DE69431473T2 - Inhibitor der stammzellproliferation und seine verwendung - Google Patents
Inhibitor der stammzellproliferation und seine verwendungInfo
- Publication number
- DE69431473T2 DE69431473T2 DE69431473T DE69431473T DE69431473T2 DE 69431473 T2 DE69431473 T2 DE 69431473T2 DE 69431473 T DE69431473 T DE 69431473T DE 69431473 T DE69431473 T DE 69431473T DE 69431473 T2 DE69431473 T2 DE 69431473T2
- Authority
- DE
- Germany
- Prior art keywords
- stem cell
- polliferation
- inhibitor
- disclosed
- accelerating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4094293A | 1993-03-31 | 1993-03-31 | |
PCT/US1994/003349 WO1994022915A1 (en) | 1993-03-31 | 1994-03-29 | Inhibitor of stem cell proliferation and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69431473D1 DE69431473D1 (de) | 2002-11-07 |
DE69431473T2 true DE69431473T2 (de) | 2003-08-07 |
Family
ID=21913839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69431473T Expired - Fee Related DE69431473T2 (de) | 1993-03-31 | 1994-03-29 | Inhibitor der stammzellproliferation und seine verwendung |
Country Status (17)
Country | Link |
---|---|
US (3) | US6022848A (de) |
EP (1) | EP0691988B1 (de) |
JP (1) | JPH08510997A (de) |
CN (1) | CN1089344C (de) |
AT (1) | ATE225370T1 (de) |
AU (1) | AU694111B2 (de) |
CA (1) | CA2159506A1 (de) |
DE (1) | DE69431473T2 (de) |
DK (1) | DK0691988T3 (de) |
ES (1) | ES2185649T3 (de) |
IL (1) | IL109177A (de) |
NZ (1) | NZ263736A (de) |
PT (1) | PT691988E (de) |
RU (1) | RU2155066C2 (de) |
TW (1) | TW403761B (de) |
UA (1) | UA40613C2 (de) |
WO (1) | WO1994022915A1 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610654B2 (en) * | 1993-03-31 | 2003-08-26 | Wellstat Therapeutics Corporation | Inhibitor of stem cell proliferation and uses thereof |
AU694111B2 (en) * | 1993-03-31 | 1998-07-16 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
EP1897553A1 (de) * | 1994-09-30 | 2008-03-12 | Wellstat Therapeutics Corporation | Stammzellenvermehrungsinhibitor und Verwendungen dafür |
US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
CA2245224A1 (en) * | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
AU762472B2 (en) | 1998-03-13 | 2003-06-26 | University Of British Columbia, The | Therapeutic chemokine receptor antagonists |
CA2305787A1 (en) * | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
US7378098B2 (en) * | 2000-04-12 | 2008-05-27 | The University Of British Columbia | CXC chemokine receptor 4 agonist peptides |
US20050059584A1 (en) * | 2002-08-16 | 2005-03-17 | Ahmed Merzouk | Novel chemokine mimetics synthesis and their use |
CA2335109A1 (en) * | 2000-04-12 | 2001-10-12 | Chemokine Therapeutics Corporation | Cxcr4 agonist treatment of hematopoietic cells |
US7368425B2 (en) * | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
ES2522890T3 (es) * | 2000-12-06 | 2014-11-19 | Anthrogenesis Corporation | Método para recolectar células troncales placentarias |
US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
IL157350A0 (en) | 2001-02-14 | 2004-02-19 | Anthrogenesis Corp | Post-partum mammalian placenta, its use and placental stem cells therefrom |
US6515001B2 (en) | 2001-03-05 | 2003-02-04 | Chemokine Therapeutic Corporation | IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
CN1668733A (zh) * | 2002-05-30 | 2005-09-14 | 细胞基因公司 | 利用jnk或mkk抑制剂调节细胞分化并治疗骨髓增生异常和脊髓发育不良综合症的方法 |
AU2002325432A1 (en) * | 2002-08-02 | 2004-02-23 | Alexandr Mikhailovich Dygay | Medicinal agent and method for curing pathological syndrome associated to hemodiscrasia |
KR101042448B1 (ko) * | 2002-11-26 | 2011-06-16 | 안트로제네시스 코포레이션 | 세포요법제, 세포요법제 단위 및 이를 이용한 치료방법 |
AU2004212009B2 (en) * | 2003-02-13 | 2010-07-29 | Celularity Inc. | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
GB0321337D0 (en) * | 2003-09-11 | 2003-10-15 | Massone Mobile Advertising Sys | Method and system for distributing advertisements |
CN101966183A (zh) * | 2003-12-02 | 2011-02-09 | 细胞基因公司 | 用于治疗和控制血红蛋白病和贫血病的方法和组合物 |
EP1778271B1 (de) * | 2004-08-18 | 2008-10-22 | IPF Pharmaceuticals GmbH | Peptide zur behandlung von infektionen mit dem herpes-virus |
RU2283654C1 (ru) * | 2005-03-30 | 2006-09-20 | Борис Владимирович Афанасьев | Способ получения ростовых факторов белковой природы, ростовой фактор белковой природы и ингибитор пролиферации фибробластов |
EP1957633B1 (de) | 2005-10-13 | 2013-12-18 | Anthrogenesis Corporation | Immunmodulation unter verwendung von plazentastammzellen |
CN103146640B (zh) | 2005-12-29 | 2015-09-09 | 人类起源公司 | 胎盘干细胞群 |
KR20080081088A (ko) | 2005-12-29 | 2008-09-05 | 안트로제네시스 코포레이션 | 태반 줄기세포와 제2 세포원으로부터 얻은 줄기세포의 공동배양 |
CA2771971A1 (en) * | 2006-06-09 | 2007-12-13 | Kabushiki Kaisha Yakult Honsha | Gene involved in immortalization of human cancer cell and use thereof |
NZ578819A (en) * | 2007-02-12 | 2012-02-24 | Anthrogenesis Corp | Treatment of inflammatory diseases using placental stem cells |
US20100172830A1 (en) * | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
TWM322542U (en) * | 2007-05-23 | 2007-11-21 | Universal Scient Ind Co Ltd | Testing machine |
US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
CN101978045A (zh) * | 2007-09-26 | 2011-02-16 | 细胞基因细胞疗法公司 | 来自人胎盘灌洗液的血管生成细胞 |
ES2530995T3 (es) | 2007-09-28 | 2015-03-09 | Anthrogenesis Corp | Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana |
NO2217329T3 (de) * | 2007-11-07 | 2018-06-09 | ||
KR101829310B1 (ko) * | 2008-06-30 | 2018-02-14 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포의 분화 |
DK2329012T3 (da) * | 2008-08-20 | 2020-08-24 | Celularity Inc | Behandling af slagtilfælde under anvendelse af isolerede placentaceller |
US10104880B2 (en) * | 2008-08-20 | 2018-10-23 | Celularity, Inc. | Cell composition and methods of making the same |
MX339068B (es) * | 2008-08-22 | 2016-05-10 | Anthrogenesis Corp | Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias. |
NZ602455A (en) * | 2008-11-19 | 2014-03-28 | Anthrogenesis Corp | Amnion derived adherent cells |
AU2009316376B2 (en) * | 2008-11-21 | 2015-08-20 | Celularity Inc. | Treatment of diseases, disorders or conditions of the lung using placental cells |
AU2010266263B2 (en) * | 2009-07-02 | 2016-05-19 | Celularity Inc. | Method of producing erythrocytes without feeder cells |
US9121007B2 (en) * | 2010-01-26 | 2015-09-01 | Anthrogenesis Corporatin | Treatment of bone-related cancers using placental stem cells |
KR20190076060A (ko) | 2010-04-07 | 2019-07-01 | 안트로제네시스 코포레이션 | 태반 줄기 세포를 사용한 혈관신생 |
US8562973B2 (en) | 2010-04-08 | 2013-10-22 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
EP2593542B1 (de) | 2010-07-13 | 2018-01-03 | Anthrogenesis Corporation | Verfahren zur erzeugung von natürlichen killerzellen |
AU2011352036A1 (en) | 2010-12-31 | 2013-07-18 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
US9040035B2 (en) | 2011-06-01 | 2015-05-26 | Anthrogenesis Corporation | Treatment of pain using placental stem cells |
US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
US9763983B2 (en) | 2013-02-05 | 2017-09-19 | Anthrogenesis Corporation | Natural killer cells from placenta |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1142466A (en) * | 1979-01-09 | 1983-03-08 | Cesar Milstein | Cell lines |
US4683194A (en) * | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
US5449759A (en) * | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
GB8711614D0 (en) * | 1987-05-16 | 1987-06-24 | Medical Res Council | Proteins |
DE69034091T2 (de) * | 1989-05-10 | 2004-04-22 | Baxter Biotech Technology S.A.R.L. | Herstellung von Hämoglobin und Analogen davon in Nicht-Erythrozytzellen |
US5545727A (en) * | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
JPH05502443A (ja) * | 1989-09-25 | 1993-04-28 | ジェネティックス・インスティテュート・インコーポレイテッド | 幹細胞の成長阻害法 |
US5239061A (en) * | 1990-06-20 | 1993-08-24 | Research Corporation Technologies, Inc. | Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin |
JPH06504056A (ja) * | 1990-12-20 | 1994-05-12 | ザ・ユニバーシティ・オブ・アラバマ・リサーチ・ファウンデーション | トランスジェニック架橋ヘモグロビン |
WO1992020369A1 (en) | 1991-05-14 | 1992-11-26 | Dana Farber Cancer Institute | Use of hemoglobin in a method for the treatment of tumors with chemotherapeutic agents |
US5334706A (en) | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
US5786334A (en) | 1992-08-14 | 1998-07-28 | Technology Resources International, Inc. | Hexapeptide having immunostimulatory activity |
AU694111B2 (en) * | 1993-03-31 | 1998-07-16 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
US5939391A (en) | 1993-03-31 | 1999-08-17 | Pro-Neuron, Inc. | Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation |
US5631219A (en) | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
US5861483A (en) | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
-
1994
- 1994-03-29 AU AU64937/94A patent/AU694111B2/en not_active Ceased
- 1994-03-29 AT AT94912327T patent/ATE225370T1/de not_active IP Right Cessation
- 1994-03-29 CN CN94192220A patent/CN1089344C/zh not_active Expired - Fee Related
- 1994-03-29 ES ES94912327T patent/ES2185649T3/es not_active Expired - Lifetime
- 1994-03-29 DK DK94912327T patent/DK0691988T3/da active
- 1994-03-29 WO PCT/US1994/003349 patent/WO1994022915A1/en active IP Right Grant
- 1994-03-29 CA CA002159506A patent/CA2159506A1/en not_active Abandoned
- 1994-03-29 PT PT94912327T patent/PT691988E/pt unknown
- 1994-03-29 NZ NZ263736A patent/NZ263736A/xx not_active IP Right Cessation
- 1994-03-29 DE DE69431473T patent/DE69431473T2/de not_active Expired - Fee Related
- 1994-03-29 EP EP94912327A patent/EP0691988B1/de not_active Expired - Lifetime
- 1994-03-29 JP JP6522261A patent/JPH08510997A/ja active Pending
- 1994-03-29 UA UA95094339A patent/UA40613C2/uk unknown
- 1994-03-29 RU RU95119854/14A patent/RU2155066C2/ru active
- 1994-03-30 IL IL10917794A patent/IL109177A/xx not_active IP Right Cessation
- 1994-04-08 TW TW083103091A patent/TW403761B/zh not_active IP Right Cessation
- 1994-09-30 US US08/316,424 patent/US6022848A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/477,669 patent/US6432917B1/en not_active Expired - Fee Related
-
2001
- 2001-04-23 US US09/839,164 patent/US20020098583A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU6493794A (en) | 1994-10-24 |
UA40613C2 (uk) | 2001-08-15 |
US6432917B1 (en) | 2002-08-13 |
AU694111B2 (en) | 1998-07-16 |
EP0691988A1 (de) | 1996-01-17 |
CA2159506A1 (en) | 1994-10-13 |
US6022848A (en) | 2000-02-08 |
PT691988E (pt) | 2003-02-28 |
CN1124491A (zh) | 1996-06-12 |
JPH08510997A (ja) | 1996-11-19 |
TW403761B (en) | 2000-09-01 |
NZ263736A (en) | 2000-12-22 |
ATE225370T1 (de) | 2002-10-15 |
DK0691988T3 (da) | 2003-04-14 |
IL109177A (en) | 2000-12-06 |
CN1089344C (zh) | 2002-08-21 |
EP0691988A4 (de) | 1997-07-30 |
EP0691988B1 (de) | 2002-10-02 |
DE69431473D1 (de) | 2002-11-07 |
WO1994022915A1 (en) | 1994-10-13 |
US20020098583A1 (en) | 2002-07-25 |
RU2155066C2 (ru) | 2000-08-27 |
IL109177A0 (en) | 1994-06-24 |
ES2185649T3 (es) | 2003-05-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE225370T1 (de) | Inhibitor der stammzellproliferation und seine verwendung | |
DE69532813D1 (de) | Inhibitor der stammzellenproliferation und dessen verwendung | |
NO984628L (no) | Inhibitor og stimulator av stamcelleproliferasjon og anvendelser derav | |
IL128221A0 (en) | Cell adhesion inhibitors | |
ES8302728A1 (es) | Procedimiento para preparar derivados de prolina . | |
NZ324921A (en) | Cathepsin K crystal structure and methods of identifying inhibitors of this protease |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: WELLSTAT THERAPEUTICS CORP.(N.D.GES.D. STAATES CAL |
|
8339 | Ceased/non-payment of the annual fee |