DE69324456T2 - Anwendung von Tyloxapol als Nanopartikelstabilisator und Dipergiermittel - Google Patents

Anwendung von Tyloxapol als Nanopartikelstabilisator und Dipergiermittel

Info

Publication number
DE69324456T2
DE69324456T2 DE69324456T DE69324456T DE69324456T2 DE 69324456 T2 DE69324456 T2 DE 69324456T2 DE 69324456 T DE69324456 T DE 69324456T DE 69324456 T DE69324456 T DE 69324456T DE 69324456 T2 DE69324456 T2 DE 69324456T2
Authority
DE
Germany
Prior art keywords
tyloxapol
nanoparticles
dipping agent
nanoparticle stabilizer
nanoparticle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69324456T
Other languages
English (en)
Other versions
DE69324456D1 (de
Inventor
Siegfied K June
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosystems LLC
Original Assignee
Nanosystems LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25536608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69324456(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nanosystems LLC filed Critical Nanosystems LLC
Publication of DE69324456D1 publication Critical patent/DE69324456D1/de
Application granted granted Critical
Publication of DE69324456T2 publication Critical patent/DE69324456T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
DE69324456T 1992-12-15 1993-12-01 Anwendung von Tyloxapol als Nanopartikelstabilisator und Dipergiermittel Expired - Lifetime DE69324456T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/990,874 US5429824A (en) 1992-12-15 1992-12-15 Use of tyloxapole as a nanoparticle stabilizer and dispersant

Publications (2)

Publication Number Publication Date
DE69324456D1 DE69324456D1 (de) 1999-05-20
DE69324456T2 true DE69324456T2 (de) 1999-10-28

Family

ID=25536608

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69324456T Expired - Lifetime DE69324456T2 (de) 1992-12-15 1993-12-01 Anwendung von Tyloxapol als Nanopartikelstabilisator und Dipergiermittel

Country Status (24)

Country Link
US (1) US5429824A (de)
EP (1) EP0602702B1 (de)
JP (3) JPH06199658A (de)
KR (1) KR100320390B1 (de)
AT (1) ATE178788T1 (de)
AU (1) AU665669B2 (de)
CA (1) CA2108192C (de)
CZ (1) CZ274793A3 (de)
DE (1) DE69324456T2 (de)
DK (1) DK0602702T3 (de)
ES (1) ES2130217T3 (de)
FI (1) FI935395A (de)
GR (1) GR3030059T3 (de)
HU (1) HU219333B (de)
IL (1) IL107874A (de)
MX (1) MX9306010A (de)
MY (1) MY110186A (de)
NO (1) NO310543B1 (de)
NZ (1) NZ248726A (de)
PH (1) PH29957A (de)
RU (1) RU2124886C1 (de)
SK (1) SK280614B6 (de)
TW (1) TW440451B (de)
UA (1) UA27760C2 (de)

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