DE69416324D1 - Heterocyclische benzolsulfonyliminderivate als inhibitoren der il-1 wirkung - Google Patents

Heterocyclische benzolsulfonyliminderivate als inhibitoren der il-1 wirkung

Info

Publication number
DE69416324D1
DE69416324D1 DE69416324T DE69416324T DE69416324D1 DE 69416324 D1 DE69416324 D1 DE 69416324D1 DE 69416324 T DE69416324 T DE 69416324T DE 69416324 T DE69416324 T DE 69416324T DE 69416324 D1 DE69416324 D1 DE 69416324D1
Authority
DE
Germany
Prior art keywords
inhibitors
pct
heterocyclic
derivatives
benzolsulfonylimine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69416324T
Other languages
English (en)
Other versions
DE69416324T2 (de
Inventor
George Ku
Boyd Harrison
David Stemerick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69416324D1 publication Critical patent/DE69416324D1/de
Publication of DE69416324T2 publication Critical patent/DE69416324T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
DE69416324T 1993-11-29 1994-11-03 Heterocyclische benzolsulfonyliminderivate als inhibitoren der il-1 wirkung Expired - Lifetime DE69416324T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15866193A 1993-11-29 1993-11-29
PCT/US1994/012575 WO1995014670A1 (en) 1993-11-29 1994-11-03 Heterocyclic benzenesulfonylimine derivatives as inhibitors of il-1 action

Publications (2)

Publication Number Publication Date
DE69416324D1 true DE69416324D1 (de) 1999-03-11
DE69416324T2 DE69416324T2 (de) 1999-06-10

Family

ID=22569128

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69416324T Expired - Lifetime DE69416324T2 (de) 1993-11-29 1994-11-03 Heterocyclische benzolsulfonyliminderivate als inhibitoren der il-1 wirkung

Country Status (20)

Country Link
US (1) US5668143A (de)
EP (1) EP0731792B1 (de)
JP (1) JP3612073B2 (de)
KR (1) KR100351884B1 (de)
CN (1) CN1045596C (de)
AT (1) ATE176225T1 (de)
AU (1) AU682736B2 (de)
CA (1) CA2177146C (de)
DE (1) DE69416324T2 (de)
DK (1) DK0731792T3 (de)
ES (1) ES2129794T3 (de)
FI (1) FI113368B (de)
GR (1) GR3029485T3 (de)
HU (1) HU222819B1 (de)
IL (1) IL111774A (de)
NO (1) NO306158B1 (de)
NZ (1) NZ276570A (de)
TW (1) TW281671B (de)
WO (1) WO1995014670A1 (de)
ZA (1) ZA949301B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09506345A (ja) * 1993-11-29 1997-06-24 メレルファーマスーティカルズ インコーポレイテッド Ｉｌ−１作用の抑制剤としての新規なベンゼンスルホニルイミン誘導体類
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
CA2451699A1 (en) * 2001-06-26 2003-01-09 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
KR100687522B1 (ko) * 2005-05-28 2007-02-27 한국화학연구원 2,2-디메틸-3-에스테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 pge2 활성에 관련된 염증질환 치료제
US9322160B2 (en) 2011-10-28 2016-04-26 Alfred Iseli Method and device for manufacturing ultralight cardboard structures having substantial mechanical stability

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US3921636A (en) * 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
GB8719102D0 (en) * 1987-08-12 1987-09-16 Merck Sharp & Dohme Therapeutic agents
JP3465794B2 (ja) * 1991-02-27 2003-11-10 メレルファーマスーティカルズ インコーポレイテッド Ｎｍｄａ拮抗剤
JPH05331169A (ja) * 1992-05-26 1993-12-14 Sumitomo Pharmaceut Co Ltd ベンゾナフチリジン誘導体

Also Published As

Publication number Publication date
EP0731792A1 (de) 1996-09-18
GR3029485T3 (en) 1999-05-28
FI113368B (fi) 2004-04-15
AU682736B2 (en) 1997-10-16
CN1045596C (zh) 1999-10-13
NO306158B1 (no) 1999-09-27
AU1086895A (en) 1995-06-13
DE69416324T2 (de) 1999-06-10
ATE176225T1 (de) 1999-02-15
ES2129794T3 (es) 1999-06-16
JPH09506344A (ja) 1997-06-24
CA2177146A1 (en) 1995-06-01
TW281671B (de) 1996-07-21
NZ276570A (en) 2001-02-23
EP0731792B1 (de) 1999-01-27
US5668143A (en) 1997-09-16
NO962156D0 (no) 1996-05-28
CN1136312A (zh) 1996-11-20
IL111774A (en) 1999-11-30
FI962236A0 (fi) 1996-05-28
HU9601434D0 (en) 1996-07-29
ZA949301B (en) 1995-08-07
IL111774A0 (en) 1995-01-24
DK0731792T3 (da) 1999-09-13
WO1995014670A1 (en) 1995-06-01
JP3612073B2 (ja) 2005-01-19
HU222819B1 (hu) 2003-11-28
HUT76272A (en) 1997-07-28
KR100351884B1 (ko) 2002-12-31
CA2177146C (en) 1999-07-06
NO962156L (no) 1996-05-28
FI962236A (fi) 1996-05-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US