DE69329295D1 - Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung - Google Patents

Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung

Info

Publication number
DE69329295D1
DE69329295D1 DE69329295T DE69329295T DE69329295D1 DE 69329295 D1 DE69329295 D1 DE 69329295D1 DE 69329295 T DE69329295 T DE 69329295T DE 69329295 T DE69329295 T DE 69329295T DE 69329295 D1 DE69329295 D1 DE 69329295D1
Authority
DE
Germany
Prior art keywords
growth hormone
microspheres
controlled release
biological activity
polymeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69329295T
Other languages
English (en)
Other versions
DE69329295T2 (de
Inventor
Henry Auer
M Amin Khan
Howard Bernstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25530460&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69329295(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Alkermes Inc
Publication of DE69329295D1 publication Critical patent/DE69329295D1/de
Application granted granted Critical
Publication of DE69329295T2 publication Critical patent/DE69329295T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
DE69329295T 1992-12-02 1993-12-02 Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung Expired - Fee Related DE69329295T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98432392A 1992-12-02 1992-12-02
PCT/US1993/011621 WO1994012158A1 (en) 1992-12-02 1993-12-02 Controlled release growth hormone containing microspheres

Publications (2)

Publication Number Publication Date
DE69329295D1 true DE69329295D1 (de) 2000-09-28
DE69329295T2 DE69329295T2 (de) 2001-03-15

Family

ID=25530460

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329295T Expired - Fee Related DE69329295T2 (de) 1992-12-02 1993-12-02 Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung

Country Status (13)

Country Link
US (6) US5667808A (de)
EP (2) EP0674506B1 (de)
JP (1) JPH08503950A (de)
KR (1) KR19990022038A (de)
AT (1) ATE195652T1 (de)
AU (2) AU670168B2 (de)
CA (1) CA2150803C (de)
DE (1) DE69329295T2 (de)
DK (1) DK0674506T3 (de)
ES (1) ES2151541T3 (de)
GR (1) GR3034873T3 (de)
PT (1) PT674506E (de)
WO (1) WO1994012158A1 (de)

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EP1013270A2 (de) 2000-06-28
CA2150803C (en) 2006-01-31
AU5683594A (en) 1994-06-22
US20030211153A1 (en) 2003-11-13
EP0674506B1 (de) 2000-08-23
ES2151541T3 (es) 2001-01-01
AU670168B2 (en) 1996-07-04
US6051259A (en) 2000-04-18
AU694378B2 (en) 1998-07-16
PT674506E (pt) 2001-01-31
GR3034873T3 (en) 2001-02-28
JPH08503950A (ja) 1996-04-30
WO1994012158A1 (en) 1994-06-09
US5654010A (en) 1997-08-05
DK0674506T3 (da) 2001-01-08
US5667808A (en) 1997-09-16
AU6802996A (en) 1996-12-19
DE69329295T2 (de) 2001-03-15
ATE195652T1 (de) 2000-09-15
EP1013270A3 (de) 2001-03-28
KR19990022038A (ko) 1999-03-25
US6500448B1 (en) 2002-12-31
US5891478A (en) 1999-04-06
CA2150803A1 (en) 1994-06-09
EP0674506A1 (de) 1995-10-04

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