DE69434258D1 - Mikroverkapselte 1,2-benzazole - Google Patents
Mikroverkapselte 1,2-benzazoleInfo
- Publication number
- DE69434258D1 DE69434258D1 DE69434258T DE69434258T DE69434258D1 DE 69434258 D1 DE69434258 D1 DE 69434258D1 DE 69434258 T DE69434258 T DE 69434258T DE 69434258 T DE69434258 T DE 69434258T DE 69434258 D1 DE69434258 D1 DE 69434258D1
- Authority
- DE
- Germany
- Prior art keywords
- benzazole
- capsulated
- micro
- risperidone
- formulated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15440393A | 1993-11-19 | 1993-11-19 | |
US154403 | 1993-11-19 | ||
PCT/EP1994/003754 WO1995013814A1 (en) | 1993-11-19 | 1994-11-11 | Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69434258D1 true DE69434258D1 (de) | 2005-03-10 |
DE69434258T2 DE69434258T2 (de) | 2006-01-19 |
Family
ID=22551225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434258T Expired - Lifetime DE69434258T2 (de) | 1993-11-19 | 1994-11-11 | Mikroverkapselte 1,2-benzazole |
Country Status (30)
Country | Link |
---|---|
US (11) | US5688801A (de) |
EP (1) | EP0729357B1 (de) |
JP (1) | JP3645906B2 (de) |
KR (1) | KR100354270B1 (de) |
CN (1) | CN1074923C (de) |
AT (1) | ATE288270T1 (de) |
AU (1) | AU694147B2 (de) |
BG (1) | BG63246B1 (de) |
CL (1) | CL2004001182A1 (de) |
CZ (1) | CZ293764B6 (de) |
DE (1) | DE69434258T2 (de) |
DK (1) | DK0729357T3 (de) |
ES (1) | ES2236700T3 (de) |
FI (1) | FI117122B (de) |
HK (1) | HK1010694A1 (de) |
HU (1) | HU219487B (de) |
IL (1) | IL111647A (de) |
MX (1) | MX9408969A (de) |
MY (1) | MY113298A (de) |
NO (1) | NO309226B1 (de) |
NZ (1) | NZ276088A (de) |
PL (1) | PL314481A1 (de) |
PT (1) | PT729357E (de) |
RO (1) | RO119224B1 (de) |
RU (1) | RU2178695C2 (de) |
SG (1) | SG47445A1 (de) |
SI (1) | SI0729357T1 (de) |
SK (1) | SK282231B6 (de) |
WO (1) | WO1995013814A1 (de) |
ZA (1) | ZA949191B (de) |
Families Citing this family (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
PT729357E (pt) * | 1993-11-19 | 2005-06-30 | Janssen Pharmaceutica Nv | 1,2-bwenzazoles microencapsulados |
EP0998917A1 (de) * | 1993-11-19 | 2000-05-10 | Alkermes Controlled Therapeutics Inc. II | Herstellung biologisch abbaubarer Mikropartikel, die einen biologisch aktiven Stoff enthalten |
WO1997035584A1 (en) * | 1996-03-25 | 1997-10-02 | Eli Lilly And Company | Method for treating pain |
EP1210942B1 (de) * | 1996-05-07 | 2007-03-21 | Alkermes, Inc. | Micropartikel |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
JP3191943B2 (ja) * | 1997-02-04 | 2001-07-23 | ドン ワ ファーマシューティカル インダストリアル カンパニー リミテッド | 3−アミノ−1,2−ベンゾイソオキサゾール誘導体類とその製造方法及び用途 |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
FR2797784B1 (fr) * | 1999-08-27 | 2001-11-30 | Mainelab | Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore |
KR100373485B1 (ko) * | 1999-09-28 | 2003-02-25 | 한국과학기술연구원 | 신규한 이소옥사졸 피페라진 유도체 및 그 제조방법 |
US6495166B1 (en) | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
US6331317B1 (en) | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
US6705757B2 (en) * | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6770478B2 (en) * | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
US6362308B1 (en) * | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
DE60140625D1 (de) * | 2000-08-15 | 2010-01-07 | Univ Illinois | Verfahren zur herstellung von mikropartikeln |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US6482440B2 (en) | 2000-09-21 | 2002-11-19 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
US7666445B2 (en) | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
US20020114843A1 (en) * | 2000-12-27 | 2002-08-22 | Ramstack J. Michael | Preparation of microparticles having improved flowability |
ATE493129T1 (de) * | 2001-10-30 | 2011-01-15 | Novartis Pharma Gmbh | Depot formulierungen von iloperidone und einem sternförmigen polymer |
KR100789567B1 (ko) * | 2001-11-06 | 2007-12-28 | 동화약품공업주식회사 | 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도 |
JP4668611B2 (ja) * | 2002-05-31 | 2011-04-13 | タイタン ファーマシューティカルズ インコーポレイテッド | ブプレノルフィンの持続放出のための埋め込み型ポリマー製装置 |
GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
KR20040034996A (ko) * | 2002-10-18 | 2004-04-29 | 한미약품 주식회사 | 리스페리돈의 개선된 제조방법 |
CN1777426A (zh) | 2003-03-31 | 2006-05-24 | 泰坦医药品公司 | 用于持续释放多巴胺受体激动剂的可植入聚合物装置 |
US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
DK1675573T4 (da) | 2003-10-23 | 2012-08-06 | Otsuka Pharma Co Ltd | Steril, injicerbr aripiprazol-formulering med kontrolleret frigivelse samt fremgangsmåde |
US7309500B2 (en) * | 2003-12-04 | 2007-12-18 | The Board Of Trustees Of The University Of Illinois | Microparticles |
WO2007011955A2 (en) * | 2005-07-18 | 2007-01-25 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
US8329203B2 (en) | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
CA2553254C (en) * | 2004-01-12 | 2013-12-17 | The Trustees Of The University Of Pennsylvania | Long-term delivery formulations and methods of use thereof |
WO2005110425A1 (en) | 2004-04-15 | 2005-11-24 | Alkermes, Inc. | Polymer-based sustained release device |
CA2565296C (en) * | 2004-04-30 | 2014-06-03 | Abraxis Bioscience, Inc. | Sustained-release microspheres and methods of making and using same |
WO2005107714A2 (en) * | 2004-05-05 | 2005-11-17 | Alkermes Controlled Therapeutics, Inc. | Method of forming microparticles that include a bisphosphonate and a polymer |
FR2869801B1 (fr) * | 2004-05-05 | 2008-09-12 | Ethypharm Sa | Procede de preparation de compositions a liberation prolongee et utilisation de ces compositions pour le traitement des affections chroniques du systeme nerveux central (snc) |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
US7748343B2 (en) | 2004-11-22 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Electrohydrodynamic spraying system |
WO2006078841A1 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
EP1743638A1 (de) | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Pharmazeutische Formulierungen von substituierten Pyrazolinderivaten |
DE102005034925B4 (de) * | 2005-07-26 | 2008-02-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Magnetorheologische Elastomerkomposite sowie deren Verwendung |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
US7669732B2 (en) * | 2005-10-25 | 2010-03-02 | Imi Cornelius Inc. | Cup lid dispenser |
PL116330U1 (en) * | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
CA2642761A1 (en) * | 2006-02-23 | 2007-08-30 | Iomedix Sleep International Srl | Compositions and methods for the induction and maintenance of quality sleep |
EP3421031A1 (de) | 2006-08-09 | 2019-01-02 | Intarcia Therapeutics, Inc | Osmotisches verabreichungssystem mit kolbenanordnung |
CN101511347B (zh) * | 2006-08-31 | 2012-11-28 | Sk化学株式会社 | 含药物微球的制造方法及由该方法制造的含药物微球 |
JP2010522196A (ja) * | 2007-03-22 | 2010-07-01 | アルカームズ,インコーポレイテッド | コアセルベーション工程 |
DE102007017589B3 (de) * | 2007-04-13 | 2008-10-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Dämpfungsvorrichtung mit feldsteuerbarer Flüssigkeit |
CN101715340A (zh) | 2007-04-23 | 2010-05-26 | 精达制药公司 | 促胰岛素释放肽的混悬制剂及其应用 |
WO2008153611A2 (en) | 2007-05-25 | 2008-12-18 | Qlt Usa, Inc. | Sustained delivery formulations of risperidone compounds |
US20080317865A1 (en) * | 2007-06-20 | 2008-12-25 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
BRPI0813274A2 (pt) * | 2007-06-25 | 2014-12-30 | Otsuka Pharma Co Ltd | Microesferas tendo estrutura de núcleo/revestimento |
CA2695178C (en) | 2007-07-31 | 2015-06-23 | Otsuka Pharmaceutical Co., Ltd. | Methods for producing aripiprazole suspension and freeze-dried formulation |
EP2240155B1 (de) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe |
MX2011004994A (es) | 2008-11-14 | 2011-09-28 | Y Sk Chemicals Co Ltd Ewha University Industry Collaboration Foundation | Metodo para preparar microesferas y microesferas producidas por el mismo. |
WO2010085607A1 (en) * | 2009-01-23 | 2010-07-29 | Surmodics Pharmaceuticals, Inc. | Continuous double emulsion process for making microparticles |
SI2462246T1 (en) | 2009-09-28 | 2018-01-31 | Intarcia Therapeutics, Inc. | Fast-setting and / or cessation of substantially unchanged delivery of the product |
EP2485767A1 (de) | 2009-10-06 | 2012-08-15 | Ascendis Pharma A/S | Trägergebundene paliperidon-prodrugs |
US8758780B2 (en) | 2009-10-06 | 2014-06-24 | Ascendis Pharma As | Subcutaneous paliperidone composition |
US8641900B2 (en) * | 2009-11-05 | 2014-02-04 | Taiwan Biotech Co., Ltd | Method and device for continuously preparing microspheres, and collection unit thereof |
EA015780B1 (ru) * | 2010-03-11 | 2011-12-30 | Общество С Ограниченной Ответственностью "Цэм" (Ооо "Цэм") | Фармацевтическая композиция пролонгированного действия для снижения аппетита |
US8088594B2 (en) * | 2010-03-16 | 2012-01-03 | Saladax Biomedical Inc. | Risperidone immunoassay |
CN103209704B (zh) * | 2010-04-22 | 2017-10-27 | 细胞内治疗公司 | 有机化合物 |
EP2394663B1 (de) | 2010-05-31 | 2021-10-13 | Laboratorios Farmaceuticos Rovi, S.A. | Zusammensetzungen für injizierbare, in-situ biologisch abbaubare Implantate |
US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
PT2394664T (pt) | 2010-05-31 | 2016-09-06 | Farm Rovi Lab Sa | Composição depot para injetável antipsicótico |
US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
US10881605B2 (en) | 2010-05-31 | 2021-01-05 | Laboratorios Farmaceuticos Rovi, S.A. | Methods for the preparation of injectable depot compositions |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
EP3586825B1 (de) * | 2010-12-29 | 2023-01-18 | Medincell S.A. | Biologisch abbaubare wirkstofffreisetzungszusammensetzungen |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
HUE046004T2 (hu) | 2011-04-25 | 2020-01-28 | Shan Dong Luye Pharm Co Ltd | Risperidon nyújtott hatóanyagleadású mikroszféra készítmény |
PL2529756T3 (pl) | 2011-05-31 | 2021-11-15 | Laboratorios Farmaceuticos Rovi, S.A. | Formulacja implantu zawierającego rysperydon i/lub paliperydon |
JO3410B1 (ar) | 2011-06-07 | 2019-10-20 | Otsuka Pharma Co Ltd | تركيبة أريبيبرازول مجفف بالتبريد |
CA2870303A1 (en) | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
RU2664700C2 (ru) | 2012-05-10 | 2018-08-21 | Пейнреформ Лтд. | Депо-составы местного анестетика и способы их получения |
DE102013011399A1 (de) | 2012-07-31 | 2014-02-06 | Amw Gmbh | Implantat mit Risperidon |
CA2882563C (en) | 2012-08-21 | 2022-11-29 | Eric Hryhorenko | Antibodies to risperidone haptens and use thereof |
CA2882594C (en) | 2012-08-21 | 2019-07-16 | Ortho-Clinical Diagnostics, Inc. | Antibodies to risperidone and use thereof |
JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス,インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
CA2882490A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone and use thereof |
ES2846823T3 (es) | 2013-03-15 | 2021-07-29 | Intra Cellular Therapies Inc | Compuestos orgánicos |
RU2552303C2 (ru) * | 2013-07-02 | 2015-06-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ получения фармацевтической композиции, содержащей алпразолам |
MX2016001607A (es) | 2013-08-06 | 2016-06-06 | Dong Kook Pharm Co Ltd | Microesferas de entecavir y composicion farmaceutica para administracion parenteral que contiene las mismas. |
US10309357B2 (en) * | 2013-09-13 | 2019-06-04 | Continental Automotive Gmbh | Fluid injector |
KR20230023817A (ko) | 2013-12-03 | 2023-02-17 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
CN106535898A (zh) | 2014-04-04 | 2017-03-22 | 细胞内治疗公司 | 有机化合物 |
WO2015154030A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10179776B2 (en) | 2014-06-09 | 2019-01-15 | Intra-Cellular Therapies, Inc. | Compounds and methods of use to treat schizophrenia |
TW201613564A (en) * | 2014-08-06 | 2016-04-16 | Tty Biopharm Co Ltd | Process for the preparation of sustained-release microparticles having a controllable release profile |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
WO2016071767A1 (en) | 2014-11-07 | 2016-05-12 | Indivior Uk Limited | Buprenorphine dosing regimens |
KR102650751B1 (ko) | 2015-06-03 | 2024-03-22 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
FI3377041T3 (fi) | 2015-11-16 | 2023-11-30 | Medincell S A | Menetelmä farmaseuttisesti aktiivisten pääainesosien morselloimiseksi ja/tai kohdentamiseksi synoviaalikudokseen |
WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
BR112018015283B1 (pt) | 2016-01-26 | 2023-09-26 | Intra-Cellular Therapies, Inc | Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central |
EP3407889B1 (de) | 2016-03-25 | 2021-05-19 | Intra-Cellular Therapies, Inc. | Organische verbindungen und deren verwendung zur behandlung oder prävention von erkrankungen des zentralen nervensystems |
JP2019510039A (ja) | 2016-03-28 | 2019-04-11 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規組成物および方法 |
SG10201913699QA (en) | 2016-05-16 | 2020-03-30 | Intarcia Therapeutics Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ-セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
US10906906B2 (en) | 2016-12-29 | 2021-02-02 | Intra-Cellular Therapies, Inc. | Organic compounds |
WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
AU2018206539A1 (en) | 2017-01-03 | 2019-07-18 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
CN116327770A (zh) | 2017-03-24 | 2023-06-27 | 细胞内治疗公司 | 新组合物和方法 |
US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
CA3071137A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | Organic compounds |
CN111093665A (zh) | 2017-07-26 | 2020-05-01 | 细胞内治疗公司 | 有机化合物 |
RU2702012C2 (ru) * | 2017-10-24 | 2019-10-03 | федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ получения фармацевтической композиции, содержащей пентоксифиллин |
AU2019240226A1 (en) | 2018-03-23 | 2020-10-22 | Intra-Cellular Therapies, Inc. | Organic compounds |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
KR20210052471A (ko) | 2018-08-31 | 2021-05-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
JP7457000B2 (ja) | 2018-08-31 | 2024-03-27 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
US20220025254A1 (en) * | 2018-10-22 | 2022-01-27 | The General Hospital Corporation | Complexes and Ligands |
HUP2100259A1 (hu) | 2021-07-07 | 2023-01-28 | Richter Gedeon Nyrt | Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények |
TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
WO2023225620A1 (en) | 2022-05-18 | 2023-11-23 | Intra-Cellular Therapies, Inc. | Novel methods |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL280825A (de) * | 1962-07-11 | |||
US3197180A (en) * | 1963-10-11 | 1965-07-27 | Chemineer | Mixing device |
US3415493A (en) * | 1967-08-21 | 1968-12-10 | Chemineer | Mixing device |
BE744162A (fr) * | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE2010115A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
GB1351811A (en) * | 1971-05-07 | 1974-05-01 | Kenics Corp | Mixing device |
JPS523342B2 (de) * | 1972-01-26 | 1977-01-27 | ||
GB1413186A (en) * | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
US4034965A (en) * | 1973-12-27 | 1977-07-12 | Komax Systems, Inc. | Material distributing and mixing apparatus |
US3923288A (en) * | 1973-12-27 | 1975-12-02 | Komax Systems Inc | Material mixing apparatus |
US4128641A (en) * | 1975-07-31 | 1978-12-05 | Hzi Research Center Inc. | Tetracyclic psychotropic drug |
US4111402A (en) * | 1976-10-05 | 1978-09-05 | Chemineer, Inc. | Motionless mixer |
JPS54127064A (en) * | 1978-03-06 | 1979-10-02 | Komax Systems Inc | Charging instrument of stationary mixer |
DE2822096A1 (de) * | 1978-05-20 | 1979-11-22 | Bayer Ag | Gebohrte mischelemente fuer statische und dynamische mischer |
US4489055A (en) * | 1978-07-19 | 1984-12-18 | N.V. Sopar S.A. | Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use |
US4208136A (en) * | 1978-12-01 | 1980-06-17 | Komax Systems, Inc. | Static mixing apparatus |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
US4329331A (en) * | 1980-03-13 | 1982-05-11 | Kallick Charles A | Diagnostic method for detection of systemic lupus erythematosus |
US4342870A (en) * | 1980-03-28 | 1982-08-03 | Janssen Pharmaceutica N.V. | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US4324870A (en) * | 1980-06-23 | 1982-04-13 | Uniroyal, Inc. | Scorch-safe acceleration of urethane vulcanization of unsaturated rubbers |
US4337261A (en) * | 1980-07-28 | 1982-06-29 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics |
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
EP0071454B1 (de) * | 1981-07-28 | 1986-12-17 | Statiflo Inc. | Statischer Mischer |
US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
US4529727A (en) * | 1982-04-21 | 1985-07-16 | Janssen Pharmaceutical, N.V. | Pyrimido[2,1-b][1,3]-thiazines |
US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
GB2120113B (en) * | 1982-05-13 | 1985-10-09 | Komax Systems Inc | Mixing in flow |
US4808007A (en) * | 1982-05-13 | 1989-02-28 | Komax Systems, Inc. | Dual viscosity mixer |
US4530840A (en) * | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4542025A (en) * | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
US4511258A (en) * | 1983-03-25 | 1985-04-16 | Koflo Corporation | Static material mixing apparatus |
US4458076A (en) * | 1983-05-31 | 1984-07-03 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidinyl)-1,2-benzisothiazoles |
DE3376660D1 (en) * | 1983-06-22 | 1988-06-23 | Stolle Res & Dev | Encapsulated cells, their method of preparation and use |
CH661206A5 (fr) * | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
US4708861A (en) * | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
US4696258A (en) * | 1984-04-04 | 1987-09-29 | The Magrath Company | Method and substance for the detection of cows in estrus |
US4585482A (en) * | 1984-05-25 | 1986-04-29 | Southern Research Institute | Long-acting biocidal compositions and method therefor |
CA1256638A (en) * | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US4665075A (en) * | 1984-12-05 | 1987-05-12 | Janssen Pharmaceutica N.V. | Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines |
US4614440A (en) * | 1985-03-21 | 1986-09-30 | Komax Systems, Inc. | Stacked motionless mixer |
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
US4689330A (en) * | 1985-04-15 | 1987-08-25 | Janssen Pharmaceutica N.V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
US4616937A (en) * | 1985-04-16 | 1986-10-14 | Komax Systems, Inc. | Intermittent mixing apparatus |
NL8601494A (nl) * | 1985-06-22 | 1987-01-16 | Sandoz Ag | Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten. |
US4643584A (en) * | 1985-09-11 | 1987-02-17 | Koch Engineering Company, Inc. | Motionless mixer |
US5102872A (en) * | 1985-09-20 | 1992-04-07 | Cetus Corporation | Controlled-release formulations of interleukin-2 |
EP0248531A3 (de) * | 1986-05-02 | 1988-09-28 | Southern Research Institute | Verkapselte Nukleinsäuren |
PT85521B (pt) * | 1986-08-11 | 1990-06-29 | Innovata Biomed Ltd | Processo para a preparacao de composicoes farmaceuticas que consistem em microcapsulas |
US4765204A (en) * | 1986-09-03 | 1988-08-23 | Koch Engineering Company, Inc. | Method of manufacturing a motionless mixer |
US4731205A (en) * | 1986-09-08 | 1988-03-15 | Koch Engineering Company, Inc. | Random packing for fluid contact devices and method of preparing said packing |
IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
US4753535A (en) * | 1987-03-16 | 1988-06-28 | Komax Systems, Inc. | Motionless mixer |
US4793713A (en) * | 1987-04-06 | 1988-12-27 | Komax Systems, Inc. | Rotary mixer |
US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
US5143661A (en) * | 1987-05-26 | 1992-09-01 | American Cyanamid Company | Silicone-hardened pharmaceutical microcapsules |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
IT1216570B (it) * | 1988-04-08 | 1990-03-08 | Vectorpharma Int | Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione. |
EP0349486A3 (de) * | 1988-06-29 | 1990-12-05 | Ciba-Geigy Ag | Azofarbstoffe, deren Herstellung und Verwendung |
US4936689A (en) * | 1988-07-11 | 1990-06-26 | Koflo Corporation | Static material mixing apparatus |
CA2000786C (en) * | 1988-11-07 | 1999-01-26 | Cornelus G. M. Janssen | 3-piperidinyl-1,2-benzisoxazoles |
US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
DK0471036T4 (da) * | 1989-05-04 | 2004-07-19 | Southern Res Inst | Indkapslingsfremgangsmåde |
HU221294B1 (en) | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
WO1991002527A1 (en) | 1989-08-21 | 1991-03-07 | Beth Israel Hospital Association | Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists |
US5478564A (en) * | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
AU7558991A (en) * | 1990-03-15 | 1991-10-10 | United States Of America, As Represented By The Secretary Of The Army, The | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
EP0452111B1 (de) | 1990-04-13 | 1998-07-15 | Takeda Chemical Industries, Ltd. | Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung |
ES2185615T3 (es) * | 1990-05-16 | 2003-05-01 | Southern Res Inst | Uso y liberacion controlada de las microcapsulas para estimular el crecimiento de la fibra nerviosa. |
MY108621A (en) * | 1990-08-01 | 1996-10-31 | Novartis Ag | Polylactide preparation and purification |
IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
JP3180421B2 (ja) * | 1992-03-30 | 2001-06-25 | 日本電気株式会社 | テスト回路を内蔵したアナログ・ディジタル混在マスタ |
DE4223169C1 (de) | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
DK0669128T3 (da) * | 1992-11-17 | 2000-06-19 | Yoshitomi Pharmaceutical | Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme |
DE4244466C2 (de) * | 1992-12-24 | 1995-02-23 | Pharmatech Gmbh | Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten |
TW376319B (en) * | 1993-04-28 | 1999-12-11 | Janssen Pharmaceutica Nv | Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine |
DK0724433T3 (da) | 1993-10-22 | 1999-08-30 | Genentech Inc | Fremgangsmåde til fremstilling af mikrosfærer med et tørringstrin i fluidiseret leje |
US6080429A (en) * | 1993-10-25 | 2000-06-27 | Genentech, Inc. | Method for drying microspheres |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
PT729357E (pt) | 1993-11-19 | 2005-06-30 | Janssen Pharmaceutica Nv | 1,2-bwenzazoles microencapsulados |
EP0998917A1 (de) * | 1993-11-19 | 2000-05-10 | Alkermes Controlled Therapeutics Inc. II | Herstellung biologisch abbaubarer Mikropartikel, die einen biologisch aktiven Stoff enthalten |
DK1125577T3 (da) * | 1994-04-08 | 2006-06-19 | Qlt Usa Inc | Væskeformige medikamentindföringspræparater |
US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
US6117455A (en) | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
CA2192782C (en) * | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
ES2205481T3 (es) | 1997-04-17 | 2004-05-01 | Amgen Inc. | Microparticulas biodegradables para la liberacion sostenida de farmacos terapeuticos. |
SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
US6224794B1 (en) * | 1998-05-06 | 2001-05-01 | Angiotech Pharmaceuticals, Inc. | Methods for microsphere production |
SE9903236D0 (sv) | 1999-09-10 | 1999-09-10 | Astra Ab | Method to obtain microparticles |
DE10055742B4 (de) | 2000-11-10 | 2006-05-11 | Schwarz Pharma Ag | Neue Polyester, Verfahren zu ihrer Herstellung und aus den Polyestern hergestellte Depot-Arzneiformen |
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1994
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- 1994-11-11 ES ES95900721T patent/ES2236700T3/es not_active Expired - Lifetime
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- 1994-11-11 DE DE69434258T patent/DE69434258T2/de not_active Expired - Lifetime
- 1994-11-11 CN CN94194190A patent/CN1074923C/zh not_active Expired - Lifetime
- 1994-11-11 EP EP95900721A patent/EP0729357B1/de not_active Expired - Lifetime
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1998
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1999
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2000
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- 2002-01-29 US US10/058,072 patent/US6544559B2/en not_active Expired - Fee Related
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2006
- 2006-03-02 US US11/365,625 patent/US20060182810A1/en not_active Abandoned
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2007
- 2007-07-13 US US11/826,384 patent/US7547452B2/en not_active Expired - Fee Related
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