DE69431066T2 - Intradermale arzneimittelabgabevorrichtung - Google Patents

Intradermale arzneimittelabgabevorrichtung

Info

Publication number
DE69431066T2
DE69431066T2 DE69431066T DE69431066T DE69431066T2 DE 69431066 T2 DE69431066 T2 DE 69431066T2 DE 69431066 T DE69431066 T DE 69431066T DE 69431066 T DE69431066 T DE 69431066T DE 69431066 T2 DE69431066 T2 DE 69431066T2
Authority
DE
Germany
Prior art keywords
subject
housing
drug
skin
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69431066T
Other languages
English (en)
Other versions
DE69431066D1 (de
Inventor
Joseph Gross
Gerard Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Corp PLC
Original Assignee
Elan Corp PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp PLC filed Critical Elan Corp PLC
Application granted granted Critical
Publication of DE69431066D1 publication Critical patent/DE69431066D1/de
Publication of DE69431066T2 publication Critical patent/DE69431066T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/14586Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
    • A61M5/14593Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm the diaphragm being actuated by fluid pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
DE69431066T 1993-11-18 1994-11-17 Intradermale arzneimittelabgabevorrichtung Expired - Lifetime DE69431066T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE930882 1993-11-18
US08/183,482 US5527288A (en) 1990-12-13 1994-01-18 Intradermal drug delivery device and method for intradermal delivery of drugs
PCT/IE1994/000055 WO1995013838A1 (en) 1993-11-18 1994-11-17 Intradermal drug delivery device

Publications (2)

Publication Number Publication Date
DE69431066D1 DE69431066D1 (de) 2002-08-29
DE69431066T2 true DE69431066T2 (de) 2003-02-27

Family

ID=26319658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431066T Expired - Lifetime DE69431066T2 (de) 1993-11-18 1994-11-17 Intradermale arzneimittelabgabevorrichtung

Country Status (11)

Country Link
US (1) US5527288A (de)
EP (1) EP0729366B9 (de)
JP (1) JPH09504974A (de)
AT (1) ATE220931T1 (de)
AU (1) AU693136B2 (de)
CA (1) CA2176342A1 (de)
DE (1) DE69431066T2 (de)
ES (1) ES2176310T4 (de)
IL (1) IL111685A (de)
NZ (1) NZ276485A (de)
WO (1) WO1995013838A1 (de)

Families Citing this family (753)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656032A (en) * 1989-06-16 1997-08-12 Science Incorporated Fluid delivery apparatus and method of making same
IE72524B1 (en) * 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
CA2151407A1 (en) * 1995-06-09 1996-12-10 Duncan Newman Injection device
IE77523B1 (en) * 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
NZ318852A (en) * 1995-09-11 1998-10-28 Elan Med Tech Medicament delivery device includes a reservoir, driving means and a hollow needle which extends through the periphery of the skin contacting surface
US5735818A (en) * 1995-10-11 1998-04-07 Science Incorporated Fluid delivery device with conformable ullage
US5693018A (en) * 1995-10-11 1997-12-02 Science Incorporated Subdermal delivery device
DE19538879C1 (de) * 1995-10-19 1996-07-18 Tricumed Gmbh Infusionspumpe
US6068751A (en) * 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
WO1998033452A1 (en) 1997-02-03 1998-08-06 Dec International Nz Limited Active delivery device and related procedures
US6010492A (en) * 1997-02-07 2000-01-04 Sarcos, Lc Apparatus for automatic administration of multiple doses of drugs
US5860957A (en) * 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US6186982B1 (en) 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
US6530900B1 (en) 1997-05-06 2003-03-11 Elan Pharma International Limited Drug delivery device
US6129710A (en) * 1997-05-12 2000-10-10 Spectrum Biotech Inc. Needle cannula attachment device for a disposable syringe
WO1998057681A1 (en) 1997-06-16 1998-12-23 Elan Corporation Plc Drug delivery kit and method of packaging the same
CA2294612A1 (en) 1997-06-16 1998-12-23 Elan Corporation Plc Pre-filled drug-delivery device and method of manufacture and assembly of same
JP2002505008A (ja) 1997-06-16 2002-02-12 エラン コーポレーション ピーエルシー 分析物のin vivo測定のためのセンサーをキャリブレートし、試験する方法と、このような方法に用いるためのデバイス
US6500150B1 (en) 1997-06-16 2002-12-31 Elan Pharma International Limited Pre-filled drug-delivery device and method of manufacture and assembly of same
US5858005A (en) 1997-08-27 1999-01-12 Science Incorporated Subcutaneous infusion set with dynamic needle
US5971722A (en) * 1997-09-05 1999-10-26 Baxter International Inc Electrochemical syringe pump having a sealed storage reservoir for a charge transfer medium
US6147970A (en) * 1997-09-30 2000-11-14 Gte Internetworking Incorporated Quality of service management for aggregated flows in a network system
US6045534A (en) * 1997-10-27 2000-04-04 Sarcos, Inc. Disposable fluid injection module
US6086562A (en) * 1997-10-27 2000-07-11 Sarcos, Inc. Disposable automatic injection device
WO1999029259A1 (en) 1997-12-05 1999-06-17 Dec Research Improvements in and/or relating to delivery devices and their use
US5980496A (en) * 1997-12-11 1999-11-09 Sarcos L.C. Topical drug dispersing apparatus
WO1999032174A1 (de) 1997-12-19 1999-07-01 Arithmed Gmbh Tragbarer medikamentspender zur zeitversetzten verabreichung von injektions- oder infusionspräparaten
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US7335186B2 (en) * 1998-03-13 2008-02-26 Alexander George Brian O'Neil Patient controlled drug delivery device
WO1999048546A1 (en) 1998-03-23 1999-09-30 Elan Corporation, Plc Drug delivery device
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
WO1999062576A1 (en) 1998-06-04 1999-12-09 Elan Corporation, Plc Gas driven drug delivery device
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
CA2330207C (en) * 1998-06-10 2005-08-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
WO2000012173A1 (en) 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
DE60018726T2 (de) 1999-04-16 2006-04-13 Johnson & Johnson Consumer Companies, Inc. Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US6461331B1 (en) * 1999-05-21 2002-10-08 Minimed Inc. Device and method for infusion of small molecule insulin mimetic materials
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
ES2248165T3 (es) * 1999-11-15 2006-03-16 Velcro Industries B.V. Elemento de fijacion a la piel.
WO2001051109A1 (en) * 2000-01-07 2001-07-19 Biovalve Technologies, Inc. Injection device
US20010041869A1 (en) * 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
US6572740B2 (en) * 2000-04-13 2003-06-03 Elan Pharma International Limited Electrolytic cell
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
ATE293466T1 (de) * 2000-08-18 2005-05-15 Becton Dickinson Co Vorrichtung zum verabreichen einer flüssigkeit mit einem konstanten volumenstrom und einem knopf für eine einstellbare bolusabgabe
BR0114634A (pt) * 2000-10-13 2004-01-27 Alza Corp Aplicador por impacto de disposição de microlâmina
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
ES2574917T3 (es) * 2000-11-30 2016-06-23 Valeritas, Inc. Sistemas y procedimientos de suministro y medición de fluido
EP1339442A4 (de) * 2000-11-30 2006-12-27 Biovalve Technologies Inc Injektionssysteme
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) * 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
JP5208347B2 (ja) 2001-02-23 2013-06-12 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 新規なワクチン
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
JP2004525713A (ja) * 2001-04-13 2004-08-26 ベクトン・ディキンソン・アンド・カンパニー 全身吸収のために皮膚の皮内層中に物質を投与するための方法および装置
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
MY134424A (en) 2001-05-30 2007-12-31 Saechsisches Serumwerk Stable influenza virus preparations with low or no amount of thiomersal
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
JP2004531578A (ja) * 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
US6943267B1 (en) 2001-08-24 2005-09-13 Utah State University Thiophosphonate inhibitors of phosphatase enzymes and metallophosphatases
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
US8152789B2 (en) 2001-10-23 2012-04-10 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) * 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
WO2003024508A2 (en) * 2001-09-21 2003-03-27 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20060122577A1 (en) * 2001-09-26 2006-06-08 Poulsen Jens U Modular drug delivery system
US20030088238A1 (en) * 2001-09-26 2003-05-08 Poulsen Jens Ulrik Modular drug delivery system
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US7311693B2 (en) * 2001-11-26 2007-12-25 Nilimedix Ltd. Drug delivery device and method
US7291126B2 (en) * 2001-11-26 2007-11-06 Nilimedix Ltd. Drug delivery device and method
US6736796B2 (en) 2001-11-26 2004-05-18 Nili-Med Ltd. Fluid drug delivery device
US7407490B2 (en) * 2001-11-29 2008-08-05 Novo Nordisk A/S Delivery device and cartridge therefore
WO2003045474A1 (en) * 2001-11-29 2003-06-05 Novo Nordisk A/S Portable delivery device, pressurised by a pumped liquid, and cartridge therefore
US6872275B2 (en) 2001-12-14 2005-03-29 Kimberly-Clark Worldwide, Inc. Process for adding superabsorbent to a pre-formed fibrous web via in situ polymerization
WO2003066126A2 (en) 2002-02-04 2003-08-14 Becton, Dickinson And Company Dermal access member
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
ES2406711T3 (es) 2002-03-26 2013-06-07 Becton, Dickinson And Company Dispositivo de suministro de fluido por etapas múltiples
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
EP3375463A1 (de) 2002-05-06 2018-09-19 Becton, Dickinson and Company Verfahren und vorrichtung zur steuerung von arzneimittelpharmakokinetik
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US6801041B2 (en) * 2002-05-14 2004-10-05 Abbott Laboratories Sensor having electrode for determining the rate of flow of a fluid
US20050005710A1 (en) * 2002-05-15 2005-01-13 Therafuse, Inc. Liquid metering system
US6932796B2 (en) * 2002-05-15 2005-08-23 Tearafuse, Inc. Liquid metering system
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US7008403B1 (en) * 2002-07-19 2006-03-07 Cognitive Ventures Corporation Infusion pump and method for use
CN100479875C (zh) * 2002-07-22 2009-04-22 贝克顿·迪金森公司 贴片状注射装置
US20040059316A1 (en) * 2002-07-31 2004-03-25 Smedegaard Jorgen K. Medical delivery device
EP1386626A1 (de) 2002-07-31 2004-02-04 Novo Nordisk A/S Abgabevorrichtung zur Behandlung von Diabetes mellitus
JP2005537054A (ja) * 2002-08-30 2005-12-08 ベクトン・ディキンソン・アンド・カンパニー 免疫調節化合物の薬物動態を制御する方法
US20040116905A1 (en) * 2002-09-09 2004-06-17 Pedersen Per Elgard Flow restrictor with safety feature
CN1723053A (zh) * 2002-09-12 2006-01-18 儿童医院医疗中心 无痛药物注射的方法和设备
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
US7014625B2 (en) * 2002-10-07 2006-03-21 Novo Nordick A/S Needle insertion device
US20050075670A1 (en) * 2002-10-07 2005-04-07 Henrik Bengtsson Signal device with electro-muscle stimulation feature
EP1556103A1 (de) * 2002-10-07 2005-07-27 Novo Nordisk A/S Nadelvorrichtung mit einer vielzahl von nadeln
US7399401B2 (en) * 2002-10-09 2008-07-15 Abbott Diabetes Care, Inc. Methods for use in assessing a flow condition of a fluid
US7388079B2 (en) * 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
US7252651B2 (en) 2003-01-07 2007-08-07 Becton, Dickinson And Company Disposable injection device
US8641987B2 (en) * 2003-01-24 2014-02-04 Applied Biosystems, Llc Sample chamber array and method for processing a biological sample
IL154243A0 (en) * 2003-02-02 2003-09-17 Silex Projectors Ltd Stable infusion device
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20060069382A1 (en) * 2003-04-11 2006-03-30 Novo Nordisk A/S Delivery device
WO2004089448A1 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Delivery device
ES2737835T3 (es) * 2003-04-23 2020-01-16 Valeritas Inc Bomba accionada hidráulicamente para la administración de medicamentos de larga duración
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
EP1624914B1 (de) 2003-05-08 2008-04-16 Novo Nordisk A/S Interne nadeleinführvorrichtung
WO2004098684A2 (en) 2003-05-08 2004-11-18 Novo Nordisk A/S Skin mountable injection device with a detachable needle insertion actuation
EP1631336B1 (de) 2003-05-08 2010-02-17 Novo Nordisk A/S Schwenkbare vorrichtung für eine injektionsnadel
EP1475113A1 (de) * 2003-05-08 2004-11-10 Novo Nordisk A/S Externer Nadeleinsetzer
AU2004272972A1 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
AU2004264839B2 (en) * 2003-06-13 2009-06-04 Becton, Dickinson And Company Improved intra-dermal delivery of biologically active agents
ATE357939T1 (de) 2003-07-08 2007-04-15 Novo Nordisk As Tragbares medikamentenabgabegerät mit einer eingekapselten nadel
EP1502613A1 (de) 2003-08-01 2005-02-02 Novo Nordisk A/S Gerät mit Rückziehvorrichting für eine Nadel
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
CA2535138C (en) 2003-08-12 2013-01-08 Becton, Dickinson And Company Patch-like infusion device
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005023328A2 (en) * 2003-08-26 2005-03-17 Becton Dickinson And Company Methods for intradermal delivery of therapeutics agents
WO2005025641A2 (en) 2003-08-28 2005-03-24 Becton, Dickinson And Company Intradermal injection device
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US7361155B2 (en) * 2003-09-16 2008-04-22 Therafuse, Inc. Compensating liquid delivery system and method
JP2005087520A (ja) * 2003-09-18 2005-04-07 Terumo Corp 薬液注入装置
EP1527792A1 (de) * 2003-10-27 2005-05-04 Novo Nordisk A/S Eine auf die Haut anbringbare medizinische Injektionsvorrichtung
EP1696981B1 (de) 2003-10-21 2009-10-21 Novo Nordisk A/S Innerer flüssigkeitskonnektor zur herstellung einer flüssigkeitsverbindung
KR20060099520A (ko) * 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 의료용 피부 장착 장치
EP2179754B1 (de) 2003-10-23 2016-06-01 Novo Nordisk A/S Eine auf der Haut anbringbare medizinische Injektionsvorrichtung
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
WO2005057175A2 (en) 2003-12-09 2005-06-23 Dexcom, Inc. Signal processing for continuous analyte sensor
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US7670314B2 (en) * 2004-02-17 2010-03-02 Children's Hospital Medical Center Injection device for administering a vaccine
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
WO2005091922A2 (en) * 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
US7108679B2 (en) * 2004-03-11 2006-09-19 Becton, Dickinson And Company Intradermal syringe and needle assembly
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
WO2005094920A1 (en) * 2004-03-30 2005-10-13 Novo Nordisk A/S Actuator system comprising lever mechanism
JP2007530860A (ja) * 2004-03-30 2007-11-01 ノボ・ノルデイスク・エー/エス 検出手段を備えるアクチュエータシステム
PL1732627T3 (pl) 2004-03-31 2010-09-30 Lilly Co Eli Urządzenie wstrzykujące z kasetą z igłami do aplikowania cieczy farmaceutycznej
CA2562643A1 (en) * 2004-04-12 2005-11-24 Allergan, Inc. Multi-site injection system
US20070135697A1 (en) * 2004-04-19 2007-06-14 Therasense, Inc. Method and apparatus for providing sensor guard for data monitoring and detection systems
WO2005115360A2 (en) * 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
WO2006024650A2 (en) * 2004-09-02 2006-03-09 Novo Nordisk A/S Medical device adapted for detection of drug condition
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
WO2006032689A1 (en) 2004-09-22 2006-03-30 Novo Nordisk A/S Medical device with transcutaneous cannula device
WO2006032692A1 (en) 2004-09-22 2006-03-30 Novo Nordisk A/S Medical device with cannula inserter
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
CN101060856B (zh) 2004-11-22 2011-01-19 诺和诺德公司 可溶、稳定的含胰岛素制剂
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
CA2891057C (en) 2004-11-22 2018-11-13 Kaleo, Inc. Medicament delivery apparatus and movable indicator
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
DE602005016298D1 (de) * 2004-12-06 2009-10-08 Novo Nordisk As Belüftete an der haut befestigbare vorrichtung
ATE514440T1 (de) * 2005-01-17 2011-07-15 Novo Nordisk As Flüssigkeitsausgabevorrichtung mit integrierter überwachung von physiologischen eigenschaften
JP2008528086A (ja) * 2005-01-24 2008-07-31 ノボ・ノルデイスク・エー/エス 保護された穿刺装置を有する医療用装置
JP4948422B2 (ja) 2005-02-01 2012-06-06 インテリジェクト,インコーポレイテッド 薬物送出の装置、システムおよび方法
WO2006089958A1 (en) 2005-02-25 2006-08-31 Novo Nordisk A/S Pump assembly with safety valve
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US20070060904A1 (en) * 2005-03-14 2007-03-15 Becton, Dickinson And Company Filling system and method for syringes with short needles
CA2601022C (en) 2005-03-23 2023-03-07 Glaxosmithkline Biologicals S.A. Use of an influenza virus an oil-in-water emulsion adjuvant to induce cd4 t-cell and/or improved b-memory cell response
TR201910900T4 (tr) 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
WO2006108809A1 (en) 2005-04-13 2006-10-19 Novo Nordisk A/S Medical skin mountable device and system
US7641649B2 (en) * 2005-05-06 2010-01-05 Medtronic Minimed, Inc. Reservoir support and method for infusion device
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US7905868B2 (en) * 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8277415B2 (en) * 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8137314B2 (en) * 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US8512288B2 (en) * 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8840586B2 (en) * 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
CN101175516B (zh) * 2005-05-13 2011-02-16 诺和诺德公司 适于检测经皮装置脱离的医疗装置
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
IL169807A (en) * 2005-07-21 2015-03-31 Steadymed Ltd Device for administering a drug
US9687186B2 (en) 2005-07-21 2017-06-27 Steadymed Ltd. Drug delivery device
IL175460A (en) 2006-05-07 2011-05-31 Doron Aurbach Drug delivery device
BRPI0614475B8 (pt) 2005-08-03 2021-05-25 Fraunhofer Usa Inc polipeptídeo, anticorpo, ácido nucleico, vetores, célula hospedeira, composição e processos de produção de anticorpo
DK1940459T3 (da) * 2005-09-06 2014-05-26 Theraject Inc Fast-opløsningsperforator indeholdende aktivstofpartikel og/eller aktivstof-adsorberede partikler
US8105279B2 (en) 2005-09-26 2012-01-31 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US8142781B2 (en) 2005-10-07 2012-03-27 Armagen Technologies, Inc. Fusion proteins for blood-brain barrier delivery
US8741260B2 (en) * 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
US8124095B2 (en) * 2005-10-07 2012-02-28 Armagen Technologies, Inc. Fusion proteins for delivery of erythropoietin to the CNS
CN101291697B (zh) * 2005-10-17 2011-05-18 诺沃-诺迪斯克有限公司 有通气孔的药物贮存单元
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US20090118592A1 (en) * 2005-12-08 2009-05-07 Novo Nordisk A/S Medical System Comprising a Sensor Device
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
WO2007092637A2 (en) 2006-02-09 2007-08-16 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
CA2642056A1 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Hpv antigens, vaccine compositions, and related methods
KR20080106433A (ko) * 2006-02-13 2008-12-05 프라운호퍼 유에스에이, 인코포레이티드 인플루엔자 항원, 백신 조성물 및 관련 방법
CA2536845C (en) 2006-02-16 2009-10-27 Pka Softtouch Corp. Drug delivery device
EP1998684A4 (de) * 2006-03-10 2014-09-17 Massachusetts Inst Technology Konjugate und nanosysteme mit ausgelöstem selbstzusammenbau
US20090062778A1 (en) * 2006-03-13 2009-03-05 Novo Nordisk A/S Medical System Comprising Dual-Purpose Communication Means
CN101401313B (zh) * 2006-03-13 2014-06-11 诺沃—诺迪斯克有限公司 用于使用成双通信装置的电子设备的安全配对的系统
MX2008011714A (es) 2006-03-14 2008-11-12 Univ Southern California Dispositivo de mems y metodo de administracion de agentes terapeuticos.
WO2007111806A2 (en) * 2006-03-23 2007-10-04 Massachusetts Eye And Ear Infirmary Cyclopentane heptanoic acid compounds for reducing body fat
SG173319A1 (en) 2006-03-30 2011-08-29 Valeritas Inc Multi-cartridge fluid delivery device
WO2008105773A2 (en) 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
US20090325944A1 (en) * 2006-04-12 2009-12-31 Suzanne Walker Kahne Methods and Compositions for Modulating Glycosylation
CN101426542A (zh) * 2006-04-26 2009-05-06 诺沃-诺迪斯克有限公司 含经涂覆的密封构件的包装件中的可安装在表皮上的装置
CA2652280C (en) 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
ES2570334T3 (es) 2006-06-02 2016-05-17 Harvard College Remodelado superficial de proteínas
WO2007141210A1 (en) * 2006-06-06 2007-12-13 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス, インコーポレイテッド スマートな非経口送達システム
US20080015494A1 (en) * 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
CN105727276A (zh) 2006-07-17 2016-07-06 葛兰素史密丝克莱恩生物有限公司 流感疫苗
US9115358B2 (en) * 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
JP2010500880A (ja) * 2006-08-14 2010-01-14 マサチューセッツ・インスティテュート・オブ・テクノロジー ヘマグルチニンポリペプチド、ならびにヘマグルチニンポリペプチドに関連する試薬および方法
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
US8759297B2 (en) * 2006-08-18 2014-06-24 Armagen Technologies, Inc. Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns
US20080051765A1 (en) * 2006-08-23 2008-02-28 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7789857B2 (en) * 2006-08-23 2010-09-07 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7828764B2 (en) * 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7811262B2 (en) * 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7794434B2 (en) * 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
DE102006047613A1 (de) * 2006-10-07 2008-04-10 Sanofi-Aventis Deutschland Gmbh Peristaltische Mikropumpe mit wechselbarem Pumpenkopf
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
WO2008062335A1 (en) * 2006-11-21 2008-05-29 Koninklijke Philips Electronics, N.V. Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system
US20100150994A1 (en) 2006-12-01 2010-06-17 Anterios, Inc. Amphiphilic entity nanoparticles
AU2007333225B2 (en) * 2006-12-08 2014-06-12 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
CA2676221C (en) 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
JP2010520409A (ja) * 2007-03-06 2010-06-10 ノボ・ノルデイスク・エー/エス アクチュエータシステムを備えるポンプ組立体
CA2680592C (en) 2007-03-15 2016-07-05 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof in treating pathological conditions
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
EP2508531B1 (de) 2007-03-28 2016-10-19 President and Fellows of Harvard College Geheftete Polypeptide
EP2144600A4 (de) 2007-04-04 2011-03-16 Massachusetts Inst Technology Poly (aminsäure)-zielmoleküle
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
CA2685558A1 (en) * 2007-04-28 2008-11-06 Fraunhofer Usa, Inc. Trypanosoma antigens, vaccine compositions, and related methods
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
WO2008136845A2 (en) * 2007-04-30 2008-11-13 Medtronic Minimed, Inc. Reservoir filling, bubble management, and infusion medium delivery systems and methods with same
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US20090011040A1 (en) * 2007-05-02 2009-01-08 Naash Muna I Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
EP2497462A1 (de) 2007-06-01 2012-09-12 Novo Nordisk A/S Stabile nichtwässrige pharmazeutische Zusammensetzungen
CA2688184A1 (en) 2007-06-08 2008-12-18 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
DK2175881T3 (da) * 2007-06-14 2012-10-22 Crucell Switzerland Ag Intradermal influenzavaccine
US8524444B2 (en) 2007-06-15 2013-09-03 President And Fellows Of Harvard College Methods and compositions for detections and modulating O-glycosylation
US8002752B2 (en) * 2007-06-25 2011-08-23 Medingo, Ltd. Protector apparatus
CA2692933C (en) * 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
CA2694762A1 (en) 2007-07-27 2009-02-05 Armagen Technologies, Inc. Methods and compositions for increasing alpha-l-iduronidase activity in the cns
US8399410B2 (en) * 2007-08-06 2013-03-19 Allergan, Inc. Methods and devices for desmopressin drug delivery
CN101820903A (zh) * 2007-08-20 2010-09-01 美国弗劳恩霍夫股份有限公司 预防性和治疗性流感疫苗、抗原、组合物和方法
US7771391B2 (en) * 2007-09-28 2010-08-10 Calibra Medical, Inc. Disposable infusion device with snap action actuation
WO2009044401A2 (en) 2007-10-02 2009-04-09 Yossi Gross External drug pump
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US10420880B2 (en) 2007-10-02 2019-09-24 West Pharma. Services IL, Ltd. Key for securing components of a drug delivery system during assembly and/or transport and methods of using same
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
EP2205074A4 (de) * 2007-10-04 2013-07-31 Harvard College Moenomycin-analoga, syntheseverfahren und verwendung
US9452258B2 (en) 2007-10-09 2016-09-27 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
ES2627233T3 (es) 2007-10-12 2017-07-27 Massachusetts Institute Of Technology Nanotecnología de vacunas
US8858787B2 (en) 2007-10-22 2014-10-14 Baxter International Inc. Dialysis system having non-invasive fluid velocity sensing
EP2211974A4 (de) 2007-10-25 2013-02-27 Proteus Digital Health Inc Informationssystem für flüssigkeitsüberströmkanal
CN101888859B (zh) * 2007-10-31 2014-09-17 诺沃-诺迪斯克有限公司 用作消毒屏障的无孔材料
US8419638B2 (en) 2007-11-19 2013-04-16 Proteus Digital Health, Inc. Body-associated fluid transport structure evaluation devices
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
EP2666510B1 (de) 2007-12-20 2017-10-18 University Of Southern California Vorrichtung zur kontrollierten Abgabe von Therapeutika
AU2008341030B2 (en) 2007-12-24 2014-04-17 Vaxxas Pty Limited Coating method
EP2237787A4 (de) * 2008-01-03 2012-03-21 Massachusetts Inst Technology Decoy-influenzatherapien
EP2266643B1 (de) 2008-01-03 2015-06-17 University Of Southern California Implantierbare Medikamentenverabreichungsvorrichtung und Apparat und und Methode zu ihrer Befüllung
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US20090191067A1 (en) * 2008-01-25 2009-07-30 Phluid,Inc. Two chamber pumps and related methods
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
CA2749347C (en) 2008-02-07 2018-03-27 The University Of Queensland Patch production
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
JP5149049B2 (ja) * 2008-03-17 2013-02-20 テルモ株式会社 薬剤注入装置
US8396528B2 (en) 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
CA2721060A1 (en) * 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
AU2009243187C1 (en) * 2008-04-28 2015-12-24 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US9199035B2 (en) 2008-05-08 2015-12-01 Minipumps, Llc. Drug-delivery pumps with dynamic, adaptive control
WO2009137780A2 (en) 2008-05-08 2009-11-12 Replenish Pumps, Llc Implantable pumps and cannulas therefor
EP2323716B1 (de) 2008-05-08 2015-03-04 MiniPumps, LLC Arzneiabgabepumpen
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
CN102202706A (zh) 2008-05-08 2011-09-28 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
PT2712622T (pt) * 2008-05-21 2016-10-13 Ferring Bv Desmopressina orodispersível para aumentar o período inicial de sono tranquilo
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
WO2009147641A2 (en) * 2008-06-06 2009-12-10 Wockhardt Research Centre A device and a system for delivery of biological material
WO2009158687A1 (en) 2008-06-26 2009-12-30 Anterios, Inc. Dermal delivery
ES2801898T3 (es) * 2008-06-26 2021-01-14 Calibra Medical Llc Dispositivo de infusión desechable con detector de oclusión
DK2318832T3 (da) 2008-07-15 2014-01-20 Academia Sinica Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder
CA2734991A1 (en) * 2008-07-23 2010-01-28 Massachusetts Institute Of Technology Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival
US20110144306A1 (en) * 2008-07-23 2011-06-16 President And Fellows Of Harvard College Ligation of stapled polypeptides
US8056582B2 (en) * 2008-08-08 2011-11-15 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
US9393369B2 (en) 2008-09-15 2016-07-19 Medimop Medical Projects Ltd. Stabilized pen injector
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
EP2334234A4 (de) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc Vorrichtung zur messung der konzentration eines gelösten stoffs und entsprechende verfahren
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) * 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
WO2010077806A1 (en) 2008-12-15 2010-07-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
CN105132387A (zh) * 2008-12-22 2015-12-09 绿光生物科学公司 用于制造化合物的组合物和方法
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
US8573027B2 (en) 2009-02-27 2013-11-05 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
EP2408474B1 (de) 2009-03-18 2019-06-26 Armagen, Inc. Zusammensetzungen und verfahren zur verabreichung von igg-köderrezeptor-fusionsproteinen in die blut-hirn-schranke
JP2012523425A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
EP2416660B1 (de) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Fettsäureamidhydrolase-hemmer
US9221886B2 (en) 2009-04-28 2015-12-29 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
JP2012528858A (ja) 2009-06-01 2012-11-15 プレジデント アンド フェロウズ オブ ハーバード カレッジ O−GlcNAc転移酵素阻害剤およびその使用
DK2442852T3 (da) 2009-06-19 2013-07-29 Sanofi Aventis Deutschland Injektionsanordning til et flydende lægemiddel
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CA2921304C (en) 2009-07-30 2018-06-05 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US20110060280A1 (en) * 2009-09-04 2011-03-10 Sean Caffey Adhesive skin patch with pump for subcutaneous drug delivery
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
US10071196B2 (en) 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
WO2011034516A1 (en) * 2009-09-15 2011-03-24 Becton, Dickinson And Company Self-injection device
USD810278S1 (en) 2009-09-15 2018-02-13 Medimop Medical Projects Ltd. Injector device
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
CN102724913A (zh) 2009-09-30 2012-10-10 德克斯康公司 经皮分析物传感器
EP2485761B1 (de) 2009-10-09 2019-02-27 Armagen, Inc. Verfahren und zusammensetzungen für erhöhte iduronat-2-sulfatase-aktivität im zns
DK2501716T3 (en) 2009-11-19 2015-04-07 Solis Biodyne Oü Formations to increase polypeptidstabilitet and activity and related practices
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US9833562B2 (en) 2009-12-16 2017-12-05 Becton, Dickinson And Company Self-injection device
WO2011075104A1 (en) 2009-12-16 2011-06-23 Becton, Dickinson And Company Self-injection device
US9555187B2 (en) 2009-12-16 2017-01-31 Becton, Dickinson And Company Self-injection device
WO2011075103A1 (en) 2009-12-16 2011-06-23 Becton, Dickinson And Company Self-injection device
CA2784488A1 (en) 2009-12-16 2011-06-23 Chrontech Pharma Ab Injection needle and device
DK2781228T3 (en) 2009-12-16 2016-03-21 Becton Dickinson Co A device for self-injection
JP5650241B2 (ja) 2009-12-16 2015-01-07 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 自己注射装置
US9180127B2 (en) 2009-12-29 2015-11-10 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
AU2011210840B2 (en) 2010-01-27 2014-12-11 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
SG182825A1 (en) 2010-02-01 2012-09-27 Proteus Biomedical Inc Data gathering system
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
KR20120114368A (ko) 2010-02-01 2012-10-16 프로테우스 디지털 헬스, 인코포레이티드 양 손목을 이용한 데이터 수집 시스템
MX361011B (es) * 2010-02-03 2018-11-26 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de ácido graso.
WO2011112635A1 (en) 2010-03-08 2011-09-15 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
CA3096110C (en) 2010-03-24 2023-11-14 Abbott Diabetes Care Inc. Medical device inserters and processes of inserting and using medical devices
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US8920376B2 (en) 2010-04-20 2014-12-30 Minipumps, Llc Fill-status sensors for drug pump devices
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル, インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
EP2566853B1 (de) 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolone als fettsäuresynthasehemmer
DK2566953T3 (en) 2010-05-07 2019-04-15 Greenlight Biosciences Inc METHODS OF MANAGING THE POWER BY METABOLIC ROADS USING ENZYMOUS LOCATION
US9452261B2 (en) 2010-05-10 2016-09-27 Medimop Medical Projects Ltd. Low volume accurate injector
CN106977429B (zh) 2010-05-11 2021-08-24 蓝瑟斯医学影像公司 用于合成和使用造影剂的组合物、方法和系统
US9061097B2 (en) 2010-06-07 2015-06-23 Amgen Inc. Drug delivery device
ES2664872T3 (es) 2010-06-18 2018-04-23 Taiho Pharmaceutical Co., Ltd Moduladores PRPK-TPRKB y sus usos
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
DE102010038733A1 (de) * 2010-07-30 2012-02-02 Robert Bosch Gmbh Modulare Mikronadel-Transportvorrichtung
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT2603600T (pt) 2010-08-13 2019-02-27 Aileron Therapeutics Inc Macrociclos peptidomiméticos
WO2012030980A1 (en) 2010-08-31 2012-03-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
EP2611478B1 (de) 2010-09-02 2022-08-17 Becton, Dickinson and Company Selbstinjektionsvorrichtung mit nadelschutz mit aktivierungsverhinderung
JP2013541528A (ja) 2010-09-21 2013-11-14 マサチューセッツ インスティテュート オブ テクノロジー ヒト適応haポリペプチド、ワクチン、およびインフルエンザの処置
US8585677B2 (en) 2010-09-21 2013-11-19 Brigham Young University Laminar injection apparatus and method
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
WO2012042517A1 (en) 2010-09-27 2012-04-05 Steadymed, Ltd. Size-efficient drug-delivery device
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
WO2012047941A2 (en) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
NZ612909A (en) 2011-01-10 2015-09-25 Infinity Pharmaceuticals Inc Processes for preparing isoquinolinones and solid forms of isoquinolinones
EP2982373B1 (de) 2011-01-19 2018-06-13 Topokine Therapeutics, Inc. Verfahren und zusammensetzungen zur reduzierung von körperfett
KR20230007537A (ko) 2011-01-24 2023-01-12 안테리오스, 인코퍼레이티드 나노입자 조성물, 이의 제형, 및 그의 용도
JP2014503586A (ja) 2011-01-24 2014-02-13 アンテリオス, インコーポレイテッド 油組成物
WO2012103035A1 (en) 2011-01-24 2012-08-02 Anterios, Inc. Nanoparticle compositions
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
JP6084932B2 (ja) * 2011-02-09 2017-02-22 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 夜間基礎投薬デバイス
US8703818B2 (en) 2011-03-03 2014-04-22 Tersus Pharmaceuticals, LLC Compositions and methods comprising C16:1n7-palmitoleate
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
US9193767B2 (en) 2011-03-30 2015-11-24 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9457183B2 (en) 2011-06-15 2016-10-04 Tripep Ab Injection needle and device
AU2012272815B2 (en) 2011-06-22 2017-09-07 The General Hospital Corporation Treatment of proteinopathies
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2014000648A (es) 2011-07-19 2014-09-25 Infinity Pharmaceuticals Inc Compuestos heterociclicos y sus usos.
US9115053B2 (en) 2011-07-22 2015-08-25 Massachusetts Institute Of Technology Activators of class I histone deacetlyases (HDACS) and uses thereof
US20140194854A1 (en) 2011-08-29 2014-07-10 Sid Technologies Llc Subcutaneous and intradermal patch infusers
TW201311663A (zh) 2011-08-29 2013-03-16 Infinity Pharmaceuticals Inc 雜環化合物及其用途
SG2014013767A (en) 2011-09-09 2014-05-29 Lantheus Medical Imaging Inc Compositions, methods, and systems for the synthesis and use of imaging agents
WO2013036787A2 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3384938A1 (de) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Manipulierte nukleinsäuren und verfahren zur verwendung davon
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
EP3682905B1 (de) 2011-10-03 2021-12-01 ModernaTX, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
US20130090633A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Osmotic patch pump
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
CA2852468A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
US8702683B2 (en) 2011-11-08 2014-04-22 Elwha Llc Systems and methods for dynamic drug therapy response to blood pressure incidents
US8753284B2 (en) 2011-11-08 2014-06-17 Elwha, Llc Blood pressure cuff
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
AT512226B1 (de) * 2011-11-22 2013-09-15 Toeth Ewald Aderlassnadel
WO2013081706A1 (en) 2011-12-02 2013-06-06 Armagen Technologies, Inc. Methods and compositions for increasing arylsulfatase a activity in the cns
FI3831283T3 (fi) 2011-12-11 2023-06-01 Abbott Diabetes Care Inc Analyyttianturilaitteita, -liitäntöjä ja -menetelmiä
RS63244B1 (sr) 2011-12-16 2022-06-30 Modernatx Inc Kompozicije modifikovane mrna
CN104114170B (zh) 2011-12-16 2021-07-06 佛罗里达大学研究基金会 4′-去铁硫素类似物的用途
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
CN104245014B (zh) * 2012-01-31 2017-05-24 麦迪麦珀医疗项目有限公司 时间依赖性的药物输送装置
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RU2017145921A (ru) 2012-02-15 2019-02-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
WO2013136327A1 (en) 2012-03-15 2013-09-19 Steadymed Ltd. Enhanced infusion-site pain-reduction for drug-delivery devices
WO2013140395A1 (en) 2012-03-19 2013-09-26 Steadymed Ltd. Fluid-connection mechanism for patch-pumps
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2833892A4 (de) 2012-04-02 2016-07-20 Moderna Therapeutics Inc Modifizierte polynukleotide zur herstellung von in der onkologie nützlichen proteinen und peptiden
US20150080844A1 (en) * 2012-04-02 2015-03-19 Medtronic, Inc. Therapy for kidney disease and/or heart failure by intradermal infusion
EP2850090B1 (de) 2012-04-06 2018-10-03 President and Fellows of Harvard College Chemoenzymatische verfahren zur synthetisierung von moenomycin-analoga
EP2850091A1 (de) 2012-04-06 2015-03-25 President and Fellows of Harvard College Verfahren und verbindungen zur identifizierung von glycosyltransferaseinhibitoren
US9273084B2 (en) 2012-04-06 2016-03-01 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
EP2846833A4 (de) 2012-05-10 2016-01-06 Massachusetts Inst Technology Mittel zur influenzaneutralisierung
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
KR101494616B1 (ko) * 2012-06-12 2015-03-04 (주)제이엠바이오텍 피부용 자가 주입기구
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014046950A1 (en) * 2012-09-24 2014-03-27 Enable Injections, Llc Medication vial and injector assemblies and methods of use
WO2014052647A2 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
PT2909204T (pt) 2012-10-12 2019-03-21 Dana Farber Cancer Inst Inc Inibidores de gsk3 e métodos de utilização dos mesmos
US20140213866A1 (en) 2012-10-12 2014-07-31 Dexcom, Inc. Sensors for continuous analyte monitoring, and related methods
JP2014079325A (ja) * 2012-10-15 2014-05-08 Seiko Epson Corp 流体注入装置
WO2014063068A1 (en) 2012-10-18 2014-04-24 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
SI2914296T2 (sl) 2012-11-01 2022-01-31 Infinity Pharmaceuticals, Inc. Zdravljenje raznih vrst raka z uporabo modulatorjev izooblik PI3-kinaze
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
WO2014071247A1 (en) 2012-11-02 2014-05-08 Dana-Farber Cancer Institute, Inc. Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors
SG11201600237YA (en) 2012-11-21 2016-02-26 Topokine Therapeutics Inc Methods and compositions for locally increasing body fat
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
WO2014082065A1 (en) 2012-11-26 2014-05-30 President And Fellows Of Harvard College Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof
WO2014100730A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
CA2899363A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
PL2935222T3 (pl) 2012-12-21 2019-02-28 Epizyme Inc Inhibitory PRMT5 i ich zastosowania
MX2015008157A (es) 2012-12-21 2016-02-22 Corium Int Inc Microarreglo para la entrega de agente terapeutico y metodos de uso.
WO2014100695A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
WO2014113089A2 (en) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
WO2014124319A2 (en) 2013-02-07 2014-08-14 Massachusetts Institute Of Technology Human adaptation of h5 influenza
AU2014214844B2 (en) 2013-02-07 2017-12-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
US9861801B2 (en) 2013-02-28 2018-01-09 Kimberly-Clark Worldwide, Inc. Drug delivery device
EP2961471B1 (de) 2013-02-28 2023-10-25 Sorrento Therapeutics, Inc. Vorrichtung zur transdermalen wirkstofffreisetzung
ES2921481T3 (es) 2013-03-12 2022-08-26 Corium Inc Aplicadores para microproyecciones
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2968118B1 (de) 2013-03-15 2022-02-09 Corium, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe und verfahren zur verwendung
WO2014151386A1 (en) 2013-03-15 2014-09-25 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP2968751B1 (de) 2013-03-15 2022-11-30 Corium, Inc. Mehrfachberührungs-mikroprojektionsapplikatoren
EP2981285B1 (de) 2013-04-03 2020-06-03 N-Fold Llc Neuartige nanopartikelzusammensetzungen
JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
US9381253B2 (en) 2013-04-09 2016-07-05 Massachusetts Institute Of Technology Drug delivery polymer and uses thereof
WO2014179464A1 (en) 2013-04-30 2014-11-06 Massachusetts Institute Of Technology Human adaptation of h3 influenza
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (de) 2013-05-10 2018-06-16
US9795775B2 (en) 2013-05-23 2017-10-24 Kimberly-Clark Worldwide, Inc. Microneedles with improved open channel cross-sectional geometries
SG11201509842SA (en) 2013-05-30 2015-12-30 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
WO2014197723A2 (en) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Human adaptation of h7 ha
US9212145B2 (en) 2013-06-11 2015-12-15 Kala Pharmaceuticals, Inc. Urea derivatives and uses thereof
CN105492460A (zh) 2013-06-14 2016-04-13 哈佛大学的校长及成员们 稳定化多肽胰岛素受体调控剂
EP3013365B1 (de) 2013-06-26 2019-06-05 Academia Sinica Rm2-antigene und verwendung davon
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
EP3024848B1 (de) 2013-07-22 2020-07-08 Armagen, Inc. Verfahren und zusammensetzungen zur erhöhung der enzymaktivität im zns
AU2014292888B2 (en) 2013-07-25 2018-03-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
DK3030286T3 (da) 2013-08-05 2019-11-11 Cam Med Llc Komfortabel patch-pumpe
EP3492097A1 (de) 2013-08-05 2019-06-05 GlaxoSmithKline Biologicals S.A. Immunogene kombinationszusammensetzungen
BR112016002494A2 (pt) 2013-08-05 2017-09-05 Greenlight Biosciences Inc Proteí-nas construídas com um sítio de clivagem de protease, ácido nucléico, vetor, célula e processo de engenharia de uma proteína recombinante e de um grande número de variantes de ácidos nucleicos que codificam proteínas recombinantes
EP2839853A1 (de) * 2013-08-23 2015-02-25 LTS LOHMANN Therapie-Systeme AG Transdermales therapeutisches System mit Druckerzeugungsvorrichtung
CN105682666B (zh) 2013-09-06 2021-06-01 中央研究院 使用醣脂激活人类iNKT细胞
WO2015048121A1 (en) 2013-09-25 2015-04-02 University Of Florida Research Foundation, Inc. Vitamin c prodrugs and uses thereof
JP5550775B1 (ja) * 2013-10-01 2014-07-16 合同会社Syndeo 封入剤送出装置
AU2014329452B2 (en) 2013-10-03 2019-06-20 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
NZ718430A (en) 2013-10-04 2021-12-24 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
WO2015057894A1 (en) 2013-10-15 2015-04-23 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
US9902986B2 (en) 2013-10-16 2018-02-27 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
US10047070B2 (en) 2013-10-18 2018-08-14 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
EP3057955B1 (de) 2013-10-18 2018-04-11 Syros Pharmaceuticals, Inc. Zur behandlung von proliferativen erkrankungen geeignete heteroaromatische verbindungen
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015066482A1 (en) 2013-11-01 2015-05-07 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US10569015B2 (en) 2013-12-02 2020-02-25 Bigfoot Biomedical, Inc. Infusion pump system and method
KR20160101162A (ko) 2013-12-24 2016-08-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 코르티스타틴 유사체 및 그의 합성 및 용도
EP3094352B1 (de) 2014-01-16 2020-09-23 Academia Sinica Zusammensetzungen und verfahren zur behandlung und zum nachweis von krebs
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド ジアゼパン誘導体の使用
EP3119415A4 (de) 2014-03-07 2017-11-29 The Arizona Board of Regents on behalf of the University of Arizona Gegen natriumkanäle gerichtete nicht-narkotische crmp2-peptide für chronische schmerzen
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
ES2868305T3 (es) 2014-03-28 2021-10-21 Univ Washington Through Its Center For Commercialization Vacunas contra el cáncer de mama y de ovario
US20150289788A1 (en) 2014-04-10 2015-10-15 Dexcom, Inc. Sensors for continuous analyte monitoring, and related methods
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
WO2015164650A1 (en) * 2014-04-24 2015-10-29 Becton, Dickinson And Company Catheter insertion device
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
KR101758587B1 (ko) 2014-04-30 2017-07-14 킴벌리-클라크 월드와이드, 인크. 경피적 약물 전달 장치 및 방법의 카트리지 부분
US10039816B2 (en) 2014-04-30 2018-08-07 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
EP3145561A1 (de) 2014-05-20 2017-03-29 Cequr SA Medikamentenabgabevorrichtung mit füllöffnung mit beschränktem zugang
US10533039B2 (en) 2014-05-21 2020-01-14 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
AU2015267052A1 (en) 2014-05-27 2016-12-15 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
AU2015267045B2 (en) 2014-05-27 2021-02-25 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
KR20220151036A (ko) 2014-05-27 2022-11-11 아카데미아 시니카 항-cd20 글리코항체 및 이의 용도
US11332523B2 (en) 2014-05-28 2022-05-17 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
JP6664338B2 (ja) 2014-06-13 2020-03-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組合せ物
MA40240B1 (fr) 2014-06-19 2019-03-29 Ariad Pharma Inc Composés hétéroaryle d'inhibition de la kinase
WO2015200425A1 (en) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Topical dosage regimen
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US10759836B2 (en) 2014-07-18 2020-09-01 University Of Washington Cancer vaccine compositions and methods of use thereof
US10137246B2 (en) 2014-08-06 2018-11-27 Bigfoot Biomedical, Inc. Infusion pump assembly and method
WO2016025643A1 (en) 2014-08-12 2016-02-18 Massachusetts Institute Of Technology Brush-poly(glycoamidoamine)-lipids and uses thereof
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
EP3188714A1 (de) 2014-09-04 2017-07-12 Corium International, Inc. Mikrostrukturanordnung, verfahren zur herstellung und verfahren zur verwendung
CN107001404B (zh) 2014-09-08 2021-06-29 中央研究院 使用醣脂激活人类iNKT细胞
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
CN112972378A (zh) 2014-09-24 2021-06-18 艾瑞朗医疗公司 拟肽大环化合物及其制剂
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
KR102331856B1 (ko) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-{2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
JP2017533238A (ja) 2014-10-28 2017-11-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 抗原特異的寛容のための組成物及び方法
EP3041948B1 (de) 2014-11-10 2019-01-09 Modernatx, Inc. Alternative nukleinsäuremoleküle mit reduziertem uracilgehalt und verwendungen davon
US10253045B2 (en) 2014-11-26 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
EP3230272B1 (de) 2014-12-10 2020-08-19 Kala Pharmaceuticals, Inc. 1-amino-triazol(1,5-a)pyridin-substituiertes harnstoffderivat und verwendungen davon
JP2017538731A (ja) 2014-12-18 2017-12-28 ウィンドギャップ メディカル, インコーポレイテッド 治療剤を溶解または可溶化するための方法および組成物。
JP7358029B2 (ja) 2014-12-23 2023-10-10 スローン - ケタリング・インスティテュート・フォー・キャンサー・リサーチ グラナチシンbの多形体
AU2015371251B2 (en) 2014-12-23 2020-06-11 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2016109539A1 (en) * 2014-12-30 2016-07-07 Minipumps, Llc Implantable electrolytic diaphragm pumps
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
KR20170104617A (ko) 2015-01-24 2017-09-15 아카데미아 시니카 신규한 글리칸 콘주게이트 및 이를 사용하는 방법
WO2016123406A1 (en) 2015-01-28 2016-08-04 Chrono Therapeutics Inc. Drug delivery methods and systems
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
CA2980004C (en) 2015-03-24 2023-10-10 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
WO2016160617A2 (en) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
JP6843065B2 (ja) 2015-03-30 2021-03-17 グリーンライト バイオサイエンシーズ インコーポレーテッドGreenlight Biosciences,Inc. リボ核酸の無細胞生産
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication
CN107708693A (zh) 2015-04-27 2018-02-16 佛罗里达大学研究基金会 代谢程序化的金属螯合剂及其用途
US9878097B2 (en) 2015-04-29 2018-01-30 Bigfoot Biomedical, Inc. Operating an infusion pump system
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
JP6784352B2 (ja) * 2015-05-11 2020-11-11 国立大学法人 東京医科歯科大学 インスリン送達用デバイス
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
AU2016260547B2 (en) 2015-05-14 2020-09-03 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
US11207465B2 (en) 2015-06-04 2021-12-28 West Pharma. Services Il. Ltd. Cartridge insertion for drug delivery device
US10463847B2 (en) 2015-06-11 2019-11-05 Steadymed Ltd. Infusion set
EP3307728A4 (de) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Kombinationstherapie von transkriptionshemmern und kinasehemmern
CA2990172A1 (en) 2015-06-19 2016-12-22 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
GB2556479B (en) 2015-06-30 2022-09-07 Kaleo Inc Auto-injectors for administration of a medicament within a prefilled syringe
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2996978A1 (en) 2015-09-09 2017-03-16 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
EP3350333B1 (de) 2015-09-17 2021-10-27 ModernaTX, Inc. Polynukleotide mit stabilisierendem schwanzbereich
AU2016324310B2 (en) 2015-09-17 2021-04-08 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
US9987432B2 (en) 2015-09-22 2018-06-05 West Pharma. Services IL, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
US9925170B2 (en) 2015-10-01 2018-03-27 Kythera Biopharmaceuticals, Inc. Methods of adipolysis and compositions useful therein
JP7017512B2 (ja) 2015-10-09 2022-02-08 ウェスト ファーマ サービシーズ イスラエル リミテッド 充填済流体容器の屈曲流体路型付属物
US9867932B2 (en) 2015-10-30 2018-01-16 International Business Machines Corporation Drug delivery device having a cavity sealed by a pressurized membrane
JP7114465B2 (ja) 2015-12-22 2022-08-08 モデルナティエックス インコーポレイテッド 薬剤の細胞内送達のための化合物および組成物
US20170188911A1 (en) 2015-12-30 2017-07-06 Dexcom, Inc. Transcutaneous analyte sensor systems and methods
WO2017120026A1 (en) 2016-01-05 2017-07-13 Bigfoot Biomedical, Inc. Operating multi-modal medicine delivery systems
JP6542481B2 (ja) 2016-01-21 2019-07-10 ウェスト ファーマ サービシーズ イスラエル リミテッド システム
EP3711793B1 (de) 2016-01-21 2021-12-01 West Pharma Services IL, Ltd. Verfahren zur verbindung einer patrone mit einem automatischen injektor
CN113041432B (zh) 2016-01-21 2023-04-07 西医药服务以色列有限公司 包括视觉指示物的药剂输送装置
CA3013706A1 (en) * 2016-02-05 2017-08-10 Nitto Denko Corporation Transdermal permeant application device
AU2017231749A1 (en) 2016-03-08 2018-09-20 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
US11389597B2 (en) 2016-03-16 2022-07-19 West Pharma. Services IL, Ltd. Staged telescopic screw assembly having different visual indicators
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
CR20180525A (es) 2016-04-06 2019-02-14 Greenlight Biosciences Inc Producción de ácido ribonucleico libre de células
KR101879934B1 (ko) * 2016-05-31 2018-07-19 중앙대학교 산학협력단 혈관 탐지 장치
EP3463526A1 (de) 2016-06-02 2019-04-10 West Pharma. Services Il, Ltd. Nadelrückzug mit drei positionen
JP7110119B2 (ja) 2016-06-03 2022-08-01 サノフィ パスツール インコーポレイティッド 改変インフルエンザヘマグルチニンポリペプチドの修飾
US10105449B2 (en) 2016-06-07 2018-10-23 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2017218704A1 (en) 2016-06-14 2017-12-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
JP6869327B2 (ja) 2016-08-01 2021-05-12 ウェスト ファーマ サービシーズ イスラエル リミテッド 回転防止カートリッジ
JP7059251B2 (ja) 2016-08-01 2022-04-25 ウェスト ファーマ サービシーズ イスラエル リミテッド ドアの半閉じを防止するスプリング
BR112019001971A2 (pt) 2016-08-05 2019-05-07 Sanofi Pasteur, Inc. composição conjugada de polissacarídeo-proteína pneumocócica multivalente
WO2018027123A1 (en) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
CN109963868B (zh) 2016-08-22 2023-11-14 醣基生医股份有限公司 抗体、结合片段及使用方法
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
BR112019010131A2 (pt) 2016-11-21 2019-10-08 Eirion Therapeutics Inc entrega transdérmica de agentes grandes
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
WO2018106723A1 (en) * 2016-12-05 2018-06-14 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
WO2018107270A1 (en) 2016-12-15 2018-06-21 Pka Softtouch Corp. Intradermal drug delivery device having a locked post-dispensing configuration
EP3558420A4 (de) 2016-12-23 2020-05-27 Kaleo, Inc. Medikamentenabgabevorrichtung und verfahren zur abgabe von arzneimitteln an säuglinge und kinder
EP3565617A1 (de) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Vorrichtungen und verfahren zur transdermalen wirkstofffreisetzung
US11071478B2 (en) 2017-01-23 2021-07-27 Abbott Diabetes Care Inc. Systems, devices and methods for analyte sensor insertion
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
AU2018234692B2 (en) 2017-03-15 2022-06-02 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
EP4306803A3 (de) 2017-03-31 2024-04-10 Vaxxas Pty Limited Vorrichtung und verfahren zur beschichtung von oberflächen
BR112019020810A2 (pt) 2017-04-05 2020-04-28 Biogen Ma Inc compostos tricíclicos como inibidores de glicogênio sintase cinase 3 (gsk3) e usos dos mesmos
CN110869072B (zh) 2017-05-30 2021-12-10 西部制药服务有限公司(以色列) 用于穿戴式注射器的模块化驱动机构
EP3639010A4 (de) 2017-06-13 2021-03-17 Vaxxas Pty Limited Qualitätskontrolle von substratbeschichtungen
EP3638678A1 (de) 2017-06-14 2020-04-22 Modernatx, Inc. Verbindungen und zusammensetzungen zur intrazellulären verabreichung von wirkstoffen
ES2963745T3 (es) 2017-06-23 2024-04-01 Dexcom Inc Sensores de analito transcutáneo, aplicadores de los mismos y cono de aguja que comprenden función anti-giro
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS AND USES THEREOF
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS
GB201712184D0 (en) * 2017-07-28 2017-09-13 Owen Mumford Ltd Medicament delivery device
EP4218893A1 (de) 2017-08-04 2023-08-02 Vaxxas Pty Limited Kompakter hoher mechanischer energiespeicher und aktuator mit geringer auslösekraft für die abgabe von mikroprojektions-array-patches (map)
MX2020002348A (es) 2017-08-31 2020-10-08 Modernatx Inc Métodos de elaboración de nanopartículas lipídicas.
CA3078726A1 (en) 2017-10-11 2019-04-18 Greenlight Biosciences, Inc. Methods and compositions for nucleoside triphosphate and ribonucleic acid production
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US20190120785A1 (en) 2017-10-24 2019-04-25 Dexcom, Inc. Pre-connected analyte sensors
EP3717033A4 (de) 2017-12-01 2021-08-25 North Carolina State University Fibrinpartikel und verfahren zu ihrer herstellung
CN114470420A (zh) 2017-12-22 2022-05-13 西氏医药包装(以色列)有限公司 适用于不同尺寸的药筒的注射器
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems
USD926325S1 (en) 2018-06-22 2021-07-27 Dexcom, Inc. Wearable medical monitoring device
US20220079911A1 (en) 2018-09-13 2022-03-17 Eirion Therapeutics, Inc. Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors
JP2021535925A (ja) 2018-09-13 2021-12-23 エイリオン セラピューティクス, インコーポレイテッド プラスミノーゲンアクチベーターインヒビター1(plasminogen activator inhibitor 1)(PAI−1)阻害剤(inhibitor)およびその使用
JP7410135B2 (ja) 2018-09-19 2024-01-09 モデルナティエックス インコーポレイテッド 治療薬の細胞内送達のための化合物及び組成物
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020117564A1 (en) 2018-12-03 2020-06-11 Eirion Therapeutics, Inc. Improved delivery of large agents
US20230072397A1 (en) 2019-01-16 2023-03-09 Curza Global, Llc Antimicrobial Compounds and Methods
CN113924292A (zh) 2019-01-16 2022-01-11 库扎环球有限责任公司 抗微生物化合物和方法
CA3128215A1 (en) 2019-01-31 2020-08-06 Modernatx, Inc. Methods of preparing lipid nanoparticles
US11464908B2 (en) 2019-02-18 2022-10-11 Tandem Diabetes Care, Inc. Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
CA3139983A1 (en) 2019-05-14 2020-11-19 Eirion Therapeutics, Inc. Delaying peak effect and/or extending duration of response
US11587839B2 (en) 2019-06-27 2023-02-21 Analog Devices, Inc. Device with chemical reaction chamber
KR20220042378A (ko) 2019-07-31 2022-04-05 사노피 파스퇴르 인코포레이티드 다가 폐렴구균 다당류-단백질 접합체 조성물 및 그 사용 방법
JP2022543773A (ja) 2019-07-31 2022-10-14 モデルナティエックス インコーポレイテッド 免疫細胞へのrna干渉剤の送達のための組成物及び方法
JP2022543523A (ja) 2019-08-09 2022-10-13 カレオ,インコーポレイテッド プレフィルドシリンジ内の物質の送達のためのデバイス及び方法
JP2023501575A (ja) 2019-11-13 2023-01-18 カーザ グローバル, エルエルシー 抗菌化合物及び方法
TW202139976A (zh) 2020-01-31 2021-11-01 美商現代公司 製備脂質奈米顆粒之方法
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
US11712516B2 (en) 2020-04-17 2023-08-01 Analog Devices, Inc. Fluid delivery device
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
JPWO2022092295A1 (de) 2020-10-30 2022-05-05
JPWO2022092294A1 (de) 2020-10-30 2022-05-05
AR124267A1 (es) 2020-12-09 2023-03-01 Genentech Inc Métodos de alto rendimiento para preparar nanopartículas lipídicas y sus usos
WO2022192176A1 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US11604084B2 (en) 2021-04-15 2023-03-14 Analog Devices, Inc. Sensor package
US11796367B2 (en) 2021-05-07 2023-10-24 Analog Devices, Inc. Fluid control system
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
TW202333778A (zh) 2021-10-08 2023-09-01 美商賽諾菲巴斯德公司 多價流感疫苗
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
US11510602B1 (en) 2021-11-08 2022-11-29 Satio, Inc. Dermal patch for collecting a physiological sample
TW202333654A (zh) 2021-12-16 2023-09-01 美商現代公司 用於製備脂質奈米顆粒之方法
CN114305868A (zh) * 2021-12-30 2022-04-12 康宇辰 一种环氧杀菌创伤敷贴
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023177577A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH60868A (de) * 1912-05-20 1913-08-16 Leo Meyhoefer Gasbeleuchtungsanlage
US3923060A (en) * 1974-04-23 1975-12-02 Jr Everett H Ellinwood Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means
US4140117A (en) * 1975-05-12 1979-02-20 Alza Corporation Cartridge for liquid infusion apparatus
US4753651A (en) * 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4522622A (en) * 1982-12-23 1985-06-11 Alza Corporation Multiple fluid pulse dispenser
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
CA1283827C (en) * 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US4734092A (en) * 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US4894054A (en) * 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
FR2649617A1 (fr) * 1989-07-12 1991-01-18 Veprol Dispositif de delivrance d'un principe actif pharmacologique par pompage electrolytique
US5090963A (en) * 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser
US5156591A (en) * 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
SE9101022D0 (sv) * 1991-01-09 1991-04-08 Paal Svedman Medicinsk suganordning
WO1993007920A1 (en) * 1991-10-24 1993-04-29 Insutech, Incorporated Gas pressure driven infusion system by hydrogel electrolysis
US5318557A (en) * 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device

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ATE220931T1 (de) 2002-08-15
JPH09504974A (ja) 1997-05-20
EP0729366B9 (de) 2002-12-11
EP0729366B1 (de) 2002-07-24
AU1076395A (en) 1995-06-06
IL111685A (en) 1998-09-24
WO1995013838A1 (en) 1995-05-26
EP0729366A1 (de) 1996-09-04
IL111685A0 (en) 1995-01-24
ES2176310T4 (es) 2003-03-16
AU693136B2 (en) 1998-06-25
NZ276485A (en) 1997-11-24
US5527288A (en) 1996-06-18
CA2176342A1 (en) 1995-05-26
DE69431066D1 (de) 2002-08-29

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