DE69333425D1 - Gegenstände mit bioaktiven Oberflächen - Google Patents

Gegenstände mit bioaktiven Oberflächen

Info

Publication number
DE69333425D1
DE69333425D1 DE69333425T DE69333425T DE69333425D1 DE 69333425 D1 DE69333425 D1 DE 69333425D1 DE 69333425 T DE69333425 T DE 69333425T DE 69333425 T DE69333425 T DE 69333425T DE 69333425 D1 DE69333425 D1 DE 69333425D1
Authority
DE
Germany
Prior art keywords
objects
bioactive surfaces
bioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69333425T
Other languages
English (en)
Other versions
DE69333425T2 (de
Inventor
Allan H Jevne
Matthew A Bergan
James R Keogh
Christopher M Hobot
John W Eaton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Application granted granted Critical
Publication of DE69333425D1 publication Critical patent/DE69333425D1/de
Publication of DE69333425T2 publication Critical patent/DE69333425T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206—Biguanides, e.g. chlorohexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/442—Colorants, dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901—Method of manufacturing prosthetic device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/921—Blood vessel
DE69333425T 1992-10-30 1993-10-14 Gegenstände mit bioaktiven Oberflächen Expired - Fee Related DE69333425T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US969692 1992-10-30
US07/969,692 US5344455A (en) 1992-10-30 1992-10-30 Graft polymer articles having bioactive surfaces

Publications (2)

Publication Number Publication Date
DE69333425D1 true DE69333425D1 (de) 2004-04-01
DE69333425T2 DE69333425T2 (de) 2004-12-02

Family

ID=25515867

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333425T Expired - Fee Related DE69333425T2 (de) 1992-10-30 1993-10-14 Gegenstände mit bioaktiven Oberflächen

Country Status (4)

Country Link
US (3) US5344455A (de)
EP (1) EP0596615B1 (de)
JP (1) JP2691854B2 (de)
DE (1) DE69333425T2 (de)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843089A (en) 1990-12-28 1998-12-01 Boston Scientific Corporation Stent lining
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5502042A (en) * 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
US5624704A (en) * 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US5679659A (en) * 1995-08-22 1997-10-21 Medtronic, Inc. Method for making heparinized biomaterials
US5672638A (en) * 1995-08-22 1997-09-30 Medtronic, Inc. Biocompatability for solid surfaces
US5607475A (en) * 1995-08-22 1997-03-04 Medtronic, Inc. Biocompatible medical article and method
US5804318A (en) * 1995-10-26 1998-09-08 Corvita Corporation Lubricious hydrogel surface modification
US5755758A (en) * 1995-11-07 1998-05-26 Medtronic, Inc. Intramuscular stimulation lead with enhanced infection resistance
US5830539A (en) * 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
US5928916A (en) * 1996-04-25 1999-07-27 Medtronic, Inc. Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces
US5766248A (en) * 1996-04-25 1998-06-16 Medtronic, Inc. Method and apparatus for forming a tissue pocket to receive an implantable device
US5821343A (en) * 1996-04-25 1998-10-13 Medtronic Inc Oxidative method for attachment of biomolecules to surfaces of medical devices
US5945319A (en) * 1996-04-25 1999-08-31 Medtronic, Inc. Periodate oxidative method for attachment of biomolecules to medical device surfaces
US6033719A (en) * 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US5728420A (en) * 1996-08-09 1998-03-17 Medtronic, Inc. Oxidative method for attachment of glycoproteins to surfaces of medical devices
US5891506A (en) * 1996-08-09 1999-04-06 Medtronic, Inc. Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices
US5925552A (en) * 1996-04-25 1999-07-20 Medtronic, Inc. Method for attachment of biomolecules to medical devices surfaces
US5811151A (en) * 1996-05-31 1998-09-22 Medtronic, Inc. Method of modifying the surface of a medical device
CA2256491A1 (en) * 1996-05-31 1997-12-11 Wan-Kei Wan Expansible bioprosthetic valve stent
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5874165A (en) * 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
US5914182A (en) * 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
JP4189889B2 (ja) * 1996-07-29 2008-12-03 株式会社ヴァーユ ポリ（２―ヒドロキシエチル（メタ）アクリレート）セグメントを分子中に含有する改質ポリマー
US6017334A (en) * 1996-10-03 2000-01-25 Board Of Regents, The University Of Texas System Modified surfaces resistant to bacterial colonization
EP0860213A3 (de) * 1997-01-03 2002-10-16 Therapol SA Bioaktive Beschichtung von Oberflächen
US6013106A (en) * 1997-01-22 2000-01-11 St. Jude Medical, Inc. Medical article with adhered antimicrobial metal ions and related methods
CA2286155A1 (en) * 1997-04-08 1998-10-15 Randall E. Ohnemus Method and apparatus for collecting blood
CA2286590C (en) * 1997-04-18 2005-08-02 California Institute Of Technology Multifunctional polymeric tissue coatings
GB2324530A (en) 1997-04-25 1998-10-28 Polybiomed Ltd Introduction of functional groups on polymers
US5911165A (en) * 1997-05-29 1999-06-08 Bayer Corporation Method and device for mechanical testing of fibrin glue strength
GB2325934A (en) * 1997-06-03 1998-12-09 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US6267782B1 (en) 1997-11-20 2001-07-31 St. Jude Medical, Inc. Medical article with adhered antimicrobial metal
DE19812160C1 (de) * 1998-03-20 1999-07-08 Bayer Ag Formkörper aus wirkstoffhaltigen thermoplastischen Polyurethanen
US6129757A (en) 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
CA2338292A1 (en) * 1998-07-21 2000-02-03 Jonathan A. Eppstein Fluid management in a continuous fluid collection and sensor device
US7037277B1 (en) 1998-07-21 2006-05-02 Spectrx, Inc. System and method for fluid management in a continuous fluid collection and sensor device
EP1104311B1 (de) * 1998-08-14 2004-05-12 Coloplast A/S Stabilisierte zusammensetzungen mit antibakterieller wirksamkeit
FR2785812B1 (fr) * 1998-11-16 2002-11-29 Commissariat Energie Atomique Protheses bioactives, notamment a proprietes immunosuppressives, antistenose et antithrombose, et leur fabrication
US20070014837A1 (en) * 1999-04-02 2007-01-18 Kci Licensing, Inc. System and method for use of agent in combination with subatmospheric pressure tissue treatment
US20070021697A1 (en) * 2004-07-26 2007-01-25 Kci Licensing, Inc. System and method for use of agent in combination with subatmospheric tissue treatment
EP1168997B1 (de) * 1999-04-02 2013-04-24 KCI Licensing, Inc. Vakuumunterstütztes wundverschlusssystem mit einrichtung zum einführen von wirkstoffen
AU769571B2 (en) * 1999-04-28 2004-01-29 Universitat Zurich Polyionic coatings in analytic and sensor devices
US6679870B1 (en) 1999-07-23 2004-01-20 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6685694B2 (en) 1999-07-23 2004-02-03 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
ES2154242B1 (es) * 1999-09-03 2001-10-16 Uriach & Cia Sa J Nuevos sistemas polimericos biocompatibles portadores de triflusal o htb.
BR0014904A (pt) * 1999-10-19 2002-06-11 Commw Scient Ind Res Org Método de aperfeiçoar uma ligação entre uma superfìcie polimérica e um revestimento ou adesivo
US7179849B2 (en) * 1999-12-15 2007-02-20 C. R. Bard, Inc. Antimicrobial compositions containing colloids of oligodynamic metals
US6579539B2 (en) 1999-12-22 2003-06-17 C. R. Bard, Inc. Dual mode antimicrobial compositions
US6506408B1 (en) * 2000-07-13 2003-01-14 Scimed Life Systems, Inc. Implantable or insertable therapeutic agent delivery device
AU2001275957B2 (en) * 2000-07-17 2007-01-11 President And Fellows Of Harvard College Surfaces that resist the adsorption of biological species
US6641607B1 (en) 2000-12-29 2003-11-04 Advanced Cardiovascular Systems, Inc. Double tube stent
US20020120333A1 (en) * 2001-01-31 2002-08-29 Keogh James R. Method for coating medical device surfaces
ATE281849T1 (de) * 2001-02-28 2004-11-15 Uroteq Inc Verfahren zur herstellung antimikrobieller polymeroberflächen
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US8101196B2 (en) 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
US6656216B1 (en) 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US7682669B1 (en) * 2001-07-30 2010-03-23 Advanced Cardiovascular Systems, Inc. Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
DE60238422D1 (de) 2001-09-24 2011-01-05 Boston Scient Ltd Optimierte dosierung bei paclitaxelhaltigen stents
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
JP4148671B2 (ja) * 2001-11-06 2008-09-10 ソニー株式会社 表示画像制御処理装置、動画像情報送受信システム、および表示画像制御処理方法、動画像情報送受信方法、並びにコンピュータ・プログラム
US7101956B2 (en) * 2001-11-14 2006-09-05 Medtronic, Inc. Compounds containing quaternary carbons, medical devices, and methods
AU2002358421A1 (en) * 2001-11-23 2003-06-10 Feg Textiltechnik Forschungs- Und Entwicklungsgesellschaft Mbh Surface-modified textile product and a corresponding method for surface modification
US7179530B2 (en) 2001-12-03 2007-02-20 Rebac Gmbh Antimicrobial composite material
EP1568275A1 (de) * 2001-12-03 2005-08-31 Luisi & Clement GmbH Antibakterielles Kompositmaterial
EP1342411A1 (de) * 2002-03-05 2003-09-10 Luisi & Clement GmbH Antibakterielles Kompositmaterial
AU2002357050A1 (en) 2001-12-03 2003-06-17 C.R. Bard, Inc. Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same
AU2003217971A1 (en) * 2002-03-08 2003-09-22 C. Mauli Agrawal Gas-plasma treatment of implants
US7241453B2 (en) * 2002-04-05 2007-07-10 Long Island University Antimicrobial surfaces
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
ATE480573T1 (de) * 2002-07-29 2010-09-15 Life Technologies Corp Pfropfcopolymere, deren herstellung und verwendung bei der kapillarelektrophorese
US20040054210A1 (en) * 2002-09-17 2004-03-18 Medtronic, Inc. Compounds containing quaternary carbons and silicon-containing groups, medical devices, and methods
WO2004026933A1 (en) * 2002-09-17 2004-04-01 Medtronic, Inc. Polymers with soft segments containing silane-containing groups, medical devices, and methods
US6984700B2 (en) * 2002-09-17 2006-01-10 Medtronic, Inc. Compounds containing silicon-containing groups, medical devices, and methods
US7169178B1 (en) 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
JP2006518251A (ja) * 2003-02-13 2006-08-10 ベクトン・ディキンソン・アンド・カンパニー 血液採取の際に成分を除去するための装置並びにその使用法
US6699282B1 (en) * 2003-03-06 2004-03-02 Gelsus Research And Consulting, Inc. Method and apparatus for delivery of medication
GB2404920A (en) * 2003-08-12 2005-02-16 Johnson & Johnson Medical Ltd Antimicrobial polymer
EP2261271B1 (de) * 2003-09-17 2014-04-30 Gambro Lundia AB Trennungsmaterial
WO2005026224A1 (en) 2003-09-17 2005-03-24 Gambro Lundia Ab Separating material
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US9561309B2 (en) 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
US7794490B2 (en) * 2004-06-22 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices with antimicrobial and biodegradable matrices
US20060009839A1 (en) * 2004-07-12 2006-01-12 Scimed Life Systems, Inc. Composite vascular graft including bioactive agent coating and biodegradable sheath
EP1771138A4 (de) * 2004-07-26 2009-08-19 Kci Licensing Inc Verfahren für beschichtungssubstrat mit antimikrobiellem wirkstoff und produkt damit
US20060115455A1 (en) * 2004-10-22 2006-06-01 Reed Kenneth C Therapeutic RNAi agents for treating psoriasis
SG158174A1 (en) * 2005-01-06 2010-01-29 Benitec Inc Rnai agents for maintenance of stem cells
US20080095735A1 (en) * 2005-01-31 2008-04-24 Kross Robert D Skin-Protective Polymer For Use In Teat Care Compositions
CN101189041A (zh) * 2005-03-11 2008-05-28 智能抗微生物解决方案有限责任公司 基于聚合物的抗微生物剂、制备所述抗微生物剂的方法以及包含所述抗微生物剂的产品
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
CN103203048A (zh) 2005-12-13 2013-07-17 埃克塞拉医学有限责任公司 用于从血液中体外去除病原微生物、炎性细胞或炎性蛋白质的方法
GB2433263A (en) * 2005-12-15 2007-06-20 Ethicon Inc Antimicrobial polyurethane foam
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US8069814B2 (en) 2006-05-04 2011-12-06 Advanced Cardiovascular Systems, Inc. Stent support devices
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8167847B2 (en) 2006-06-22 2012-05-01 Excelsior Medical Corporation Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
US7803498B2 (en) * 2006-08-25 2010-09-28 The United States Of America As Represented By The Secretary Of The Navy Materials and structures thereof useful as electrocatalysts
US8278406B2 (en) * 2007-04-27 2012-10-02 Wisconsin Alumni Research Foundation Bioactive and biocompatible polyurethane-buthanediol-glycosaminoglycan salt copolymers
JP2010529228A (ja) * 2007-05-30 2010-08-26 リサーチ・ファウンデーション・オブ・ザ・シティー・ユニヴァーシティー・オブ・ニュー・ヨーク 固体ポリマー中への抗生物質の埋込み
EP2209817A4 (de) * 2007-05-30 2011-09-21 Univ City New York Res Found Viruzidzusammensetzungen
US9832998B2 (en) 2007-05-30 2017-12-05 Research Foundation Of The City University Of New York Antiviral compositions
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
ES2359321B1 (es) * 2009-11-10 2012-03-26 Consejo Superior De Investigaciones Cientificas (Csis) Pol�?meros hidrófilos como sistemas de liberación de compuestos bioactivos en mallas de aplicación quirúrgica.
AU2010326028B2 (en) 2009-12-01 2014-10-02 Exthera Medical Corporation Method for removing cytokines from blood with surface immobilized polysaccharides
EP2624871B1 (de) * 2010-10-06 2019-11-06 AST Products, Inc. Funktionalisierte hydrophile und gleitfähige polymermatrix und verwendungsverfahren dafür
US20120156433A1 (en) 2010-12-21 2012-06-21 Natarajan Sriram N Silicone polymer substrates having improved biological response from hkdcs
US20120156780A1 (en) 2010-12-21 2012-06-21 Cooper Kevin L Polymer Substrates Having Improved Biological Response From HKDCS
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
US20120321776A1 (en) 2011-06-17 2012-12-20 Robert Vetrecin Process for in situ plasma polymerization of silicone coatings for surgical needles
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
US9033956B2 (en) * 2011-09-06 2015-05-19 Cook Medical Technologies Llc Electrically charged medical device
US8545951B2 (en) 2012-02-29 2013-10-01 Kimberly-Clark Worldwide, Inc. Endotracheal tubes and other polymer substrates including an anti-fouling treatment
ES2647577T3 (es) 2012-06-13 2017-12-22 Exthera Medical Corporation Uso de heparina y carbohidratos para tratar el cáncer
CA3105562C (en) 2013-04-26 2023-03-07 Biointeractions Limited Bioactive coatings
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
EP3620218A1 (de) 2013-06-24 2020-03-11 ExThera Medical Corporation Blutfiltrationssystem mit mannose beschichtetem substrat
CA2928866C (en) 2013-11-08 2021-11-09 Exthera Medical Corporation Methods for diagnosing infectious diseases using adsorption media
CN106255520B (zh) * 2014-04-24 2022-08-12 艾克塞拉医疗公司 使用高流速从血液除去细菌的方法
EP2985043A1 (de) * 2014-08-14 2016-02-17 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Verfahren zur Herstellung eines medizinischen Geräts und hieraus hergestelltes Gerät
AU2015321601B2 (en) 2014-09-22 2020-04-23 Exthera Medical Corporation Wearable hemoperfusion device
US9763814B2 (en) 2014-10-24 2017-09-19 Cook Medical Technologies Llc Elongate medical device
US10786615B2 (en) 2016-03-02 2020-09-29 Exthera Medical Corporation Method for treating drug intoxication
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
KR102621860B1 (ko) * 2021-01-08 2024-01-09 한국전력공사 측면 가교화된 다기능성 폴리우레탄 및 이의 제조방법
CN113877006A (zh) * 2021-09-24 2022-01-04 宁波健世科技股份有限公司 一种改性高分子膜材料及其制备方法
CN116410510A (zh) * 2021-12-31 2023-07-11 江苏百赛飞生物科技有限公司 一种材料表面改性的方法和基于该方法得到的表面改性的材料
CN116271261A (zh) * 2023-05-24 2023-06-23 北京清瀚医疗科技有限公司 用于体外循环氧合装置的复合抗凝血涂层制作方法及涂层

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538964B2 (de) * 1972-05-16 1980-10-07
US3826678A (en) * 1972-06-06 1974-07-30 Atomic Energy Commission Method for preparation of biocompatible and biofunctional materials and product thereof
US4451568A (en) * 1981-07-13 1984-05-29 Battelle Memorial Institute Composition for binding bioactive substances
US4459318A (en) * 1981-11-09 1984-07-10 American Hospital Supply Corporation Method for forming a self-lubricating fill tube
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
JPS60227763A (ja) * 1984-04-27 1985-11-13 筏　義人 抗血栓性医用材料
US4879135A (en) * 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US4728328A (en) * 1984-10-19 1988-03-01 Research Corporation Cuffed tubular organic prostheses
US4678660A (en) * 1984-12-07 1987-07-07 Deseret Medical, Inc. Thermoplastic polyurethane anticoagulant alloy coating
US4612337A (en) * 1985-05-30 1986-09-16 The Trustees Of Columbia University In The City Of New York Method for preparing infection-resistant materials
CH665954A5 (fr) * 1985-07-08 1988-06-30 Battelle Memorial Institute Substrat dont la surface presente une activite antithrombogenique.
US4829098A (en) * 1986-06-19 1989-05-09 Washington Research Foundation Immobilized biomolecules and method of making same
US4895566A (en) * 1986-07-25 1990-01-23 C. R. Bard, Inc. Coating medical devices with cationic antibiotics
US5263992A (en) * 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
NL8701337A (nl) * 1987-06-09 1989-01-02 Sentron V O F Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.
US5073171A (en) * 1989-01-12 1991-12-17 Eaton John W Biocompatible materials comprising albumin-binding dyes
US5004461A (en) * 1989-03-23 1991-04-02 Wilson Joseph E Methods for rendering plastics thromboresistant and product
US5080924A (en) * 1989-04-24 1992-01-14 Drexel University Method of making biocompatible, surface modified materials
JP2743480B2 (ja) * 1989-06-12 1998-04-22 三菱化学株式会社 抗血栓性高分子材料
GB9009570D0 (en) * 1990-04-27 1990-06-20 Biocompatibles Ltd Antithrombogenic polymers
US5328698A (en) * 1990-08-06 1994-07-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic and/or anti-infective
US5295978A (en) * 1990-12-28 1994-03-22 Union Carbide Chemicals & Plastics Technology Corporation Biocompatible hydrophilic complexes and process for preparation and use
JP2957021B2 (ja) * 1991-01-25 1999-10-04 テルモ株式会社 医療用材料および医療用器具ならびに医療用材料の製造方法
DE69125828T2 (de) * 1991-05-21 1997-07-31 Hewlett Packard Gmbh Verfahren zur Vorbehandlung der Oberfläche eines medizinischen Artikels
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5229172A (en) * 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization

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US5545213A (en) 1996-08-13
EP0596615A1 (de) 1994-05-11
JP2691854B2 (ja) 1997-12-17
EP0596615B1 (de) 2004-02-25
JPH0716291A (ja) 1995-01-20
US5344455A (en) 1994-09-06
DE69333425T2 (de) 2004-12-02
US5476509A (en) 1995-12-19

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