DE69420138D1 - Medium zur langfristige vermehrung und entwicklung von zellen - Google Patents
Medium zur langfristige vermehrung und entwicklung von zellenInfo
- Publication number
- DE69420138D1 DE69420138D1 DE69420138T DE69420138T DE69420138D1 DE 69420138 D1 DE69420138 D1 DE 69420138D1 DE 69420138 T DE69420138 T DE 69420138T DE 69420138 T DE69420138 T DE 69420138T DE 69420138 D1 DE69420138 D1 DE 69420138D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- medium
- development
- growth factor
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/40—Nucleotides, nucleosides, bases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1394—Bone marrow stromal cells; whole marrow
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/079,719 US5405772A (en) | 1993-06-18 | 1993-06-18 | Medium for long-term proliferation and development of cells |
PCT/US1994/006893 WO1995000632A1 (en) | 1993-06-18 | 1994-06-17 | Medium for long-term proliferation and development of cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69420138D1 true DE69420138D1 (de) | 1999-09-23 |
Family
ID=22152362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69420138T Expired - Lifetime DE69420138D1 (de) | 1993-06-18 | 1994-06-17 | Medium zur langfristige vermehrung und entwicklung von zellen |
Country Status (11)
Country | Link |
---|---|
US (1) | US5405772A (de) |
EP (1) | EP0703978B1 (de) |
JP (1) | JP2866742B2 (de) |
AT (1) | ATE183544T1 (de) |
AU (1) | AU678836B2 (de) |
CA (1) | CA2165335A1 (de) |
DE (1) | DE69420138D1 (de) |
DK (1) | DK0703978T3 (de) |
ES (1) | ES2135589T3 (de) |
GR (1) | GR3031218T3 (de) |
WO (1) | WO1995000632A1 (de) |
Families Citing this family (95)
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US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
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US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US6037174A (en) * | 1993-08-23 | 2000-03-14 | Nexell Therapeutics, Inc. | Preparation of serum-free suspensions of human hematopoietic cells or precursor cells |
JPH07227278A (ja) * | 1994-02-18 | 1995-08-29 | Kyorin Pharmaceut Co Ltd | 成熟中枢神経細胞用の無血清培地 |
US7083979B1 (en) * | 1994-03-25 | 2006-08-01 | Indiana University Foundation | Methods for enhanced retroviral-mediated gene transfer |
DE4422667A1 (de) * | 1994-06-30 | 1996-01-04 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Züchtung hämatopoetischer Vorläuferzellen |
US5985554A (en) * | 1994-11-02 | 1999-11-16 | Takeda Chemical Industries, Ltd. | Method of probing the function of proteins or peptides encoded by partially sequenced cDNAs by inhibiting protein synthesis with antisense oligonucleotides |
US5719058A (en) * | 1995-04-10 | 1998-02-17 | Merck & Co., Inc. | Method for producing a highly enriched population of osteoclast cells |
WO1996040866A1 (en) * | 1995-06-07 | 1996-12-19 | Novartis Ag | Serum-free media for primitive hematopoietic cells and methods of use thereof |
CA2233316C (en) * | 1995-09-29 | 2010-12-14 | Indiana University Foundation | Methods for enhanced virus-mediated dna transfer using molecules with virus- and cell-binding domains |
JP3631496B2 (ja) | 1995-10-04 | 2005-03-23 | イミュネックス・コーポレーション | 樹状細胞刺激因子 |
WO1997033978A1 (en) * | 1996-03-12 | 1997-09-18 | Life Technologies, Inc. | Hematopoietic cell culture nutrient supplement |
US6043092A (en) * | 1996-03-18 | 2000-03-28 | University Of Pittsburgh | Cell culture media for mammalian cells |
EP0920490A2 (de) * | 1996-07-25 | 1999-06-09 | Genzyme Corporation | Chondrozyten-medien formeln und kulturverfahren |
WO1998004680A1 (en) * | 1996-07-26 | 1998-02-05 | University Of Manitoba | Serum-free medium for growth of anchorage-dependant mammalian cells |
EP1482031B1 (de) | 1996-08-30 | 2015-10-28 | Life Technologies Corporation | Serumfreies Kulturmedium für Säugerzellen und seine Verwendung |
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US5945337A (en) * | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
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US5948426A (en) * | 1997-05-03 | 1999-09-07 | Jefferies; Steven R. | Method and article to induce hematopoietic expansion |
AU7984498A (en) * | 1997-06-25 | 1999-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Serum-free cell growth medium |
US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
US6800480B1 (en) | 1997-10-23 | 2004-10-05 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
WO1999031222A1 (en) * | 1997-12-18 | 1999-06-24 | Willem Frederik Van Eelen | Industrial scale production of meat from in vitro cell cultures |
WO1999053021A1 (en) * | 1998-04-09 | 1999-10-21 | Bresagen Limited | Cell differentiation/proliferation and maintenance factor and uses thereof |
JP2002513545A (ja) * | 1998-05-07 | 2002-05-14 | ザ ユニヴァーシティー オブ サウス フロリダ | 脳および脊髄修復のためのニューロン源としての骨髄細胞 |
US20020168766A1 (en) * | 2000-01-11 | 2002-11-14 | Gold Joseph D. | Genetically altered human pluripotent stem cells |
US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
RU2272839C2 (ru) * | 1998-11-09 | 2006-03-27 | Консорцио Пер Ла Джестионе Дель Чентро Ди Биотекнолоджие Аванцате | Бессывороточная среда для культуры клеток, используемых для реконструкции костных и хрящевых сегментов (варианты) |
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CN114381428A (zh) * | 2022-01-21 | 2022-04-22 | 广东善玺迦纳栗生物科技股份有限公司 | 作用于注射皮下或损伤组织部位的细胞培养基 |
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US4443546A (en) * | 1980-07-07 | 1984-04-17 | The Beth Israel Hospital Association | Process and composition for propagating mammalian cells |
JPS57194787A (en) * | 1981-05-28 | 1982-11-30 | Ajinomoto Co Inc | Culture medium for animal cell |
US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
NZ206699A (en) * | 1982-12-30 | 1989-08-29 | Bio Response Inc | Process for the production of serum independent cell lines |
FR2543158B1 (fr) * | 1983-03-24 | 1985-11-15 | Inst Nat Sante Rech Med | Milieu de culture de cellules animales sans serum, sans hormones et sans facteurs de croissance et procedes de culture primaire et d'obtention de lignees cellulaires utilisant ce milieu |
US4940666A (en) * | 1983-07-15 | 1990-07-10 | University Patents, Inc. | Process and defined medium for growth of human epidermal keratinocyte cells |
US5132223A (en) * | 1983-11-10 | 1992-07-21 | Thomas Jefferson University | Process and medium for cloning and long-term serial cultivation of adult human endothelial cells |
JPS60196186A (ja) * | 1984-03-17 | 1985-10-04 | Agency Of Ind Science & Technol | 低分子ゼラチンを含む付着依存性細胞用無血清培地組成物を用いる培養方法 |
US5030105A (en) * | 1985-06-06 | 1991-07-09 | Centro De Investigacion Y Estudios Avanzados Del Instituto Politecnico Nacional | Process for the long-term surviving culture of hepatocytes |
US4816401A (en) * | 1985-09-09 | 1989-03-28 | University Of Rochester | Serum free cell culture medium |
US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
NO162160C (no) * | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
DE3871206D1 (de) * | 1987-03-24 | 1992-06-25 | Grace W R & Co | Basisnaehrmedium fuer eine zellkultur. |
US5143842A (en) * | 1988-11-01 | 1992-09-01 | The University Of Colorado Foundation, Inc. | Media for normal human muscle satellite cells |
US5135866A (en) * | 1989-03-03 | 1992-08-04 | W. R. Grace & Co.-Conn. | Very low protein nutrient medium for cell culture |
US5328844A (en) * | 1990-05-09 | 1994-07-12 | University Of Colorado Foundation, Inc. | Culture media for mammalian cells |
WO1991018620A1 (en) * | 1990-06-08 | 1991-12-12 | New York University | Stimulation of bone marrow stromal and progenitor cells |
US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
JPH0789908B2 (ja) * | 1991-02-28 | 1995-10-04 | 倉敷紡績株式会社 | 動物細胞培養用無血清培地 |
JPH06508987A (ja) * | 1991-04-09 | 1994-10-13 | インディアナ・ユニバーシティ・ファンデーション | 造血細胞を支持するシステム及び方法 |
AU2882992A (en) * | 1991-11-06 | 1993-06-07 | Arthur A. Axelrad | Cell culture medium |
-
1993
- 1993-06-18 US US08/079,719 patent/US5405772A/en not_active Expired - Lifetime
-
1994
- 1994-06-17 DK DK94920264T patent/DK0703978T3/da active
- 1994-06-17 JP JP7502993A patent/JP2866742B2/ja not_active Expired - Lifetime
- 1994-06-17 EP EP94920264A patent/EP0703978B1/de not_active Expired - Lifetime
- 1994-06-17 CA CA002165335A patent/CA2165335A1/en not_active Abandoned
- 1994-06-17 WO PCT/US1994/006893 patent/WO1995000632A1/en active IP Right Grant
- 1994-06-17 ES ES94920264T patent/ES2135589T3/es not_active Expired - Lifetime
- 1994-06-17 DE DE69420138T patent/DE69420138D1/de not_active Expired - Lifetime
- 1994-06-17 AT AT94920264T patent/ATE183544T1/de not_active IP Right Cessation
- 1994-06-17 AU AU71124/94A patent/AU678836B2/en not_active Ceased
-
1999
- 1999-09-16 GR GR990402309T patent/GR3031218T3/el unknown
Also Published As
Publication number | Publication date |
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AU678836B2 (en) | 1997-06-12 |
CA2165335A1 (en) | 1995-01-05 |
GR3031218T3 (en) | 1999-12-31 |
JPH08508891A (ja) | 1996-09-24 |
US5405772A (en) | 1995-04-11 |
DK0703978T3 (da) | 2000-01-17 |
EP0703978A1 (de) | 1996-04-03 |
EP0703978B1 (de) | 1999-08-18 |
JP2866742B2 (ja) | 1999-03-08 |
WO1995000632A1 (en) | 1995-01-05 |
AU7112494A (en) | 1995-01-17 |
ES2135589T3 (es) | 1999-11-01 |
ATE183544T1 (de) | 1999-09-15 |
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