DE69430069T2 - Förmige materialien auf der basis von länglichen knochenteilchen und verfahren zu ihrer herstellung - Google Patents

Förmige materialien auf der basis von länglichen knochenteilchen und verfahren zu ihrer herstellung

Info

Publication number
DE69430069T2
DE69430069T2 DE69430069T DE69430069T DE69430069T2 DE 69430069 T2 DE69430069 T2 DE 69430069T2 DE 69430069 T DE69430069 T DE 69430069T DE 69430069 T DE69430069 T DE 69430069T DE 69430069 T2 DE69430069 T2 DE 69430069T2
Authority
DE
Germany
Prior art keywords
production
shaped materials
bone particles
materials based
long bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69430069T
Other languages
English (en)
Other versions
DE69430069D1 (de
Inventor
Michael Dowd
G Dyke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osteotech Inc
Original Assignee
Osteotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteotech Inc filed Critical Osteotech Inc
Publication of DE69430069D1 publication Critical patent/DE69430069D1/de
Application granted granted Critical
Publication of DE69430069T2 publication Critical patent/DE69430069T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A61F2002/2839—Bone plugs or bone graft dowels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
DE69430069T 1993-12-09 1994-12-08 Förmige materialien auf der basis von länglichen knochenteilchen und verfahren zu ihrer herstellung Expired - Lifetime DE69430069T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/164,152 US5507813A (en) 1993-12-09 1993-12-09 Shaped materials derived from elongate bone particles
PCT/US1994/014138 WO1995015776A1 (en) 1993-12-09 1994-12-08 Shaped materials derived from elongate bone particles and process for making same

Publications (2)

Publication Number Publication Date
DE69430069D1 DE69430069D1 (de) 2002-04-11
DE69430069T2 true DE69430069T2 (de) 2002-10-10

Family

ID=22593208

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430069T Expired - Lifetime DE69430069T2 (de) 1993-12-09 1994-12-08 Förmige materialien auf der basis von länglichen knochenteilchen und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US5507813A (de)
EP (1) EP0732947B1 (de)
JP (1) JP3471359B2 (de)
AT (1) ATE213958T1 (de)
CA (1) CA2177017C (de)
DE (1) DE69430069T2 (de)
ES (1) ES2173946T3 (de)
WO (1) WO1995015776A1 (de)

Families Citing this family (284)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1304085A3 (de) * 1994-09-16 2004-01-21 Ethicon Endo-Surgery, Inc. Aus biologisch abbaubarem Material hergestellte Gewebemarkierungsvorrichtung
US5697932A (en) 1994-11-09 1997-12-16 Osteonics Corp. Bone graft delivery system and method
US6206922B1 (en) * 1995-03-27 2001-03-27 Sdgi Holdings, Inc. Methods and instruments for interbody fusion
US5782919A (en) 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
EP0880345B1 (de) * 1996-01-17 2006-04-05 Osteotech, Inc. Verfahren zur herstellung flexibler schichten aus deminaralisierten,länglichen knochenpartikeln
US5824078A (en) * 1996-03-11 1998-10-20 The Board Of Trustees Of The University Of Arkansas Composite allograft, press, and methods
US6652260B2 (en) 1996-03-11 2003-11-25 The Board Of Trustees Of The University Of Arkansas Composite allograft press
US5868749A (en) * 1996-04-05 1999-02-09 Reed; Thomas M. Fixation devices
US5676146B1 (en) * 1996-09-13 2000-04-18 Osteotech Inc Surgical implant containing a resorbable radiopaque marker and method of locating such within a body
US6165487A (en) * 1996-09-30 2000-12-26 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
WO1998014222A1 (en) * 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
US20010031254A1 (en) * 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
US6482584B1 (en) 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
US6309420B1 (en) 1997-10-14 2001-10-30 Parallax Medical, Inc. Enhanced visibility materials for implantation in hard tissue
US6090998A (en) * 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6652592B1 (en) 1997-10-27 2003-11-25 Regeneration Technologies, Inc. Segmentally demineralized bone implant
US6270464B1 (en) 1998-06-22 2001-08-07 Artemis Medical, Inc. Biopsy localization method and device
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6986788B2 (en) * 1998-01-30 2006-01-17 Synthes (U.S.A.) Intervertebral allograft spacer
US6290718B1 (en) 1998-02-02 2001-09-18 Regeneration Technologies, Inc. Luminal graft, stent or conduit made of cortical bone
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6998135B1 (en) 1998-02-27 2006-02-14 Musculoskeletal Transplant Foundation Demineralized corticocancellous bone sheet
US6326018B1 (en) 1998-02-27 2001-12-04 Musculoskeletal Transplant Foundation Flexible sheet of demineralized bone
US6030635A (en) * 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US7019192B2 (en) * 1998-02-27 2006-03-28 Musculoskeletal Transplant Foundation Composition for filling bone defects
US7045141B2 (en) 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
USRE38522E1 (en) * 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6911212B2 (en) 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
US7572263B2 (en) * 1998-04-01 2009-08-11 Arthrocare Corporation High pressure applicator
AU3203599A (en) * 1998-04-01 1999-10-18 Parallax Medical, Inc. Pressure applicator for hard tissue implant placement
US20020058882A1 (en) * 1998-06-22 2002-05-16 Artemis Medical, Incorporated Biopsy localization method and device
US7063726B2 (en) * 1998-06-30 2006-06-20 Lifenet Plasticized bone grafts and methods of making and using same
US20030217415A1 (en) * 1998-06-30 2003-11-27 Katrina Crouch Plasticized bone grafts and methods of making and using same
US20100030340A1 (en) * 1998-06-30 2010-02-04 Wolfinbarger Jr Lloyd Plasticized Grafts and Methods of Making and Using Same
US6293970B1 (en) * 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US8563232B2 (en) * 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US6214054B1 (en) * 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
US6497726B1 (en) * 2000-01-11 2002-12-24 Regeneration Technologies, Inc. Materials and methods for improved bone tendon bone transplantation
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
CA2355046A1 (en) * 1998-12-14 2000-06-22 Osteotech, Inc. Bone graft and guided bone regeneration method
US9669113B1 (en) 1998-12-24 2017-06-06 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US6371904B1 (en) * 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6356782B1 (en) * 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6206923B1 (en) * 1999-01-08 2001-03-27 Sdgi Holdings, Inc. Flexible implant using partially demineralized bone
US6547823B2 (en) * 1999-01-22 2003-04-15 Osteotech, Inc. Intervertebral implant
WO2000045870A1 (en) * 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Osteogenic paste compositions and uses thereof
US6696073B2 (en) * 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US20070233272A1 (en) * 1999-02-23 2007-10-04 Boyce Todd M Shaped load-bearing osteoimplant and methods of making same
US8133421B2 (en) * 1999-02-23 2012-03-13 Warsaw Orthopedic, Inc. Methods of making shaped load-bearing osteoimplant
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6113638A (en) * 1999-02-26 2000-09-05 Williams; Lytton A. Method and apparatus for intervertebral implant anchorage
US6241770B1 (en) * 1999-03-05 2001-06-05 Gary K. Michelson Interbody spinal fusion implant having an anatomically conformed trailing end
AU6168699A (en) 1999-03-24 2000-10-09 Parallax Medical, Inc. Non-compliant system for delivery of implant material
CA2381268A1 (en) * 1999-04-02 2000-10-12 Osteotech, Inc. Surgical bone screw
EP1198208B1 (de) * 1999-05-05 2013-07-10 Warsaw Orthopedic, Inc. Ineinanderstellbare Wirbelfusionsimplantate, welche zwischen die Wirbelkörper eingebracht werden
US7371408B1 (en) 1999-06-07 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
US7435260B2 (en) * 1999-08-13 2008-10-14 Ferree Bret A Use of morphogenetic proteins to treat human disc disease
DE19944681A1 (de) * 1999-08-20 2001-03-01 Metz Stavenhagen Peter Knochenersatzstoff zur Implantation im menschlichen oder tierischen Körper
US6162258A (en) * 1999-08-25 2000-12-19 Osteotech, Inc. Lyophilized monolithic bone implant and method for treating bone
US6783515B1 (en) 1999-09-30 2004-08-31 Arthrocare Corporation High pressure delivery system
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
AU2624801A (en) * 1999-12-30 2001-07-16 Osteotech, Inc. Intervertebral implants
US6379385B1 (en) 2000-01-06 2002-04-30 Tutogen Medical Gmbh Implant of bone matter
US20030023304A1 (en) * 2000-01-11 2003-01-30 Carter Kevin C. Materials and methods for improved bone tendon bone transplantation
US20030097179A1 (en) * 2000-01-11 2003-05-22 Carter Kevin C. Materials and methods for improved bone tendon bone transplantation
US7635390B1 (en) 2000-01-14 2009-12-22 Marctec, Llc Joint replacement component having a modular articulating surface
US6814756B1 (en) 2000-02-04 2004-11-09 Gary K. Michelson Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion
US6500205B1 (en) * 2000-04-19 2002-12-31 Gary K. Michelson Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion
US6716247B2 (en) 2000-02-04 2004-04-06 Gary K. Michelson Expandable push-in interbody spinal fusion implant
EP1645248B8 (de) * 2000-02-04 2010-06-16 Warsaw Orthopedic, Inc. Ausdehnbares interspinales Fusionsimplantat mit schwenkbarem Blocker
US6709458B2 (en) 2000-02-04 2004-03-23 Gary Karlin Michelson Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion
WO2001078798A1 (en) * 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
AU2001288840B2 (en) * 2000-02-10 2008-02-21 Rti Biologics, Inc. Assembled implant, including mixed-composition segment
AR027685A1 (es) 2000-03-22 2003-04-09 Synthes Ag Forma de tejido y metodo para realizarlo
US7462195B1 (en) 2000-04-19 2008-12-09 Warsaw Orthopedic, Inc. Artificial lumbar interbody spinal implant having an asymmetrical leading end
US6350283B1 (en) * 2000-04-19 2002-02-26 Gary K. Michelson Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof
AU2001255530A1 (en) * 2000-04-20 2001-11-07 Regeneration Technologies, Inc. Cortical bone interference screw
DE10026306A1 (de) * 2000-05-26 2001-11-29 Tutogen Medical Gmbh Transplantat
US6332779B1 (en) 2000-07-03 2001-12-25 Osteotech, Inc. Method of hard tissue repair
US6863694B1 (en) 2000-07-03 2005-03-08 Osteotech, Inc. Osteogenic implants derived from bone
TR200400527T4 (tr) * 2000-07-03 2004-07-21 Osteotech Inc. Kemikten türetilmiş osteojenik implantlar
US6808537B2 (en) * 2000-07-07 2004-10-26 Gary Karlin Michelson Expandable implant with interlocking walls
US7001551B2 (en) * 2000-07-13 2006-02-21 Allograft Research Technologies, Inc. Method of forming a composite bone material implant
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
JP2004503330A (ja) * 2000-07-19 2004-02-05 オステオテック　インコーポレーテッド 骨インプラント及びその製法
US6638310B2 (en) 2000-07-26 2003-10-28 Osteotech, Inc. Intervertebral spacer and implant insertion instrumentation
US7726319B1 (en) 2000-08-24 2010-06-01 Osteotech, Inc. Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization
CZ20022557A3 (cs) * 2000-09-19 2003-01-15 Aldecoa Eduardo Anitua Způsob povrchového oąetřování implantátů nebo protéz z titanu a jiných materiálů
US6761738B1 (en) * 2000-09-19 2004-07-13 Sdgi Holdings, Inc. Reinforced molded implant formed of cortical bone
US6432436B1 (en) * 2000-10-03 2002-08-13 Musculoskeletal Transplant Foundation Partially demineralized cortical bone constructs
CA2425556C (en) * 2000-10-13 2011-12-06 Osteotech, Inc. Volume maintaining osteoinductive/oesteoconductive compositions
US20030120274A1 (en) * 2000-10-20 2003-06-26 Morris John W. Implant retaining device
DE60121017T2 (de) * 2000-10-24 2007-01-11 SDGI Holdings, Inc., Wilmington Vorrichtung und verfahren zum knochenbildenden vollstopfen
US6576249B1 (en) 2000-11-13 2003-06-10 El Gendler Bone putty and method
US6579319B2 (en) 2000-11-29 2003-06-17 Medicinelodge, Inc. Facet joint replacement
US20050080486A1 (en) 2000-11-29 2005-04-14 Fallin T. Wade Facet joint replacement
EP1341484B1 (de) * 2000-12-08 2009-05-06 Osteotech, Inc. Implantat für orthopädische anwendungen
US6752831B2 (en) 2000-12-08 2004-06-22 Osteotech, Inc. Biocompatible osteogenic band for repair of spinal disorders
US6419703B1 (en) 2001-03-01 2002-07-16 T. Wade Fallin Prosthesis for the replacement of a posterior element of a vertebra
US6565605B2 (en) * 2000-12-13 2003-05-20 Medicinelodge, Inc. Multiple facet joint replacement
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
AU2002230852A1 (en) * 2000-12-14 2002-06-24 Osteotech, Inc. Method of making demineralized bone particles
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7118579B2 (en) 2001-02-04 2006-10-10 Sdgi Holdings, Inc. Instrumentation for inserting an expandable interbody spinal fusion implant
US6855169B2 (en) 2001-02-28 2005-02-15 Synthes (Usa) Demineralized bone-derived implants
US7090698B2 (en) 2001-03-02 2006-08-15 Facet Solutions Method and apparatus for spine joint replacement
US6890355B2 (en) 2001-04-02 2005-05-10 Gary K. Michelson Artificial contoured spinal fusion implants made of a material other than bone
US6749636B2 (en) * 2001-04-02 2004-06-15 Gary K. Michelson Contoured spinal fusion implants made of bone or a bone composite material
US6989031B2 (en) * 2001-04-02 2006-01-24 Sdgi Holdings, Inc. Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite
US20070191964A1 (en) * 2001-04-04 2007-08-16 Arthrocare Corporation Enhanced visibility materials for implantation in hard tissue
EP1492475B1 (de) * 2001-04-16 2011-12-21 Wright Medical Technology, Inc. Dichte/poröse strukturen zur verwendung als knochenersatz
US8740987B2 (en) * 2001-06-04 2014-06-03 Warsaw Orthopedic, Inc. Tissue-derived mesh for orthopedic regeneration
JP2003013329A (ja) * 2001-06-26 2003-01-15 Sanai Fujita 動物骨製繊維及びその製造方法
US20050107795A1 (en) * 2001-08-10 2005-05-19 John Morris Bone plating system and method of use
US7371409B2 (en) 2001-09-06 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
KR20040047746A (ko) 2001-10-12 2004-06-05 오스테오테크, 인코포레이티드 향상된 골 이식물
US6855167B2 (en) * 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
AU2002362220A1 (en) * 2001-12-27 2003-07-24 Osteotech Inc. Bone fasteners and method for stabilizing vertebral bone facets using the bone fasteners
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US7708776B1 (en) 2002-01-16 2010-05-04 Nuvasive, Inc. Intervertebral disk replacement system and methods
US20040127563A1 (en) * 2002-03-22 2004-07-01 Deslauriers Richard J. Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions
DE60333179D1 (de) * 2002-03-29 2010-08-12 Osteotech Inc Verfahren zur herstellung von knochenteilchen
DE60335248D1 (de) 2002-03-29 2011-01-20 Wright Medical Tech Inc Knochentransplantat-ersatzzusammensetzung
AU2003228391A1 (en) * 2002-03-30 2003-10-20 Cool Brace Intervertebral device and method of use
US20060204544A1 (en) * 2002-05-20 2006-09-14 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
WO2003101175A2 (en) * 2002-05-30 2003-12-11 Osteotech, Inc. Method and apparatus for machining a surgical implant
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US6652887B1 (en) 2002-06-24 2003-11-25 Wright Medical Technology, Inc. Bone graft substitute composition
US7291179B2 (en) 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
US7744597B2 (en) 2002-06-26 2010-06-29 Lifenet Health Device and process for producing fiber products and fiber products produced thereby
SG145565A1 (en) * 2002-08-12 2008-09-29 Osteotech Inc Synthesis of a bone-polymer composite material
WO2004032988A2 (en) * 2002-10-08 2004-04-22 Osteotech, Inc. Coupling agents for orthopedic biomaterials
US7582309B2 (en) * 2002-11-15 2009-09-01 Etex Corporation Cohesive demineralized bone compositions
US20060034881A1 (en) * 2002-11-26 2006-02-16 Eccera Co. Ltd. Animal bone fiber and method of producing the same
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
JP2006516467A (ja) 2003-02-04 2006-07-06 オステオテック，インコーポレイテッド 骨インプラントのためのポリウレタン
US7507257B2 (en) * 2003-02-04 2009-03-24 Wright Medical Technology, Inc. Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7494811B2 (en) * 2003-05-01 2009-02-24 Lifenet Health In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) * 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7252685B2 (en) * 2003-06-05 2007-08-07 Sdgi Holdings, Inc. Fusion implant and method of making same
US7351262B2 (en) * 2003-06-05 2008-04-01 Warsaw Orthopedic, Inc. Bone implants and methods of making same
US7537617B2 (en) * 2003-06-05 2009-05-26 Warsaw Orthopedic, Inc. Bone strip implants and method of making same
JP2007503292A (ja) 2003-06-11 2007-02-22 オステオテック インコーポレーテッド 骨インプラント及びその製造方法
US20050065607A1 (en) * 2003-09-24 2005-03-24 Gross Jeffrey M. Assembled fusion implant
US20050065613A1 (en) * 2003-09-24 2005-03-24 Gross Jeffrey M. Reinforced fusion implant
US20050074476A1 (en) * 2003-10-03 2005-04-07 El Gendler Cartilidge and bone induction by artificially perforated organic bone matrix augmented by undifferentiated cells suspended in bone gel
US7588590B2 (en) * 2003-12-10 2009-09-15 Facet Solutions, Inc Spinal facet implant with spherical implant apposition surface and bone bed and methods of use
CA2535169A1 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
US20120245703A1 (en) * 2004-01-02 2012-09-27 Meredith Thomas L Composite bone material implant and method
US8012210B2 (en) * 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
CA2554571A1 (en) 2004-01-27 2005-08-11 Osteotech, Inc. Stabilized bone graft
US20060064101A1 (en) * 2004-02-12 2006-03-23 Arthrocare Corporation Bone access system
US7993373B2 (en) 2005-02-22 2011-08-09 Hoy Robert W Polyaxial orthopedic fastening apparatus
US8562649B2 (en) 2004-02-17 2013-10-22 Gmedelaware 2 Llc System and method for multiple level facet joint arthroplasty and fusion
US8353933B2 (en) * 2007-04-17 2013-01-15 Gmedelaware 2 Llc Facet joint replacement
US20050196460A1 (en) * 2004-03-08 2005-09-08 Malinin Theodore I. Particulate cartilage compositions, processes for their preparation and methods for regenerating cartilage
EP1789088A4 (de) 2004-03-24 2009-12-30 Doctor S Res Group Inc Verfahren zur durchführung von medizinischen verfahren zur förderung des knochenwachstums, verfahren zur herstellung von zusammensetzungen zur förderung des knochenwachstums und gerät zur verwendung bei solchen verfahren
US7678385B2 (en) * 2004-04-28 2010-03-16 Biomet Manufacturing Corp. Irradiated implantable bone material
US20050244450A1 (en) * 2004-04-28 2005-11-03 Reddi A H Heat-treated implantable bone material
US7507242B2 (en) 2004-06-02 2009-03-24 Facet Solutions Surgical measurement and resection framework
US8764801B2 (en) * 2005-03-28 2014-07-01 Gmedelaware 2 Llc Facet joint implant crosslinking apparatus and method
DE102004036882A1 (de) * 2004-07-22 2006-02-16 Ossacur Ag Bioresorbierbares Material zur Füllung von Knochendefekten
DE102004036881A1 (de) * 2004-07-22 2006-02-16 Ossacur Ag Bioresorbierbares Material zur Füllung von Knochendefekten
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7670384B2 (en) 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
US20060083769A1 (en) 2004-10-14 2006-04-20 Mukesh Kumar Method and apparatus for preparing bone
US7250550B2 (en) * 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
CN101141934B (zh) * 2005-01-14 2010-11-24 骨骼技术股份有限公司 可膨胀的骨植入物
US20060164913A1 (en) * 2005-01-21 2006-07-27 Arthrocare Corporation Multi-chamber integrated mixing and delivery system
US8202259B2 (en) 2005-03-04 2012-06-19 C. R. Bard, Inc. Systems and methods for identifying an access port
EP1858565B1 (de) 2005-03-04 2021-08-11 C.R. Bard, Inc. Identifikationssystem und verfahren für zugangsport
US8029482B2 (en) 2005-03-04 2011-10-04 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US7722647B1 (en) 2005-03-14 2010-05-25 Facet Solutions, Inc. Apparatus and method for posterior vertebral stabilization
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
EP1868539A2 (de) 2005-04-15 2007-12-26 Musculoskeletal Transplant Foundation Bandscheibenreparatur
EP1874393B1 (de) 2005-04-27 2017-09-06 C.R.Bard, Inc. Infusionsvorrichtungen
EP2324878B1 (de) * 2005-04-27 2014-08-20 C.R. Bard, Inc. Infusionsvorrichtungen mit Septum
US10307581B2 (en) 2005-04-27 2019-06-04 C. R. Bard, Inc. Reinforced septum for an implantable medical device
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8025903B2 (en) * 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
KR101270876B1 (ko) * 2005-09-09 2013-06-07 아그노보스 헬스케어 엘엘씨 복합 골이식 대용 시멘트 및 그로부터 제조된 물품
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US20070093900A1 (en) * 2005-09-26 2007-04-26 Williams Lytton A Modular articulating and fusion spinal disc implant system
CN101365499A (zh) * 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
EP1976460A4 (de) 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Injizierbare und formbare knochenersatzmaterialien
CA2637606C (en) * 2006-01-19 2013-03-19 Osteotech, Inc. Porous osteoimplant
US7838022B2 (en) * 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
EP2076220A2 (de) 2006-07-25 2009-07-08 Musculoskeletal Transplant Foundation Verkapselte entmineralisierte spongiosagewebeformen für bandscheibenkernaugmentation, wiederherstellung oder ersatz sowie implantierverfahren
US8043377B2 (en) * 2006-09-02 2011-10-25 Osprey Biomedical, Inc. Implantable intervertebral fusion device
CA2666485C (en) 2006-10-27 2015-10-06 Edwards Lifesciences Corporation Biological tissue for surgical implantation
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US20080114465A1 (en) * 2006-11-14 2008-05-15 Zanella John M Surface treatments of an allograft to improve binding of growth factors and cells
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8974496B2 (en) * 2007-08-30 2015-03-10 Jeffrey Chun Wang Interspinous implant, tools and methods of implanting
AU2008204784A1 (en) * 2007-01-10 2008-07-17 Facet Solutions, Inc. Taper-locking fixation system
USD580551S1 (en) * 2007-02-01 2008-11-11 Zimmer Spine, Inc. Spinal implant
CA2677903A1 (en) * 2007-02-12 2008-08-21 Osteotech, Inc. Joint revision implant
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US9381047B2 (en) * 2007-05-09 2016-07-05 Ebi, Llc Interspinous implant
US20080279825A1 (en) 2007-05-10 2008-11-13 Malinin Theodore I Cartilage material
US8574825B2 (en) 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
US9101691B2 (en) * 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US8642061B2 (en) * 2007-06-15 2014-02-04 Warsaw Orthopedic, Inc. Method of treating bone tissue
US9554920B2 (en) * 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
MX2009014100A (es) 2007-06-20 2010-09-14 Medical Components Inc Puerto de acceso venoso con marcas moldeadas y/o radioopacas.
US20090012620A1 (en) * 2007-07-06 2009-01-08 Jim Youssef Implantable Cervical Fusion Device
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US9358113B2 (en) * 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
US20090024224A1 (en) 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
WO2009012395A1 (en) 2007-07-19 2009-01-22 Innovative Medical Devices, Llc Venous access port assembly with x-ray discernable indicia
EP3311877A1 (de) 2007-07-19 2018-04-25 Medical Components, Inc. Venöser zugangsport mit röntgendichten kennzeichnungsmerkmalen
US8512342B2 (en) * 2007-08-11 2013-08-20 Thomas L. Meredith Portable bone grinder
US9138509B2 (en) * 2007-09-14 2015-09-22 Musculoskeletal Transplant Foundation Composition for filling bone defects
ES2446544T3 (es) * 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Composiciones de matrices óseas desmineralizadas y métodos
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
AU2008340390B2 (en) 2007-11-09 2014-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US8961571B2 (en) * 2007-11-19 2015-02-24 David Lee Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20090226668A1 (en) * 2008-03-10 2009-09-10 Ebi, L.P. Optimized surface for cellular proliferation and differentiation
US20100082072A1 (en) * 2008-03-28 2010-04-01 Sybert Daryl R Bone anchors for orthopedic applications
EP2358352B1 (de) * 2008-10-24 2018-08-29 Warsaw Orthopedic, Inc. Zusammensetzungen und verfahren zur förderung von knochenbildung
WO2012134540A2 (en) 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
AU2009317974A1 (en) * 2008-10-30 2010-05-27 Vanderbilt University Bone/polyurethane composites and methods thereof
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US11890443B2 (en) 2008-11-13 2024-02-06 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US9101475B2 (en) * 2009-02-12 2015-08-11 Warsaw Orthopedic, Inc. Segmented delivery system
US8715244B2 (en) 2009-07-07 2014-05-06 C. R. Bard, Inc. Extensible internal bolster for a medical device
WO2011017284A2 (en) 2009-08-03 2011-02-10 Osteotech, Inc. Bone matrix compositions and methods
US20110098816A1 (en) * 2009-10-28 2011-04-28 Warsaw Orthopedic, Inc. Sacro-iliac joint implant system and method
ES2695907T3 (es) 2009-11-17 2019-01-11 Bard Inc C R Puerto de acceso sobremoldeado que incluye características de anclaje e identificación
NZ602066A (en) 2010-03-23 2013-09-27 Edwards Lifesciences Corp Methods of conditioning sheet bioprosthetic tissue
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
AU2011293202B2 (en) 2010-08-26 2017-01-19 University Of Louisville Research Foundation, Inc. Compositions and methods for treating bone defects
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
US8920511B2 (en) 2011-11-17 2014-12-30 Allosource Multi-piece machine graft systems and methods
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
US9585764B2 (en) * 2012-07-26 2017-03-07 Warsaw Orthopedic, Inc. Bone implant device
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
US9265609B2 (en) * 2013-01-08 2016-02-23 Warsaw Orthopedic, Inc. Osteograft implant
CA2894750C (en) 2013-02-22 2021-12-14 Allosource Cartilage mosaic compositions and methods
AU2014225458A1 (en) 2013-03-07 2015-07-09 Allosource Consistent calcium content bone allograft systems and methods
EP2967874B1 (de) 2013-03-15 2019-11-20 AlloSource Perforierte osteochondrale allograft-zusammensetzungen
CA2899713C (en) 2013-03-15 2022-07-19 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
WO2014172692A1 (en) 2013-04-19 2014-10-23 Theracell, Inc. Demineralized bone fibers having controlled geometry and shapes and methods thereof
CN103357112B (zh) * 2013-07-05 2015-02-18 西安邮电大学 基于量子纠缠传态的脊髓损伤神经信号中继系统及方法
US9861724B2 (en) * 2013-08-06 2018-01-09 Fusion Innovations, Llc Method for fusion of fractured or voided sternum post sternotomy
CA2926421C (en) 2013-10-08 2022-05-03 Vivorte, Inc. Processed bone particle compositions and related methods
US10173375B2 (en) 2014-03-05 2019-01-08 Bacterin International, Inc. Shaped fiber-based products and method of manufacture thereof
US9730796B2 (en) 2014-05-16 2017-08-15 Allosource Composite bone constructs and methods
US10660685B2 (en) 2014-11-14 2020-05-26 Warsaw Orthopedic, Inc. Bone graft materials, devices and methods of use
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10821004B2 (en) * 2015-06-30 2020-11-03 Bacterin Interational, Inc. Expandable bone grafts and methods of manufacture thereof
US10549011B2 (en) 2015-10-26 2020-02-04 Osteolife Biomedical, Llc Bone putty and gel systems and methods
US20170128633A1 (en) 2015-11-10 2017-05-11 Theodore Malinin Bioactive Implants and Methods of Making and Using
USD849946S1 (en) 2015-12-30 2019-05-28 Nuvasive, Inc. Interspinous process spacer
US11090411B2 (en) 2016-01-28 2021-08-17 Warsaw Orthopedic, Inc. Electron beam irradiated osteoinductive bone implant
WO2017218545A1 (en) * 2016-06-13 2017-12-21 Lifenet Health Demineralized bone fibers and preparation thereof
US10813763B2 (en) 2016-07-26 2020-10-27 Warsaw Orthopedic, Inc. Implantable mesh
CN114364418A (zh) 2019-09-11 2022-04-15 华沙整形外科股份有限公司 可水合骨材料和使用方法
US11927393B2 (en) * 2020-04-30 2024-03-12 Dci Donor Services, Inc. Fiber slurry tray and process
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3739773A (en) * 1963-10-31 1973-06-19 American Cyanamid Co Polyglycolic acid prosthetic devices
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4472840A (en) * 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4932973A (en) * 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US5053049A (en) * 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US5061286A (en) * 1989-08-18 1991-10-29 Osteotech, Inc. Osteoprosthetic implant
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5073373A (en) * 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5112354A (en) * 1989-11-16 1992-05-12 Northwestern University Bone allograft material and method
ES2076467T3 (es) * 1990-10-31 1995-11-01 El Gendler Membranas flexibles producidas con materia de hueso organica para la reparacion y reconstruccion de partes del esqueleto.
US5092887A (en) * 1991-08-12 1992-03-03 El Gendler Artificial ligament produced from demineralized bone for the replacement and augmentation of ligaments, tendons and other fibrous connective tissue
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
DE69304092T2 (de) * 1992-02-10 1997-01-02 Matsumoto Dental College Shioj Knochenersatzwerkstoff und Verfahren zu seiner Herstellung

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WO1995015776A1 (en) 1995-06-15
CA2177017A1 (en) 1995-06-15
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