DE69414709T2 - Liposomale antisense methylphosphonat oligo-nukleotide und verfahren zu deren herstellung sowie deren verwendung - Google Patents

Liposomale antisense methylphosphonat oligo-nukleotide und verfahren zu deren herstellung sowie deren verwendung

Info

Publication number
DE69414709T2
DE69414709T2 DE69414709T DE69414709T DE69414709T2 DE 69414709 T2 DE69414709 T2 DE 69414709T2 DE 69414709 T DE69414709 T DE 69414709T DE 69414709 T DE69414709 T DE 69414709T DE 69414709 T2 DE69414709 T2 DE 69414709T2
Authority
DE
Germany
Prior art keywords
methyl phosphonate
phospholipid
liposome
nucleotides
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414709T
Other languages
English (en)
Other versions
DE69414709D1 (de
Inventor
Ana Maria Tari
Gabriel Lopez-Berestein
Albert B Deisseroth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of DE69414709D1 publication Critical patent/DE69414709D1/de
Application granted granted Critical
Publication of DE69414709T2 publication Critical patent/DE69414709T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
DE69414709T 1993-07-29 1994-07-29 Liposomale antisense methylphosphonat oligo-nukleotide und verfahren zu deren herstellung sowie deren verwendung Expired - Fee Related DE69414709T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/099,229 US5417978A (en) 1993-07-29 1993-07-29 Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use
PCT/US1994/008568 WO1995003788A1 (en) 1993-07-29 1994-07-29 Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use

Publications (2)

Publication Number Publication Date
DE69414709D1 DE69414709D1 (de) 1998-12-24
DE69414709T2 true DE69414709T2 (de) 1999-04-22

Family

ID=22273733

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414709T Expired - Fee Related DE69414709T2 (de) 1993-07-29 1994-07-29 Liposomale antisense methylphosphonat oligo-nukleotide und verfahren zu deren herstellung sowie deren verwendung

Country Status (10)

Country Link
US (1) US5417978A (de)
EP (1) EP0711149B1 (de)
JP (1) JPH09501160A (de)
AT (1) ATE173397T1 (de)
AU (1) AU677417B2 (de)
CA (1) CA2168243A1 (de)
DE (1) DE69414709T2 (de)
ES (1) ES2124421T3 (de)
HK (1) HK1016409A1 (de)
WO (1) WO1995003788A1 (de)

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CA2168243A1 (en) 1995-02-09
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ATE173397T1 (de) 1998-12-15
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