DE69430432T2 - Mikrobläschen, eingekapseld mit polymere tenside, und deren verwendung beim ultraschall-diagnostik - Google Patents

Mikrobläschen, eingekapseld mit polymere tenside, und deren verwendung beim ultraschall-diagnostik

Info

Publication number
DE69430432T2
DE69430432T2 DE69430432T DE69430432T DE69430432T2 DE 69430432 T2 DE69430432 T2 DE 69430432T2 DE 69430432 T DE69430432 T DE 69430432T DE 69430432 T DE69430432 T DE 69430432T DE 69430432 T2 DE69430432 T2 DE 69430432T2
Authority
DE
Germany
Prior art keywords
pct
date mar
sec
microbubles
capsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430432T
Other languages
English (en)
Other versions
DE69430432D1 (de
Inventor
Harald Dugstad
Antonius Foss
Jo Klaveness
Keith Redford
Pal Rongved
Roald Skurtveit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Publication of DE69430432D1 publication Critical patent/DE69430432D1/de
Application granted granted Critical
Publication of DE69430432T2 publication Critical patent/DE69430432T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/34—Higher-molecular-weight carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
DE69430432T 1993-09-03 1994-09-05 Mikrobläschen, eingekapseld mit polymere tenside, und deren verwendung beim ultraschall-diagnostik Expired - Fee Related DE69430432T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939318288A GB9318288D0 (en) 1993-09-03 1993-09-03 Improvements in or relating to contrast agents
PCT/GB1994/001923 WO1995006518A1 (en) 1993-09-03 1994-09-05 Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging

Publications (2)

Publication Number Publication Date
DE69430432D1 DE69430432D1 (de) 2002-05-23
DE69430432T2 true DE69430432T2 (de) 2002-12-12

Family

ID=10741456

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430432T Expired - Fee Related DE69430432T2 (de) 1993-09-03 1994-09-05 Mikrobläschen, eingekapseld mit polymere tenside, und deren verwendung beim ultraschall-diagnostik

Country Status (22)

Country Link
US (1) US5919434A (de)
EP (1) EP0717658B1 (de)
JP (1) JP3552721B2 (de)
CN (1) CN1072521C (de)
AT (1) ATE216282T1 (de)
AU (1) AU689495B2 (de)
BG (1) BG100467A (de)
CA (1) CA2170906A1 (de)
CZ (1) CZ62796A3 (de)
DE (1) DE69430432T2 (de)
EE (1) EE03237B1 (de)
ES (1) ES2177582T3 (de)
FI (1) FI960983A (de)
GB (1) GB9318288D0 (de)
HU (1) HUT75289A (de)
LV (1) LV11438B (de)
NO (1) NO960824L (de)
NZ (1) NZ271704A (de)
PL (1) PL313290A1 (de)
SG (1) SG46373A1 (de)
SK (1) SK26096A3 (de)
WO (1) WO1995006518A1 (de)

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DE102008013620A1 (de) * 2008-02-12 2009-08-13 Charité - Universitätsmedizin Berlin Knochenzementmischung zur Herstellung eines MRT-signalgebenden Knochenzements

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US7919119B2 (en) * 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
WO2001012069A1 (en) * 1999-08-13 2001-02-22 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
AU6635900A (en) 1999-08-13 2001-03-13 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for lymphatic system
US20020153508A1 (en) * 2000-06-29 2002-10-24 Lynch Matthew Lawrence Cubic liquid crystalline compositions and methods for their preparation
US20070191964A1 (en) * 2001-04-04 2007-08-16 Arthrocare Corporation Enhanced visibility materials for implantation in hard tissue
DE60223239T2 (de) * 2001-04-06 2008-08-14 Bracco Research S.A. Vorrichtung zur Messung lokaler physikalischer Parameter in einem flüssigkeitsgefüllten Hohlraum
EP1485196A1 (de) * 2002-03-20 2004-12-15 Rhodia Inc. Ein amphiphiles diblockcopolymer und eine hydrophobe verbindung enthaltende vesikel
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
DE602004028930D1 (de) 2003-04-29 2010-10-14 Avi Biopharma Inc Zusammensetzungen zur verbesserung der antisense-wirksamkeit und des transports von nukleinsäureanalog in zellen
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8048086B2 (en) * 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8052669B2 (en) * 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
WO2005115603A2 (en) * 2004-05-17 2005-12-08 Exxonmobil Upstream Research Company Corp-Urc-Sw348 Oil spill dispersants and dispersion methods
US20080269163A1 (en) * 2004-10-19 2008-10-30 Sostaric Joe Z Methods and Compositions for Protecting Cells from Ultrasound-Mediated Cytolysis
US7608567B2 (en) * 2005-05-12 2009-10-27 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7677315B2 (en) 2005-05-12 2010-03-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7662753B2 (en) 2005-05-12 2010-02-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US8123693B2 (en) 2005-06-20 2012-02-28 Conceptus, Inc. Methods and devices for determining lumen occlusion
JP5214114B2 (ja) * 2006-05-25 2013-06-19 花王株式会社 微細気泡含有液体組成物の製造法
DE102006047617B4 (de) 2006-10-09 2008-11-27 Clariant International Limited Verfahren zur Herstellung basischer (Meth)acrylamide
NZ578626A (en) * 2007-01-30 2012-04-27 Exxonmobil Upstream Res Co Floating dispersant paste
DE102008017216B4 (de) 2008-04-04 2013-08-14 Clariant International Ltd. Kontinuierliches Verfahren zur Herstellung von Fettsäureamiden
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
DK2346573T3 (da) * 2008-11-20 2014-10-06 Derivati Organici Lab Anvendelse af heparansulfat i kosmetologiske og dermatologiske præparater
EP2370143B1 (de) * 2008-12-31 2017-08-02 KCI Licensing, Inc. Systeme zur bereitstellung eines flüssigkeitsflusses in nervengewebe
DE102009031059A1 (de) 2009-06-30 2011-01-05 Clariant International Ltd. Vorrichtung zur kontinuierlichen Durchführung chemischer Reaktionen bei hohen Temperaturen
DE102009042522A1 (de) 2009-09-22 2011-04-07 Clariant International Ltd. Kontinuierliches Umesterungsverfahren
DE102009042523B4 (de) 2009-09-22 2012-02-16 Clariant International Ltd. Vorrichtung und Verfahren zur kontinuierlichen Durchführung heterogen katalysierter chemischer Reaktionen bei hohen Temperaturen
US8585616B2 (en) * 2009-10-09 2013-11-19 Conceptus, Inc. Methods and apparatus for determining fallopian tube occlusion
DE102010056564A1 (de) 2010-12-30 2012-07-05 Clariant International Limited Hydroxylgruppen und Estergruppen tragende Polymere und Verfahren zu ihrer Herstellung
DE102010056565A1 (de) 2010-12-30 2012-07-05 Clariant International Ltd. Verfahren zur Modifizierung Hydroxylgruppen tragender Polymere
DE102011005444A1 (de) * 2011-03-11 2012-09-13 Innora Gmbh Festes, negatives Röntgenkontrastmittel zur Darstellung des Gastrointestinaltraktes
CA2941242A1 (en) * 2014-03-10 2015-09-17 Saint-Gobain Performance Plastics Corporation Multilayer flexible tube and methods for making same
US10295089B2 (en) * 2014-03-10 2019-05-21 Saint-Gobain Performance Plastics Corporation Multilayer flexible tube and methods for making same
TWI556837B (zh) * 2014-07-18 2016-11-11 國立清華大學 用於藥物傳遞之奈/微米氣泡
CA2972423A1 (en) 2014-12-31 2016-07-07 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
TWI740937B (zh) 2016-05-04 2021-10-01 美商藍瑟斯醫學影像公司 用於製備超音波顯影劑之裝置及方法
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10717812B2 (en) * 2017-03-16 2020-07-21 Board Of Regents, The University Of Texas System Lactone-epoxide statistical copolymers
US11890370B2 (en) 2018-09-21 2024-02-06 Sahmyook University Industry-Academic Cooperation Foundation Ultrasound-induced drug delivery system using drug carrier comprising nanobubbles and drug
CN112341870A (zh) * 2019-08-08 2021-02-09 李石良 一种增强超声介导成像的涂层材料

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DE102008013620A1 (de) * 2008-02-12 2009-08-13 Charité - Universitätsmedizin Berlin Knochenzementmischung zur Herstellung eines MRT-signalgebenden Knochenzements

Also Published As

Publication number Publication date
EP0717658A1 (de) 1996-06-26
BG100467A (en) 1996-12-31
CN1136285A (zh) 1996-11-20
JPH09503202A (ja) 1997-03-31
DE69430432D1 (de) 2002-05-23
NZ271704A (en) 1997-12-19
AU7541594A (en) 1995-03-22
ES2177582T3 (es) 2002-12-16
WO1995006518A1 (en) 1995-03-09
CZ62796A3 (en) 1997-03-12
CN1072521C (zh) 2001-10-10
FI960983A0 (fi) 1996-03-01
NO960824L (no) 1996-04-29
US5919434A (en) 1999-07-06
PL313290A1 (en) 1996-06-24
ATE216282T1 (de) 2002-05-15
GB9318288D0 (en) 1993-10-20
NO960824D0 (no) 1996-02-29
LV11438A (lv) 1996-08-20
LV11438B (en) 1996-12-20
JP3552721B2 (ja) 2004-08-11
HUT75289A (en) 1997-05-28
AU689495B2 (en) 1998-04-02
SK26096A3 (en) 1996-08-07
EE03237B1 (et) 1999-12-15
CA2170906A1 (en) 1995-03-09
SG46373A1 (en) 1998-01-20
FI960983A (fi) 1996-03-01
HU9600515D0 (en) 1996-04-29
EP0717658B1 (de) 2002-04-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS RECHTSANWAELTE PATENTANWAELTE, 80539 MUEN

8339 Ceased/non-payment of the annual fee