DE69400215T2 - Tramadol enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe - Google Patents
Tramadol enthaltendes Arzneimittel mit verzögerter WirkstoffabgabeInfo
- Publication number
- DE69400215T2 DE69400215T2 DE69400215T DE69400215T DE69400215T2 DE 69400215 T2 DE69400215 T2 DE 69400215T2 DE 69400215 T DE69400215 T DE 69400215T DE 69400215 T DE69400215 T DE 69400215T DE 69400215 T2 DE69400215 T2 DE 69400215T2
- Authority
- DE
- Germany
- Prior art keywords
- tramadol
- active ingredient
- delayed release
- containing medicine
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315525A DE4315525B4 (de) | 1993-05-10 | 1993-05-10 | Pharmazeutische Zusammensetzung |
GB9324045A GB2284760B (en) | 1993-11-23 | 1993-11-23 | A method of preparing pharmaceutical compositions by melt pelletisation |
GB9404544A GB9404544D0 (en) | 1994-03-09 | 1994-03-09 | Controlled release formulation |
GB9404928A GB2287880A (en) | 1994-03-14 | 1994-03-14 | Production of sustained release compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69400215D1 DE69400215D1 (de) | 1996-07-04 |
DE69400215T2 true DE69400215T2 (de) | 1996-10-31 |
Family
ID=27435744
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE9422335U Expired - Lifetime DE9422335U1 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit kontrollierter Freisetzung |
DE0729751T Pending DE729751T1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit verzögerter Wirkstoffabgabe |
DE09004973T Active DE09004973T8 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit gesteuerter Freisetzung |
DE69434479T Expired - Lifetime DE69434479T2 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69435295T Expired - Lifetime DE69435295D1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE0699436T Pending DE699436T1 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE69427472T Expired - Lifetime DE69427472T3 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE69400215T Revoked DE69400215T2 (de) | 1993-05-10 | 1994-04-29 | Tramadol enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe |
Family Applications Before (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE9422335U Expired - Lifetime DE9422335U1 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit kontrollierter Freisetzung |
DE0729751T Pending DE729751T1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit verzögerter Wirkstoffabgabe |
DE09004973T Active DE09004973T8 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit gesteuerter Freisetzung |
DE69434479T Expired - Lifetime DE69434479T2 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69435295T Expired - Lifetime DE69435295D1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE0699436T Pending DE699436T1 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE69427472T Expired - Lifetime DE69427472T3 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
Country Status (22)
Country | Link |
---|---|
US (6) | US5591452A (de) |
EP (6) | EP0624366B1 (de) |
JP (3) | JP3045924B2 (de) |
CN (2) | CN1094755C (de) |
AT (5) | ATE303140T1 (de) |
AU (2) | AU6196394A (de) |
CA (1) | CA2123160C (de) |
CZ (1) | CZ288517B6 (de) |
DE (8) | DE9422335U1 (de) |
DK (4) | DK0624366T3 (de) |
ES (5) | ES2088312T3 (de) |
FI (3) | FI942092A (de) |
GR (2) | GR3020084T3 (de) |
HU (1) | HU228177B1 (de) |
ID (1) | ID25988A (de) |
IL (3) | IL119660A (de) |
NO (3) | NO306446B1 (de) |
NZ (1) | NZ260408A (de) |
PT (3) | PT1468679E (de) |
SG (1) | SG67347A1 (de) |
SK (2) | SK279971B6 (de) |
TW (1) | TW496736B (de) |
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
US8114384B2 (en) | 2004-07-01 | 2012-02-14 | Gruenenthal Gmbh | Process for the production of an abuse-proofed solid dosage form |
US8114383B2 (en) | 2003-08-06 | 2012-02-14 | Gruenenthal Gmbh | Abuse-proofed dosage form |
US8192722B2 (en) | 2003-08-06 | 2012-06-05 | Grunenthal Gmbh | Abuse-proof dosage form |
US8383152B2 (en) | 2008-01-25 | 2013-02-26 | Gruenenthal Gmbh | Pharmaceutical dosage form |
US8722086B2 (en) | 2007-03-07 | 2014-05-13 | Gruenenthal Gmbh | Dosage form with impeded abuse |
US9161917B2 (en) | 2008-05-09 | 2015-10-20 | Grünenthal GmbH | Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet |
US9636303B2 (en) | 2010-09-02 | 2017-05-02 | Gruenenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
US9655853B2 (en) | 2012-02-28 | 2017-05-23 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
US9675610B2 (en) | 2002-06-17 | 2017-06-13 | Grünenthal GmbH | Abuse-proofed dosage form |
US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
US9855263B2 (en) | 2015-04-24 | 2018-01-02 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
US9913814B2 (en) | 2014-05-12 | 2018-03-13 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
US9925146B2 (en) | 2009-07-22 | 2018-03-27 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
US10058548B2 (en) | 2003-08-06 | 2018-08-28 | Grünenthal GmbH | Abuse-proofed dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
US10080721B2 (en) | 2009-07-22 | 2018-09-25 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
US10300141B2 (en) | 2010-09-02 | 2019-05-28 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
US10335373B2 (en) | 2012-04-18 | 2019-07-02 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10449547B2 (en) | 2013-11-26 | 2019-10-22 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
US10695297B2 (en) | 2011-07-29 | 2020-06-30 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US10729658B2 (en) | 2005-02-04 | 2020-08-04 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
US11007156B2 (en) | 2001-10-24 | 2021-05-18 | Gruenenthal Gmbh | Prolonged release pharmaceutical composition containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol |
US11224576B2 (en) | 2003-12-24 | 2022-01-18 | Grünenthal GmbH | Process for the production of an abuse-proofed dosage form |
Families Citing this family (168)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
DE4329794C2 (de) * | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
KR100354702B1 (ko) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
US5698210A (en) | 1995-03-17 | 1997-12-16 | Lee County Mosquito Control District | Controlled delivery compositions and processes for treating organisms in a column of water or on land |
US6262115B1 (en) * | 1995-05-22 | 2001-07-17 | Alza Coporation | Method for the management of incontinence |
US5912268A (en) * | 1995-05-22 | 1999-06-15 | Alza Corporation | Dosage form and method for treating incontinence |
GB9519363D0 (en) * | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
PL335619A1 (en) * | 1997-03-11 | 2000-05-08 | Darwin Discovery Ltd | Dosage forms including separate parts containing r and s enantiomers |
DE19710008A1 (de) * | 1997-03-12 | 1998-09-17 | Basf Ag | Feste, mindestens zweiphasige Zubereitungsformen eines Opioid-Analgeticums mit verzögerter Freisetzung |
ATE302597T1 (de) | 1997-06-06 | 2005-09-15 | Depomed Inc | Im magen verweilende orale dosierungsformen von wasserlöslichen arzneistoffen mit kontrollierter freisetzung |
US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
ATE322892T1 (de) * | 1997-07-02 | 2006-04-15 | Euro Celtique Sa | Stabilisierte tramadol formulierungen mit verzögerter freisetzung |
DE19729487A1 (de) * | 1997-07-10 | 1999-01-14 | Dresden Arzneimittel | Verfahren zur Herstellung von Wirkstoff-Zubereitungen mit kontrollierter Freisetzung aus einer Matrix |
US6228863B1 (en) * | 1997-12-22 | 2001-05-08 | Euro-Celtique S.A. | Method of preventing abuse of opioid dosage forms |
KR100417489B1 (ko) * | 1997-12-22 | 2004-02-05 | 유로-셀티크 소시에떼 아노뉨 | 오피오이드 효능제/길항제 혼합물 |
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
CN1148171C (zh) * | 1998-04-17 | 2004-05-05 | 大正制药株式会社 | 多单元缓释片剂 |
JP4367722B2 (ja) * | 1998-04-17 | 2009-11-18 | 大正製薬株式会社 | マルチプルユニットタイプ徐放性錠剤 |
US6156342A (en) * | 1998-05-26 | 2000-12-05 | Andex Pharmaceuticals, Inc. | Controlled release oral dosage form |
US20060128806A1 (en) * | 1998-05-28 | 2006-06-15 | Medical Research Institute | Controlled release arginine alpha-ketoglutarate |
US6264974B1 (en) | 1998-07-07 | 2001-07-24 | Salvagnini Italia Spa | Buccal and sublingual administration of physostigmine |
US6806294B2 (en) | 1998-10-15 | 2004-10-19 | Euro-Celtique S.A. | Opioid analgesic |
DE29818454U1 (de) * | 1998-10-15 | 1999-01-14 | Euro Celtique Sa | Opioid-Analgetikum |
WO2000040205A2 (en) * | 1999-01-05 | 2000-07-13 | Copley Pharmaceutical Inc. | Sustained release formulation with reduced moisture sensitivity |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
MXPA02002193A (es) * | 1999-08-31 | 2002-09-30 | Gr Nenthal Gmbh | Forma de administracion de accion retardada que contiene sacarinato de tramadol. |
SK285128B6 (sk) * | 1999-12-28 | 2006-07-07 | Zentiva, A. S. | Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy |
DK1299104T3 (da) | 2000-02-08 | 2009-08-03 | Euro Celtique Sa | Orale opioidagonistformuleringer sikret mod forfalskning |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US20030119916A1 (en) | 2000-03-01 | 2003-06-26 | David Fowler | Treatment of functional gastrointestinal disorders |
BR0114395A (pt) * | 2000-10-03 | 2005-08-16 | Penwest Pharmaceuticals Compan | Composição farmacêutica para administração por suprimento via oral |
US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
DE10108122A1 (de) | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
NZ528935A (en) * | 2001-03-16 | 2004-10-29 | Dmi Biosciences Inc | Method of delaying ejaculation |
US7858118B2 (en) * | 2001-04-11 | 2010-12-28 | Galephar Pharmaceutical Research, Inc. | Extended release composition containing Tramadol |
US20030065002A1 (en) | 2001-05-11 | 2003-04-03 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US7052706B2 (en) * | 2001-06-08 | 2006-05-30 | Nostrum Pharmaceuticals, Inc. | Control release formulation containing a hydrophobic material as the sustained release agent |
US7968119B2 (en) * | 2001-06-26 | 2011-06-28 | Farrell John J | Tamper-proof narcotic delivery system |
JP4256259B2 (ja) * | 2001-07-18 | 2009-04-22 | ユーロ−セルティーク エス.エイ. | オキシコドン及びナロキソンの医薬配合物 |
AU2002323032B2 (en) | 2001-08-06 | 2005-02-24 | Euro-Celtique S.A. | Opioid agonist formulations with releasable and sequestered antagonist |
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- 1994-04-27 NZ NZ260408A patent/NZ260408A/en not_active IP Right Cessation
- 1994-04-29 ES ES94303128T patent/ES2088312T3/es not_active Expired - Lifetime
- 1994-04-29 DE DE9422335U patent/DE9422335U1/de not_active Expired - Lifetime
- 1994-04-29 DK DK94303128.6T patent/DK0624366T3/da active
- 1994-04-29 DE DE0729751T patent/DE729751T1/de active Pending
- 1994-04-29 DE DE09004973T patent/DE09004973T8/de active Active
- 1994-04-29 DK DK95114527.5T patent/DK0699436T4/da active
- 1994-04-29 AT AT04014719T patent/ATE303140T1/de active
- 1994-04-29 AT AT04030658T patent/ATE468850T1/de active
- 1994-04-29 AT AT95114527T patent/ATE201989T1/de active
- 1994-04-29 EP EP94303128A patent/EP0624366B1/de not_active Revoked
- 1994-04-29 ES ES09004973T patent/ES2331046T1/es active Pending
- 1994-04-29 DE DE69434479T patent/DE69434479T2/de not_active Expired - Lifetime
- 1994-04-29 ES ES95114527T patent/ES2159591T5/es not_active Expired - Lifetime
- 1994-04-29 ES ES04014719T patent/ES2247574T3/es not_active Expired - Lifetime
- 1994-04-29 DK DK04030658.1T patent/DK1527775T3/da active
- 1994-04-29 SG SG1996008705A patent/SG67347A1/en unknown
- 1994-04-29 PT PT04014719T patent/PT1468679E/pt unknown
- 1994-04-29 DK DK04014719T patent/DK1468679T3/da active
- 1994-04-29 EP EP09004973.5A patent/EP2103303B1/de not_active Expired - Lifetime
- 1994-04-29 DE DE69435295T patent/DE69435295D1/de not_active Expired - Lifetime
- 1994-04-29 EP EP96101147A patent/EP0729751A1/de not_active Ceased
- 1994-04-29 ES ES04030658T patent/ES2346651T3/es not_active Expired - Lifetime
- 1994-04-29 AT AT94303128T patent/ATE138566T1/de not_active IP Right Cessation
- 1994-04-29 DE DE0699436T patent/DE699436T1/de active Pending
- 1994-04-29 PT PT95114527T patent/PT699436E/pt unknown
- 1994-04-29 EP EP95114527A patent/EP0699436B2/de not_active Expired - Lifetime
- 1994-04-29 DE DE69427472T patent/DE69427472T3/de not_active Expired - Lifetime
- 1994-04-29 EP EP04030658A patent/EP1527775B1/de not_active Expired - Lifetime
- 1994-04-29 PT PT04030658T patent/PT1527775E/pt unknown
- 1994-04-29 DE DE69400215T patent/DE69400215T2/de not_active Revoked
- 1994-04-29 EP EP04014719A patent/EP1468679B1/de not_active Expired - Lifetime
- 1994-05-04 CZ CZ19941093A patent/CZ288517B6/cs not_active IP Right Cessation
- 1994-05-06 HU HU9401478A patent/HU228177B1/hu unknown
- 1994-05-06 FI FI942092A patent/FI942092A/fi not_active Application Discontinuation
- 1994-05-09 CA CA002123160A patent/CA2123160C/en not_active Expired - Lifetime
- 1994-05-09 NO NO941719A patent/NO306446B1/no not_active IP Right Cessation
- 1994-05-09 AU AU61963/94A patent/AU6196394A/en not_active Abandoned
- 1994-05-10 ID IDP991104D patent/ID25988A/id unknown
- 1994-05-10 JP JP6096671A patent/JP3045924B2/ja not_active Expired - Lifetime
- 1994-05-10 SK SK541-94A patent/SK279971B6/sk not_active IP Right Cessation
- 1994-05-10 US US08/241,129 patent/US5591452A/en not_active Expired - Lifetime
- 1994-05-10 SK SK1437-98A patent/SK283143B6/sk not_active IP Right Cessation
- 1994-05-10 CN CN94105356A patent/CN1094755C/zh not_active Expired - Lifetime
- 1994-05-12 TW TW085103273A patent/TW496736B/zh not_active IP Right Cessation
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1995
- 1995-05-24 US US08/449,772 patent/US6326027B1/en not_active Expired - Lifetime
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1996
- 1996-05-30 GR GR960401422T patent/GR3020084T3/el unknown
- 1996-07-10 US US08/677,798 patent/US6254887B1/en not_active Expired - Lifetime
- 1996-11-20 IL IL11966096A patent/IL119660A0/xx unknown
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1997
- 1997-10-07 AU AU39957/97A patent/AU3995797A/en not_active Abandoned
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1998
- 1998-08-14 JP JP22971898A patent/JP3267561B2/ja not_active Expired - Lifetime
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1999
- 1999-05-17 CN CNB991066421A patent/CN1146410C/zh not_active Expired - Lifetime
- 1999-07-15 NO NO19993484A patent/NO313124B1/no not_active IP Right Cessation
- 1999-11-25 AT AT0081699U patent/AT3413U3/de not_active IP Right Cessation
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2001
- 2001-03-06 US US09/800,204 patent/US7074430B2/en not_active Expired - Fee Related
- 2001-07-19 NO NO20013566A patent/NO331650B1/no unknown
- 2001-09-06 GR GR20010401419T patent/GR3036565T3/el unknown
- 2001-09-27 JP JP2001297270A patent/JP3443574B2/ja not_active Expired - Lifetime
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2003
- 2003-04-14 FI FI20030560A patent/FI121565B/fi not_active IP Right Cessation
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2006
- 2006-05-16 US US11/435,015 patent/US20060269603A1/en not_active Abandoned
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2008
- 2008-05-14 US US12/152,474 patent/US20090117191A1/en not_active Abandoned
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2010
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