DE69333466D1 - Herstellung von transplantatgeweben aus extrazellulärer matrix - Google Patents

Herstellung von transplantatgeweben aus extrazellulärer matrix

Info

Publication number
DE69333466D1
DE69333466D1 DE69333466T DE69333466T DE69333466D1 DE 69333466 D1 DE69333466 D1 DE 69333466D1 DE 69333466 T DE69333466 T DE 69333466T DE 69333466 T DE69333466 T DE 69333466T DE 69333466 D1 DE69333466 D1 DE 69333466D1
Authority
DE
Germany
Prior art keywords
production
extracellular matrix
transplant tissue
transplant
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69333466T
Other languages
English (en)
Other versions
DE69333466T2 (de
Inventor
Eugene Bell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TEI Biosciences Inc
Original Assignee
TEI Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TEI Biosciences Inc filed Critical TEI Biosciences Inc
Application granted granted Critical
Publication of DE69333466D1 publication Critical patent/DE69333466D1/de
Publication of DE69333466T2 publication Critical patent/DE69333466T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
DE69333466T 1992-08-07 1993-08-05 Herstellung von transplantatgeweben aus extrazellulärer matrix Expired - Fee Related DE69333466T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92688592A 1992-08-07 1992-08-07
US926885 1992-08-07
PCT/US1993/007364 WO1994003584A1 (en) 1992-08-07 1993-08-05 Production of graft tissue from extracellular matrix

Publications (2)

Publication Number Publication Date
DE69333466D1 true DE69333466D1 (de) 2004-05-06
DE69333466T2 DE69333466T2 (de) 2004-08-19

Family

ID=25453844

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333466T Expired - Fee Related DE69333466T2 (de) 1992-08-07 1993-08-05 Herstellung von transplantatgeweben aus extrazellulärer matrix

Country Status (6)

Country Link
US (1) US5893888A (de)
EP (1) EP0656939B1 (de)
JP (2) JPH07509638A (de)
CA (1) CA2141851A1 (de)
DE (1) DE69333466T2 (de)
WO (1) WO1994003584A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6334872B1 (en) 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
US5562946A (en) * 1994-11-02 1996-10-08 Tissue Engineering, Inc. Apparatus and method for spinning and processing collagen fiber
US5709934A (en) * 1994-11-22 1998-01-20 Tissue Engineering, Inc. Bipolymer foams having extracellular matrix particulates
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US20020095218A1 (en) 1996-03-12 2002-07-18 Carr Robert M. Tissue repair fabric
US5911942A (en) * 1995-11-02 1999-06-15 Tissue Engineering, Inc. Method for spinning and processing collagen fiber
CN1061812C (zh) * 1996-04-01 2001-02-14 胡杰 制备皮肤移植体的方法
US6545042B2 (en) 1996-11-05 2003-04-08 Gp Medical Acellular biological material chemically treated with genipin
US6998418B1 (en) 1996-11-05 2006-02-14 Gp Medical, Inc. Acellular biological material chemically treated with genipin
US5882929A (en) * 1998-04-07 1999-03-16 Tissue Engineering, Inc. Methods and apparatus for the conditioning of cartilage replacement tissue
ATE423577T1 (de) * 1998-06-05 2009-03-15 Organogenesis Inc Biologisch modellierte implantierbare prothesen
WO1999063051A2 (en) * 1998-06-05 1999-12-09 Organogenesis Inc. Bioengineered flat sheet graft prostheses
MXPA00012061A (es) * 1998-06-05 2003-04-22 Organogenesis Inc Protesis de injerto vascular biodisenadas.
AU763724B2 (en) * 1998-06-05 2003-07-31 Duke University School Of Medicine Bioengineered vascular graft support prostheses
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
DE69941216D1 (de) * 1998-06-19 2009-09-17 Lifecell Corp Teilchenförmige zellfreie gewebematrix
DE10026482A1 (de) * 2000-05-29 2001-12-13 Augustinus Bader Verfahren zur Herstellung eines bioartifiziellen Transplantats
CA2777791A1 (en) * 2000-09-18 2002-03-21 Organogenesis Inc. Methods for treating a patient using a bioengineered flat sheet graft prostheses
AU2002322255A1 (en) * 2001-06-15 2003-01-02 The Cleveland Clinic Foundation Tissue engineered mitral valve chrodae and methods of making and using same
ATE502660T1 (de) * 2001-07-16 2011-04-15 Depuy Products Inc Poröses freisetzungsgerüst und verfahren
US20030033021A1 (en) * 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method
EP1425024A4 (de) * 2001-07-16 2007-04-18 Depuy Products Inc Poröses extrazelluläres matrixgerüst und verfahren
JP2003193328A (ja) * 2001-12-19 2003-07-09 Nipro Corp コラーゲン単糸の製造方法
JP2004305260A (ja) * 2003-04-02 2004-11-04 Olympus Corp 生体組織補填体とその製造方法
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) * 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7097579B2 (en) 2003-10-15 2006-08-29 Borgwarner Inc. Pivoting chain guide and tensioner assembly
US8916184B2 (en) * 2003-11-07 2014-12-23 University Of Connecticut Artificial tissue systems and uses thereof
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US9138445B2 (en) * 2005-03-09 2015-09-22 Cook Biotech Incorporated Medical graft materials with adherent extracellular matrix fibrous mass
JP4356654B2 (ja) * 2005-06-02 2009-11-04 ニプロ株式会社 コラーゲン単糸の製造方法
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US8673640B2 (en) * 2005-09-20 2014-03-18 National Institute For Materials Science Porous scaffold, method of producing the same and method of using the porous scaffold
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
JP5538217B2 (ja) * 2007-07-10 2014-07-02 ライフセル コーポレーション 組織修復用無細胞組織基質構成体
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8469779B1 (en) 2009-01-02 2013-06-25 Lifecell Corporation Method for debristling animal skin
CN102858381B (zh) * 2010-03-01 2015-09-30 富士胶片株式会社 包括具有生物相容性的聚合物块和细胞的细胞构建体
US9089523B2 (en) 2011-07-28 2015-07-28 Lifecell Corporation Natural tissue scaffolds as tissue fillers
ES2729712T3 (es) * 2011-12-20 2019-11-05 Lifecell Corp Productos de tejido de lámina
BR112014014975B1 (pt) * 2011-12-20 2019-06-25 Lifecell Corporation Produto de tecido, e método para produzir uma composição de tecido
CA2861048C (en) 2012-01-24 2021-01-12 Lifecell Corporation Elongated tissue matrices
EP2872191B1 (de) 2012-07-13 2019-08-07 LifeCell Corporation Verfahren zur behandlung von adipösem gewebe
ES2663014T3 (es) 2012-09-26 2018-04-10 Lifecell Corporation Tejido adiposo procesado
AU2014215646B2 (en) 2013-02-06 2017-10-19 Lifecell Corporation Methods for localized modification of tissue products
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
WO2014181767A1 (ja) 2013-05-07 2014-11-13 国立大学法人 東京医科歯科大学 粒子状脱細胞化組織の製造方法
EP3027235A1 (de) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Aus einem azellulären weichgewebe gewonnene matrizen und verfahren zur herstellung davon
CN106999627B (zh) * 2014-10-10 2021-01-29 奥托细胞有限公司 胶原构建物及用于产生所述胶原构建物的方法
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
EP3463500A1 (de) 2016-06-03 2019-04-10 LifeCell Corporation Verfahren zur lokalisierten modifizierung von gewebeprodukten
RU2627844C1 (ru) * 2016-10-24 2017-08-14 Общество С Ограниченной Ответственностью "Ниармедик Плюс" Способ получения суспензионной формы измельченного децеллюляризованного внеклеточного матрикса
EP3558405A1 (de) 2016-12-22 2019-10-30 LifeCell Corporation Vorrichtungen und verfahren zum kryogenen mahlen von gewebe
CN110664509A (zh) * 2019-10-21 2020-01-10 南方医科大学 一种植入耳支架及其制备方法
EP4070824A1 (de) 2021-04-09 2022-10-12 Regen i Göteborg AB Meeresgerüste zur erzeugung menschlicher gewebe

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4642292A (en) * 1979-10-29 1987-02-10 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method for isolation of connective tissue biomatrix
US4501815A (en) * 1979-10-29 1985-02-26 Albert Einstein College Of Medicine Of Yeshiva University Article for culturing differentiated cells
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4645669A (en) * 1982-10-04 1987-02-24 Albert Einstein College Of Medicine Of Yeshiva University Culturing and emplacement of differentiated cells in vivo
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
GB8618374D0 (en) * 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
US4795459A (en) * 1987-05-18 1989-01-03 Rhode Island Hospital Implantable prosthetic device with lectin linked endothelial cells
FR2617488B1 (fr) * 1987-07-01 1990-03-09 Tab Procede de fabrication de structures organisees de collagene, notamment d'origine humaine, et structures organisees de collagene correspondantes
US4969912A (en) * 1988-02-18 1990-11-13 Kelman Charles D Human collagen processing and autoimplant use
US5201745A (en) * 1988-03-15 1993-04-13 Imedex Visceral surgery patch
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5110604A (en) * 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5171273A (en) * 1989-01-13 1992-12-15 University Of Medicine And Dentistry Of New Jersey Synthetic collagen orthopaedic structures such as grafts, tendons and other structures
US5026381A (en) * 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US5378469A (en) * 1990-04-06 1995-01-03 Organogenesis, Inc. Collagen threads
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
US5562946A (en) * 1994-11-02 1996-10-08 Tissue Engineering, Inc. Apparatus and method for spinning and processing collagen fiber

Also Published As

Publication number Publication date
US5893888A (en) 1999-04-13
CA2141851A1 (en) 1994-02-17
EP0656939B1 (de) 2004-03-31
DE69333466T2 (de) 2004-08-19
JPH07509638A (ja) 1995-10-26
EP0656939A1 (de) 1995-06-14
JP2003047652A (ja) 2003-02-18
WO1994003584A1 (en) 1994-02-17

Similar Documents

Publication Publication Date Title
DE69333466D1 (de) Herstellung von transplantatgeweben aus extrazellulärer matrix
DE69405732D1 (de) Herstellung von perfluor(alkylvinylethern)
ATE169616T1 (de) Zwischenverbindungen zur herstellung von fungiziden
DE69729864D1 (de) Herstellung von laktamen aus aliphatischen alpha, omega-dinitrilen
DE69413710D1 (de) Herstellung von polyglycerol
DE69116826D1 (de) Herstellung von Alkoxyalkansäuren
DE3850244T2 (de) Herstellung von polymorphisch reinem Terfenadine.
DE69503632T2 (de) Herstellung von enthydroxylierten träger
DE69410266D1 (de) Herstellung von dimethyl cyclohexandicarboxylaten
DE69321109D1 (de) Herstellung von trifluorvinylethern
DE69410455D1 (de) Herstellung von difluoromethan
DE69804513D1 (de) Herstellung von zeolith-l
DE59405004D1 (de) Herstellung von 2-H-Heptafluorpropan
DE69502001T2 (de) Herstellung von uranoxid
DE69605202D1 (de) Herstellung von alpha-tocopherol
DE69117237D1 (de) Neues Zwischenprodukt zur Herstellung von 3-Oxo-4-aza-androst-1-en-17-beta-Ketonen
DE69604976T2 (de) Herstellung von Diamanteinkristallen aus amorphen hydrogenierten Kohlstoff
DE69410957T2 (de) Herstellung von Thioetherverbindungen
DE69509497T2 (de) Herstellung von polyglycerol
DE69502395T2 (de) Herstellung von triarylboran
DE69623986D1 (de) Herstellung von Allomelanin
DE69503379T2 (de) Herstellung von tintenzusammensetzungen
PT86606A (pt) Bakterienlysierendes enzymprodukt aus streptomyceten seine herstellung und seine verwendung zur konservierung von kaese
DE69101849D1 (de) Herstellung von Amiden.
DE59606574D1 (de) Para-Hydroxyphenylessigsäure zur Reduktion der Repellenz von Insektiziden

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee