DE69332858D1 - EINGESCHRÄNKTES MULTIFUNKTIONELLES REAGENs ZUR OBERFLÄCHENMODIFIKATION - Google Patents

EINGESCHRÄNKTES MULTIFUNKTIONELLES REAGENs ZUR OBERFLÄCHENMODIFIKATION

Info

Publication number
DE69332858D1
DE69332858D1 DE69332858T DE69332858T DE69332858D1 DE 69332858 D1 DE69332858 D1 DE 69332858D1 DE 69332858 T DE69332858 T DE 69332858T DE 69332858 T DE69332858 T DE 69332858T DE 69332858 D1 DE69332858 D1 DE 69332858D1
Authority
DE
Germany
Prior art keywords
restricted
surface modification
groups
multifunctional reagents
activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332858T
Other languages
English (en)
Other versions
DE69332858T2 (de
Inventor
Dale G Swan
Charles A Hastings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Application granted granted Critical
Publication of DE69332858D1 publication Critical patent/DE69332858D1/de
Publication of DE69332858T2 publication Critical patent/DE69332858T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
DE69332858T 1992-11-06 1993-11-03 EINGESCHRÄNKTES MULTIFUNKTIONELLES REAGENs ZUR OBERFLÄCHENMODIFIKATION Expired - Lifetime DE69332858T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/972,533 US5414075A (en) 1992-11-06 1992-11-06 Restrained multifunctional reagent for surface modification
PCT/US1993/010523 WO1994011032A1 (en) 1992-11-06 1993-11-03 Restrained multifunctional reagent for surface modification

Publications (2)

Publication Number Publication Date
DE69332858D1 true DE69332858D1 (de) 2003-05-15
DE69332858T2 DE69332858T2 (de) 2003-11-20

Family

ID=25519767

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332858T Expired - Lifetime DE69332858T2 (de) 1992-11-06 1993-11-03 EINGESCHRÄNKTES MULTIFUNKTIONELLES REAGENs ZUR OBERFLÄCHENMODIFIKATION

Country Status (9)

Country Link
US (2) US5414075A (de)
EP (1) EP0669837B1 (de)
JP (2) JP3939748B2 (de)
AT (1) ATE236656T1 (de)
AU (1) AU688286B2 (de)
CA (1) CA2148801C (de)
DE (1) DE69332858T2 (de)
ES (1) ES2196011T3 (de)
WO (1) WO1994011032A1 (de)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH671345A5 (de) 1986-08-15 1989-08-31 Castolin Sa
ATE147613T1 (de) * 1989-09-15 1997-02-15 Chiron Vision Corp Synthetisches material, das die anlagerung, das wachstum und die befestigung von epithelzellen fördert, prosthetische vorrichtung zur subepithelialen implantation sowie behandelte linse
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
US7008634B2 (en) * 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6782886B2 (en) 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
US5886126A (en) * 1996-08-28 1999-03-23 University Of South Florida Combinatorial method of forming cascade polymer surfaces
US6150164A (en) * 1996-09-30 2000-11-21 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5792821A (en) 1997-01-06 1998-08-11 American Dental Association Health Foundation Polymerizable cyclodextrin derivatives
US5873362A (en) * 1997-03-18 1999-02-23 Parker Medical Limited Partnership Endotracheal tube
DE19715504C2 (de) * 1997-04-14 2000-10-26 Max Planck Gesellschaft PMMA-Membranen mit Polyethylenglykol-gekoppelten Wirksubstanzen
CA2286590C (en) * 1997-04-18 2005-08-02 California Institute Of Technology Multifunctional polymeric tissue coatings
US6391655B1 (en) 1997-07-30 2002-05-21 Corning Incorporated Oxidized styrenic polymers for DNA binding
US6177282B1 (en) 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6506895B2 (en) 1997-08-15 2003-01-14 Surmodics, Inc. Photoactivatable nucleic acids
US6762019B2 (en) 1997-09-30 2004-07-13 Surmodics, Inc. Epoxide polymer surfaces
US6465178B2 (en) * 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US5858653A (en) * 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
DE19753848A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Modifikation von Oberflächen zur Steigerung der Oberflächenspannung
US6120939A (en) * 1998-01-13 2000-09-19 Daramic, Inc. Meltblown fiber battery separator
AU760408B2 (en) * 1998-04-27 2003-05-15 Surmodics, Inc. Bioactive agent release coating
US6254634B1 (en) 1998-06-10 2001-07-03 Surmodics, Inc. Coating compositions
US6528107B2 (en) 1999-01-19 2003-03-04 Sulzer Carbomedics Inc. Method for producing antimicrobial antithrombogenic medical devices
US6514768B1 (en) 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
EP1190252B1 (de) * 1999-04-28 2008-12-31 Eidgenössische Technische Hochschule Zürich Polyionische beschichtungen für analytische und sensor-vorrichtungen
US6416549B1 (en) 1999-07-19 2002-07-09 Sulzer Carbomedics Inc. Antithrombogenic annuloplasty ring having a biodegradable insert
US6416548B2 (en) 1999-07-20 2002-07-09 Sulzer Carbomedics Inc. Antimicrobial annuloplasty ring having a biodegradable insert
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
AU770404B2 (en) * 1999-09-22 2004-02-19 Surmodics, Inc. Water-soluble coating agents bearing initiator groups and coating process
US6278018B1 (en) * 1999-12-14 2001-08-21 Surmodics, Inc. Surface coating agents
US7220276B1 (en) 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
US6410643B1 (en) 2000-03-09 2002-06-25 Surmodics, Inc. Solid phase synthesis method and reagent
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US7100600B2 (en) * 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US6543443B1 (en) 2000-07-12 2003-04-08 Aerogen, Inc. Methods and devices for nebulizing fluids
DE10041542A1 (de) * 2000-08-24 2002-03-07 Febit Ferrarius Biotech Gmbh Neue Strategie zur Synthese von Polymeren auf Oberflächen
US6562136B1 (en) 2000-09-08 2003-05-13 Surmodics, Inc. Coating apparatus and method
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
US6550472B2 (en) 2001-03-16 2003-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids using flow directors
US6554201B2 (en) 2001-05-02 2003-04-29 Aerogen, Inc. Insert molded aerosol generator and methods
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
US6444318B1 (en) 2001-07-17 2002-09-03 Surmodics, Inc. Self assembling monolayer compositions
US7332330B2 (en) 2001-09-11 2008-02-19 Renamed Biologics, Inc. Device for maintaining vascularization near an implant
US7348055B2 (en) * 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
AU2003202925B2 (en) 2002-01-07 2008-12-18 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
JP4761709B2 (ja) 2002-01-15 2011-08-31 エアロジェン，インコーポレイテッド エアロゾル発生器を作動するための方法およびシステム
US7442546B2 (en) * 2002-03-15 2008-10-28 The Regents Of The University Of Michigan Method of modulating inflammatory response
US6706408B2 (en) 2002-05-16 2004-03-16 Surmodics, Inc. Silane coating composition
EP1509259B1 (de) 2002-05-20 2016-04-20 Novartis AG Gerät zur bereitstellung eines aerosols für die medizinische behandlung und verfahren
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
ATE548097T1 (de) * 2002-09-03 2012-03-15 Whatman Ltd Poröse verbundmembran und herstellungsverfahren dafür
US7285363B2 (en) * 2002-11-08 2007-10-23 The University Of Connecticut Photoactivators, methods of use, and the articles derived therefrom
US20040111144A1 (en) * 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
US7041174B2 (en) * 2003-02-19 2006-05-09 Sunmodics,Inc. Grafting apparatus and method of using
JP4630817B2 (ja) * 2003-03-31 2011-02-09 独立行政法人理化学研究所 物質固定化剤、それを用いた物質固定化方法及びそれを用いた物質固定化基体
US7077910B2 (en) * 2003-04-07 2006-07-18 Surmodics, Inc. Linear rail coating apparatus and method
CA2821376A1 (en) 2003-04-16 2004-11-04 The Children's Hospital Of Philadelphia Magnetically controllable drug and gene delivery stents
US9694103B2 (en) 2003-04-16 2017-07-04 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
IES20030294A2 (en) * 2003-04-17 2004-10-20 Medtronic Vascular Connaught Coating for biomedical devices
TWI259106B (en) 2003-06-30 2006-08-01 China Petrochemical Technology Catalyst conversion process for increasing yield of light olefins
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
DE602004026612D1 (de) * 2003-09-09 2010-05-27 Univ Colorado Regents Verwendung der photopolymerisierung zur amplifikation und zum nachweis eines molekularen erkennungsereignisses
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
US7309593B2 (en) * 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
JP2007530169A (ja) * 2004-03-26 2007-11-01 サーモディクス，インコーポレイティド 生物適合性表面を調製するための組成物及び方法
JP2007530173A (ja) * 2004-03-26 2007-11-01 サーモディクス，インコーポレイティド 生体適合性表面のための方法およびシステム
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
WO2005099786A1 (en) * 2004-04-06 2005-10-27 Surmodics, Inc. Coating compositions for bioactive agents
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US20050281857A1 (en) * 2004-05-25 2005-12-22 Heyer Toni M Methods and reagents for preparing biomolecule-containing coatings
WO2006050110A2 (en) * 2004-10-28 2006-05-11 Surmodics, Inc. Pro-fibrotic coatings comprising collagen for medical implants
WO2006063181A1 (en) * 2004-12-06 2006-06-15 Surmodics, Inc. Multifunctional medical articles
JP2008531125A (ja) * 2005-02-23 2008-08-14 サーモディクス，インコーポレイティド ラミニンコーティングを有する移植可能な医療装置、及び使用方法
WO2006099470A2 (en) * 2005-03-15 2006-09-21 Surmodics, Inc. Compliant polymeric coatings for insertable medical articles
CA2607747C (en) 2005-05-25 2015-12-01 Aerogen, Inc. Vibration systems and methods
JP2008541950A (ja) * 2005-06-02 2008-11-27 サーモディクス，インコーポレイティド 医療用製品向けの親水性ポリマーコーティング
US7772393B2 (en) * 2005-06-13 2010-08-10 Innovative Surface Technologies, Inc. Photochemical crosslinkers for polymer coatings and substrate tie-layer
US7989619B2 (en) * 2005-07-14 2011-08-02 Innovative Surface Technoloiges, Inc. Nanotextured surfaces
EP1904118B1 (de) * 2005-07-20 2018-01-17 Surmodics, Inc. Polymerbeschichtungen und verfahren zur zellanhaftung
CA2615717A1 (en) * 2005-07-20 2007-01-25 Surmodics, Inc. Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation
US20070141365A1 (en) * 2005-08-26 2007-06-21 Jelle Bruce M Silane Coating Compositions, Coating Systems, and Methods
WO2007025059A1 (en) * 2005-08-26 2007-03-01 Surmodics, Inc. Silane coating compositions, coating systems, and methods
US20070065483A1 (en) 2005-09-21 2007-03-22 Chudzik Stephen J In vivo formed matrices including natural biodegradable polysaccharides and uses thereof
WO2008006083A2 (en) * 2006-07-07 2008-01-10 Surmodics, Inc. Beaded wound spacer device
US20080057298A1 (en) * 2006-08-29 2008-03-06 Surmodics, Inc. Low friction particulate coatings
US20080063627A1 (en) * 2006-09-12 2008-03-13 Surmodics, Inc. Tissue graft materials containing biocompatible agent and methods of making and using same
US20080075753A1 (en) * 2006-09-25 2008-03-27 Chappa Ralph A Multi-layered coatings and methods for controlling elution of active agents
EP2171135A2 (de) 2007-06-22 2010-04-07 Innovative Surface Technologies, Inc. Auf stimuli reagierende nanofasern
JP5393662B2 (ja) * 2007-06-22 2014-01-22 イノベイティブ サーフェイス テクノロジーズ， インコーポレイテッド 潜在反応基を含有するナノ繊維
WO2009005718A1 (en) * 2007-06-28 2009-01-08 Surmodics, Inc. Polypeptide microparticles having sustained release characteristics, methods and uses
US8383589B2 (en) * 2007-07-09 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Aegyptin and uses thereof
US20090137405A1 (en) * 2007-11-16 2009-05-28 Christopher Bowman Detection of nucleic acid biomarkers using polymerization-based amplification
US20090202609A1 (en) * 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
MX2010010663A (es) 2008-03-28 2010-11-09 Surmodics Inc Dispositivos medicos insertables que tienen substratos elasticos asociados con microparticulas, y metodos de suministro de farmacos.
WO2009137689A2 (en) 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
EP2331644A1 (de) * 2008-09-05 2011-06-15 Innovative Surface Technologies, Inc. Lichtaktivierbare vernetzungszusammensetzung für oberflächenmodifikation
US8691983B2 (en) * 2009-03-03 2014-04-08 Innovative Surface Technologies, Inc. Brush polymer coating by in situ polymerization from photoreactive surface
CA2760187C (en) 2009-04-28 2018-01-02 Ralph A. Chappa Devices and methods for delivery of bioactive agents
US8246576B2 (en) 2009-05-18 2012-08-21 Surmodics, Inc. Method and apparatus for delivery of a therapeutic agent with an expandable medical device
WO2011072199A2 (en) * 2009-12-10 2011-06-16 Surmodics, Inc. Water-soluble degradable photo-crosslinker
US20110144746A1 (en) * 2009-12-11 2011-06-16 Vanderbilt David P Intraocular Lens
US8287890B2 (en) * 2009-12-15 2012-10-16 C.R. Bard, Inc. Hydrophilic coating
EP2588156B1 (de) 2010-06-29 2014-08-13 SurModics, Inc. Fluorierte polymere und schmiermittelbeschichtungen
US10596355B2 (en) 2010-06-30 2020-03-24 Surmodics, Inc. Catheter assembly
US8927000B2 (en) 2010-06-30 2015-01-06 Surmodics, Inc. Lipid coating for medical devices delivering bioactive agent
US8541498B2 (en) 2010-09-08 2013-09-24 Biointeractions Ltd. Lubricious coatings for medical devices
US8961457B2 (en) 2010-09-30 2015-02-24 Surmodics, Inc. Catheter assembly with guard
US8722076B2 (en) 2010-09-30 2014-05-13 Surmodics, Inc. Photochrome- or near IR dye-coupled polymeric matrices for medical articles
US10315987B2 (en) 2010-12-13 2019-06-11 Surmodics, Inc. Photo-crosslinker
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
WO2012092566A1 (en) 2010-12-30 2012-07-05 Surmodics, Inc. Cell attachment coatings and methods
US8668667B2 (en) 2010-12-30 2014-03-11 Surmodics, Inc. Double wall catheter for delivering therapeutic agent
US9861727B2 (en) 2011-05-20 2018-01-09 Surmodics, Inc. Delivery of hydrophobic active agent particles
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US9757497B2 (en) 2011-05-20 2017-09-12 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
EP2716669B1 (de) 2011-06-03 2018-11-07 Sumitomo Rubber Industries, Ltd. Reifen und dichtung für spritzen
EP2731429A4 (de) * 2011-07-15 2015-03-04 Univ Georgia Verbindungen, herstellungsverfahren dafür und verwendungsverfahren dafür
US9375517B2 (en) 2012-01-18 2016-06-28 Surmodies, Inc. Lubricious medical device coating with low particulates
JP5763565B2 (ja) 2012-02-02 2015-08-12 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US8956682B2 (en) 2012-04-02 2015-02-17 Surmodics, Inc. Hydrophilic polymeric coatings for medical articles with visualization moiety
JP5812935B2 (ja) 2012-05-16 2015-11-17 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
MX351261B (es) 2012-06-01 2017-10-06 Surmodics Inc Aparato y método para recubrir catéteres con globo.
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
US9631190B2 (en) 2012-06-29 2017-04-25 Surmodics, Inc. Cell attachment coatings and methods using phosphorous-containing photoreagent
JP6063167B2 (ja) * 2012-08-02 2017-01-18 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
EP2894191B1 (de) 2012-09-10 2020-03-18 Sumitomo Rubber Industries, Ltd. Oberflächenmodifizierungsverfahren und oberflächenmodifizierter elastischer körper
WO2014062839A1 (en) 2012-10-16 2014-04-24 Surmodics, Inc. Wound packing device and methods
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
WO2014071387A1 (en) 2012-11-05 2014-05-08 Surmodics, Inc. Composition and method for delivery of hydrophobic active agents
JP5620456B2 (ja) 2012-11-20 2014-11-05 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6053482B2 (ja) 2012-11-30 2016-12-27 住友ゴム工業株式会社 注射器用ガスケットの製造方法
US9629945B2 (en) 2012-12-12 2017-04-25 Surmodics, Inc. Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence
EP4276161A3 (de) 2013-01-04 2024-01-17 SurModics, Inc. Partikelarme gleitmittelbeschichtung mit vinylpyrrolidon und sauren polymerhaltigen schichten
JP6105292B2 (ja) * 2013-01-07 2017-03-29 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP5816222B2 (ja) 2013-04-25 2015-11-18 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
CA2912690C (en) 2013-05-16 2022-05-03 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
JP5797239B2 (ja) 2013-06-11 2015-10-21 住友ゴム工業株式会社 立体形状物の表面改質方法及び注射器用ガスケット
US10647829B2 (en) 2013-06-20 2020-05-12 Sumitomo Rubber Industries, Ltd. Surface modification method and surface modification body
US10800931B2 (en) 2013-08-25 2020-10-13 Heraeus Medical Components Llc Conductive polymeric coatings, medical devices, coating solutions and methods
EP3038521B1 (de) 2013-10-12 2019-05-01 Innovative Surface Technologies, Inc. Gewebematrizen für elektrisch erregbare zellen
JP5820489B2 (ja) 2014-01-06 2015-11-24 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
MX2017001440A (es) 2014-08-01 2017-05-23 Surmodics Inc Dispositivo de recubrmiento de heridas con superficie nanotexturizada.
CA2956721C (en) 2014-08-08 2023-09-12 Surmodics, Inc. Article coatings including oligomerized polyphenol layer and biological methods of use
KR20230048175A (ko) 2014-08-15 2023-04-10 더 존스 홉킨스 유니버시티 조직 복원용 복합 재료
US10124088B2 (en) 2014-09-29 2018-11-13 Surmodics, Inc. Lubricious medical device elements
JP6338504B2 (ja) 2014-10-02 2018-06-06 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6752799B2 (ja) * 2015-01-14 2020-09-09 サーモディクス，インコーポレイティド 医療器具のための挿入用具
BR112017016342B1 (pt) 2015-01-29 2021-05-11 Surmodics, Inc revestimento de entrega de fármacos
JP6551022B2 (ja) 2015-08-03 2019-07-31 住友ゴム工業株式会社 表面改質方法及び表面改質体
JP6613692B2 (ja) 2015-08-03 2019-12-04 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US20190060516A1 (en) 2015-08-17 2019-02-28 The Johns Hopkins University In situ forming composite material for tissue restoration
US10478546B2 (en) 2015-09-15 2019-11-19 Surmodics, Inc. Hemodialysis catheter sleeve
US11174447B2 (en) 2015-12-29 2021-11-16 Surmodics, Inc. Lubricious coatings with surface salt groups
US10342898B2 (en) 2015-12-29 2019-07-09 Surmodics, Inc. Lubricious coatings with surface salt groups
US20170281914A1 (en) 2016-03-31 2017-10-05 Surmodics, Inc. Localized treatment of tissues through transcatheter delivery of active agents
EP3436096A1 (de) 2016-03-31 2019-02-06 Surmodics, Inc. Schmierende beschichtung für medizinische vorrichtung
US10806904B2 (en) 2016-03-31 2020-10-20 Surmodics, Inc. Two-part insertion tool and methods
US10918835B2 (en) 2016-03-31 2021-02-16 Surmodics, Inc. Delivery system for active agent coated balloon
US10391292B2 (en) 2016-06-15 2019-08-27 Surmodics, Inc. Hemostasis sealing device with constriction ring
CA3036822A1 (en) 2016-09-16 2018-03-22 Surmodics, Inc. Lubricious insertion tools for medical devices and methods for using
US10758719B2 (en) 2016-12-15 2020-09-01 Surmodics, Inc. Low-friction sealing devices
US11123459B2 (en) 2016-12-16 2021-09-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
WO2019217767A1 (en) 2018-05-09 2019-11-14 The Johns Hopkins University Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
EP3790602A1 (de) 2018-05-09 2021-03-17 The Johns Hopkins University Nanofaserhydrogel-verbundstoffe für zell- und gewebefreisetzung
US20190351198A1 (en) 2018-05-16 2019-11-21 Surmodics, Inc. Catheters with structurally supported expandable elements and methods for same
WO2019222335A1 (en) 2018-05-16 2019-11-21 Surmodics, Inc. High-pressure balloon catheters and methods
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US11359156B2 (en) 2019-10-21 2022-06-14 Biocoat, Inc. UV cure basecoatings for medical devices
US20230127826A1 (en) 2021-10-08 2023-04-27 Surmodics Md, Llc Catheter with multiple braid layers
WO2023172686A1 (en) 2022-03-09 2023-09-14 Surmodics Coatings, LLC Thromboresistant coatings, coated devices, and methods
WO2023211937A1 (en) 2022-04-25 2023-11-02 Surmodics, Inc. Medical device coatings with microcrystalline active agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3616229A (en) * 1968-09-27 1971-10-26 Monsanto Co Polymer-enzyme products comprising plurality of enzymes covalently bound to polymer
US3959078A (en) * 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US5258041A (en) * 1982-09-29 1993-11-02 Bio-Metric Systems, Inc. Method of biomolecule attachment to hydrophobic surfaces
US5002582A (en) * 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
CA1335721C (en) * 1987-12-24 1995-05-30 Patrick E. Guire Biomolecule attached to a solid surface by means of a spacer and methods of attaching biomolecules to surfaces
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification

Also Published As

Publication number Publication date
ATE236656T1 (de) 2003-04-15
JP3939748B2 (ja) 2007-07-04
DE69332858T2 (de) 2003-11-20
JPH08505839A (ja) 1996-06-25
AU688286B2 (en) 1998-03-12
CA2148801C (en) 2000-03-21
US5414075A (en) 1995-05-09
ES2196011T3 (es) 2003-12-16
EP0669837B1 (de) 2003-04-09
AU5456794A (en) 1994-06-08
EP0669837A1 (de) 1995-09-06
JP2005145979A (ja) 2005-06-09
US5637460A (en) 1997-06-10
WO1994011032A1 (en) 1994-05-26

Similar Documents

Publication Publication Date Title
DE69332858D1 (de) EINGESCHRÄNKTES MULTIFUNKTIONELLES REAGENs ZUR OBERFLÄCHENMODIFIKATION
WO1999016907A3 (en) Reagent and method for attaching target molecules to a surface
ATE289321T1 (de) Verfahren zur herstellung von konjugaten vom faktor viii mit einem biologisch verträglichen polymer
NO992167L (no) Preparater og fremgangsmÕter for immobilisering av nukleinsyrer til faste bµrere
DE69121849D1 (de) Bindung von Liganden an Gold
ES2106742T3 (es) Procedimiento de purificacion de proteinas.
ATE414171T1 (de) Verfahren zur immobilisierung von oligonukleotiden auf festem trägermaterial
DK0495820T3 (da) Fremgangsmåde til fremstilling af overflademodificerede faste underlag
BR9007483A (pt) Substrato e metodo para cultura de fungos,incluindo shiitake(lentinus edodes)
ATE190522T1 (de) Verfahren zur metathese von alkanen
DE69029398D1 (de) Hemmung von padgem-vermittelter zellbindung
DE50213370D1 (de) Mikrofluidisches extraktionsverfahren
NO180558C (no) Ligandholdig medium for kromatografisk adsorpsjon, fremgangsmåte for fremstilling av mediet, samt anvendelse av mediet
DE68925588D1 (de) Verfahren zur aktivierung von polymeren trägern und damit hergestellte zusammensetzungen zur verwendung in der affinitätschromatographie
ATE319735T1 (de) Aufreinigung von substanzen aus einer biologischen probe
DE69010030D1 (de) Verfahren zur Produktion von Fruktose-1,6-diphosphat.
AU1856300A (en) Derivatisation of support surfaces
EP1944321A3 (de) Verfahren und Verbindungen zur Bestimmung der Reinheit von chemisch synthetisierten Nukleinsäuren
DE58904672D1 (de) Verfahren zur herstellung einer festphasenmatrix.
ES2017153A6 (es) Portadores inmunorreactivos que tienen un nuevo recubrimiento intermedio biocompatible y su procedimiento de fabricacion.
WO2003054514A3 (en) Novel parallel throughput system
EP0569086A3 (de) Verfahren und Testsatz zum Befestigung von Verbindungen an carboxylierten Substraten unter Verwendung vom Uroniumsalz
DE29521625U1 (de) Reagenzträger zur Zugabe von Reagenzien
DE4499550D2 (de) Verfahren zur Immobilisierung von Biomolekülen und Affinitätsliganden an polymere Träger

Legal Events

Date Code Title Description
8364 No opposition during term of opposition