DE69330344T2 - Vernetzte biokompatible verkapselungszusammensetzungen und verfahren - Google Patents

Vernetzte biokompatible verkapselungszusammensetzungen und verfahren

Info

Publication number
DE69330344T2
DE69330344T2 DE69330344T DE69330344T DE69330344T2 DE 69330344 T2 DE69330344 T2 DE 69330344T2 DE 69330344 T DE69330344 T DE 69330344T DE 69330344 T DE69330344 T DE 69330344T DE 69330344 T2 DE69330344 T2 DE 69330344T2
Authority
DE
Germany
Prior art keywords
compositions
methods
crosslinked
networked
biocompatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69330344T
Other languages
English (en)
Other versions
DE69330344D1 (de
Inventor
P Desai
Patrick Soon-Shiong
A Sandford
Roswitha Heintz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AmCyte Inc
Original Assignee
AmCyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AmCyte Inc filed Critical AmCyte Inc
Application granted granted Critical
Publication of DE69330344D1 publication Critical patent/DE69330344D1/de
Publication of DE69330344T2 publication Critical patent/DE69330344T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate
DE69330344T 1992-04-08 1993-04-01 Vernetzte biokompatible verkapselungszusammensetzungen und verfahren Expired - Lifetime DE69330344T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/866,038 US5334640A (en) 1992-04-08 1992-04-08 Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
PCT/US1993/003066 WO1993021266A1 (en) 1992-04-08 1993-04-01 Crosslinked biocompatible encapsulation compositions and methods

Publications (2)

Publication Number Publication Date
DE69330344D1 DE69330344D1 (de) 2001-07-19
DE69330344T2 true DE69330344T2 (de) 2002-04-25

Family

ID=25346803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330344T Expired - Lifetime DE69330344T2 (de) 1992-04-08 1993-04-01 Vernetzte biokompatible verkapselungszusammensetzungen und verfahren

Country Status (13)

Country Link
US (2) US5334640A (de)
EP (1) EP0635040B1 (de)
JP (1) JPH07508048A (de)
AT (1) ATE202132T1 (de)
AU (1) AU661250B2 (de)
BR (1) BR9306219A (de)
CA (1) CA2132977C (de)
DE (1) DE69330344T2 (de)
DK (1) DK0635040T3 (de)
ES (1) ES2159523T3 (de)
GR (1) GR3036210T3 (de)
PT (1) PT635040E (de)
WO (1) WO1993021266A1 (de)

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EP0635040A4 (de) 1995-10-04
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AU4277493A (en) 1993-11-18
ATE202132T1 (de) 2001-06-15
CA2132977A1 (en) 1993-10-28
PT635040E (pt) 2001-12-28
CA2132977C (en) 2007-01-30
US5550178A (en) 1996-08-27
EP0635040B1 (de) 2001-06-13
DK0635040T3 (da) 2001-10-01
GR3036210T3 (en) 2001-10-31
ES2159523T3 (es) 2001-10-16
DE69330344D1 (de) 2001-07-19
BR9306219A (pt) 1998-06-30
US5334640A (en) 1994-08-02
JPH07508048A (ja) 1995-09-07
WO1993021266A1 (en) 1993-10-28

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