DE69420024T2 - Zelleinkapselungsvorrichtung - Google Patents

Zelleinkapselungsvorrichtung

Info

Publication number
DE69420024T2
DE69420024T2 DE69420024T DE69420024T DE69420024T2 DE 69420024 T2 DE69420024 T2 DE 69420024T2 DE 69420024 T DE69420024 T DE 69420024T DE 69420024 T DE69420024 T DE 69420024T DE 69420024 T2 DE69420024 T2 DE 69420024T2
Authority
DE
Germany
Prior art keywords
permeable membrane
core
devices
cells
zone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69420024T
Other languages
English (en)
Other versions
DE69420024D1 (de
Inventor
Mark D Butler
Stanley L Mish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WL Gore and Associates Inc
Original Assignee
WL Gore and Associates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WL Gore and Associates Inc filed Critical WL Gore and Associates Inc
Publication of DE69420024D1 publication Critical patent/DE69420024D1/de
Application granted granted Critical
Publication of DE69420024T2 publication Critical patent/DE69420024T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
DE69420024T 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung Expired - Lifetime DE69420024T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10501193A 1993-08-10 1993-08-10
PCT/US1994/007190 WO1995004521A1 (en) 1993-08-10 1994-06-24 Cell encapsulating device

Publications (2)

Publication Number Publication Date
DE69420024D1 DE69420024D1 (de) 1999-09-16
DE69420024T2 true DE69420024T2 (de) 2000-02-24

Family

ID=22303587

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69420024T Expired - Lifetime DE69420024T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE69433970T Expired - Lifetime DE69433970T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE0938893T Pending DE938893T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69433970T Expired - Lifetime DE69433970T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE0938893T Pending DE938893T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Country Status (9)

Country Link
US (2) US5980889A (de)
EP (2) EP0663817B1 (de)
AT (2) ATE274340T1 (de)
AU (1) AU678843B2 (de)
CA (1) CA2147626C (de)
DE (3) DE69420024T2 (de)
DK (1) DK0663817T3 (de)
ES (1) ES2138665T3 (de)
WO (1) WO1995004521A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2138665T3 (es) * 1993-08-10 2000-01-16 Gore & Ass Dispositivo para encapsular celulas.
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
WO1997010807A1 (en) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
US6306491B1 (en) * 1996-12-20 2001-10-23 Gore Enterprise Holdings, Inc. Respiratory aids
US6368858B1 (en) * 1997-07-22 2002-04-09 The General Hospital Corporation Modulation of multicellular aggregates by pressure from growth in a matrix
US6287558B1 (en) * 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
WO2001054593A1 (en) * 2000-01-31 2001-08-02 The General Hospital Corporation Neural regeneration conduit
US20020127265A1 (en) * 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
CZ298160B6 (cs) * 2001-01-18 2007-07-11 Prístroj pro vyvolání imunitní odezvy pri lécbe rakoviny
US20040191246A1 (en) 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
MXPA03011009A (es) * 2001-06-08 2004-02-27 Boehringer Ingelheim Pharma Metodos para mejorar la actividad de lineas celulares en dispositivos de inmunoaislamiento.
AU2002323217B2 (en) 2001-08-15 2008-04-10 Brown University Research Foundation Treatment of muscular dystrophies and related disorders
US20040005298A1 (en) 2002-02-08 2004-01-08 Xcyte Therapies, Inc. Compositions and methods for restoring immune responsiveness in patients with immunological defects
US20030170278A1 (en) * 2002-03-11 2003-09-11 Wolf David E. Microreactor and method of determining a microreactor suitable for a predetermined mammal
ES2422193T3 (es) 2002-06-28 2013-09-09 Life Technologies Corp Métodos para restaurar el repertorio inmune en pacientes con defectos inmunológicos relacionados con la autoinmunidad y trasplante de órganos o de células madre hematopoyéticas
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
JP2006524991A (ja) * 2003-05-08 2006-11-09 エクサイト セラピーズ インコーポレーティッド 抗原特異的ｔ細胞の作製および単離の方法
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
GB2407394A (en) 2003-10-23 2005-04-27 Dow Corning Ltd Optical waveguide with two differently dimensioned waveguiding layers on substrate
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8657881B2 (en) 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US20060257368A1 (en) * 2005-05-03 2006-11-16 Clemson University Devices and methods for improved viability of cells
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
US20100080784A1 (en) * 2008-09-12 2010-04-01 Torrey Pines Institute For Molecular Studies Methods for treating cachexia and lymphopenia
CN102361971A (zh) 2009-01-23 2012-02-22 Ns基因公司 改善的细胞系以及在胶囊化细胞生物递送中的用途
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
JP5852655B2 (ja) * 2010-09-27 2016-02-03 エヌエスジーン・アクティーゼルスカブＮｓＧｅｎｅ Ａ／Ｓ 支持・放射状拡散スカフォールディングを備える埋込み型細胞デバイス
JP6228010B2 (ja) 2010-12-27 2017-11-08 ブラウン ユニバーシティ ビグリカンおよびユートロフィンに関する治療法および診断法
WO2013036531A1 (en) * 2011-09-06 2013-03-14 Spedden Richard H Surgical sutures and methods of making and using same
US9644179B2 (en) 2011-11-23 2017-05-09 The Trustees Of The University Of Pennsylvania Use of PDL1 expressing cells to convert T cells into regulatory T cells
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US10418143B2 (en) 2015-08-05 2019-09-17 Lockheed Martin Corporation Perforatable sheets of graphene-based material
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
WO2014164621A1 (en) 2013-03-12 2014-10-09 Lockheed Martin Corporation Method for forming filter with uniform aperture size
JP6392315B2 (ja) 2013-03-14 2018-09-19 イミュソフト コーポレーション インビトロでのメモリーｂ細胞分化方法およびｖｓｖ−ｇ偽型ウイルスベクターを用いる形質導入方法
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
EP3099645A4 (de) 2014-01-31 2017-09-27 Lockheed Martin Corporation Verfahren zur formung von verbundstrukturen mit einem zweidimensionalen material unter verwendung einer porösen, nichtbeschädigenden trägerschicht
CN105940479A (zh) 2014-01-31 2016-09-14 洛克希德马丁公司 使用宽离子场穿孔二维材料
CN106232205A (zh) 2014-03-12 2016-12-14 洛克希德马丁公司 由有孔石墨烯形成的分离膜
AU2015311978A1 (en) 2014-09-02 2017-05-11 Lockheed Martin Corporation Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
CN107106609A (zh) 2014-10-31 2017-08-29 宾夕法尼亚大学董事会 刺激和扩展t细胞的组合物和方法
CA2964948A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Altering gene expression in modified t cells and uses thereof
EP3234107B1 (de) 2014-12-19 2022-09-14 Immusoft Corporation B-zellen zur in-vivo-verabreichung von therapeutika
EP4223873A3 (de) 2015-01-31 2023-09-06 The Trustees of the University of Pennsylvania Zusammensetzungen und verfahren zur t-zell-freisetzung von therapeutischen molekülen
US10414812B2 (en) 2015-02-16 2019-09-17 The Trustees Of The University Of Pennsylvania Fully-human T-cell receptor specific for the 369-377 epitope derived from the Her2/neu (ERBB2) receptor protein
MX2018001559A (es) 2015-08-06 2018-09-27 Lockheed Corp Modificacion de nanoparticula y perforacion de grafeno.
WO2017147431A1 (en) * 2016-02-24 2017-08-31 Georgia Tech Research Corporation Surgical suture materials with porous sheaths for drug delivery
JP2019521055A (ja) 2016-04-14 2019-07-25 ロッキード・マーチン・コーポレーション グラフェン欠陥の選択的界面緩和
WO2017180134A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
EP3442786A4 (de) 2016-04-14 2020-03-18 Lockheed Martin Corporation Zweidimensionale membranstrukturen mit strömungskanälen
SG11201808961QA (en) 2016-04-14 2018-11-29 Lockheed Corp Methods for in situ monitoring and control of defect formation or healing
CA3020686A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
KR20190022563A (ko) * 2016-06-28 2019-03-06 고쿠리츠겐큐가이하츠호징 노우교 · 쇼쿠힝 산교기쥬츠 소고겐큐기코 세포 봉입용 디바이스 및 그 사용
WO2018144099A1 (en) 2016-11-03 2018-08-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
EP3534834A4 (de) 2016-11-03 2020-05-13 Arizona Board of Regents on behalf of the University of Arizona Verkapselungsvorrichtungssysteme mit sauerstoffsensoren mit oder ohne exogener sauerstoffzufuhr
US11052230B2 (en) 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
US11707611B2 (en) 2016-11-08 2023-07-25 W. L. Gore & Associates, Inc. Implantable apparatus for retention of biological moieties
JP7088564B2 (ja) 2016-11-10 2022-06-21 ヴィアサイト，インコーポレイテッド 細胞送達装置におけるｐｄｘ１膵臓内胚葉細胞及びその方法
RU2020133851A (ru) 2018-03-16 2022-04-19 Иммьюсофт Корпорейшн B-клетки, генетически модифицированные для секреции фоллистатина, и способы их применения для лечения связанных с фоллистатином заболеваний, состояний, нарушений и для увеличения роста и силы мышц
SG11202102910VA (en) * 2018-09-24 2021-04-29 Procyon Tech Llc Methods and systems for implantable medical devices and vascularization membranes

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
CA1085104A (en) * 1977-03-21 1980-09-09 Anthony M. Sun Artificial endocrine pancreas
US4743545A (en) * 1984-08-09 1988-05-10 Torobin Leonard B Hollow porous microspheres containing biocatalyst
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4420589A (en) * 1980-07-07 1983-12-13 Stoy Vladimir A Polymer composition including polyacrylonitrile polymers and process for preparing same
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
EP0120061A4 (de) * 1982-09-29 1986-08-21 Theodore E Spielberg Eingekapselte lebende genetisch programmierte organismen die arzneimittel erzeugen.
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
EP0147939A2 (de) * 1983-11-15 1985-07-10 JOHNSON & JOHNSON Einpflanzbarer Modul zur Regulierung der Glykämie
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4722898A (en) * 1985-04-29 1988-02-02 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
AU589438B2 (en) * 1985-08-26 1989-10-12 Hana Biologics, Inc. Transplantable artificial tissue and process
US5030225A (en) * 1987-03-13 1991-07-09 Brown University Research Foundation Electrically-charged nerve guidance channels
US5218039A (en) * 1987-04-28 1993-06-08 Kingston Technologies, Inc. Pan emulsion
US4911717A (en) * 1987-06-18 1990-03-27 Gaskill Iii Harold V Intravasular artificial organ
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
JPH037751A (ja) * 1988-03-04 1991-01-14 Kingston Technol Ltd Partnership 新規ポリアクリロニトリル組成物およびその製造方法
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
US4941812A (en) * 1988-05-10 1990-07-17 E. I. Du Pont De Nemours And Company Spinneret for production of a hollow filament within a hollow filament composite fiber having spacing means
FR2634382B1 (fr) * 1988-07-21 1990-10-26 Applic Techn Photoniques Pancreas artificiel
WO1990001498A1 (en) * 1988-08-12 1990-02-22 Cell Biotech, Inc. Process for purification of islet cells; monoclonal antibodies directed to islet and acinar cells; and process for making and using same
CA1323959C (en) * 1988-09-16 1993-11-09 Andreas F. Von Recum Soft tissue implant with micron-scale surface texture to optimize anchorage
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5017490A (en) * 1989-03-10 1991-05-21 Baxter International Inc. Method for in vitro reproduction and growth of cells in culture medium
CA2031532C (en) * 1989-04-25 2003-02-25 Joseph P. Vacanti Method for implanting large volumes of cells on polymeric matrices
CA2062746C (en) * 1989-06-21 1999-02-02 Patrick Aebischer Neurological therapy system
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5002661A (en) * 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5100392A (en) * 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US4969705A (en) * 1990-01-19 1990-11-13 Kingston Technologies, L.P. Memory polymer multiple cavity fiber splicer
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
BR9106205A (pt) * 1990-10-31 1993-03-30 Baxter Int Dispositivo para implantacao em hospedeiro,processo de implantacao,dispositivo implantado,e recipiente de imunoisolamento
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
DE4108772A1 (de) * 1991-03-18 1992-09-24 Inst Textil & Faserforschung Implantierbares biohybrides organ
DK0585368T3 (da) * 1991-04-25 1998-03-16 Univ Brown Res Found Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US5116753A (en) * 1991-07-30 1992-05-26 The Salk Institute For Biological Studies Maintenance of pancreatic islets
WO1993008850A1 (en) * 1991-10-30 1993-05-13 Massachusetts Institute Of Technology Prevascularized polymeric implants for organ transplantation
CA2132016A1 (en) * 1992-04-01 1994-10-14 James H. Brauker Angiogenic tissue implant systems and methods
WO1993021902A1 (en) * 1992-04-24 1993-11-11 Somatix Therapy Corporation Biocompatible, therapeutic, implantable device
AU4114493A (en) * 1992-04-24 1993-11-29 Polymer Technology Group, Inc., The Method of culturing viable cells and method of regulating the level of a compound in a body fluid
DE69331997T2 (de) * 1992-09-28 2003-01-02 Univ Brown Res Found Chitozanmatrizes für eingekapselte zellen
ES2138665T3 (es) * 1993-08-10 2000-01-16 Gore & Ass Dispositivo para encapsular celulas.
EP0688196B1 (de) * 1994-01-11 2002-04-17 Baxter International Inc. Offenes gewebe-implantat-system

Also Published As

Publication number Publication date
AU7356394A (en) 1995-02-28
DE69420024D1 (de) 1999-09-16
EP0938893B1 (de) 2004-08-25
DK0663817T3 (da) 2000-03-13
CA2147626A1 (en) 1995-02-16
ES2138665T3 (es) 2000-01-16
ATE274340T1 (de) 2004-09-15
EP0938893A1 (de) 1999-09-01
AU678843B2 (en) 1997-06-12
US6426214B1 (en) 2002-07-30
ATE183078T1 (de) 1999-08-15
DE69433970T2 (de) 2005-08-11
WO1995004521A1 (en) 1995-02-16
DE69433970D1 (de) 2004-09-30
DE938893T1 (de) 2000-03-09
CA2147626C (en) 1998-04-21
EP0663817B1 (de) 1999-08-11
EP0663817A1 (de) 1995-07-26
US5980889A (en) 1999-11-09

Similar Documents

Publication Publication Date Title
DE69420024T2 (de) Zelleinkapselungsvorrichtung
ES2178654T3 (es) Capsulas biocompatibles inmonoaisladoras que contienen celulas geneticamente alteradas para el suministro de moleculas biologicamente activas.
AU2544201A (en) Implantable device
KR960703343A (ko) 밀봉주입식 박막 캡슐장치 및 그 제조방법(method and apparatus for sealing implantable, membrane encapsulation devices)
FI930883A (fi) In vivo -dosering av aktiva faktorer med hjaelp av samodlade cellimplantat
DK463586A (da) Fsh
ATE232401T1 (de) Terminal-sterilisierte osteogene vorrichtungen und ihre herstellung
ES2173142T3 (es) Dispositivo y procedimiento para la captura y recuperacion de celulas.
SE9504310D0 (sv) Doseringsanordning
GB2271465B (en) Silicon-on-porous-silicon;method of production and material
DE68906488T2 (de) Verwendung von asymmetrischen membranen in abgabevorrichtungen.
CA2346644A1 (en) Method for preventing xenograft transplant rejection using photodynamic therapy
PL298890A1 (en) Sulfonylobenzyl substituted benzo- and pyridopyridones, method of obtaining sames and therapeutic agents containing them
ATE410054T1 (de) Durch elektroporation vermittelter molekulartransfer in intakten pflanzen
NO975545L (no) Cellelinje som produserer analgetiske forbindelser for behandling av smerte
FR2695828B1 (fr) Dispositif de décontamination de déchets.
DK273490A (da) Fremgangsmaade til udvinding af humant interleukin-4 fra bakterier
AU567940B2 (en) Controlled release tablet
DE59604491D1 (de) Polymerisierbare aromatische carbonsäuren und carbonsäureanhydride mit cyclischen carbonatgruppen sowie zubereitungen, enthaltend diese verbindungen
NO170936C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive, substituerte vinylcefalosporiner
SU1662315A1 (ru) Активный элемент для твердотельных лазеров из кристалла галлий-скандий-гадолиниевого граната
DK0514311T4 (da) Fremgangsmåde til desinfektion og rensning af kontaktlinser
NO20010555L (no) Anordning og fremgangsmÕte for fremstilling av singlett- oksygen
JPS5367390A (en) Semiconductor laser device
Tyroler Selected Sources On Central America

Legal Events

Date Code Title Description
8364 No opposition during term of opposition