DE69321729T2 - Aminosäure-gebundene senfgas derivate und ihre verwendung als wirkstoffvorstufe in der behandlung von tumoren - Google Patents

Aminosäure-gebundene senfgas derivate und ihre verwendung als wirkstoffvorstufe in der behandlung von tumoren

Info

Publication number
DE69321729T2
DE69321729T2 DE69321729T DE69321729T DE69321729T2 DE 69321729 T2 DE69321729 T2 DE 69321729T2 DE 69321729 T DE69321729 T DE 69321729T DE 69321729 T DE69321729 T DE 69321729T DE 69321729 T2 DE69321729 T2 DE 69321729T2
Authority
DE
Germany
Prior art keywords
binded
tumors
treatment
amino acid
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69321729T
Other languages
English (en)
Other versions
DE69321729D1 (de
Inventor
Philip John Burke
Robert Ian Dowell
Anthony Mauger
Caroline Springer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
Syngenta Ltd
Original Assignee
Cancer Research Campaign Technology Ltd
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929215636A external-priority patent/GB9215636D0/en
Priority claimed from GB939310884A external-priority patent/GB9310884D0/en
Application filed by Cancer Research Campaign Technology Ltd, Zeneca Ltd filed Critical Cancer Research Campaign Technology Ltd
Application granted granted Critical
Publication of DE69321729D1 publication Critical patent/DE69321729D1/de
Publication of DE69321729T2 publication Critical patent/DE69321729T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
DE69321729T 1992-07-23 1993-07-23 Aminosäure-gebundene senfgas derivate und ihre verwendung als wirkstoffvorstufe in der behandlung von tumoren Expired - Fee Related DE69321729T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929215636A GB9215636D0 (en) 1992-07-23 1992-07-23 Chemical compounds
GB939310884A GB9310884D0 (en) 1993-05-26 1993-05-26 Chemical compounds
PCT/GB1993/001560 WO1994002450A1 (en) 1992-07-23 1993-07-23 Amino acid linked nitrogen mustard derivatives and their use as prodrugs in the treatment of tumours

Publications (2)

Publication Number Publication Date
DE69321729D1 DE69321729D1 (de) 1998-11-26
DE69321729T2 true DE69321729T2 (de) 1999-03-18

Family

ID=26301303

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69321729T Expired - Fee Related DE69321729T2 (de) 1992-07-23 1993-07-23 Aminosäure-gebundene senfgas derivate und ihre verwendung als wirkstoffvorstufe in der behandlung von tumoren

Country Status (25)

Country Link
US (6) US5405990A (de)
EP (1) EP0651740B1 (de)
JP (1) JP3541037B2 (de)
KR (1) KR100268654B1 (de)
AT (1) ATE172450T1 (de)
AU (1) AU681349B2 (de)
CA (1) CA2101104C (de)
CZ (1) CZ287028B6 (de)
DE (1) DE69321729T2 (de)
DK (1) DK0651740T3 (de)
ES (1) ES2123662T3 (de)
FI (1) FI115048B (de)
GB (1) GB9314960D0 (de)
HK (1) HK1002683A1 (de)
HU (1) HUT69288A (de)
IL (1) IL106459A (de)
MY (1) MY111635A (de)
NZ (1) NZ254864A (de)
PH (1) PH30004A (de)
PL (1) PL174617B1 (de)
RU (1) RU2129542C1 (de)
SK (1) SK281338B6 (de)
TW (1) TW272971B (de)
WO (1) WO1994002450A1 (de)
ZW (1) ZW9293A1 (de)

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US6962702B2 (en) 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
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EP1303481A1 (de) * 2000-07-26 2003-04-23 Patrick Anthony Riley Phenylethylamin-derivate und ihre anwendung in der behandlung von melanomen
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US20040175378A1 (en) 2002-07-15 2004-09-09 Board Of Regents, The University Of Texas System Selected antibody compositions and methods for binding to aminophospholipids
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
JP4733635B2 (ja) 2003-07-31 2011-07-27 イミューノメディクス、インコーポレイテッド 抗ｃｄ１９抗体
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
US7517903B2 (en) * 2004-05-19 2009-04-14 Medarex, Inc. Cytotoxic compounds and conjugates
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
US20080279868A1 (en) * 2005-09-26 2008-11-13 Medarex, Inc. Antibody-Drug Conjugates and Methods of Use
DK1940789T3 (da) 2005-10-26 2012-03-19 Medarex Inc Fremgangsmåder og forbindelser til fremstilling af CC-1065-analoger
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
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JP6133431B2 (ja) 2012-11-24 2017-05-24 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
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CN116143678A (zh) 2016-11-14 2023-05-23 杭州多禧生物科技有限公司 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
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Also Published As

Publication number Publication date
ATE172450T1 (de) 1998-11-15
CZ15195A3 (en) 1995-11-15
ES2123662T3 (es) 1999-01-16
IL106459A0 (en) 1994-11-11
US5660829A (en) 1997-08-26
NZ254864A (en) 1996-11-26
PH30004A (en) 1996-10-29
US5714148A (en) 1998-02-03
AU4715693A (en) 1994-02-14
PL307226A1 (en) 1995-05-15
AU681349B2 (en) 1997-08-28
TW272971B (de) 1996-03-21
CZ287028B6 (en) 2000-08-16
FI950230A0 (fi) 1995-01-19
FI950230A (fi) 1995-01-19
US5958971A (en) 1999-09-28
IL106459A (en) 1998-02-08
HK1002683A1 (en) 1998-09-11
RU2129542C1 (ru) 1999-04-27
HUT69288A (en) 1995-09-28
DE69321729D1 (de) 1998-11-26
WO1994002450A1 (en) 1994-02-03
US6277880B1 (en) 2001-08-21
CA2101104C (en) 2007-01-23
JPH07509461A (ja) 1995-10-19
ZW9293A1 (en) 1994-03-30
SK6995A3 (en) 1995-07-11
SK281338B6 (sk) 2001-02-12
KR100268654B1 (ko) 2000-10-16
PL174617B1 (pl) 1998-08-31
EP0651740A1 (de) 1995-05-10
FI115048B (fi) 2005-02-28
GB9314960D0 (en) 1993-09-01
HU9500145D0 (en) 1995-03-28
US5405990A (en) 1995-04-11
DK0651740T3 (da) 1999-06-28
RU95105246A (ru) 1997-04-27
US5587161A (en) 1996-12-24
MY111635A (en) 2000-10-31
JP3541037B2 (ja) 2004-07-07
CA2101104A1 (en) 1994-01-24
EP0651740B1 (de) 1998-10-21

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