DE69405233D1 - Biochemisches mehrfach-kapillaranalysegerat - Google Patents

Biochemisches mehrfach-kapillaranalysegerat

Info

Publication number
DE69405233D1
DE69405233D1 DE69405233T DE69405233T DE69405233D1 DE 69405233 D1 DE69405233 D1 DE 69405233D1 DE 69405233 T DE69405233 T DE 69405233T DE 69405233 T DE69405233 T DE 69405233T DE 69405233 D1 DE69405233 D1 DE 69405233D1
Authority
DE
Germany
Prior art keywords
capillaries
chamber
sample
retainer
light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69405233T
Other languages
English (en)
Other versions
DE69405233T2 (de
Inventor
Norman J Dovichi
Jian Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
University of Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Alberta filed Critical University of Alberta
Publication of DE69405233D1 publication Critical patent/DE69405233D1/de
Application granted granted Critical
Publication of DE69405233T2 publication Critical patent/DE69405233T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
DE69405233T 1993-06-03 1994-06-02 Biochemisches mehrfach-kapillaranalysegerat Expired - Fee Related DE69405233T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/072,096 US5439578A (en) 1993-06-03 1993-06-03 Multiple capillary biochemical analyzer
PCT/CA1994/000304 WO1994029712A1 (en) 1993-06-03 1994-06-02 Multiple capillary biochemical analyzer

Publications (2)

Publication Number Publication Date
DE69405233D1 true DE69405233D1 (de) 1997-10-02
DE69405233T2 DE69405233T2 (de) 1998-03-19

Family

ID=22105539

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69405233T Expired - Fee Related DE69405233T2 (de) 1993-06-03 1994-06-02 Biochemisches mehrfach-kapillaranalysegerat

Country Status (10)

Country Link
US (3) US5439578A (de)
EP (1) EP0701694B1 (de)
AT (1) ATE157452T1 (de)
AU (1) AU695154B2 (de)
CA (1) CA2164207A1 (de)
DE (1) DE69405233T2 (de)
DK (1) DK0701694T3 (de)
ES (1) ES2106545T3 (de)
NZ (1) NZ267045A (de)
WO (1) WO1994029712A1 (de)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516409A (en) * 1991-02-28 1996-05-14 Hitachi, Ltd. DNA detector and DNA detection method
US6156177A (en) * 1991-02-28 2000-12-05 Hitachi, Ltd. DNA detector and DNA detection method
US5529679A (en) * 1992-02-28 1996-06-25 Hitachi, Ltd. DNA detector and DNA detection method
US5730850A (en) * 1993-04-23 1998-03-24 Hitachi, Ltd. Capillary array electrophoresis system
JP3563140B2 (ja) * 1995-01-19 2004-09-08 株式会社日立製作所 キャピラリーアレイ電気泳動装置
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
US5721613A (en) * 1994-03-21 1998-02-24 Hewlett Packard Company Fluorescence spectrometer
US5710628A (en) * 1994-12-12 1998-01-20 Visible Genetics Inc. Automated electrophoresis and fluorescence detection apparatus and method
US6014213A (en) * 1994-12-12 2000-01-11 Visible Genetics Inc. High dynamic range apparatus for separation and detection of polynucleotide fragments
US5560811A (en) * 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
US5582705A (en) * 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
US5759779A (en) * 1995-08-29 1998-06-02 Dehlinger; Peter J. Polynucleotide-array assay and methods
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
US20010041333A1 (en) * 1997-06-16 2001-11-15 Short Jay M. High throughput screening for a bioactivity or biomolecule
US6794127B1 (en) 1997-06-16 2004-09-21 Diversa Corporation Capillary array-based sample screening
US20020048809A1 (en) * 1997-06-16 2002-04-25 Lafferty William Micharl Capillary array-based sample screening
CA2192262C (en) * 1995-12-08 2011-03-15 Yoshihide Hayashizaki Method for purification and transfer to separation/detection systems of dna sequencing samples and plates used therefor
US5567294A (en) * 1996-01-30 1996-10-22 Board Of Governors, University Of Alberta Multiple capillary biochemical analyzer with barrier member
WO1997030338A1 (en) * 1996-02-16 1997-08-21 Inphocyte, Inc. System and method for rapid analysis of cells using spectral cytometry
US5694215A (en) * 1996-03-04 1997-12-02 Carver; David R. Optical array and processing electronics and method therefor for use in spectroscopy
US20030211507A1 (en) * 1996-03-29 2003-11-13 Anson Hatch Microscale diffusion immunoassay in hydrogels
US20020090644A1 (en) * 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
US6541213B1 (en) * 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US6120666A (en) * 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US5858187A (en) * 1996-09-26 1999-01-12 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing electrodynamic focusing on a microchip
US6063251A (en) * 1997-05-30 2000-05-16 Spectrumedix Corporation Electrically insulated capillary arrays for electrophoretic applications
WO1998014773A1 (en) * 1996-10-04 1998-04-09 Spectrumedix Corporation Capillary tube holder for electrophoretic applications
US5885430A (en) * 1996-10-04 1999-03-23 Spectrumedix Corporation Capillary tube holder for an electrophoretic apparatus
JP3467995B2 (ja) * 1996-11-28 2003-11-17 株式会社日立製作所 キャピラリー電気泳動装置
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US5833826A (en) * 1996-12-13 1998-11-10 The Perkin-Elmer Corporation Method and apparatus for reducing the distortion of a sample zone eluting from a capillary electrophoresis capillary
US5827748A (en) * 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
JPH10227740A (ja) 1997-02-18 1998-08-25 Hitachi Ltd 多色蛍光検出電気泳動分析装置
EP0864860A1 (de) * 1997-03-10 1998-09-16 Japan Science and Technology Corporation Probenplatte und Vielfachkapillarelektrophoresegerät
US6084667A (en) * 1997-03-12 2000-07-04 Nz Applied Technologies System and method for molecular sample measurement
US5903348A (en) * 1997-03-12 1999-05-11 Nz Applied Technologies, Inc. System and method for molecular sample measurements
US6445448B1 (en) 1997-03-12 2002-09-03 Corning Applied Technologies, Corp. System and method for molecular sample measurement
US20020015997A1 (en) * 1997-06-16 2002-02-07 Lafferty William Michael Capillary array-based sample screening
US20050070005A1 (en) * 1997-06-16 2005-03-31 Martin Keller High throughput or capillary-based screening for a bioactivity or biomolecule
US20040241759A1 (en) * 1997-06-16 2004-12-02 Eileen Tozer High throughput screening of libraries
US20030013115A1 (en) * 1997-06-16 2003-01-16 Diversa Corporation, A Delaware Corporation Capillary array-based sample screening
US20030077620A1 (en) * 1997-06-16 2003-04-24 Diversa Corporation, A Delaware Corporation High throughput screening for sequences of interest
WO1999000664A1 (en) * 1997-06-30 1999-01-07 Spectrumedix Corporation Automated parallel capillary electrophoretic system
US6365024B1 (en) 1997-06-30 2002-04-02 Spectrumedix Corporation Motorized positioning apparatus having coaxial carrousels
US6027627A (en) * 1997-06-30 2000-02-22 Spectrumedix Corporation Automated parallel capillary electrophoretic system
JPH1151900A (ja) * 1997-08-07 1999-02-26 Hitachi Electron Eng Co Ltd 蛍光検出装置
JP3481828B2 (ja) 1997-08-26 2003-12-22 株式会社日立製作所 電気泳動分析装置，電気泳動分析方法及びそれに用いる試料容器
GB9719673D0 (en) 1997-09-17 1997-11-19 Glaxo Group Ltd Novel apparatus
US6126804A (en) * 1997-09-23 2000-10-03 The Regents Of The University Of California Integrated polymerase chain reaction/electrophoresis instrument
EP0905511A1 (de) * 1997-09-25 1999-03-31 Beckman Coulter, Inc. Kapillarhalter
JP2001518624A (ja) * 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン 同時の粒子分離および化学反応
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6054032A (en) * 1998-01-27 2000-04-25 3M Innovative Properties Company Capillary electrophoresis array
DE19803753C1 (de) * 1998-01-30 1999-12-02 Max Planck Gesellschaft Vorrichtung und Verfahren zur Kapillarelektrophorese
FR2774472B1 (fr) * 1998-01-30 2000-04-21 Centre Nat Rech Scient Perfectionnements aux systemes d'electrophorese multicapillaire
US6475361B1 (en) 1998-02-20 2002-11-05 Tetragen Sa Capillary electrophoresis apparatus having filling/refilling system and methods for use thereof
US6103083A (en) * 1998-02-20 2000-08-15 Tetragen Capillary electrophoresis apparatus and method
FR2776072B1 (fr) * 1998-03-11 2000-06-02 Centre Nat Rech Scient Perfectionnements aux dispositifs d'electrophorese multicapillaires du type a detection en sortie des capillaires
US6113767A (en) * 1998-04-24 2000-09-05 Apogee Designs, Ltd. Electrophoresis sequencing apparatus
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
AU759974B2 (en) 1998-05-16 2003-05-01 Applied Biosystems, Llc Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) * 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
SE9802558D0 (sv) 1998-07-16 1998-07-16 Hanning Instr Ab Device for detection of fluorescent
AU5311699A (en) * 1998-07-28 2000-02-21 Ce Resources Pte Ltd Optical detection system
US6357484B1 (en) 1998-08-31 2002-03-19 Uop Llc Microporous structure defined by a multiplicity of singular channels and method of making
AU2002301178B2 (en) * 1998-09-11 2005-02-17 Applied Biosystems, Llc. Multi-channel capillary electrophoresis device including sheath-flow cuvette and replaceable capillary array
US6162341A (en) * 1998-09-11 2000-12-19 The Perkin-Elmer Corporation Multi-channel capillary electrophoresis device including sheath-flow cuvette and replacable capillary array
US6132582A (en) * 1998-09-14 2000-10-17 The Perkin-Elmer Corporation Sample handling system for a multi-channel capillary electrophoresis device
US6103199A (en) * 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
EP0999443A3 (de) * 1998-11-02 2002-09-18 The Institute of Physical and Chemical Research Kapillarelektroforesesvorrichtung, Probenplatte, und Probeneinspritzverfahren
NZ511560A (en) 1998-11-05 2002-11-26 Chemometec As A method for the assessment of particles and a system and a device for use in the method
US6174352B1 (en) 1998-11-24 2001-01-16 Uop Llc Round profile multi-capillary assembly and method of making
EP1006355A3 (de) 1998-11-30 2000-11-08 The Institute of Physical and Chemical Research Kapillarelektrophoresegerät
US6464852B1 (en) * 1998-12-03 2002-10-15 State University Of New York At Stony Brook Multicapillary bundle for electrophoresis and detection for DNA
US6497804B1 (en) * 1998-12-03 2002-12-24 Research Foundation Of The State University Of New York Method and apparatus for DNA sequencing
US6913679B1 (en) 1999-02-11 2005-07-05 The Regents Of The University Of California Apparatus and methods for high resolution separation of sample components on microfabricated channel devices
JP2002544486A (ja) * 1999-05-10 2002-12-24 プロリンクス・インコーポレイテッド 細胞分離装置およびその使用法
JP4159702B2 (ja) * 1999-05-12 2008-10-01 独立行政法人理化学研究所 キャピラリーカラムへのゲル充填装置
US6838680B2 (en) * 1999-05-12 2005-01-04 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US6352633B1 (en) * 1999-08-31 2002-03-05 Spectrumedix Corporation Automated parallel capillary electrophoresis system with hydrodynamic sample injection
US6676819B1 (en) * 1999-09-14 2004-01-13 Yaoqing Diana Liu Methods and apparatus for automatic on-line multi-dimensional electrophoresis
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6592733B1 (en) 1999-11-12 2003-07-15 Motorola, Inc. Capillary electrophoresis devices incorporating optical waveguides
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US20020028160A1 (en) * 2000-02-22 2002-03-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
US6580507B2 (en) * 2000-03-02 2003-06-17 Sd Acquisition Inc. Single source, single detector chip, multiple-longitudinal channel electromagnetic radiation absorbance and fluorescence monitoring system
US6571651B1 (en) * 2000-03-27 2003-06-03 Lifescan, Inc. Method of preventing short sampling of a capillary or wicking fill device
JP3918403B2 (ja) * 2000-05-15 2007-05-23 株式会社日立製作所 キャピラリアレイ
JP4003374B2 (ja) * 2000-05-15 2007-11-07 株式会社日立製作所 キャピラリアレイ電気泳動装置及び試料の分離・分析方法
JP4103302B2 (ja) * 2000-05-15 2008-06-18 株式会社日立製作所 キャピラリアレイを用いた電気泳動装置及びそれに用いられるサンプルプレートアセンブリ
US6805784B2 (en) 2000-05-15 2004-10-19 Hitachi, Ltd. Capillary array
US6547943B1 (en) * 2000-05-25 2003-04-15 Spectrumedix Llc Capillary system providing multiple analysis of sample from same body of liquid
KR100360069B1 (ko) * 2000-05-29 2002-11-07 김성호 분석장치 및 생화학적 시료의 정량 방법
US6562214B1 (en) 2000-06-30 2003-05-13 Beckman Coulter, Inc. Laminated capillary array assembly
US6531041B1 (en) 2000-07-20 2003-03-11 Symyx Technologies, Inc. Multiplexed capillary electrophoresis system with rotatable photodetector
US6544396B1 (en) * 2000-07-20 2003-04-08 Symyx Technologies, Inc. Multiplexed capillary electrophoresis system
US6462816B1 (en) 2000-07-21 2002-10-08 Symyx Technologies, Inc. Parallel capillary electrophoresis system having signal averaging and noise cancellation
US6572750B1 (en) * 2000-07-21 2003-06-03 Symyx Technologies, Inc. Hydrodynamic injector
US20020029203A1 (en) * 2000-09-01 2002-03-07 Pelland David M. Electronic personal assistant with personality adaptation
GB0023041D0 (en) * 2000-09-20 2000-11-01 Univ Manchester Identification apparatus
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
DE60220497T2 (de) 2001-01-26 2008-01-31 Biocal Technology, Inc., Irvine Optische detektion in einem mehrkanaligen bioseparationssystem
US7309409B2 (en) * 2001-01-26 2007-12-18 Biocal Technology, Inc. Multi-channel bio-separation cartridge
MXPA02001147A (es) * 2001-03-19 2004-04-21 Warner Lambert Co Sintesis de ligandos bisfosina no-c2-simetricos como catalizadores para la hidrogenacion asimetrica.
US6797139B2 (en) 2001-03-19 2004-09-28 Applera Corporation Detection cell for guiding excitation light therein and method for using same
NO314325B1 (no) * 2001-03-29 2003-03-03 Torbjoern Kvassheim Anordning ved gjennomsiktig rör for optisk telling og måling
US6839564B2 (en) * 2001-04-25 2005-01-04 Nokia Corporation Synchronization of database data
US6596140B2 (en) * 2001-05-01 2003-07-22 Applera Corporation Multi-channel capillary electrophoresis device and method
US6731437B2 (en) 2001-05-04 2004-05-04 Applera Corporation Energy beam guide for an electrophoresis system
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US6932940B2 (en) * 2001-06-22 2005-08-23 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation input
US6929779B2 (en) 2001-06-22 2005-08-16 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation output
KR100442412B1 (ko) * 2001-07-20 2004-07-30 학교법인 포항공과대학교 모세관으로 연결된 랩온어칩 시스템
US7280207B2 (en) * 2001-07-25 2007-10-09 Applera Corporation Time-delay integration in a flow cytometry system
CA2453390A1 (en) * 2001-07-25 2003-02-06 Applera Corporation Time-delay integration in electrophoretic detection systems
US7265833B2 (en) * 2001-07-25 2007-09-04 Applera Corporation Electrophoretic system with multi-notch filter and laser excitation source
WO2003013703A1 (en) * 2001-08-03 2003-02-20 Aclara Biosciences, Inc. Straightflow system
US7019831B2 (en) * 2001-08-24 2006-03-28 Applera Corporation Separation device substrate including non-fluorescent quencher dye
US6627433B2 (en) * 2001-08-24 2003-09-30 Applera Corporation Multi-channel analyte-separation device employing side-entry excitation
US20080288178A1 (en) * 2001-08-24 2008-11-20 Applera Corporation Sequencing system with memory
US7250098B2 (en) * 2001-09-28 2007-07-31 Applera Corporation Multi-capillary array electrophoresis device
AU2002327802B2 (en) * 2001-09-28 2005-10-20 Applied Biosystems, Llc. Multi-capillary array electrophoresis device
US6870165B2 (en) 2001-10-19 2005-03-22 Biocal Technology, Inc. Multi-color multiplexed analysis in a bio-separation system
US7189361B2 (en) * 2001-12-19 2007-03-13 3M Innovative Properties Company Analytical device with lightguide Illumination of capillary and microgrooves arrays
US7208072B2 (en) * 2002-01-18 2007-04-24 Biocal Technology, Inc. Multi-segment cartridge for bio-separation with multiplexed fluorescence detection
US7312432B2 (en) * 2002-07-08 2007-12-25 Dmetrix, Inc. Single axis illumination for multi-axis imaging system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
MXPA05001100A (es) 2002-08-01 2005-04-28 Xy Inc Sistema de separacion de baja presion para celulas de esperma.
MXPA05001654A (es) 2002-08-15 2005-10-18 Xy Inc Citometro de flujo de alta resolucion.
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US6833919B2 (en) * 2002-10-11 2004-12-21 Combisep Multiplexed, absorbance-based capillary electrophoresis system and method
US7544932B2 (en) * 2002-10-21 2009-06-09 The United States Of America, As Represented By The Secretary, Of The Department Of Health And Human Services Contiguous capillary electrospray sources and analytical devices
US7108775B2 (en) * 2002-11-08 2006-09-19 Applera Corporation Apparatus and method for confining eluted samples in electrophoresis systems
WO2004059312A1 (en) * 2002-12-20 2004-07-15 Corning Incorporated Capillary assay device and method
MX347048B (es) 2003-03-28 2017-04-07 Inguran Llc * Aparato de muestreo digital y métodos para separar partículas.
ES2541121T3 (es) 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
US6972413B1 (en) * 2003-05-22 2005-12-06 Henkel Corporation UV curing system
US7715105B2 (en) * 2003-09-10 2010-05-11 Precision Optics Corporation Acylindrical optical device
US7116486B2 (en) * 2003-09-10 2006-10-03 Precision Optics Corporation, Inc. Cylindrical optical devices and method of manufacture
WO2005047882A2 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8007724B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having at least one auxiliary buffer passage
CN1316244C (zh) * 2004-02-26 2007-05-16 复旦大学 基于阵列毛细管等电聚焦的多维色谱－电泳分离与检测系统
US20050214737A1 (en) * 2004-03-26 2005-09-29 Dejneka Matthew J Transparent filtered capillaries
CA2561661C (en) 2004-03-29 2015-11-24 Monsanto Technology Llc Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
RU2252411C1 (ru) * 2004-04-09 2005-05-20 Общество с ограниченной ответственностью "Институт рентгеновской оптики" Флюоресцентный сенсор на основе многоканальных структур
AR049732A1 (es) 2004-07-22 2006-08-30 Monsanto Co Proceso para enriquecer una poblacion de celulas de esperma
US7550267B2 (en) * 2004-09-23 2009-06-23 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
JP4616051B2 (ja) * 2005-04-05 2011-01-19 株式会社日立ハイテクノロジーズ 電気泳動装置、及び電気泳動方法
CA2616376A1 (en) * 2005-07-25 2007-02-01 Duke University Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
WO2007056560A2 (en) * 2005-11-09 2007-05-18 Chemimage Corporation System and method for cytological analysis by raman spectroscopic imaging
US20070209938A1 (en) * 2006-03-13 2007-09-13 Jianzhong Zhang Method and apparatus for biopolymer analysis
EP2001352A4 (de) * 2006-03-17 2010-04-07 Univ Duke Auf monte-carlo-simulation basierendes modell für fluoreszenz in trüben medien sowie verfahren und systeme zu seiner verwendung zur bestimmung der intrinsischen fluoreszenz trüber medien
US7751039B2 (en) * 2006-03-30 2010-07-06 Duke University Optical assay system for intraoperative assessment of tumor margins
US8797644B2 (en) 2006-08-11 2014-08-05 The Regents Of The University Of California Capillary-based cell and tissue acquisition system (CTAS)
WO2008103486A1 (en) * 2007-02-23 2008-08-28 Duke University Scaling method for fast monte carlo simulation of diffuse reflectance spectra
WO2009043050A2 (en) * 2007-09-27 2009-04-02 Duke University Optical assay system with a multi-probe imaging array
WO2009043045A1 (en) * 2007-09-28 2009-04-02 Duke University Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a monte carlo or a diffusion algorithm
US20110105865A1 (en) * 2008-04-24 2011-05-05 Duke University Diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering
JP4661942B2 (ja) * 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
DE102009030688A1 (de) * 2009-06-26 2010-12-30 Carl Zeiss Ag Mikroskopische Detektion von Objekten in einem Fluidstrom
US8634076B2 (en) * 2009-08-17 2014-01-21 Malvern Instruments, Ltd. Multi-sample scattering measurements
AT508806B1 (de) * 2009-10-07 2013-06-15 Onkotec Gmbh Analysegerät und verfahren
US9091637B2 (en) 2009-12-04 2015-07-28 Duke University Smart fiber optic sensors systems and methods for quantitative optical spectroscopy
US9057702B2 (en) * 2010-12-21 2015-06-16 The Regents Of The University Of California Compact wide-field fluorescent imaging on a mobile device
JP5870497B2 (ja) * 2011-03-18 2016-03-01 セイコーエプソン株式会社 測定装置及び測定方法
US8663562B2 (en) 2011-09-13 2014-03-04 Sabic Innovative Plastics Ip B.V. Flow cell for measuring electromagnetic radiation absorption spectra in a continuously flowing immiscible liquid(s) or liquids with entrained gas phases
PL2812675T3 (pl) 2012-02-06 2021-12-13 The Regents Of The University Of California Przenośny czytnik szybkich testów diagnostycznych
WO2014014587A2 (en) * 2012-07-16 2014-01-23 Schlumberger Canada Limited Capillary electrophoresis for reservoir fluid analysis at wellsite and laboratory
US10018590B2 (en) 2013-08-15 2018-07-10 Schlumberger Technology Corporation Capillary electrophoresis for subterranean applications
US9766206B2 (en) * 2013-09-27 2017-09-19 ProteinSimple Apparatus, systems, and methods for capillary electrophoresis
US10274460B2 (en) 2014-03-07 2019-04-30 Life Technologies Corporation Capillary array cartridge for capillary electrophoresis systems
US11280759B2 (en) 2014-03-07 2022-03-22 Life Technologies Corporation Optical system for capillary electrophoresis
US9804093B2 (en) * 2014-05-23 2017-10-31 University Of Notre Dame Du Lac Ultrasensitive SERS flow detector
WO2017205985A1 (en) * 2016-06-03 2017-12-07 Valorbec Societe En Commandite System and method for the transfer of fluid from one flow to another
WO2018200123A1 (en) * 2017-04-28 2018-11-01 Becton, Dickinson And Company Particle detection cartridges, systems thereof and methods for using the same
CN109390206A (zh) * 2017-08-04 2019-02-26 中国科学技术大学 小型化便携式质谱仪及用于产生水团簇离子的离子源装置
US11222779B2 (en) * 2018-05-17 2022-01-11 GMJ Technologies, Inc. Apparatuses for optical and mass spectrometry detection
CN111337416A (zh) * 2020-03-13 2020-06-26 山东大学 多通道鞘流结构及其免标记微流控细胞仪与方法
DE102021200214A1 (de) 2021-01-12 2022-07-14 Anvajo GmbH Probenaufnahmevorrichtung
KR20230156312A (ko) 2021-01-12 2023-11-14 안바조 게엠베하 샘플 수용 장치
DE102021214685A1 (de) 2021-12-20 2023-06-22 Anvajo GmbH Probenaufnahmevorrichtung

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766047A (en) * 1972-09-11 1973-10-16 F Elevitch Gel for electrophoresis
US4284491A (en) * 1978-11-13 1981-08-18 C. Desaga Gmbh Nachf. Erich Fecht Apparatus for electrophoresis
US4337131A (en) * 1978-11-13 1982-06-29 C. Desaga Gmbh Nachf. Erich Fecht Process for electrophoresis
DE2929478A1 (de) * 1979-07-20 1981-02-05 Max Planck Gesellschaft Verfahren und vorrichtung zur durchfuehrung einer ein- und zweidimensionalen mikro-gelelektrophorese
US4574040A (en) * 1984-04-17 1986-03-04 Bio-Rad Laboratories, Inc. Apparatus for vertical gel electrophoresis
JPS6162843A (ja) * 1984-08-13 1986-03-31 Hitachi Ltd 螢光検出型電気泳動装置
US4675300A (en) * 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US5242796A (en) * 1986-07-02 1993-09-07 E. I. Du Pont De Nemours And Company Method, system and reagents for DNA sequencing
DE3752148T2 (de) * 1987-06-09 1998-09-17 Perkin Elmer Corp Echtzeitabtastvorrichtung in einem Elektrophoreseapparat zur DNS-Sequenzbestimmung
DE3821454A1 (de) * 1987-06-24 1989-02-09 Hitachi Ltd Verfahren zur aufbereitung gebrauchter elektrophorese-gele fuer die wiederverwendung
JP2550106B2 (ja) * 1987-10-30 1996-11-06 株式会社日立製作所 光分散検出型電気泳動装置
JPH0774802B2 (ja) * 1988-01-30 1995-08-09 豊明 青木 トリハロメタンの定量方法および分析装置
US5062942A (en) * 1989-04-12 1991-11-05 Hitachi, Ltd. Fluorescence detection type electrophoresis apparatus
JP2853745B2 (ja) * 1989-04-12 1999-02-03 株式会社日立製作所 光検出電気泳動装置
US4979824A (en) * 1989-05-26 1990-12-25 Board Of Trustees Of The Leland Stanford Junior University High sensitivity fluorescent single particle and single molecule detection apparatus and method
US5032247A (en) * 1989-09-14 1991-07-16 Separations Technology, Inc. Method and apparatus for electrophoretic separations
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5104512A (en) * 1990-05-14 1992-04-14 Labintelligence, Inc. Gel electrophoresis system
DE4139211C2 (de) * 1990-11-30 1994-03-24 Hitachi Ltd Elektrophoresegerät
US5516409A (en) * 1991-02-28 1996-05-14 Hitachi, Ltd. DNA detector and DNA detection method
US5529679A (en) * 1992-02-28 1996-06-25 Hitachi, Ltd. DNA detector and DNA detection method
JPH04271800A (ja) * 1991-02-28 1992-09-28 Hitachi Ltd 電気泳動装置
DE4230354B4 (de) * 1991-09-13 2004-08-12 Hitachi, Ltd. Elektrophoresegerät
JP2785530B2 (ja) * 1991-09-13 1998-08-13 株式会社日立製作所 電気泳動装置
US5114551A (en) * 1991-09-30 1992-05-19 Bio-Rad Laboratories, Inc. Multi-point detection method for electrophoresis and chromatography in capillaries
JPH05240774A (ja) * 1992-03-02 1993-09-17 Hitachi Ltd 光学セル及び光学検出装置とこれを用いる試料分離検出装置
DE4313367C2 (de) * 1992-04-24 1997-08-14 Hitachi Ltd Elektrophoresegerät
DE4312267C2 (de) * 1992-04-27 1994-12-15 Zueblin Ag Segment-Schacht für Deponien und andere hohe Aufschüttungen
US5413686A (en) * 1992-07-17 1995-05-09 Beckman Instruments, Inc. Multi-channel automated capillary electrophoresis analyzer
JP3563140B2 (ja) * 1995-01-19 2004-09-08 株式会社日立製作所 キャピラリーアレイ電気泳動装置
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer

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US5439578A (en) 1995-08-08
EP0701694B1 (de) 1997-08-27
US5584982A (en) 1996-12-17
WO1994029712A1 (en) 1994-12-22
DE69405233T2 (de) 1998-03-19
CA2164207A1 (en) 1994-12-22
ATE157452T1 (de) 1997-09-15
DK0701694T3 (da) 1997-10-27
EP0701694A1 (de) 1996-03-20
AU6922394A (en) 1995-01-03
ES2106545T3 (es) 1997-11-01
NZ267045A (en) 1997-10-24
AU695154B2 (en) 1998-08-06

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