DE69430317D1 - Wasserlösliche aktive sulfone von polyethylenglycolen - Google Patents
Wasserlösliche aktive sulfone von polyethylenglycolenInfo
- Publication number
- DE69430317D1 DE69430317D1 DE69430317T DE69430317T DE69430317D1 DE 69430317 D1 DE69430317 D1 DE 69430317D1 DE 69430317 T DE69430317 T DE 69430317T DE 69430317 T DE69430317 T DE 69430317T DE 69430317 D1 DE69430317 D1 DE 69430317D1
- Authority
- DE
- Germany
- Prior art keywords
- peg
- substances
- water
- soluble active
- active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
- C08G65/326—Polymers modified by chemical after-treatment with inorganic compounds containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/151,481 US5446090A (en) | 1993-11-12 | 1993-11-12 | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| PCT/US1994/013013 WO1995013312A1 (en) | 1993-11-12 | 1994-11-14 | Water soluble active sulfones of poly(ethylene glycol) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69430317D1 true DE69430317D1 (de) | 2002-05-08 |
| DE69430317T2 DE69430317T2 (de) | 2002-10-02 |
Family
ID=22538958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69430317T Expired - Lifetime DE69430317T2 (de) | 1993-11-12 | 1994-11-14 | Wasserlösliche aktive sulfone von polyethylenglycolen |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US5446090A (de) |
| EP (2) | EP0728155B1 (de) |
| JP (1) | JP3114998B2 (de) |
| KR (1) | KR100225746B1 (de) |
| CN (1) | CN1085689C (de) |
| AT (1) | ATE215577T1 (de) |
| AU (1) | AU687937B2 (de) |
| BG (1) | BG63399B1 (de) |
| BR (1) | BR9408048A (de) |
| CA (1) | CA2176203C (de) |
| CZ (1) | CZ295640B6 (de) |
| DE (1) | DE69430317T2 (de) |
| DK (1) | DK0728155T3 (de) |
| EE (1) | EE03448B1 (de) |
| ES (1) | ES2173943T3 (de) |
| FI (1) | FI117441B (de) |
| HK (1) | HK1042312A1 (de) |
| HU (1) | HU225649B1 (de) |
| NO (1) | NO315377B1 (de) |
| NZ (1) | NZ276313A (de) |
| PL (1) | PL180149B1 (de) |
| RO (2) | RO118434B1 (de) |
| RU (1) | RU2176253C2 (de) |
| SK (1) | SK284527B6 (de) |
| UA (1) | UA58481C2 (de) |
| WO (1) | WO1995013312A1 (de) |
Families Citing this family (440)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143866A (en) * | 1989-07-18 | 2000-11-07 | Amgen, Inc. | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
| US5583114A (en) | 1994-07-27 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Adhesive sealant composition |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| KR20040010739A (ko) | 1996-02-09 | 2004-01-31 | 암젠 인코포레이티드 | 인터루킨-1 수용체 길항물질을 포함하는 융합 단백질 및 이를 포함하는 제약학적 조성물 |
| US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
| TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| WO1998012274A1 (en) * | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| US8003705B2 (en) * | 1996-09-23 | 2011-08-23 | Incept Llc | Biocompatible hydrogels made with small molecule precursors |
| DE69713517D1 (de) | 1996-10-15 | 2002-07-25 | Medical Analysis Systems Inc | Verfahren zur Stabilisierung von Troponin I (CTnI) durch Konjugation mit einem activen Polymer |
| AU5696198A (en) | 1996-12-06 | 1998-06-29 | Amgen, Inc. | Combination therapy using a tnf binding protein for treating tnf-mediated diseases |
| ES2615357T3 (es) | 1996-12-06 | 2017-06-06 | Amgen Inc. | Terapia de combinación usando un inhibidor de IL-1 para tratar enfermedades mediadas por IL-1 |
| US6743248B2 (en) | 1996-12-18 | 2004-06-01 | Neomend, Inc. | Pretreatment method for enhancing tissue adhesion |
| US6371975B2 (en) | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
| US20040176801A1 (en) * | 1997-03-12 | 2004-09-09 | Neomend, Inc. | Pretreatment method for enhancing tissue adhesion |
| US20030191496A1 (en) * | 1997-03-12 | 2003-10-09 | Neomend, Inc. | Vascular sealing device with microwave antenna |
| AU7282698A (en) * | 1997-05-15 | 1998-12-08 | Theratech, Inc. | Targeted delivery to t lymphocytes |
| US6284246B1 (en) | 1997-07-30 | 2001-09-04 | The Procter & Gamble Co. | Modified polypeptides with high activity and reduced allergenicity |
| US6251866B1 (en) | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
| US6168784B1 (en) | 1997-09-03 | 2001-01-02 | Gryphon Sciences | N-terminal modifications of RANTES and methods of use |
| US6129928A (en) * | 1997-09-05 | 2000-10-10 | Icet, Inc. | Biomimetic calcium phosphate implant coatings and methods for making the same |
| US7229841B2 (en) * | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
| US6407218B1 (en) * | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
| ES2307865T3 (es) | 1998-03-12 | 2008-12-01 | Nektar Therapeutics Al, Corporation | Metodo para preparar conjugados polimericos. |
| US6066673A (en) * | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
| US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
| CN1301305A (zh) | 1998-03-26 | 2001-06-27 | 宝洁公司 | 具有氨基酸取代的丝氨酸蛋白酶变体 |
| US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
| US6632457B1 (en) * | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6458147B1 (en) | 1998-11-06 | 2002-10-01 | Neomend, Inc. | Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue |
| US6994686B2 (en) * | 1998-08-26 | 2006-02-07 | Neomend, Inc. | Systems for applying cross-linked mechanical barriers |
| CN1330675A (zh) | 1998-08-28 | 2002-01-09 | 格莱风科学公司 | 精确长度的聚酰胺链、其制备方法和其与蛋白质的缀合物 |
| US6551613B1 (en) * | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
| AU743363B2 (en) | 1998-09-22 | 2002-01-24 | Procter & Gamble Company, The | Personal care compositions containing active proteins tethered to a water insoluble substrate |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7279001B2 (en) * | 1998-11-06 | 2007-10-09 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
| US6899889B1 (en) * | 1998-11-06 | 2005-05-31 | Neomend, Inc. | Biocompatible material composition adaptable to diverse therapeutic indications |
| US6949114B2 (en) | 1998-11-06 | 2005-09-27 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
| US6830756B2 (en) * | 1998-11-06 | 2004-12-14 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
| WO2000033764A1 (en) | 1998-12-04 | 2000-06-15 | Pathak Chandrashekhar P | Biocompatible crosslinked polymers |
| US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| CA2359318C (en) | 1999-02-01 | 2009-06-30 | Donald Elbert | Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups |
| WO2000078285A1 (en) * | 1999-06-18 | 2000-12-28 | University Of Medicine And Dentistry Of New Jersey | Controlled release of therapeutics by in-situ entrapment by matrix cross-linking |
| MXPA02000842A (es) | 1999-07-22 | 2002-07-30 | Procter & Gamble | Conjugados de proteasa que tienen sitios de corte protegidos estericamente. |
| CZ2002220A3 (cs) | 1999-07-22 | 2002-05-15 | The Procter & Gamble Company | Varianty subtilisinové proteasy s delecemi a substitucemi aminokyselin v definovaných epitopových regionech |
| US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
| CZ2002212A3 (cs) | 1999-07-22 | 2002-07-17 | The Procter & Gamble Company | Varianty subtilisinové proteasy mající aminokyselinové substituce v definovaných epitopových oblastech |
| US7008635B1 (en) | 1999-09-10 | 2006-03-07 | Genzyme Corporation | Hydrogels for orthopedic repair |
| US6303119B1 (en) | 1999-09-22 | 2001-10-16 | The Procter & Gamble Company | Personal care compositions containing subtilisin enzymes bound to water insoluble substrates |
| US7074878B1 (en) * | 1999-12-10 | 2006-07-11 | Harris J Milton | Hydrolytically degradable polymers and hydrogels made therefrom |
| US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
| ES2327606T3 (es) | 2000-01-10 | 2009-11-02 | Maxygen Holdings Ltd | Conjugados de g-csf. |
| DE60138364D1 (de) | 2000-02-11 | 2009-05-28 | Bayer Healthcare Llc | Gerinnungsfaktor vii oder viia konjugate |
| EP1284818B1 (de) | 2000-05-15 | 2006-11-22 | Tecan Trading AG | Zweirichtungs-durchfluss-zentrifugalmikrofluid-vorrichtungen |
| NZ522847A (en) * | 2000-05-16 | 2004-11-26 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| US7291673B2 (en) * | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| KR20030032977A (ko) * | 2000-07-12 | 2003-04-26 | 그리폰 테라퓨틱스, 인코포레이티드 | 키모카인 수용체 조절제, 제조 및 사용 |
| US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
| RU2003109746A (ru) * | 2000-09-08 | 2005-01-27 | Грифон Терапьютикс, Инк. (Us) | Синтетические белки, стимулирующие эритропоэз |
| JP4070605B2 (ja) * | 2000-10-19 | 2008-04-02 | アイトゲノッシスシェ・テヒニッシュ・ホーホシューレ・ツューリヒ | 多官能性自己集成系のためのブロックコポリマー |
| CN1507357A (zh) | 2000-10-31 | 2004-06-23 | PRҩƷ����˾ | 提高生物活性分子传递的方法和组合物 |
| TW593427B (en) * | 2000-12-18 | 2004-06-21 | Nektar Therapeutics Al Corp | Synthesis of high molecular weight non-peptidic polymer derivatives |
| US7053150B2 (en) * | 2000-12-18 | 2006-05-30 | Nektar Therapeutics Al, Corporation | Segmented polymers and their conjugates |
| YU48703A (sh) | 2001-02-27 | 2006-05-25 | Maxygen Aps | Novi interferonu beta-slični molekuli |
| MXPA03008498A (es) * | 2001-03-20 | 2005-06-30 | Univ Zuerich | Procesamiento en dos fases de polimeros termosensibles para uso como biomateriales. |
| US6538104B2 (en) | 2001-04-27 | 2003-03-25 | Medical Analysis Systems, Inc. | Stabilization of cardiac troponin I subunits and complexes |
| US20040077835A1 (en) * | 2001-07-12 | 2004-04-22 | Robin Offord | Chemokine receptor modulators, production and use |
| WO2003018665A1 (en) * | 2001-08-22 | 2003-03-06 | Bioartificial Gel Technologies Inc. | Process for the preparation of activated polyethylene glycols |
| NZ532027A (en) | 2001-10-10 | 2008-09-26 | Neose Technologies Inc | Remodeling and glycoconjugation of peptides |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| US7795210B2 (en) | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
| CN105131104B (zh) | 2001-10-10 | 2018-11-16 | 诺和诺德公司 | 肽的重构和糖缀合 |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| EP2939696B1 (de) | 2001-10-18 | 2016-03-09 | Nektar Therapeutics | Polymerkonjugate von opioid-antagonisten |
| JP2005509444A (ja) * | 2001-11-23 | 2005-04-14 | シモン・フレデリックソン | 多価近接プローブにより近接プロービングするための方法およびキット |
| EA009783B1 (ru) | 2002-01-18 | 2008-04-28 | Байоджен Айдек Ма Инк. | Полиалкиленгликоль с остатком для конъюгации биологически активного соединения |
| US20030179692A1 (en) * | 2002-03-19 | 2003-09-25 | Yoshitaka Ohotomo | Storage medium |
| US8282912B2 (en) * | 2002-03-22 | 2012-10-09 | Kuros Biosurgery, AG | Compositions for tissue augmentation |
| JP2005534647A (ja) | 2002-06-07 | 2005-11-17 | ダイアックス、コープ | 失血の予防及び軽減 |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| DK1517710T3 (da) | 2002-06-21 | 2011-07-18 | Novo Nordisk Healthcare Ag | Pegylerede faktor VII-glycoformer |
| DE60336555D1 (de) | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | Pegylierte glykoformen von faktor vii |
| US7034127B2 (en) * | 2002-07-02 | 2006-04-25 | Genzyme Corporation | Hydrophilic biopolymer-drug conjugates, their preparation and use |
| CA2497777A1 (en) * | 2002-09-05 | 2004-03-18 | The General Hospital Corporation | Modified asialo-interferons and uses thereof |
| AU2003268463A1 (en) * | 2002-09-05 | 2004-03-29 | The General Hospital Corporation | Asialo-interferons and the treatment of liver cancer |
| ES2315526T3 (es) | 2002-09-09 | 2009-04-01 | Nektar Therapeutics Al, Corporation | Metodo para preparar derivados polimericos solubles en agua que llevan un acido carboxilico terminal. |
| CN1312279C (zh) * | 2002-11-07 | 2007-04-25 | 连云港新阳医药有限公司 | 聚乙二醇修饰门冬酰胺酶的制备方法 |
| PL219741B1 (pl) * | 2002-12-26 | 2015-07-31 | Mountain View Pharmaceuticals | Sposób zwiększania antyproliferacyjnego potencjału nieglikozylowanego interferonu-beta-1b in vitro, koniugat wytworzony tym sposobem i jego zastosowanie oraz kompozycja farmaceutyczna zawierająca koniugat i jej zastosowanie |
| TWI364295B (en) * | 2002-12-26 | 2012-05-21 | Mountain View Pharmaceuticals | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| WO2004061094A1 (en) | 2002-12-30 | 2004-07-22 | Gryphon Therapeutics, Inc. | Water-soluble thioester and selenoester compounds and methods for making and using the same |
| US20060014248A1 (en) * | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity |
| US20050130892A1 (en) * | 2003-03-07 | 2005-06-16 | Xencor, Inc. | BAFF variants and methods thereof |
| DE602004029646D1 (en) | 2003-01-06 | 2010-12-02 | Nektar Therapeutics San Carlos | Thiolselektive wasserlösliche polymerderivate |
| US20050221443A1 (en) * | 2003-01-06 | 2005-10-06 | Xencor, Inc. | Tumor necrosis factor super family agonists |
| CN1723232B (zh) * | 2003-01-06 | 2012-08-22 | 尼克塔治疗公司 | 巯基选择性水溶性聚合物衍生物 |
| US7553930B2 (en) * | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
| SI1596887T1 (sl) * | 2003-02-26 | 2022-05-31 | Nektar Therapeutics | Konjugati polimer-del faktorja VIII |
| CA2517145C (en) * | 2003-03-05 | 2017-08-01 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US20090123367A1 (en) * | 2003-03-05 | 2009-05-14 | Delfmems | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases |
| KR20060003862A (ko) | 2003-03-14 | 2006-01-11 | 네오스 테크놀로지스, 인크. | 수용성분기폴리머 및 그 접합체 |
| US7642340B2 (en) | 2003-03-31 | 2010-01-05 | Xencor, Inc. | PEGylated TNF-α variant proteins |
| AU2004227937B2 (en) * | 2003-03-31 | 2007-09-20 | Xencor, Inc | Methods for rational pegylation of proteins |
| US7610156B2 (en) * | 2003-03-31 | 2009-10-27 | Xencor, Inc. | Methods for rational pegylation of proteins |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2006127896A2 (en) * | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated factor ix |
| AU2004229461A1 (en) | 2003-04-11 | 2004-10-28 | Pr Pharmaceuticals Inc. | Method for preparation of site-specific protein conjugates |
| WO2004091517A2 (en) | 2003-04-15 | 2004-10-28 | Smithkline Beecham Corporation | Conjugates comprising human il-18 and substitution mutants thereof |
| US7932364B2 (en) | 2003-05-09 | 2011-04-26 | Novo Nordisk A/S | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
| US20040249119A1 (en) * | 2003-06-05 | 2004-12-09 | Fox Martin Edward | Novel mPEG propionaldehyde precursor |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| EP1656410B1 (de) | 2003-07-22 | 2010-03-10 | Nektar Therapeutics | Verfahren zur herstellung von funktionalisierten polymeren aus polymeralkoholen |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| CA2536873C (en) * | 2003-08-29 | 2019-09-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| PL1675622T3 (pl) | 2003-09-17 | 2017-11-30 | Nektar Therapeutics | Proleki na bazie wieloramiennego polimeru |
| SG143252A1 (en) * | 2003-10-09 | 2008-06-27 | Ambrx Inc | Polymer derivatives |
| US7524813B2 (en) * | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
| CN102516386A (zh) | 2003-10-10 | 2012-06-27 | 诺沃挪第克公司 | Il-21衍生物 |
| EP1675871A2 (de) | 2003-10-10 | 2006-07-05 | Xencor Inc. | Tnf-alpha-varianten auf proteinbasis zur behandlung von erkrankungen in verbindung mit tnf-alpha |
| EP2641611A3 (de) | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Kombinationstherapie |
| EP1725572B1 (de) | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| EP1694347B1 (de) * | 2003-11-24 | 2013-11-20 | BioGeneriX AG | Glycopegyliertes Erythropoetin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| EP1694301A4 (de) | 2003-12-02 | 2009-11-18 | Cytimmune Sciences Inc | Verfahren und zusammensetzungen zur herstellung von monoklonalen antikörpern |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| KR101439880B1 (ko) * | 2004-01-08 | 2014-09-12 | 라티오팜 게엠베하 | 펩티드의 오-결합형 글리코실화 |
| JP4833862B2 (ja) * | 2004-01-28 | 2011-12-07 | サイトイミューン サイエンシズ インコーポレイテッド | 官能化コロイド金属組成物および方法 |
| AU2005211362B2 (en) | 2004-02-02 | 2008-03-13 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
| AU2005319099B2 (en) * | 2004-02-02 | 2010-09-16 | Ambrx, Inc. | Modified human growth hormone |
| KR100580644B1 (ko) * | 2004-02-16 | 2006-05-16 | 삼성전자주식회사 | 생물분자를 고체 기판상에 비공유적으로 고정화 하는 방법및 그에 의하여 제조되는 마이크로어레이 |
| US7351787B2 (en) * | 2004-03-05 | 2008-04-01 | Bioartificial Gel Technologies, Inc. | Process for the preparation of activated polyethylene glycols |
| CN101132812A (zh) * | 2004-03-15 | 2008-02-27 | 阿拉巴马耐科塔医药公司 | Hiv进入抑制剂的聚合物基组合物和结合物 |
| US20070265200A1 (en) * | 2004-03-17 | 2007-11-15 | Eli Lilly And Company | Glycol Linked Fgf-21 Compounds |
| WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
| CA2568952C (en) * | 2004-06-18 | 2019-05-21 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
| EP1771066A2 (de) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Remodellierung von verzweigtem peg und klykolysierung von glucagonähnlichem peptide-1 glp-1 |
| AU2005275062A1 (en) | 2004-07-14 | 2006-02-23 | University Of Utah Research Foundation | Netrin-related compositions and uses |
| MX2007000728A (es) * | 2004-07-21 | 2007-03-15 | Ambrx Inc | Polipeptidos biosinteticos que utilizan amino acidos no naturalmente codificados. |
| US8268967B2 (en) | 2004-09-10 | 2012-09-18 | Novo Nordisk A/S | Glycopegylated interferon α |
| US20060204512A1 (en) | 2004-09-23 | 2006-09-14 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| JP4920593B2 (ja) * | 2004-10-25 | 2012-04-18 | インテザイン テクノロジーズ， インコーポレイテッド | ヘテロ二官能性ポリ（エチレングリコール）およびそれらの使用 |
| ES2572779T3 (es) | 2004-10-29 | 2016-06-02 | Ratiopharm Gmbh | Remodelación y glucopegilación del Factor de Crecimiento de Fibroblastos (FGF) |
| US7851565B2 (en) | 2004-12-21 | 2010-12-14 | Nektar Therapeutics | Stabilized polymeric thiol reagents |
| NZ555386A (en) * | 2004-12-22 | 2011-01-28 | Ambrx Inc | Formulations of human growth hormone comprising a non-naturally encoded amino acid |
| EP1836316A4 (de) | 2004-12-22 | 2009-07-22 | Ambrx Inc | Verfahren zur expression und reinigung von rekombinantem menschlichem wachstumshormon |
| JP5425398B2 (ja) | 2004-12-22 | 2014-02-26 | アンブレツクス・インコーポレイテツド | 非天然アミノ酸及びポリペプチドを含む組成物、非天然アミノ酸及びポリペプチドに関連する方法並び非天然アミノ酸及びポリペプチドその使用 |
| JP4990792B2 (ja) * | 2004-12-22 | 2012-08-01 | アンブレツクス・インコーポレイテツド | アミノアシル−ｔＲＮＡシンテターゼの組成物およびこの使用 |
| ES2449195T3 (es) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Factor estimulante de colonias de granulocitos glicopegilado |
| US7402730B1 (en) | 2005-02-03 | 2008-07-22 | Lexicon Pharmaceuticals, Inc. | Knockout animals manifesting hyperlipidemia |
| AU2006213822B2 (en) * | 2005-02-09 | 2011-05-26 | Covidien Lp | Synthetic sealants |
| JP2008534640A (ja) | 2005-04-05 | 2008-08-28 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | タンパク質の機能部位またはエピトープの遮蔽方法 |
| EP2386571B1 (de) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Zusammensetzungen und Verfahren zur Herstellung von Glycosylierungsmutanten eines Proteaseresistenten menschlichen Wachstumshormons |
| WO2006110776A2 (en) | 2005-04-12 | 2006-10-19 | Nektar Therapeutics Al, Corporation | Polyethylene glycol cojugates of antimicrobial agents |
| RU2412199C2 (ru) | 2005-04-18 | 2011-02-20 | Ново Нордиск А/С | Варианты ил-21 |
| US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| PT1881850E (pt) | 2005-05-13 | 2010-11-26 | Lilly Co Eli | Compostos peguilados de glp-1 |
| EP1888098A2 (de) | 2005-05-25 | 2008-02-20 | Neose Technologies, Inc. | Glykopegylierte erythropoetin-formulierungen |
| US9505867B2 (en) * | 2005-05-31 | 2016-11-29 | Ecole Polytechmique Fédérale De Lausanne | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| ATE529442T1 (de) * | 2005-06-03 | 2011-11-15 | Ambrx Inc | Verbesserte humane interferon-moleküle und ihre verwendungen |
| US20060281712A1 (en) | 2005-06-14 | 2006-12-14 | Chi-Feng Yen | Pyrimidine compounds |
| US8193206B2 (en) | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
| JP5335422B2 (ja) | 2005-06-17 | 2013-11-06 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 少なくとも１つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化 |
| EP2412744B1 (de) | 2005-07-18 | 2014-01-22 | Nektar Therapeutics | Verfahren zur Herstellung von verzweigten funktionalisierten Polymeren mithilfe von verzweigten Polyol-Kernen |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| CN103103238B (zh) * | 2005-08-18 | 2016-08-10 | Ambrx公司 | 一种在细胞中制造在特定位置处具有所选氨基酸的抗体或抗体片段多肽的方法 |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| AU2006311568B2 (en) * | 2005-11-08 | 2010-11-11 | Ambrx, Inc. | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides |
| EP1951890A4 (de) * | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
| DK1968635T3 (en) * | 2005-12-14 | 2014-12-15 | Ambrx Inc | Compositions and Methods of, and uses of non-natural amino acids and polypeptides |
| US8293869B2 (en) * | 2005-12-16 | 2012-10-23 | Nektar Therapeutics | Polymer conjugates of GLP-1 |
| US7743730B2 (en) * | 2005-12-21 | 2010-06-29 | Lam Research Corporation | Apparatus for an optimized plasma chamber grounded electrode assembly |
| EP1981525B1 (de) * | 2005-12-30 | 2015-01-21 | Zensun (Shanghai) Science and Technology Limited | Verlängerte freisetzung von neuregulin für verbesserte herzfunktion |
| RU2427383C2 (ru) * | 2006-01-18 | 2011-08-27 | КьюПиЭс, ЭлЭлСи | Фармацевтические композиции с повышенной стабильностью |
| EP2319542B1 (de) | 2006-02-21 | 2018-03-21 | Nektar Therapeutics | Segmentierte abbaubare Polymere und daraus hergestellte Konjugate |
| EP2004231A4 (de) | 2006-04-07 | 2013-07-10 | Nektar Therapeutics | Konjugate eines anti-tnf-alpha-antikörpers |
| EP2573111A1 (de) | 2006-04-20 | 2013-03-27 | Amgen Inc. | GLP-1-Verbindungen |
| CA2861601A1 (en) * | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Poly (ethylene glycol) containing chemically disparate endgroups |
| EP2213733A3 (de) | 2006-05-24 | 2010-12-29 | Novo Nordisk Health Care AG | Analoge des Faktor IX mit verlängerter Halbwertszeit in vivo |
| US8242179B2 (en) * | 2006-06-23 | 2012-08-14 | Surmodics, Inc. | Hydrogel-based joint repair system and method |
| WO2007149594A2 (en) | 2006-06-23 | 2007-12-27 | Quintessence Biosciences, Inc. | Modified ribonucleases |
| US8298801B2 (en) * | 2006-07-17 | 2012-10-30 | Quintessence Biosciences, Inc. | Methods and compositions for the treatment of cancer |
| US9187532B2 (en) | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
| EP2615108B1 (de) * | 2006-09-08 | 2016-10-26 | Ambrx, Inc. | Modifiziertes humanes Plasmapolypeptid oder Fc-Gerüste und deren Verwendungen |
| DK2061878T3 (da) * | 2006-09-08 | 2014-04-07 | Ambrx Inc | Hybridsuppressor-trna for hvirveldyrceller |
| MX2009002526A (es) * | 2006-09-08 | 2009-04-16 | Ambrx Inc | Transcripcion de tarn supresor en celulas de vertebrados. |
| US7985783B2 (en) | 2006-09-21 | 2011-07-26 | The Regents Of The University Of California | Aldehyde tags, uses thereof in site-specific protein modification |
| EP2054521A4 (de) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Verfahren zur reinigung von polypeptid-konjugate |
| JP5457185B2 (ja) * | 2006-10-04 | 2014-04-02 | ノヴォ ノルディスク アー／エス | グリセロール連結のｐｅｇ化された糖および糖ペプチド |
| PE20081140A1 (es) * | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| CN101553501A (zh) | 2006-10-26 | 2009-10-07 | 诺沃-诺迪斯克有限公司 | Il-21变种 |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| CN101583380B (zh) * | 2006-11-30 | 2013-07-10 | 尼克塔治疗公司 | 用于制备聚合物轭合物的方法 |
| PT2121751T (pt) | 2006-12-08 | 2017-04-18 | Lexicon Pharmaceuticals Inc | Anticorpos monoclonais contra angptl3 |
| WO2008076933A2 (en) | 2006-12-14 | 2008-06-26 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
| WO2008075192A2 (en) * | 2006-12-19 | 2008-06-26 | Bracco International Bv | Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds |
| JP5340956B2 (ja) | 2006-12-20 | 2013-11-13 | アーケマ・インコーポレイテッド | ポリマーの封入および／または結合 |
| PT2842967T (pt) | 2007-01-18 | 2017-01-13 | Lilly Co Eli | Fab beta amilóide peguilado |
| AU2008210434C8 (en) | 2007-01-31 | 2014-03-27 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| US20100144599A1 (en) | 2007-02-02 | 2010-06-10 | Bristol-Myers Squibb Company | Vegf pathway blockade |
| US20090227689A1 (en) * | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| US20090227981A1 (en) * | 2007-03-05 | 2009-09-10 | Bennett Steven L | Low-Swelling Biocompatible Hydrogels |
| ATE554785T1 (de) | 2007-03-30 | 2012-05-15 | Ambrx Inc | Modifizierte fgf-21 polypeptide und ihre verwendung |
| CA2682897C (en) | 2007-04-03 | 2016-11-22 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
| PL2136850T3 (pl) * | 2007-04-13 | 2012-07-31 | Kuros Biosurgery Ag | Polimeryczny uszczelniacz tkankowy |
| WO2008137471A2 (en) * | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
| MX2009012609A (es) | 2007-05-22 | 2009-12-07 | Amgen Inc | Composiciones y metodos para producir proteinas de fusion bioactivas. |
| CN101778859B (zh) | 2007-06-12 | 2014-03-26 | 诺和诺德公司 | 改良的用于生产核苷酸糖的方法 |
| US7968811B2 (en) * | 2007-06-29 | 2011-06-28 | Harley-Davidson Motor Company Group, Inc. | Integrated ignition and key switch |
| US9125807B2 (en) * | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
| CN101361968B (zh) | 2007-08-06 | 2011-08-03 | 健能隆医药技术（上海）有限公司 | 白介素-22在治疗脂肪肝中的应用 |
| CA2695991A1 (en) * | 2007-08-09 | 2009-02-12 | Daiichi Sankyo Company, Limited | Immunoliposome inducing apoptosis into cell expressing death domain-containing receptor |
| US8067028B2 (en) * | 2007-08-13 | 2011-11-29 | Confluent Surgical Inc. | Drug delivery device |
| US20090075887A1 (en) * | 2007-08-21 | 2009-03-19 | Genzyme Corporation | Treatment with Kallikrein Inhibitors |
| US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| US20110014118A1 (en) * | 2007-09-21 | 2011-01-20 | Lawrence Tamarkin | Nanotherapeutic colloidal metal compositions and methods |
| EP2200932A4 (de) * | 2007-09-21 | 2014-09-10 | Cytimmune Sciences Inc | Nanotherapeutische kolloidale metallzusammensetzungen und verfahren |
| EP2205271B1 (de) * | 2007-10-08 | 2014-05-21 | Quintessence Biosciences, Inc. | Zusammensetzungen und verfahren für therapien auf ribonukleasebasis |
| EP2214716B1 (de) | 2007-10-23 | 2021-11-17 | Nektar Therapeutics | Auf hydroxyapatite gezielrichtete multiarm polymere und daraus hergestellte konjugate |
| WO2009062151A1 (en) * | 2007-11-08 | 2009-05-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
| US20090123519A1 (en) * | 2007-11-12 | 2009-05-14 | Surmodics, Inc. | Swellable hydrogel matrix and methods |
| JP2011504463A (ja) * | 2007-11-12 | 2011-02-10 | イントラダイム コーポレイション | ヘテロ二官能性のポリエチレングリコール試薬 |
| EP2930182A1 (de) | 2007-11-20 | 2015-10-14 | Ambrx, Inc. | Modifizierte insulinpolypeptide und deren verwendungen |
| SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| US20130189239A1 (en) | 2008-02-27 | 2013-07-25 | Novo Nordisk A/S | Conjugated Factor VIII Molecules |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| US20090226531A1 (en) * | 2008-03-07 | 2009-09-10 | Allergan, Inc. | Methods and composition for intraocular delivery of therapeutic sirna |
| SG187427A1 (en) | 2008-04-14 | 2013-02-28 | Halozyme Inc | Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions |
| AU2008355098B2 (en) | 2008-04-21 | 2012-11-15 | Gpcr Therapeutics, Inc | Heterocyclic compounds |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| KR20110008075A (ko) * | 2008-05-16 | 2011-01-25 | 넥타르 테라퓨틱스 | 콜린에스테라아제 부분 및 폴리머의 콘쥬게이트 |
| AR071874A1 (es) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| ES2536882T3 (es) * | 2008-07-21 | 2015-05-29 | Polytherics Limited | Nuevos reactivos y procedimiento de conjugación de moléculas biológicas |
| US10138283B2 (en) | 2008-07-23 | 2018-11-27 | Ambrx, Inc. | Modified bovine G-CSF polypeptides and their uses |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| WO2010033224A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
| EP2334337A1 (de) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymerkonjugate von opioid-wachstumsfaktor-peptiden |
| EP2344200A2 (de) * | 2008-09-19 | 2011-07-20 | Nektar Therapeutics | Modifizierte therapeutische peptide, herstellungsverfahren und verwendung |
| EP2344199A1 (de) * | 2008-09-19 | 2011-07-20 | Nektar Therapeutics | Polymer-konjugate von thymosin-alpha1-peptiden |
| EP2334338A2 (de) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymerkonjugate von c-peptiden |
| WO2010033205A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of v681-like peptides |
| US20110171164A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of glp-2-like peptides |
| WO2010033215A2 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of aod-like peptides |
| US20110171166A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of osteocalcin peptides |
| WO2010033222A2 (en) * | 2008-09-19 | 2010-03-25 | Netkar Therapeutics | Polymer conjugates of ziconotide peptides |
| US20110171161A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of protegrin peptides |
| WO2010033216A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of nesiritide peptides |
| EP2350118B1 (de) | 2008-09-19 | 2016-03-30 | Nektar Therapeutics | Kohlenhydratbasisierte polymere zur wirkstoffabgabe und konjugate davon |
| CN102232085A (zh) | 2008-09-26 | 2011-11-02 | Ambrx公司 | 修饰的动物促红细胞生成素多肽和其用途 |
| MX2011003196A (es) | 2008-09-26 | 2011-04-27 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. |
| BRPI0920743A2 (pt) | 2008-10-01 | 2016-09-20 | Quintessence Biosciences Inc | ribonucleases terapeuticas |
| WO2010056847A2 (en) | 2008-11-13 | 2010-05-20 | Taigen Biotechnology Co., Ltd. | Lyophilization formulation |
| JP5814793B2 (ja) | 2008-11-25 | 2015-11-17 | エコール ポリテクニク フェデラル ド ローザンヌ（エーペーエフエル） | ブロックコポリマーおよびその使用 |
| KR101546563B1 (ko) | 2008-12-09 | 2015-08-28 | 할로자임, 아이엔씨 | 연장된 가용성 ｐｈ20 폴리펩티드 및 그의 용도 |
| GB0823309D0 (en) * | 2008-12-19 | 2009-01-28 | Univ Bath | Functionalising reagents and their uses |
| AU2010203712A1 (en) * | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| US20110318322A1 (en) | 2009-01-12 | 2011-12-29 | Nektar Therapeutics | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer |
| EP2396070A4 (de) | 2009-02-12 | 2012-09-19 | Incept Llc | Wirkstofffreisetzung mit hydrogel-plugs |
| US9005598B2 (en) | 2009-03-04 | 2015-04-14 | Polytherics Limited | Conjugated proteins and peptides |
| US8067201B2 (en) * | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
| AU2010258752B2 (en) | 2009-06-09 | 2015-07-09 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| IN2012DN00407A (de) | 2009-08-05 | 2015-08-21 | Pieris Ag | |
| IN2012DN03219A (de) | 2009-09-17 | 2015-10-23 | Baxter Healthcare Sa | |
| WO2011050938A1 (de) | 2009-10-26 | 2011-05-05 | Genovoxx Gmbh | Konjugate von nukleotiden und methoden zu deren anwendung |
| CA2778678A1 (en) | 2009-10-30 | 2011-05-05 | Cns Therapeutics, Inc. | Improved neurturin molecules |
| MX349301B (es) | 2009-12-21 | 2017-07-21 | Ambrx Inc | Polipéptidos de somatotropina bovina modificados y sus usos. |
| BR112012015597A2 (pt) | 2009-12-21 | 2017-01-31 | Ambrx Inc | peptídeos de somatotropina suínos modificados e seus usos |
| JO2976B1 (en) | 2009-12-22 | 2016-03-15 | ايلي ليلي اند كومباني | Axentomodulin polypeptide |
| AR079344A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
| SI2521568T1 (sl) * | 2010-01-06 | 2019-01-31 | Dyax Corp. | Proteini, ki vežejo plazemski kalikrein |
| CN102161754B (zh) * | 2010-02-13 | 2012-06-13 | 华中科技大学同济医学院附属协和医院 | 枝化状聚乙二醇衍生物的功能化修饰方法 |
| US9815876B2 (en) | 2010-03-05 | 2017-11-14 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| JP6294074B2 (ja) | 2010-04-27 | 2018-03-14 | エータイアー ファーマ， インコーポレイテッド | イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| WO2011139853A2 (en) | 2010-04-28 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
| US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
| CA2797393C (en) | 2010-04-29 | 2020-03-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
| CN103096925A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103096912A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CA2797978C (en) | 2010-05-03 | 2019-12-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
| CN102985103A (zh) | 2010-05-04 | 2013-03-20 | Atyr医药公司 | 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现 |
| WO2011143274A1 (en) | 2010-05-10 | 2011-11-17 | Perseid Therapeutics | Polypeptide inhibitors of vla4 |
| JP6396656B2 (ja) | 2010-05-14 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | フェニルアラニルβｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP6027965B2 (ja) | 2010-05-17 | 2016-11-16 | エータイアー ファーマ， インコーポレイテッド | ロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| MX2012013375A (es) | 2010-05-17 | 2013-04-11 | Cebix Inc | Peptido c pegilado. |
| ES2573108T3 (es) | 2010-05-26 | 2016-06-06 | Bristol-Myers Squibb Company | Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada |
| US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
| CA2804416C (en) | 2010-07-12 | 2020-04-28 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
| EP2595624B1 (de) | 2010-07-20 | 2018-01-31 | Halozyme, Inc. | Verfahren zur linderung bzw. vermeidung der nebenwirkungen im zusammenhang mit der verabreichung eines anti-hyaluronan-mittels |
| KR102139022B1 (ko) | 2010-07-30 | 2020-07-29 | 알콘 인코포레이티드 | 가교된 친수성 코팅을 갖는 실리콘 히드로겔 렌즈 |
| HUE045845T2 (hu) | 2010-08-17 | 2021-12-28 | Ambrx Inc | Módosított relaxin polipeptidek és felhasználásuk |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| AU2011293294B2 (en) | 2010-08-25 | 2016-03-24 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases |
| US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
| AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
| WO2012054822A1 (en) | 2010-10-22 | 2012-04-26 | Nektar Therapeutics | Pharmacologically active polymer-glp-1 conjugates |
| AU2011325910B2 (en) | 2010-11-12 | 2016-03-24 | Dana Farber Cancer Institute, Inc. | Cancer therapies and diagnostics |
| LT2637694T (lt) | 2010-11-12 | 2021-05-25 | Nektar Therapeutics | Il-2 fragmento konjugatai ir polimeras |
| RU2013123793A (ru) | 2010-11-24 | 2014-12-27 | Лексикон Фармасьютикалз, Инк. | Антитела, связывающиеся с notum пектинацетилэстеразой |
| US20140371258A1 (en) | 2010-12-17 | 2014-12-18 | Nektar Therapeutics | Water-Soluble Polymer Conjugates of Topotecan |
| US10736969B2 (en) | 2010-12-21 | 2020-08-11 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| CN103635489B (zh) | 2011-01-06 | 2016-04-13 | 戴埃克斯有限公司 | 血浆前激肽释放酶结合蛋白 |
| EP2672958A1 (de) | 2011-02-08 | 2013-12-18 | Halozyme, Inc. | Zusammensetzung und lipidformulierung eines hyaluronan-abbauenden enzym und seine verwendung zur behandlung von benigner prostatahyperplasie |
| CN103930437A (zh) | 2011-03-16 | 2014-07-16 | 安姆根有限公司 | Nav1.3和Nav1.7的强效及选择性抑制剂 |
| EP2709669A1 (de) | 2011-05-17 | 2014-03-26 | Bristol-Myers Squibb Company | Verfahren zur aufrechterhaltung der pegylierung von polypeptiden |
| WO2012166555A1 (en) | 2011-05-27 | 2012-12-06 | Nektar Therapeutics | Water - soluble polymer - linked binding moiety and drug compounds |
| US9592251B2 (en) | 2011-06-16 | 2017-03-14 | The Hong Kong University Of Science And Technology | Multi-vinylsulfone containing molecule |
| JP2014518216A (ja) | 2011-06-17 | 2014-07-28 | ハロザイム インコーポレイテッド | ヒアルロナン分解酵素の安定な製剤 |
| EP2720713A2 (de) | 2011-06-17 | 2014-04-23 | Halozyme, Inc. | Kontinuierliches subkutanes insulininfusionsverfahren mit einem hyaluronanabbauenden enzym |
| US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
| CA2840552A1 (en) | 2011-07-01 | 2013-01-10 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| AU2012278944B2 (en) | 2011-07-05 | 2015-09-17 | Bioasis Technologies Inc. | p97-antibody conjugates and methods of use |
| WO2013020079A2 (en) | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| US20130071394A1 (en) | 2011-09-16 | 2013-03-21 | John K. Troyer | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use |
| SG11201401797TA (en) | 2011-10-24 | 2014-09-26 | Halozyme Inc | Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof |
| US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
| WO2013075117A2 (en) | 2011-11-17 | 2013-05-23 | John Wahren | Pegylated c-peptide |
| US9205150B2 (en) | 2011-12-05 | 2015-12-08 | Incept, Llc | Medical organogel processes and compositions |
| EP2858661B1 (de) | 2011-12-29 | 2020-04-22 | Dana-Farber Cancer Institute, Inc. | Stabilisierte antivirale fusionsspiralen |
| PT3130347T (pt) | 2011-12-30 | 2019-12-10 | Halozyme Inc | Variantes de polipéptidos de ph20, suas formulações e utilizações |
| RU2659423C2 (ru) | 2012-02-16 | 2018-07-02 | ЭйТИР ФАРМА, ИНК. | ГИСТИДИЛ-тРНК-СИНТЕТАЗЫ ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ |
| WO2013149161A1 (en) | 2012-03-30 | 2013-10-03 | Deangelis Paul L | High molecular weight heparosan polymers and methods of production and use thereof |
| WO2013151991A1 (en) | 2012-04-02 | 2013-10-10 | Surmodics, Inc. | Hydrophilic polymeric coatings for medical articles with visualization moiety |
| PT2833905T (pt) | 2012-04-04 | 2018-08-06 | Halozyme Inc | Terapia de combinação com hialuronidase e um taxano dirigido a tumor |
| US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| AU2013267161A1 (en) | 2012-05-31 | 2014-11-20 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
| AU2013270684B2 (en) | 2012-06-08 | 2018-04-19 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| US10377827B2 (en) | 2012-06-21 | 2019-08-13 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind c-met |
| JP6438391B2 (ja) | 2012-06-22 | 2018-12-12 | ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｃｃｒ２に結合する抗原結合タンパク質 |
| DK2863955T3 (en) | 2012-06-26 | 2017-01-23 | Sutro Biopharma Inc | MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF |
| JP6433424B2 (ja) | 2012-07-31 | 2018-12-05 | バイオアシス テクノロジーズ インコーポレイテッド | 脱リン酸化されたリソソーム蓄積症タンパク質およびその使用方法 |
| US9395468B2 (en) | 2012-08-27 | 2016-07-19 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
| ES2907763T3 (es) | 2012-08-31 | 2022-04-26 | Sutro Biopharma Inc | Aminoácidos modificados que comprenden un grupo azido |
| WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| AU2013341711A1 (en) | 2012-11-12 | 2015-05-21 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| JP2016505528A (ja) | 2012-11-16 | 2016-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | タンパク質の化学修飾のためのピクテ−スペングラーライゲーション |
| US9310374B2 (en) | 2012-11-16 | 2016-04-12 | Redwood Bioscience, Inc. | Hydrazinyl-indole compounds and methods for producing a conjugate |
| US9383357B2 (en) | 2012-12-07 | 2016-07-05 | Northwestern University | Biomarker for replicative senescence |
| JP6426107B2 (ja) | 2012-12-20 | 2018-11-21 | アムジエン・インコーポレーテツド | Ａｐｊ受容体アゴニストおよびその使用 |
| EP2951206A2 (de) | 2013-02-01 | 2015-12-09 | Bristol-Myers Squibb Company | Fibronectin-basierte gerüstproteine |
| UY35397A (es) | 2013-03-12 | 2014-10-31 | Amgen Inc | INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7 |
| WO2014160438A1 (en) | 2013-03-13 | 2014-10-02 | Bioasis Technologies Inc. | Fragments of p97 and uses thereof |
| US10087215B2 (en) | 2013-03-15 | 2018-10-02 | Dana-Farber Cancer Institute, Inc. | Stabilized SOS1 peptides |
| CA2906572A1 (en) | 2013-03-15 | 2014-09-25 | Dana-Farber Cancer Institute, Inc. | Stabilized ezh2 peptides |
| EP2970417B1 (de) | 2013-03-15 | 2019-06-19 | Dana-Farber Cancer Institute, Inc. | Bh4-stabilisierte peptide und verwendungen davon |
| CN105683217B (zh) | 2013-05-31 | 2019-12-10 | 索伦托治疗有限公司 | 与pd-1结合的抗原结合蛋白 |
| TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ｐｈ２０玻尿酸酶變異體及其用途 |
| ES2658039T3 (es) | 2013-07-10 | 2018-03-08 | Sutro Biopharma, Inc. | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
| WO2015013510A1 (en) | 2013-07-25 | 2015-01-29 | Ecole Polytechnique Federale De Lausanne Epfl | High aspect ratio nanofibril materials |
| US20150093399A1 (en) | 2013-08-28 | 2015-04-02 | Bioasis Technologies, Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
| WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
| CN104623637A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术（上海）有限公司 | Il-22二聚体在制备静脉注射药物中的应用 |
| CA2930552C (en) | 2013-11-15 | 2022-12-13 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
| WO2015081282A1 (en) | 2013-11-27 | 2015-06-04 | Redwood Bioscience, Inc. | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate |
| CN112043835B (zh) | 2013-12-06 | 2022-10-21 | 韩捷 | 用于含氮和羟基的药物的生物可逆引入基团 |
| CN106459210A (zh) | 2014-03-27 | 2017-02-22 | 戴埃克斯有限公司 | 用于治疗糖尿病黄斑性水肿的组合物和方法 |
| MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| JP7059003B2 (ja) | 2014-05-14 | 2022-04-25 | トラスティーズ・オブ・ダートマス・カレッジ | 脱免疫化リゾスタフィン及び使用方法 |
| JP6803236B2 (ja) | 2014-06-10 | 2020-12-23 | アムジェン インコーポレイテッド | アペリンポリペプチド |
| DK3180018T3 (da) | 2014-08-12 | 2019-10-28 | Massachusetts Inst Technology | Synergistisk tumorbehandling med IL-2 og integrinbindende Fc-fusionsprotein |
| US20170216403A1 (en) | 2014-08-12 | 2017-08-03 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker |
| MX2017002380A (es) | 2014-08-22 | 2017-09-15 | Sorrento Therapeutics Inc | Proteinas de union de antigeno que se unen a cxcr3. |
| EP3186281B1 (de) | 2014-08-28 | 2019-04-10 | Halozyme, Inc. | Kombinationstherapie mit einer hyaluronanabbauendem enzym und einem immun-checkpoint-hemmer |
| WO2016059377A1 (en) | 2014-10-14 | 2016-04-21 | Polytherics Limited | Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of peg |
| NZ730563A (en) | 2014-10-14 | 2019-05-31 | Halozyme Inc | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
| EA036697B1 (ru) | 2014-10-24 | 2020-12-09 | Бристол-Майерс Сквибб Компани | Модифицированные полипептиды fgf-21 и их применение |
| SG11201701342XA (en) * | 2014-10-24 | 2017-03-30 | Polytherics Ltd | Conjugates and conjugating reagents |
| GB201419108D0 (en) | 2014-10-27 | 2014-12-10 | Glythera Ltd | Materials and methods relating to linkers for use in antibody drug conjugates |
| CN107206119B (zh) * | 2014-12-09 | 2021-01-29 | 实体科学公司 | 具有生物相容性层的医疗设备涂层 |
| EP3270945A4 (de) | 2015-03-18 | 2018-09-05 | Massachusetts Institute of Technology | Selektive mcl-1-bindende peptide |
| CN108026146A (zh) | 2015-07-02 | 2018-05-11 | 达纳-法伯癌症研究所股份有限公司 | 稳定的抗微生物肽 |
| EP3341008A4 (de) | 2015-08-28 | 2019-05-15 | Dana-Farber Cancer Institute, Inc. | An bfl-1 bindende peptide |
| EA201891388A1 (ru) | 2015-12-11 | 2018-11-30 | Дайэкс Корп. | Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека |
| JP6883590B2 (ja) | 2016-01-29 | 2021-06-09 | ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐｄ−ｌ１に結合する抗原結合性タンパク質 |
| US20170247423A1 (en) | 2016-02-29 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Stapled intracellular-targeting antimicrobial peptides to treat infection |
| US10421785B2 (en) | 2016-04-11 | 2019-09-24 | Bar-Ilan University | Delta receptor agonist peptides and use thereof |
| CN109328069B (zh) | 2016-04-15 | 2023-09-01 | 亿一生物医药开发(上海)有限公司 | Il-22在治疗坏死性小肠结肠炎中的用途 |
| WO2018017922A2 (en) | 2016-07-22 | 2018-01-25 | Massachusetts Institute Of Technology | Selective bfl-1 peptides |
| WO2018031361A2 (en) | 2016-08-09 | 2018-02-15 | Eli Lilly And Company | Combination therapy |
| US11466064B2 (en) | 2016-08-26 | 2022-10-11 | Dana-Farber Cancer Institute, Inc. | Bcl-w polypeptides and mimetics for treating or preventing chemotherapy-induced peripheral neuropathy and hearing loss |
| CA3052639A1 (en) | 2017-02-08 | 2018-08-16 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| WO2018170299A1 (en) | 2017-03-15 | 2018-09-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of prokaryotic gene transcription and uses thereof |
| WO2018172503A2 (en) | 2017-03-24 | 2018-09-27 | Basf Se | Liquid laundry detergent comprising modified saccharide or polysaccharide |
| CN111107870A (zh) | 2017-06-22 | 2020-05-05 | 催化剂生物科学公司 | 经修饰的膜型丝氨酸蛋白酶1（mtsp-1）多肽及其使用方法 |
| JP7305614B2 (ja) | 2017-07-19 | 2023-07-10 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド |
| EP3684811A2 (de) | 2017-08-17 | 2020-07-29 | Massachusetts Institute of Technology | Multispezifitätsbinder von cxc-chemokinen und ihre verwendung |
| US11897917B2 (en) | 2017-09-27 | 2024-02-13 | The University Of York | Bioconjugation of polypeptides |
| CN112119085A (zh) | 2017-12-15 | 2020-12-22 | 丹娜-法伯癌症研究院有限公司 | 稳定肽-介导的靶向蛋白降解 |
| JP2021506800A (ja) | 2017-12-15 | 2021-02-22 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 構造安定化および／またはシステイン反応性ｎｏｘａペプチドによるアポトーシスタンパク質の選択的標的化 |
| CN111094462A (zh) | 2017-12-26 | 2020-05-01 | 贝克顿·迪金森公司 | 深紫外线可激发的水溶剂化聚合物染料 |
| US11952432B2 (en) | 2018-02-07 | 2024-04-09 | Dana-Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| US20200408746A1 (en) | 2018-03-14 | 2020-12-31 | Dana-Farber Cancer Institute, Inc. | Stabilized Peptides for Biomarker Detection |
| JP2021519841A (ja) | 2018-03-30 | 2021-08-12 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | ペンダントクロモフォアを有する水溶性ポリマー色素 |
| US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
| KR102167755B1 (ko) | 2018-05-23 | 2020-10-19 | 주식회사 큐어바이오 | 단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도 |
| EP3813867A1 (de) | 2018-07-22 | 2021-05-05 | Bioasis Technologies Inc. | Behandlung von lymphatischen metastasen |
| CN111417655A (zh) | 2018-08-28 | 2020-07-14 | 润俊(中国)有限公司 | 抗cd3抗体叶酸生物偶联物及其用途 |
| FI3849614T3 (fi) | 2018-09-11 | 2024-02-08 | Ambrx Inc | Interleukiini-2-polypeptidikonjugaatteja ja niiden käyttöjä |
| EP3852783A1 (de) | 2018-09-17 | 2021-07-28 | Massachusetts Institute of Technology | Für proteine der bcl-2-familie selektive peptide |
| JP2022512746A (ja) | 2018-10-19 | 2022-02-07 | アンブルックス，インコーポレイテッド | インターロイキン－１０ポリペプチド複合体、その二量体、およびそれらの使用 |
| US20200262887A1 (en) | 2018-11-30 | 2020-08-20 | Opko Ireland Global Holdings, Ltd. | Oxyntomodulin peptide analog formulations |
| US20220075098A1 (en) * | 2018-12-19 | 2022-03-10 | Tangible Science, Inc. | Systems and methods of treating a hydrogel-coated medical device |
| KR20210110848A (ko) | 2018-12-28 | 2021-09-09 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 변형된 유로키나제 유형 플라스미노겐 활성제 폴리펩타이드 및 사용 방법 |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| WO2020154032A1 (en) | 2019-01-23 | 2020-07-30 | Massachusetts Institute Of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
| BR112021015832A2 (pt) | 2019-02-12 | 2022-01-18 | Ambrx Inc | Composições que contêm conjugados de anticorpo-agonista de tlr, métodos e usos dos mesmos |
| EP3962933A1 (de) | 2019-04-18 | 2022-03-09 | Dana-Farber Cancer Institute, Inc. | Selektives targeting von ubiquitin- und ubiquitin-ähnlichen e1-aktivierenden enzymen durch strukturell stabilisierte peptide |
| EP3958983A1 (de) | 2019-04-26 | 2022-03-02 | The Procter & Gamble Company | Reduktion von zahnverfärbung aus kationischen antimikrobiellen mitteln |
| US20230116760A1 (en) | 2019-12-16 | 2023-04-13 | Dana-Farber Cancer Institute, Inc. | Structurally-stabilized oncolytic peptides and uses thereof |
| EP4077366A1 (de) | 2019-12-20 | 2022-10-26 | Dana Farber Cancer Institute, Inc. | Strukturell stabilisierte glucagonähnliche peptid-1-peptide und verwendungen davon |
| CA3166509A1 (en) | 2020-01-14 | 2021-07-22 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
| WO2021173889A1 (en) | 2020-02-26 | 2021-09-02 | Ambrx, Inc. | Uses of anti-cd3 antibody folate bioconjugates |
| JP2023517293A (ja) | 2020-03-04 | 2023-04-25 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 抗ウイルスの構造的に安定化されたＳＡＲＳ－ＣｏＶ－２ペプチドおよびその使用 |
| AU2021233909A1 (en) | 2020-03-11 | 2022-09-29 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and methods of use thereof |
| CA3179872A1 (en) | 2020-04-22 | 2021-10-28 | Dana-Farber Cancer Institute, Inc. | Antiviral structurally-stabilized ace2 helix 1 peptides and uses thereof |
| US20230192789A1 (en) | 2020-04-27 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Structurally-stabilized and hdmx-selective p53 peptides and uses thereof |
| US20210355468A1 (en) | 2020-05-18 | 2021-11-18 | Bioasis Technologies, Inc. | Compositions and methods for treating lewy body dementia |
| US20210393787A1 (en) | 2020-06-17 | 2021-12-23 | Bioasis Technologies, Inc. | Compositions and methods for treating frontotemporal dementia |
| AU2021327396A1 (en) | 2020-08-20 | 2023-03-23 | Ambrx, Inc. | Antibody-TLR agonist conjugates, methods and uses thereof |
| US20230330238A1 (en) | 2020-10-14 | 2023-10-19 | Dana-Farber Cancer Institute, Inc. | Chimeric conjugates for degradation of viral and host proteins and methods of use |
| WO2022098848A1 (en) | 2020-11-05 | 2022-05-12 | Dana-Farber Cancer Institute, Inc. | Antiviral structurally-stabilized ebolavirus peptides and uses thereof |
| WO2022212899A1 (en) | 2021-04-03 | 2022-10-06 | Ambrx, Inc. | Anti-her2 antibody-drug conjugates and uses thereof |
| IL311151A (en) | 2021-09-08 | 2024-04-01 | Dana Farber Cancer Inst Inc | Structurally clamped antiviral SARS-COV-2 peptide-cholesterol conjugates and uses thereof |
| EP4155349A1 (de) | 2021-09-24 | 2023-03-29 | Becton, Dickinson and Company | Wasserlösliche gelbe grünabsorbierende farbstoffe |
| WO2023215784A1 (en) | 2022-05-04 | 2023-11-09 | Dana-Farber Cancer Institute, Inc. | Ebolavirus surface glycoprotein peptides, conjugates, and uses thereof |
| WO2024007016A2 (en) | 2022-07-01 | 2024-01-04 | Beckman Coulter, Inc. | Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives |
| WO2024044327A1 (en) | 2022-08-26 | 2024-02-29 | Beckman Coulter, Inc. | Dhnt monomers and polymer dyes with modified photophysical properties |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3784524A (en) * | 1971-06-25 | 1974-01-08 | Grace W R & Co | Urethane/thioether-containing polyene composition and the reaction product thereof |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4134887A (en) * | 1973-10-17 | 1979-01-16 | Hoechst Aktiengesellschaft | Phenyl-azo-phenyl dyestuffs |
| CH586739A5 (de) * | 1973-10-17 | 1977-04-15 | Hoechst Ag | |
| US4179387A (en) * | 1974-03-12 | 1979-12-18 | Fuji Photo Film Co., Ltd. | Process for producing magnetic FE oxide |
| IL47468A (en) * | 1975-06-12 | 1979-05-31 | Rehovot Res Prod | Process for the cross-linking of proteins using water soluble cross-linking agents |
| US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| DE2607766C3 (de) * | 1976-02-26 | 1978-12-07 | Behringwerke Ag, 3550 Marburg | Verfahren zur Herstellung von trägergebundenen biologisch aktiven Substanzen |
| US4228019A (en) * | 1978-06-19 | 1980-10-14 | Texaco Development Corp. | Secondary recovery process |
| US4473693A (en) * | 1978-08-04 | 1984-09-25 | Stewart Walter W | Aminonaphthalimide dyes for intracellular labelling |
| US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
| US4430260A (en) * | 1979-02-27 | 1984-02-07 | Lee Weng Y | Penicillin-polyvinyl alcohol conjugate and process of preparation |
| US4296097A (en) * | 1979-02-27 | 1981-10-20 | Lee Weng Y | Suppression of reaginic antibodies to drugs employing polyvinyl alcohol as carrier therefor |
| US4241199A (en) * | 1979-09-18 | 1980-12-23 | Union Carbide Corporation | Novel polyester diols |
| US4280979A (en) * | 1979-09-18 | 1981-07-28 | Union Carbide Corporation | Copolymers, compositions, and articles, and methods for making same |
| JPS585320A (ja) * | 1981-07-01 | 1983-01-12 | Toray Ind Inc | グラフト共重合体 |
| US4973493A (en) * | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
| JPS59204144A (ja) * | 1983-04-12 | 1984-11-19 | Daikin Ind Ltd | 新規含フッ素化合物およびその製法 |
| SE470099B (sv) * | 1984-05-17 | 1993-11-08 | Jerker Porath | Sulfonaktiverade tioeteradsorbenter för separation av t ex protein |
| SE454885B (sv) * | 1984-10-19 | 1988-06-06 | Exploaterings Ab Tbf | Polymerbelagda partiklar med immobiliserade metalljoner pa sin yta jemte forfarande for framstellning derav |
| US4616644A (en) * | 1985-06-14 | 1986-10-14 | Johnson & Johnson Products, Inc. | Hemostatic adhesive bandage |
| DE3675588D1 (de) * | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| JP2524586B2 (ja) * | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
| US4917888A (en) * | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4883864A (en) * | 1985-09-06 | 1989-11-28 | Minnesota Mining And Manufacturing Company | Modified collagen compound and method of preparation |
| US4983494A (en) * | 1985-10-16 | 1991-01-08 | Fuji Photo Film Co., Ltd. | Image forming process including heating step |
| CA1283046C (en) * | 1986-05-29 | 1991-04-16 | Nandini Katre | Tumor necrosis factor formulation |
| US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4871785A (en) * | 1986-08-13 | 1989-10-03 | Michael Froix | Clouding-resistant contact lens compositions |
| DE3628717A1 (de) * | 1986-08-23 | 1988-02-25 | Agfa Gevaert Ag | Haertungsmittel fuer proteine, eine damit gehaertete bindemittelschicht und eine solche schicht enthaltendes fotografisches aufzeichnungsmaterial |
| US4931544A (en) * | 1986-09-04 | 1990-06-05 | Cetus Corporation | Succinylated interleukin-2 for pharmaceutical compositions |
| DE3634525A1 (de) * | 1986-10-10 | 1988-04-21 | Miles Lab | Testmittel und indikatoren zum nachweis von thiolgruppen und verfahren zu deren herstellung |
| US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5153265A (en) * | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| NL8800577A (nl) * | 1988-03-08 | 1989-10-02 | Stichting Tech Wetenschapp | Werkwijze voor het aanbrengen van een bloedcompatibele bekleding op polyetherurethaanvormstukken. |
| GB8824593D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
| GB8824592D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Purification process |
| GB8824591D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
| US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US5089261A (en) * | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US4902502A (en) * | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| WO1990015628A1 (en) * | 1989-06-14 | 1990-12-27 | Cetus Corporation | Polymer/antibiotic conjugate |
| US5234903A (en) * | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| US5171264A (en) * | 1990-02-28 | 1992-12-15 | Massachusetts Institute Of Technology | Immobilized polyethylene oxide star molecules for bioapplications |
| EP0546055B1 (de) * | 1990-08-31 | 1996-07-10 | Regents Of The University Of Minnesota | Polyäthylenglykolderivate zur festphaseanwendungen |
| US5380536A (en) * | 1990-10-15 | 1995-01-10 | The Board Of Regents, The University Of Texas System | Biocompatible microcapsules |
| SE467308B (sv) * | 1990-10-22 | 1992-06-29 | Berol Nobel Ab | Fast yta belagd med ett hydrofilt ytterskikt med kovalent bundna biopolymerer, saett att framstaella en saadan yta och ett konjugat daerfoer |
| SG63617A1 (en) * | 1991-01-18 | 1999-03-30 | Amgen Boulder Inc | Methods for treating tumar necrosis factor mediated diseases |
| SG47099A1 (en) * | 1991-03-15 | 1998-03-20 | Amgen Boulder Inc | Pegylation of polypeptides |
| WO1992016555A1 (en) * | 1991-03-18 | 1992-10-01 | Enzon, Inc. | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
| DK52791D0 (da) * | 1991-03-22 | 1991-03-22 | Kem En Tec As | Adsorptionsmatricer |
| DK130991D0 (da) * | 1991-07-04 | 1991-07-04 | Immunodex K S | Polymere konjugater |
| DK0594772T3 (de) * | 1991-07-04 | 1997-02-24 | Immunodex K S | |
| US5414135A (en) | 1991-12-30 | 1995-05-09 | Sterling Winthrop Inc. | Vinyl sulfone coupling of polyoxyalkylenes to proteins |
| EP0622394A1 (de) * | 1993-04-30 | 1994-11-02 | S.A. Laboratoires S.M.B. | Umkehrbare Modifikation von Verbindungen, Schwefel enthaltend, mit Polyalkylengycol und ihre Verwendung |
-
1993
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