DE69431432D1 - Untereinheiten von menschlichen n-methyl-d-aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung - Google Patents

Untereinheiten von menschlichen n-methyl-d-aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung

Info

Publication number
DE69431432D1
DE69431432D1 DE69431432T DE69431432T DE69431432D1 DE 69431432 D1 DE69431432 D1 DE 69431432D1 DE 69431432 T DE69431432 T DE 69431432T DE 69431432 T DE69431432 T DE 69431432T DE 69431432 D1 DE69431432 D1 DE 69431432D1
Authority
DE
Germany
Prior art keywords
subunits
nucleic acids
human
receptors
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69431432T
Other languages
English (en)
Other versions
DE69431432T2 (de
Inventor
Lorrie P Daggett
Steven B Ellis
Chen Wang Liaw
Chin-Chun Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21977682&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69431432(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69431432D1 publication Critical patent/DE69431432D1/de
Publication of DE69431432T2 publication Critical patent/DE69431432T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
DE69431432T 1993-04-20 1994-04-20 Untereinheiten von menschlichen n-methyl-d-aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung Revoked DE69431432T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5244993A 1993-04-20 1993-04-20
PCT/US1994/004387 WO1994024284A1 (en) 1993-04-20 1994-04-20 Human n-methyl-d-aspartate receptor subunits, nucleic acids encoding same and uses therefor

Publications (2)

Publication Number Publication Date
DE69431432D1 true DE69431432D1 (de) 2002-10-31
DE69431432T2 DE69431432T2 (de) 2003-04-24

Family

ID=21977682

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431432T Revoked DE69431432T2 (de) 1993-04-20 1994-04-20 Untereinheiten von menschlichen n-methyl-d-aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung

Country Status (10)

Country Link
US (11) US5849895A (de)
EP (1) EP0696320B1 (de)
JP (1) JPH08509607A (de)
AT (1) ATE224952T1 (de)
AU (1) AU696922B2 (de)
CA (1) CA2159106C (de)
DE (1) DE69431432T2 (de)
ES (1) ES2182843T3 (de)
GB (1) GB2286188B (de)
WO (1) WO1994024284A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2110934A1 (en) 1992-12-11 1994-06-12 Robert L. Foldes Human cns receptors of the nmda-r1 family
DE69431432T2 (de) 1993-04-20 2003-04-24 Merck & Co Inc Untereinheiten von menschlichen n-methyl-d-aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung
EP0674003A3 (de) * 1994-03-25 1997-09-10 Allelix Biopharma Proteine die menschliche CNS Rezeptoren modulieren.
GB9414997D0 (en) * 1994-07-26 1994-09-14 Merck Sharp & Dohme Receptor cloning
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
US6822084B1 (en) * 1999-06-25 2004-11-23 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins
US20040204490A1 (en) * 1999-08-31 2004-10-14 Farb David H. Effect of steroids on NMDA receptors depends on subunit composition
WO2001016601A1 (en) * 1999-08-31 2001-03-08 Trustees Of Boston University Effect of steroids on nmda receptors depends on subunit composition
US6916816B2 (en) * 1999-12-16 2005-07-12 The Board Of Regents Of The University Of Nebraska Phenanthryl piperazinyl dicarboxylic acids as selective NMDA receptor modulating agents
GB9929582D0 (en) * 1999-12-16 2000-02-09 Univ Bristol Chemical compounds
CA2398250A1 (en) * 2000-02-01 2001-08-09 Agy Therapeutics, Inc. Interaction of nmda receptor with protein tyrosine phosphatase
US20030092071A1 (en) * 2000-02-01 2003-05-15 Jasna Jerecic Interaction of NMDA receptor with protein tyrosine phosphatase
JP4037268B2 (ja) * 2001-01-30 2008-01-23 塩野義製薬株式会社 ヒトｎｍｄａレセプタースプライスバリアント
US6896872B2 (en) * 2001-06-27 2005-05-24 Svetlana A. Dambinova Rapid multiple panel of biomarkers in laboratory blood tests for TIA/stroke
US20030022253A1 (en) * 2001-07-25 2003-01-30 Nyxis Neurotherapies, Inc. Method for identifying, isolating and producing neuroactive binding agents and binding agents derived thereby
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US6701482B2 (en) * 2001-09-20 2004-03-02 Qualcomm Incorporated Method and apparatus for coding bits of data in parallel
WO2003072014A2 (en) 2002-02-25 2003-09-04 Mpex Bioscience, Inc. Minicell compositions and methods
US6884473B2 (en) * 2002-12-24 2005-04-26 Macronix International Co., Ltd. Method for fabricating metal silicide
US7354834B2 (en) 2003-06-04 2008-04-08 Dongbu Electronics Co., Ltd. Semiconductor devices and methods to form trenches in semiconductor devices
US20050202407A1 (en) * 2003-12-01 2005-09-15 Baylor College Of Medicine Methods and assays for screening anti-neoplastic therapeutic agents
US20060257943A1 (en) * 2005-01-25 2006-11-16 Cis Biotech, Inc. Ischemic biomarkers and their use to predict adverse neurological events from surgery
DE602006018145D1 (de) * 2005-06-13 2010-12-23 Cis Biotech Inc Verfahren zur diagnose und behandlung auf nr2-peptiden beruhender zerebrovaskulärer ereignisse
CA2615147A1 (en) * 2005-07-14 2007-01-18 The University Of British Columbia Neuroprotective modulation of nmda receptor subtype activities
EP1902733A1 (de) * 2006-09-19 2008-03-26 Laboratorios Del Dr. Esteve, S.A. Kombination von einem NMDA Rezeptorligand und einer Verbindung mit 5-HT6 Rezeptor-Affinität
WO2008073984A2 (en) * 2006-12-12 2008-06-19 Cis Biotech, Inc. Nmdar biomarkers for diagnosing and treating cerebral ischemia
WO2009000038A1 (en) * 2007-06-28 2008-12-31 Cnsbio Pty Ltd Combination methods and compositions for treatment of neuropathic pain
CA2716080C (en) 2008-02-20 2016-12-13 Targia Pharmaceuticals Cns pharmaceutical compositions and methods of use
AU2009296457A1 (en) 2008-09-27 2010-04-01 Taraxos Inc. Topical formulations for treatment of neuropathy
WO2017109709A2 (en) * 2015-12-22 2017-06-29 Novartis Ag A high-throughput assay method for identifying allosteric nmda receptor modulators
RU2668534C1 (ru) * 2017-07-18 2018-10-01 Общество с ограниченной ответственностью "ДРД" Диагностический набор реагентов для выявления хронических патологий мозга ишемического генеза

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
US4929555A (en) * 1987-10-19 1990-05-29 Phillips Petroleum Company Pichia transformation
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JP3149133B2 (ja) * 1989-10-27 2001-03-26 ザ ソーク インスティチュート フォア バイオロジカル スタディーズ グルタメート受容体組成物および方法
US5028707A (en) * 1989-11-20 1991-07-02 Board Of Regents, University Of Texas 4-hydroxyquinaldic acid derivatives
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5146257A (en) 1991-02-19 1992-09-08 Minnesota Mining And Manufacturing Company Developer solution replenishment control system for a digital imaging system
US5455279A (en) * 1991-04-19 1995-10-03 The Children's Medical Center Corporation Regimen method of mediating neuronal damage using nitroglycerine
US5502168A (en) * 1991-10-24 1996-03-26 The Johns Hopkins University Monoclonal antibodies to a continuous and cross-reactive epitope and an isolated protein of a sexual stage of P. falciparum
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
JPH0614783A (ja) * 1992-06-30 1994-01-25 Mitsubishi Kasei Corp 新規なタンパク質およびそれをコードする遺伝子
JP3353841B2 (ja) * 1992-11-13 2002-12-03 三菱化学株式会社 新規なタンパク質およびそれをコードする遺伝子
US5502166A (en) * 1992-02-26 1996-03-26 Mitsubishi Chemical Corporation NMDH receptor proteins and genes encoding the same
JP3400470B2 (ja) * 1992-08-12 2003-04-28 三菱化学株式会社 新規なタンパク質およびそれをコードする遺伝子
DE4216321A1 (de) * 1992-05-16 1993-11-18 Basf Ag Untereinheiten von NMDA-Rezeptoren, Verfahren zu ihrer Herstellung und ihre Verwendung
DK68592D0 (da) * 1992-05-25 1992-05-25 Novo Nordisk As Celle
FR2692268B1 (fr) * 1992-06-15 1994-08-19 Rhone Poulenc Rorer Sa Nouveaux polypeptides ayant une activité de récepteur NMDA, acides nucléiques codant pour ces polypeptides et utilisations.
DE4222826A1 (de) * 1992-07-09 1994-01-13 Schering Ag Arzneimittel zur Verhinderung der Toleranzentwicklung während der Behandlung mit Benzodiazepin-Rezeptor-Bindenen Wirkstoffen
DE4227657A1 (de) 1992-08-21 1994-02-24 Hydac Technology Gmbh Ultraschall-Prüfeinrichtung für Gasdruckspeicher
EP0672140B1 (de) * 1992-11-12 2003-02-26 MERCK SHARP & DOHME LTD. Transfektierte zelllinie, exprimierend dns die für die nmda-r2a rezeptor untereinheit und für isoformen der nmda-r1 untereinheit des menschlichen nmda-rezeptors kodieren
GB9307026D0 (en) 1993-04-02 1993-05-26 Merck Sharp & Dohme Receptor cloning
GB9223769D0 (en) 1992-11-12 1992-12-23 Merck Sharp & Dohme Receptor cloning
CA2110934A1 (en) * 1992-12-11 1994-06-12 Robert L. Foldes Human cns receptors of the nmda-r1 family
DE69431432T2 (de) * 1993-04-20 2003-04-24 Merck & Co Inc Untereinheiten von menschlichen n-methyl-d-aspartat rezeptoren, diese kodierende nukleinsäure und dessen verwendung
US5364590A (en) 1993-05-07 1994-11-15 American Sterlizer Company Method for sterilization of objects
EP0674003A3 (de) * 1994-03-25 1997-09-10 Allelix Biopharma Proteine die menschliche CNS Rezeptoren modulieren.
DE4410882A1 (de) * 1994-03-29 1995-10-05 Basf Ag Verfahren zur permanenten Expression von Glutamatrezeptoren
GB9414997D0 (en) * 1994-07-26 1994-09-14 Merck Sharp & Dohme Receptor cloning

Also Published As

Publication number Publication date
US5985586A (en) 1999-11-16
CA2159106C (en) 2009-10-06
US20030013866A1 (en) 2003-01-16
US20020161215A1 (en) 2002-10-31
ES2182843T3 (es) 2003-03-16
GB2286188B (en) 1997-11-12
US6956102B2 (en) 2005-10-18
US6033865A (en) 2000-03-07
US5849895A (en) 1998-12-15
US6825322B2 (en) 2004-11-30
EP0696320B1 (de) 2002-09-25
US20020161193A1 (en) 2002-10-31
US6469142B1 (en) 2002-10-22
GB2286188A (en) 1995-08-09
ATE224952T1 (de) 2002-10-15
US6316611B1 (en) 2001-11-13
JPH08509607A (ja) 1996-10-15
GB9503689D0 (en) 1995-04-12
DE69431432T2 (de) 2003-04-24
US6864358B2 (en) 2005-03-08
CA2159106A1 (en) 1994-10-27
US6521413B1 (en) 2003-02-18
AU6817594A (en) 1994-11-08
EP0696320A1 (de) 1996-02-14
US6111091A (en) 2000-08-29
WO1994024284A1 (en) 1994-10-27
US6376660B1 (en) 2002-04-23
AU696922B2 (en) 1998-09-24

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8380 Miscellaneous part iii

Free format text: DIE ZURUECKNAHME VOM 14.02.2008 WURDE GELOESCHT.