DE69434067D1 - Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes - Google Patents

Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes

Info

Publication number
DE69434067D1
DE69434067D1 DE1994634067 DE69434067T DE69434067D1 DE 69434067 D1 DE69434067 D1 DE 69434067D1 DE 1994634067 DE1994634067 DE 1994634067 DE 69434067 T DE69434067 T DE 69434067T DE 69434067 D1 DE69434067 D1 DE 69434067D1
Authority
DE
Germany
Prior art keywords
subunits
alpha
methods
acetylcholine receptor
human neuronal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1994634067
Other languages
English (en)
Other versions
DE69434067T2 (de
Inventor
Kathryn J Elliott
Steven B Ellis
Michael M Harpold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69434067D1 publication Critical patent/DE69434067D1/de
Application granted granted Critical
Publication of DE69434067T2 publication Critical patent/DE69434067T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
DE69434067T 1993-03-08 1994-03-08 Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes Expired - Fee Related DE69434067T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2803193A 1993-03-08 1993-03-08
US28031 1993-03-08
PCT/US1994/002447 WO1994020617A2 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Publications (2)

Publication Number Publication Date
DE69434067D1 true DE69434067D1 (de) 2004-11-18
DE69434067T2 DE69434067T2 (de) 2006-03-02

Family

ID=21841175

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434067T Expired - Fee Related DE69434067T2 (de) 1993-03-08 1994-03-08 Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes

Country Status (10)

Country Link
US (5) US5837489A (de)
EP (2) EP0688361B1 (de)
JP (2) JP3628691B2 (de)
AT (1) ATE279516T1 (de)
AU (1) AU694424B2 (de)
CA (1) CA2155330C (de)
DE (1) DE69434067T2 (de)
ES (1) ES2229216T3 (de)
GB (1) GB2286397C (de)
WO (1) WO1994020617A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936457B1 (en) * 1990-04-03 2005-08-30 Merck & Co., Inc. DNA ENCODING HUMAN α AND β SUBUNITS OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR, CELLS TRANSFORMED THEREWITH, AND RECOMBINANT CELL LINE EXPRESSING A HUMAN α AND β SUBUNIT OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR
EP0688361B1 (de) 1993-03-08 2004-10-13 Merck & Co., Inc. Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes
US6485967B1 (en) * 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
CA2190304A1 (en) * 1995-12-15 1997-06-16 Elazar Rabbani Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses
US6323000B2 (en) * 1996-12-20 2001-11-27 Clark A. Briggs Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
CA2293254A1 (en) * 1997-06-13 1998-12-23 Allelix Biopharmaceuticals Inc. Assay methods and compositions useful for measuring receptor ligand binding
US6875606B1 (en) * 1997-10-23 2005-04-05 The United States Of America As Represented By The Department Of Veterans Affairs Human α-7 nicotinic receptor promoter
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
EP0953637A3 (de) * 1998-03-24 2001-04-25 Smithkline Beecham Plc Acetylcholine Receptor
US6252132B1 (en) 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor
US6693172B1 (en) 1999-05-27 2004-02-17 Pharmacia And Upjohn Company Double mutant alpha-7 nicotinic acetylcholine receptor
JP2003501022A (ja) 1999-05-27 2003-01-14 ファルマシア・アンド・アップジョン・カンパニー イオンチャネルコンダクタンスを測定するための方法およびその組成物
GB9913248D0 (en) * 1999-06-09 1999-08-04 Babraham Inst Recombinant nematode nicotinic receptor and uses
US6737270B1 (en) 1999-12-07 2004-05-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education Long-term three dimensional tissue culture system
US20030096411A1 (en) * 1999-12-07 2003-05-22 George Michalopoulos Novel long-term three-dimensional tissue culture system
DE19959582A1 (de) * 1999-12-10 2001-06-13 Bayer Ag Nukleinsäuren, die für neue Acetylcholinrezeptor-beta-Untereinheiten von Insekten kodieren
GB2364385B (en) * 2000-03-29 2002-08-14 Synaptica Ltd Alpha 7 nicotinic receptor screening assays
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
JP2004506735A (ja) 2000-08-18 2004-03-04 ファルマシア・アンド・アップジョン・カンパニー 疾患治療用キヌクリジン置換アリール化合物
WO2002016357A2 (en) 2000-08-18 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2002215977A1 (en) * 2000-10-31 2002-05-15 Bayer Aktiengesellschaft Regulation of human serotonin receptor precursor
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
AU2002324842C9 (en) * 2001-08-31 2008-07-10 Agensys, Inc. 205P1B5 in treatment and detection of cancer
WO2003023014A2 (en) * 2001-09-12 2003-03-20 Pharmacia & Upjohn Company Human ion channels
US7229779B2 (en) 2001-09-18 2007-06-12 Abbott Laboratories Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof
US20060126682A1 (en) * 2001-10-08 2006-06-15 Geola Technologies Ltd. Pulsed multiple colour laser system
AU2003267174A1 (en) * 2002-05-09 2003-11-11 Memory Pharmaceuticals Corporation Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
JP2005537297A (ja) * 2002-08-01 2005-12-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー アルファ−７ｎａｃｈｒ活性を有する１ｈ−ピラゾールおよび１ｈ−ピロール−アザビシクロ化合物
US20040151729A1 (en) * 2002-10-28 2004-08-05 George Michalopoulos Novel long-term three-dimensional culture system
US20060142188A1 (en) * 2003-02-14 2006-06-29 Memory Pharmaceuticals Corporation Monkey alpha-7 nicotinic acetylcholine receptor and methods of use thereof
US7576878B2 (en) * 2003-04-03 2009-08-18 Hewlett-Packard Development Company, L.P. Enhanced management of raster image processing resources
WO2005030145A2 (en) * 2003-09-24 2005-04-07 Targacept, Inc. Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors
WO2005085416A1 (ja) * 2004-03-04 2005-09-15 Riken 糸状菌特異的抗菌剤のスクリーニング方法及びそのためのキット
DE602006019653D1 (de) * 2005-01-20 2011-03-03 Lg Electronics Inc Plasmaanzeigetafel
CN101180543B (zh) * 2005-02-23 2014-06-18 美国陶氏益农公司 使用烟碱乙酰胆碱受体亚单位的新检测方法
US7879913B2 (en) * 2005-06-28 2011-02-01 Catholic Healthcare West Iptakalim hydrochloride for decreasing nicotine use
WO2018057837A1 (en) * 2016-09-23 2018-03-29 Ionis Pharmaceuticals, Inc. Gene therapy and targeted delivery of conjugated compounds
CN111741760A (zh) * 2017-11-27 2020-10-02 科达生物治疗医药有限公司 用于神经疾病的组合物和方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
US4929555A (en) * 1987-10-19 1990-05-29 Phillips Petroleum Company Pichia transformation
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5449606A (en) * 1988-03-18 1995-09-12 The Salk Institute For Biological Studies DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit
CA1341554C (en) * 1988-03-18 2007-10-09 The Salk Institute For Biological Studies Neuronal nicotinic acetylcholine receptor compositions and assay
CA1341170C (en) * 1988-04-04 2001-01-16 Steven B. Ellis Calcium channel compositions and methods
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
CA2047683C (en) * 1989-03-14 2000-06-06 Stephen F. Heinemann Neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit
AU648523B2 (en) * 1989-10-25 1994-04-28 Salk Institute For Biological Studies, The Receptor infection assay
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
EP0688361B1 (de) 1993-03-08 2004-10-13 Merck & Co., Inc. Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes
WO1995013299A1 (en) * 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Also Published As

Publication number Publication date
ATE279516T1 (de) 2004-10-15
ES2229216T3 (es) 2005-04-16
CA2155330A1 (en) 1994-09-15
JPH08507441A (ja) 1996-08-13
US5910582A (en) 1999-06-08
US5837489A (en) 1998-11-17
US6664375B2 (en) 2003-12-16
JP2004194667A (ja) 2004-07-15
US6022704A (en) 2000-02-08
CA2155330C (en) 2002-01-29
EP0688361A1 (de) 1995-12-27
GB2286397B (en) 1997-09-10
EP0688361B1 (de) 2004-10-13
WO1994020617A2 (en) 1994-09-15
WO1994020617A3 (en) 1994-10-27
GB2286397A (en) 1995-08-16
GB9503688D0 (en) 1995-04-12
US6303753B1 (en) 2001-10-16
AU6517394A (en) 1994-09-26
US20020111463A1 (en) 2002-08-15
AU694424B2 (en) 1998-07-23
DE69434067T2 (de) 2006-03-02
EP1508614A1 (de) 2005-02-23
JP3628691B2 (ja) 2005-03-16
GB2286397C (en) 1997-09-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK & CO., INC., RAHWAY, N.J., US

8339 Ceased/non-payment of the annual fee