DE69334304D1 - Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure - Google Patents
Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäureInfo
- Publication number
- DE69334304D1 DE69334304D1 DE69334304T DE69334304T DE69334304D1 DE 69334304 D1 DE69334304 D1 DE 69334304D1 DE 69334304 T DE69334304 T DE 69334304T DE 69334304 T DE69334304 T DE 69334304T DE 69334304 D1 DE69334304 D1 DE 69334304D1
- Authority
- DE
- Germany
- Prior art keywords
- microspheres
- wall
- hyaluronic acid
- diagnostic means
- micro capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 title 1
- 229960003160 hyaluronic acid Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003094 microcapsule Substances 0.000 title 1
- 239000004005 microsphere Substances 0.000 abstract 6
- 239000000463 material Substances 0.000 abstract 3
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929221329A GB9221329D0 (en) | 1992-10-10 | 1992-10-10 | Preparation of further diagnostic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69334304D1 true DE69334304D1 (de) | 2010-01-21 |
Family
ID=10723265
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333345T Revoked DE69333345T2 (de) | 1992-10-10 | 1993-10-08 | Verfahren zur herstellung von mikrokapseln |
DE69334304T Expired - Lifetime DE69334304D1 (de) | 1992-10-10 | 1993-10-08 | Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333345T Revoked DE69333345T2 (de) | 1992-10-10 | 1993-10-08 | Verfahren zur herstellung von mikrokapseln |
Country Status (11)
Country | Link |
---|---|
US (7) | US6344182B1 (de) |
EP (2) | EP1226832B1 (de) |
JP (2) | JPH08505366A (de) |
AT (2) | ATE451127T1 (de) |
CA (1) | CA2146783C (de) |
DE (2) | DE69333345T2 (de) |
DK (1) | DK0663840T3 (de) |
ES (2) | ES2214477T3 (de) |
GB (4) | GB9221329D0 (de) |
HK (3) | HK1007960A1 (de) |
WO (1) | WO1994008627A1 (de) |
Families Citing this family (130)
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1992
- 1992-10-10 GB GB929221329A patent/GB9221329D0/en active Pending
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1993
- 1993-10-08 US US08/411,815 patent/US6344182B1/en not_active Expired - Fee Related
- 1993-10-08 CA CA002146783A patent/CA2146783C/en not_active Expired - Fee Related
- 1993-10-08 EP EP02076722A patent/EP1226832B1/de not_active Expired - Lifetime
- 1993-10-08 AT AT02076722T patent/ATE451127T1/de not_active IP Right Cessation
- 1993-10-08 GB GB9616116A patent/GB2302649B/en not_active Expired - Fee Related
- 1993-10-08 ES ES93922577T patent/ES2214477T3/es not_active Expired - Lifetime
- 1993-10-08 EP EP93922577A patent/EP0663840B1/de not_active Revoked
- 1993-10-08 GB GB9507191A patent/GB2286122B/en not_active Expired - Fee Related
- 1993-10-08 JP JP6509745A patent/JPH08505366A/ja not_active Withdrawn
- 1993-10-08 GB GB9616117A patent/GB2302650B/en not_active Expired - Fee Related
- 1993-10-08 ES ES02076722T patent/ES2356372T3/es not_active Expired - Lifetime
- 1993-10-08 WO PCT/GB1993/002091 patent/WO1994008627A1/en active IP Right Grant
- 1993-10-08 DK DK93922577T patent/DK0663840T3/da active
- 1993-10-08 DE DE69333345T patent/DE69333345T2/de not_active Revoked
- 1993-10-08 DE DE69334304T patent/DE69334304D1/de not_active Expired - Lifetime
- 1993-10-08 AT AT93922577T patent/ATE255911T1/de active
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1995
- 1995-06-05 US US08/465,622 patent/US5957848A/en not_active Expired - Fee Related
- 1995-06-05 US US08/465,236 patent/US6348186B1/en not_active Expired - Fee Related
- 1995-06-05 US US08/465,621 patent/US6015546A/en not_active Expired - Fee Related
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1998
- 1998-06-27 HK HK98107199A patent/HK1007960A1/xx not_active IP Right Cessation
- 1998-06-27 HK HK98107197A patent/HK1007958A1/xx not_active IP Right Cessation
- 1998-06-27 HK HK98107198A patent/HK1007959A1/xx not_active IP Right Cessation
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1999
- 1999-09-03 US US09/390,467 patent/US6416741B1/en not_active Expired - Fee Related
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2002
- 2002-06-21 US US10/175,853 patent/US6939530B2/en not_active Expired - Fee Related
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2005
- 2005-06-23 US US11/159,209 patent/US20050238586A1/en not_active Abandoned
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2006
- 2006-07-10 JP JP2006189610A patent/JP2006273874A/ja not_active Ceased
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