06-29 1989-09-19 City Of Hope Method for promoting nerve regeneration
US4955892A (en) * 1988-10-24 1990-09-11 Louisiana State University Neural cell adhesion protein nerve prosthesis
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4920962A (en) * 1988-11-23 1990-05-01 Claude Proulx Splint-like element for use in end-to-end nerve suture
US4963146A (en) * 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
ATE203166T1 (de) * 1991-03-11 2001-08-15 Curis Inc Protein-induzierende morphogenese
DK0592562T3 (da) * 1991-06-25 1999-08-30 Genetics Inst BMP-9-præparater
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
CA2141554C (en) * 1992-07-31 2003-02-11 David C. Rueger Morphogen-induced nerve regeneration and repair

Also Published As

Publication number Publication date
KR100328752B1 (ko) 2002-09-26
AU7868294A (en) 1995-03-21
WO1995005846A1 (en) 1995-03-02
EP0716610B1 (de) 2006-05-17
OA10358A (en) 2001-10-22
NO960711L (no) 1996-02-22
FI960809A0 (fi) 1996-02-22
JP2007130027A (ja) 2007-05-31
JPH09501932A (ja) 1997-02-25
KR960703615A (ko) 1996-08-31
CA2169191C (en) 2008-01-15
AU677866B2 (en) 1997-05-08
DE69434739T2 (de) 2007-05-10
KR100329409B1 (ko) 2002-03-20
FI960809A (fi) 1996-02-22
ATE326234T1 (de) 2006-06-15
EP0716610A1 (de) 1996-06-19
CA2169191A1 (en) 1995-03-02
ES2265146T3 (es) 2007-02-01
US5756457A (en) 1998-05-26
EP1716864A1 (de) 2006-11-02
PT716610E (pt) 2006-08-31
DK0716610T3 (da) 2006-09-04
JP2005007196A (ja) 2005-01-13
NO960711D0 (no) 1996-02-22

Similar Documents

Publication Publication Date Title
DE69434739D1 (de) Menschliche knochen-morphogenetische proteine zur verwendung bei neuronaler regeneration
WO2000009179A3 (en) Methods, instruments and materials for chondrocyte cell transplantation
CY1109742T1 (el) Μεθοδοι και συνθεσεις για επουλωση και αποκατασταση αρθρικου χονδρου
ATE296087T1 (de) Apparat und verfahren zur behandlung von augenerkrankungen
DE69927512D1 (de) Verwendung von op-1 zur herstellung einer pharmazeutischen zusammensetzung zur reparatur von nicht-gelenksknorpeldefekten eines säugers
NO307735B1 (no) Vekstfaktorinneholdende matrise for behandling av brusklesjoner, samt anvendelse derav
NO970155D0 (no) Kunstig ekstracellulær biologisk matrise samt fremgangsmåte ved fremstilling derav
EP1958651A3 (de) Variable Gewebereparaturimplantate und Verwendungsverfahren dafür
DE69322741D1 (de) Vorrichtung und Methode zur Verwendung im Ausrichten von zweisprachigen Corpora
AU7853287A (en) Method and artificial intraocular lens device for the phakic treatment of myopia
DE69631387D1 (de) Vorrichtung zur implantation von filamenten in den körper
AUPP785098A0 (en) Treatment of heart disease
DE3883957D1 (de) Verfahren und Vorrichtung zur Kontrolle der Oberflächenladung in der Ionen-Implantation.
DE3483934D1 (de) Verfahren und apparat zum einpflanzen eines fremdstoffes in lebende zelle.
DE69332405T2 (de) Biomaterial für knochenersatz
DE68913991D1 (de) Implantat zur verwendung in der knochenchirurgie.
Khurgel et al. Kindling causes changes in the composition of the astrocytic cytoskeleton
DE68923028D1 (de) Gleitmittel und dessen Verwendung zum Vulkanisieren von Reifen.
ATE142696T1 (de) Mittel und verfahren zur herstellung eines rekombinanten, menschlichen interleukin-1 alpha- polypeptides
DE59703371D1 (de) Schichtmaterial für stützkörper für dentale prothesen, stützkörper und verfahren zur herstellung eines stützkörpers
AU2007229982B2 (en) A method and a mould for manufacturing a nerve regeneration device
DE69409710T2 (de) Verfahren zur Behandlung von natürlichen Apatiten zum Lagern von bestrahlten Brennelementen
Yannas Device for treatment of peripheral nerve injury
DE1083935T1 (de) Prosthetisches implantat und verfahren zur verwendung für therapeutische genexpression
AU4275989A (en) Apparatus and procedure for verifying prosthetic implant seating

Legal Events

Date Code Title Description
8364 No opposition during term of opposition