DE69433146D1 - Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen - Google Patents

Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen

Info

Publication number: DE69433146D1
Authority: DE; Germany
Prior art keywords: substd; opt; nhcoocme3; substits; succinyl
Prior art date: 1993-06-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69433146T

Other languages

English (en)

Other versions

DE69433146T2 (de

Inventor

Robert C Kelly

Roy A Johnson

Harvey I Skulnick

Eldon G Nidy

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee

Pharmacia and Upjohn Co

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

1994-06-03

Publication date

2003-10-16

1993-12-13 Priority claimed from PCT/US1993/011827 external-priority patent/WO1994013655A1/en

1994-06-03 Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co

2003-10-16 Publication of DE69433146D1 publication Critical patent/DE69433146D1/de

2004-06-09 Application granted granted Critical

2004-06-09 Publication of DE69433146T2 publication Critical patent/DE69433146T2/de

2014-06-04 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

DE69433146T 1993-06-11 1994-06-03 Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen Expired - Fee Related DE69433146T2 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US7633793A	1993-06-11	1993-06-11
US76337		1993-06-11
US12297493A	1993-09-17	1993-09-17
US122974		1993-09-17
PCT/US1993/011827 WO1994013655A1 (en)	1992-12-15	1993-12-13	7-HALO- AND 7β,8β-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WOPCT/US93/11827		1993-12-13

Publications (2)

Publication Number	Publication Date
DE69433146D1 true DE69433146D1 (de)	2003-10-16
DE69433146T2 DE69433146T2 (de)	2004-06-09

Family

ID=26757982

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE69433146T Expired - Fee Related DE69433146T2 (de)	1993-06-11	1994-06-03	Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen
DE69424166T Expired - Fee Related DE69424166T2 (de)	1993-06-11	1994-06-03	Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
DE69433715T Expired - Fee Related DE69433715T2 (de)	1993-06-11	1994-06-03	Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DE69424166T Expired - Fee Related DE69424166T2 (de)	1993-06-11	1994-06-03	Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
DE69433715T Expired - Fee Related DE69433715T2 (de)	1993-06-11	1994-06-03	Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen

Country Status (18)

Country	Link
US (2)	US5965739A (de)
EP (3)	EP0982302B1 (de)
JP (1)	JPH09511212A (de)
AT (3)	ATE264316T1 (de)
AU (1)	AU7138894A (de)
CA (1)	CA2161328A1 (de)
DE (3)	DE69433146T2 (de)
DK (3)	DK0982302T3 (de)
ES (3)	ES2205663T3 (de)
GR (1)	GR3033836T3 (de)
IL (1)	IL109957A (de)
LV (2)	LV12692B (de)
NZ (2)	NZ268475A (de)
PT (3)	PT703909E (de)
SI (2)	SI0703909T1 (de)
TW (1)	TW401407B (de)
WO (1)	WO1994029288A1 (de)
ZA (1)	ZA944034B (de)

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HUP0200759A3 (en)	2000-02-02	2002-10-28	Univ Florida State Res Found	C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
AR030188A1 (es) *	2000-02-02	2003-08-13	Univ Florida State Res Found	Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
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WO2001057033A1 (en)	2000-02-02	2001-08-09	Florida State University Research Foundation, Inc.	C10 carbamoyloxy substituted taxanes as antitumor agents
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DE60237671D1 (de)	2001-01-16	2010-10-28	Vascular Therapies Llc	Implantierbare vorrichtung enthaltend resorbierbares matrixmaterial und antiproliferative wirkstoffe zur vorbeugung oder behandlung von versagen vaskulärer hämodialysezugänge und anderer vaskulärer transplantate
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CN103980232A (zh) *	2014-06-05	2014-08-13	北京诺普德医药科技有限公司	10-乙酰基多西紫杉醇及其用途
CN111138386A (zh) *	2019-12-30	2020-05-12	重庆市碚圣医药科技股份有限公司	一种多西他赛的半合成方法
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1994
- 1994-06-03 AU AU71388/94A patent/AU7138894A/en not_active Abandoned
- 1994-06-03 EP EP99118034A patent/EP0982302B1/de not_active Expired - Lifetime
- 1994-06-03 NZ NZ268475A patent/NZ268475A/en unknown
- 1994-06-03 SI SI9430317T patent/SI0703909T1/xx unknown
- 1994-06-03 AT AT99118034T patent/ATE264316T1/de not_active IP Right Cessation
- 1994-06-03 EP EP99118033A patent/EP0982301B1/de not_active Expired - Lifetime
- 1994-06-03 DE DE69433146T patent/DE69433146T2/de not_active Expired - Fee Related
- 1994-06-03 EP EP94920688A patent/EP0703909B1/de not_active Expired - Lifetime
- 1994-06-03 AT AT99118033T patent/ATE249448T1/de not_active IP Right Cessation
- 1994-06-03 ES ES99118033T patent/ES2205663T3/es not_active Expired - Lifetime
- 1994-06-03 DE DE69424166T patent/DE69424166T2/de not_active Expired - Fee Related
- 1994-06-03 DE DE69433715T patent/DE69433715T2/de not_active Expired - Fee Related
- 1994-06-03 JP JP7501878A patent/JPH09511212A/ja not_active Ceased
- 1994-06-03 NZ NZ330671A patent/NZ330671A/xx unknown
- 1994-06-03 SI SI9430464T patent/SI0982302T1/xx unknown
- 1994-06-03 PT PT94920688T patent/PT703909E/pt unknown
- 1994-06-03 ES ES94920688T patent/ES2145829T3/es not_active Expired - Lifetime
- 1994-06-03 DK DK99118034T patent/DK0982302T3/da active
- 1994-06-03 CA CA002161328A patent/CA2161328A1/en not_active Abandoned
- 1994-06-03 PT PT99118033T patent/PT982301E/pt unknown
- 1994-06-03 WO PCT/US1994/006035 patent/WO1994029288A1/en active IP Right Grant
- 1994-06-03 DK DK99118033T patent/DK0982301T3/da active
- 1994-06-03 AT AT94920688T patent/ATE192147T1/de not_active IP Right Cessation
- 1994-06-03 US US08/557,034 patent/US5965739A/en not_active Expired - Fee Related
- 1994-06-03 DK DK94920688T patent/DK0703909T3/da active
- 1994-06-03 ES ES99118034T patent/ES2219968T3/es not_active Expired - Lifetime
- 1994-06-03 PT PT99118034T patent/PT982302E/pt unknown
- 1994-06-08 ZA ZA944034A patent/ZA944034B/xx unknown
- 1994-06-09 TW TW083105245A patent/TW401407B/zh not_active IP Right Cessation
- 1994-06-09 IL IL10995794A patent/IL109957A/en not_active IP Right Cessation
- 1994-06-10 US US08/258,019 patent/US5556878A/en not_active Expired - Fee Related
2000
- 2000-06-30 GR GR20000401537T patent/GR3033836T3/el not_active IP Right Cessation
2001
- 2001-04-26 LV LV010064A patent/LV12692B/xx unknown
2005
- 2005-04-14 LV LVP-05-45A patent/LV13319B/en unknown

Also Published As

Publication number	Publication date
SI0982302T1 (en)	2004-08-31
LV13319B (en)	2005-08-20
GR3033836T3 (en)	2000-10-31
DK0703909T3 (da)	2000-09-11
JPH09511212A (ja)	1997-11-11
ATE192147T1 (de)	2000-05-15
IL109957A (en)	2001-01-11
DK0982302T3 (da)	2004-08-02
ES2145829T3 (es)	2000-07-16
TW401407B (en)	2000-08-11
ATE249448T1 (de)	2003-09-15
PT982302E (pt)	2004-07-30
PT703909E (pt)	2000-10-31
NZ268475A (en)	1998-08-26
EP0982301A3 (de)	2000-11-08
EP0982301A2 (de)	2000-03-01
LV12692B (lv)	2001-09-20
CA2161328A1 (en)	1994-12-22
NZ330671A (en)	2000-01-28
DE69424166D1 (de)	2000-05-31
LV12692A (lv)	2001-07-20
DK0982301T3 (da)	2003-12-08
EP0982302B1 (de)	2004-04-14
EP0703909A1 (de)	1996-04-03
DE69424166T2 (de)	2000-10-05
EP0982302A3 (de)	2000-07-19
EP0982301B1 (de)	2003-09-10
ES2205663T3 (es)	2004-05-01
US5556878A (en)	1996-09-17
ZA944034B (en)	1995-12-08
WO1994029288A1 (en)	1994-12-22
DE69433715D1 (de)	2004-05-19
DE69433146T2 (de)	2004-06-09
SI0703909T1 (en)	2000-08-31
US5965739A (en)	1999-10-12
AU7138894A (en)	1995-01-03
ES2219968T3 (es)	2004-12-01
PT982301E (pt)	2004-02-27
EP0982302A2 (de)	2000-03-01
DE69433715T2 (de)	2005-03-24
ATE264316T1 (de)	2004-04-15
EP0703909B1 (de)	2000-04-26
IL109957A0 (en)	1994-10-07

Legal Events

Date	Code	Title	Description
2004-10-07	8364	No opposition during term of opposition
2007-04-19	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE69433146D1 (de)	2003-10-16	Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen
FI941649A (fi)	1994-05-31	Retroviirusproteaasi-inhibiittoreina käytettäviä syklisiä ureoita ja analogeja
YU47066B (sh)	1994-12-28	Postupak za dobijanje derivata tiazolidin-2,4-diona
DE59706313D1 (de)	2002-03-21	Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung
FI943142A0 (fi)	1994-06-30	Amidi- ja ureajohdannaiset, joilla on veren korkeita kolesteroliarvoja vastustava vaikutus, niiden valmistus ja terapeuttiset käytöt
PT1468692E (pt)	2006-09-29	Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma
ATE250586T1 (de)	2003-10-15	Imidazoline derivate,ihre herstellung und pharmazeutische zusammensetzungen die sie enthalten
FI955238A (fi)	1996-05-04	Uudet 5-(aryylioksimetyyli)oksatsoliinit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EA200101170A1 (ru)	2002-04-25	Галоидпроизводные 9-деоксо-9а-аза-9а-гомоэритромицина а
DE69619088T2 (de)	2002-07-11	Quinoxalin-Derivate zur Behandlung von Tinnitus
DE69819002D1 (de)	2003-11-20	Polyhydroxyalkylpyrazine derivate,deren herstellung und diese enthaltende arzneimitteln
RU2220954C2 (ru)	2004-01-10	ЗАМЕЩЕННЫЕ β-АЛАНИНЫ
ATE125793T1 (de)	1995-08-15	Substituierte alkensäure und ihre derivate.
MY111111A (en)	1999-08-30	Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl -1-heterocyclyl) methylamine drrivatives
DE68909961T2 (de)	1994-02-10	2-Aminoacetamid Derivate.
NO20004774L (no)	2000-09-25	Alifatiske aminokarboksyl- og aminofosfonsyrer, aminonitriler og aminotetrazoler som cellulære redningsmidler