DE69333050D1 - Anordnung zur probenbestimmung - Google Patents
Anordnung zur probenbestimmungInfo
- Publication number
- DE69333050D1 DE69333050D1 DE69333050T DE69333050T DE69333050D1 DE 69333050 D1 DE69333050 D1 DE 69333050D1 DE 69333050 T DE69333050 T DE 69333050T DE 69333050 T DE69333050 T DE 69333050T DE 69333050 D1 DE69333050 D1 DE 69333050D1
- Authority
- DE
- Germany
- Prior art keywords
- beads
- excitation
- focal region
- conduit
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US924720 | 1992-08-03 | ||
US07/924,720 US5372783A (en) | 1992-08-03 | 1992-08-03 | Assay system |
PCT/US1993/006967 WO1994003104A1 (en) | 1992-08-03 | 1993-07-23 | Assay system |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69333050D1 true DE69333050D1 (de) | 2003-07-24 |
DE69333050T2 DE69333050T2 (de) | 2004-05-27 |
Family
ID=25450611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333050T Expired - Lifetime DE69333050T2 (de) | 1992-08-03 | 1993-07-23 | Anordnung zur probenbestimmung |
Country Status (8)
Country | Link |
---|---|
US (3) | US5372783A (de) |
EP (1) | EP0606460B1 (de) |
JP (4) | JP3534756B2 (de) |
AT (1) | ATE242996T1 (de) |
CA (2) | CA2518356C (de) |
DE (1) | DE69333050T2 (de) |
DK (1) | DK0606460T3 (de) |
WO (1) | WO1994003104A1 (de) |
Families Citing this family (80)
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WO1996008703A1 (en) * | 1994-09-14 | 1996-03-21 | X-Rite, Incorporated | Scanning colorimeter |
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USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
GB2324603B (en) * | 1996-02-09 | 1999-08-04 | Kalibrant Limited | Assay apparatus |
WO1997029376A1 (en) * | 1996-02-09 | 1997-08-14 | Kalibrant Limited | Assay apparatus |
US5670375A (en) * | 1996-02-21 | 1997-09-23 | Biomerieux Vitek, Inc. | Sample card transport method for biological sample testing machine |
US6025189A (en) * | 1997-05-14 | 2000-02-15 | 3M Innovative Properties Company | Apparatus for reading a plurality of biological indicators |
EP0985142A4 (de) * | 1997-05-23 | 2006-09-13 | Lynx Therapeutics Inc | System und gerät zur sequentiellen behandlung von analyten |
GB9717020D0 (en) * | 1997-08-12 | 1997-10-15 | Kalibrant Limited | An assay apparatus with multiple detectors |
US7348181B2 (en) | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
US7115884B1 (en) * | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
US6100541A (en) | 1998-02-24 | 2000-08-08 | Caliper Technologies Corporation | Microfluidic devices and systems incorporating integrated optical elements |
US7220596B2 (en) * | 1998-04-15 | 2007-05-22 | Utah State University | Real time detection of antigens |
US6290912B1 (en) * | 1998-07-14 | 2001-09-18 | Bayer Corporation | Read head for luminometer |
US6623971B2 (en) * | 1999-01-11 | 2003-09-23 | Bayer Corporation | Method and apparatus for conducting a stat immunoassay analysis in a capsule chemistry analysis system |
JP2001004628A (ja) * | 1999-06-18 | 2001-01-12 | Kanagawa Acad Of Sci & Technol | 免疫分析装置と免疫分析方法 |
US6867859B1 (en) | 1999-08-03 | 2005-03-15 | Lightwind Corporation | Inductively coupled plasma spectrometer for process diagnostics and control |
US6239871B1 (en) * | 1999-08-24 | 2001-05-29 | Waters Investments Limited | Laser induced fluorescence capillary interface |
US20020004246A1 (en) * | 2000-02-07 | 2002-01-10 | Daniels Robert H. | Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels |
US6690467B1 (en) * | 2000-05-05 | 2004-02-10 | Pe Corporation | Optical system and method for optically analyzing light from a sample |
AU1106902A (en) | 2000-09-27 | 2002-04-08 | Univ Leiden | Method for applying nmr for ligand discovery or as a drug screening tool |
DE50107386D1 (de) * | 2000-10-17 | 2005-10-13 | Febit Ag | Verfahren und vorrichtung zur integrierten synthese und analytbestimmung an einem träger |
US6538734B2 (en) * | 2000-11-29 | 2003-03-25 | Lightwind Corporation | Method and device utilizing real-time gas sampling |
US7691645B2 (en) * | 2001-01-09 | 2010-04-06 | Agilent Technologies, Inc. | Immunosubtraction method |
WO2002071029A1 (en) | 2001-03-02 | 2002-09-12 | Waters Investments Limited | Fluorescence detector geometry |
US6519033B1 (en) | 2001-11-19 | 2003-02-11 | Point Source Technologies, Llc | Identification of particles in fluid |
US6774995B2 (en) * | 2001-08-03 | 2004-08-10 | Pointsource Technologies, Llc | Identification of particles in fluid |
US6573992B1 (en) | 2001-11-13 | 2003-06-03 | Pointsource Technologies, Llc | Plano convex fluid carrier for scattering correction |
US6590652B2 (en) | 2001-11-02 | 2003-07-08 | Pointsource Technologies, Inc. | Flow through light scattering device |
US6628386B2 (en) | 2001-12-12 | 2003-09-30 | Pointsource Technologies, Llc | Particle detection beam |
US6930769B1 (en) | 2002-03-21 | 2005-08-16 | Pointsource Technologies, Llc | Optical sensor module tester |
US7057724B1 (en) | 2002-03-21 | 2006-06-06 | Institute Of Critical Care Medicine | Particulate info to field units |
US6972424B1 (en) | 2002-04-16 | 2005-12-06 | Pointsource Technologies, Llc | High detection rate particle identifier |
JP2004069397A (ja) * | 2002-08-02 | 2004-03-04 | Nec Corp | 分析チップおよび分析装置 |
US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
US7441703B2 (en) | 2002-08-20 | 2008-10-28 | Illumina, Inc. | Optical reader for diffraction grating-based encoded optical identification elements |
US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
US7619819B2 (en) | 2002-08-20 | 2009-11-17 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
US7164533B2 (en) | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
AU2003267192A1 (en) | 2002-09-12 | 2004-04-30 | Cyvera Corporation | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
CA2499046A1 (en) | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
US20100255603A9 (en) | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
SE0203548D0 (sv) * | 2002-12-02 | 2002-12-02 | Biacore Ab | Method of determining site-specificity and kit therefor |
US20040175821A1 (en) * | 2003-03-07 | 2004-09-09 | Ehman Michael F. | Integrated photodetector for heavy metals and biological activity analysis |
US6819421B1 (en) | 2003-04-11 | 2004-11-16 | Point Source Technologies, Llc | Detection of new species of particles |
EP2457586A1 (de) | 2003-06-27 | 2012-05-30 | Amgen Fremont Inc. | Auf die Deletionsmutanten des epidermalen Wachstumsfaktorrezeptors gerichtete Antikörper und ihre Verwendungen |
US7433123B2 (en) | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
JP4579593B2 (ja) * | 2004-03-05 | 2010-11-10 | キヤノン株式会社 | 標的物質認識素子、検出方法及び装置 |
US7177023B2 (en) * | 2004-03-19 | 2007-02-13 | Applera Corporation | Fluorescent light detection |
ATE473442T1 (de) * | 2004-07-23 | 2010-07-15 | Biosystem Dev Llc | Vorrichtung für einen immunoassay und verfahren zu ihrer verwendung |
EP1626278A3 (de) * | 2004-08-03 | 2006-06-21 | OnChip Cellomics Consortium | Cellomics System |
ATE459933T1 (de) | 2004-11-16 | 2010-03-15 | Illumina Inc | Verfahren und vorrichtung zum lesen von kodierten mikrokugeln |
US7604173B2 (en) | 2004-11-16 | 2009-10-20 | Illumina, Inc. | Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same |
WO2006055735A2 (en) | 2004-11-16 | 2006-05-26 | Illumina, Inc | Scanner having spatial light modulator |
CN101278186A (zh) * | 2005-10-03 | 2008-10-01 | 皇家飞利浦电子股份有限公司 | 提高灵敏度的生物传感器 |
US7623624B2 (en) | 2005-11-22 | 2009-11-24 | Illumina, Inc. | Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction |
JP4782593B2 (ja) * | 2006-03-13 | 2011-09-28 | 株式会社日立製作所 | 光検出装置 |
US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
WO2007130669A2 (en) * | 2006-05-07 | 2007-11-15 | Zu Jianping Lily | Optical ball lens light scattering apparatus and method for use thereof |
US8012349B2 (en) * | 2006-11-20 | 2011-09-06 | Orbital Biosciences, Llc | Small volume unitary molded filters and supports for adsorbent beds |
DE102007020610A1 (de) * | 2007-04-30 | 2008-11-20 | Thomas Dr. Ruckstuhl | Behälter und Verfahren zum Nachweis von Fluoreszenz |
DE102007033124B4 (de) * | 2007-07-16 | 2012-12-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zur optischen Detektion von Substanzen in einem flüssigen oder gasförmigen Medium |
WO2009098867A1 (ja) * | 2008-02-07 | 2009-08-13 | Mitsui Engineering & Shipbuilding Co., Ltd. | 蛍光検出装置および蛍光検出方法 |
US8576396B2 (en) * | 2008-11-19 | 2013-11-05 | Postnova Analytics Gmbh | Cell construction for light scatter detectors having self-focusing properties |
US7957002B2 (en) * | 2009-03-13 | 2011-06-07 | The Furukawa Electric Co., Ltd. | Method for optical measurement and optical measurement apparatus |
US20130011928A1 (en) * | 2010-03-29 | 2013-01-10 | Analogic Corporation | Optical detection system and/or method |
CA2815951A1 (en) | 2010-11-03 | 2012-05-10 | Reametrix Inc. | Measurement system for fluorescent detection, and method therefor |
CA2855746A1 (en) | 2011-11-16 | 2013-05-23 | John Stephen HILL | Methods of treating epidermal growth factor deletion mutant viii related disorders |
WO2013136891A1 (ja) * | 2012-03-12 | 2013-09-19 | オリンパス株式会社 | 光分析装置、光分析用レンズおよび光分析用容器 |
DE102016113042A1 (de) * | 2016-07-15 | 2018-01-18 | B. Braun Melsungen Ag | Durchflussmesszellenvorrichtung zur Messung von Fluidparametern |
DE102019219949A1 (de) * | 2019-12-18 | 2021-06-24 | Robert Bosch Gmbh | Substrat |
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US2978718A (en) * | 1957-08-27 | 1961-04-11 | Service Metal Fabricators Inc | Vehicle wheel washing device |
US3025142A (en) * | 1959-10-30 | 1962-03-13 | Dale D Williams | Method and means of detecting ammonia and amine vapor |
US3492396A (en) * | 1967-03-13 | 1970-01-27 | Becton Dickinson Co | Agglutinate separation method and apparatus |
US3600063A (en) * | 1969-04-28 | 1971-08-17 | Thomas R Bowen | Varifocal beam spreader |
US3896217A (en) * | 1973-03-19 | 1975-07-22 | Summa Corp | Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent |
US4036946A (en) * | 1975-10-20 | 1977-07-19 | Marcos Kleinerman | Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances |
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US5183740A (en) * | 1990-02-23 | 1993-02-02 | The United States Of America As Represented By The Secretary Of The Navy | Flow immunosensor method and apparatus |
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-
1992
- 1992-08-03 US US07/924,720 patent/US5372783A/en not_active Expired - Lifetime
-
1993
- 1993-07-23 CA CA002518356A patent/CA2518356C/en not_active Expired - Lifetime
- 1993-07-23 DE DE69333050T patent/DE69333050T2/de not_active Expired - Lifetime
- 1993-07-23 JP JP50537394A patent/JP3534756B2/ja not_active Expired - Lifetime
- 1993-07-23 AT AT93918363T patent/ATE242996T1/de active
- 1993-07-23 DK DK93918363T patent/DK0606460T3/da active
- 1993-07-23 CA CA002120481A patent/CA2120481C/en not_active Expired - Lifetime
- 1993-07-23 WO PCT/US1993/006967 patent/WO1994003104A1/en active IP Right Grant
- 1993-07-23 EP EP93918363A patent/EP0606460B1/de not_active Expired - Lifetime
-
1994
- 1994-06-24 US US08/265,648 patent/US6120734A/en not_active Expired - Lifetime
-
1995
- 1995-10-23 US US08/546,657 patent/US5554340A/en not_active Expired - Lifetime
-
2003
- 2003-09-29 JP JP2003337774A patent/JP2004069716A/ja not_active Withdrawn
-
2005
- 2005-08-05 JP JP2005227435A patent/JP2005321416A/ja not_active Withdrawn
-
2006
- 2006-05-23 JP JP2006143443A patent/JP4102837B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69333050T2 (de) | 2004-05-27 |
CA2120481C (en) | 2005-12-20 |
JP2006258824A (ja) | 2006-09-28 |
EP0606460A1 (de) | 1994-07-20 |
US6120734A (en) | 2000-09-19 |
JPH07500191A (ja) | 1995-01-05 |
EP0606460A4 (de) | 1994-12-07 |
CA2518356A1 (en) | 1994-02-17 |
US5554340A (en) | 1996-09-10 |
JP2004069716A (ja) | 2004-03-04 |
DK0606460T3 (da) | 2003-10-13 |
EP0606460B1 (de) | 2003-06-18 |
JP2005321416A (ja) | 2005-11-17 |
CA2120481A1 (en) | 1994-02-17 |
CA2518356C (en) | 2009-11-24 |
ATE242996T1 (de) | 2003-07-15 |
JP4102837B2 (ja) | 2008-06-18 |
JP3534756B2 (ja) | 2004-06-07 |
US5372783A (en) | 1994-12-13 |
WO1994003104A1 (en) | 1994-02-17 |
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