DE69319205T2 - Fluoreszierende mikroteilchen mit steuerbarem verbesserten stokes shift - Google Patents

Fluoreszierende mikroteilchen mit steuerbarem verbesserten stokes shift

Info

Publication number
DE69319205T2
DE69319205T2 DE69319205T DE69319205T DE69319205T2 DE 69319205 T2 DE69319205 T2 DE 69319205T2 DE 69319205 T DE69319205 T DE 69319205T DE 69319205 T DE69319205 T DE 69319205T DE 69319205 T2 DE69319205 T2 DE 69319205T2
Authority
DE
Germany
Prior art keywords
microparticles
dyes
series
unique
stokes shift
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69319205T
Other languages
English (en)
Other versions
DE69319205D1 (de
Inventor
John Brinkley
Richard Haugland
Victoria Singer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Probes Inc
Original Assignee
Molecular Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Probes Inc filed Critical Molecular Probes Inc
Application granted granted Critical
Publication of DE69319205D1 publication Critical patent/DE69319205D1/de
Publication of DE69319205T2 publication Critical patent/DE69319205T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
DE69319205T 1992-05-13 1993-05-07 Fluoreszierende mikroteilchen mit steuerbarem verbesserten stokes shift Expired - Lifetime DE69319205T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07882299 US5326692B1 (en) 1992-05-13 1992-05-13 Fluorescent microparticles with controllable enhanced stokes shift
PCT/US1993/004334 WO1993023492A1 (en) 1992-05-13 1993-05-07 Fluorescent microparticles with controllable enhanced stokes shift

Publications (2)

Publication Number Publication Date
DE69319205D1 DE69319205D1 (de) 1998-07-23
DE69319205T2 true DE69319205T2 (de) 1998-12-10

Family

ID=25380293

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69319205T Expired - Lifetime DE69319205T2 (de) 1992-05-13 1993-05-07 Fluoreszierende mikroteilchen mit steuerbarem verbesserten stokes shift

Country Status (7)

Country Link
US (2) US5326692B1 (de)
EP (1) EP0596098B1 (de)
JP (2) JP3442777B2 (de)
AT (1) ATE167511T1 (de)
CA (1) CA2113106C (de)
DE (1) DE69319205T2 (de)
WO (1) WO1993023492A1 (de)

Families Citing this family (398)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863403A (en) * 1984-03-29 1999-01-26 The Board Of Regents Of The University Of Nebraska Digital DNA typing
US6004446A (en) * 1984-03-29 1999-12-21 Li-Cor, Inc. DNA Sequencing
US5360523A (en) * 1984-03-29 1994-11-01 Li-Cor, Inc. DNA sequencing
US5571388A (en) * 1984-03-29 1996-11-05 Li-Cor, Inc. Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof
US4729947A (en) * 1984-03-29 1988-03-08 The Board Of Regents Of The University Of Nebraska DNA sequencing
US6086737A (en) * 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US5723218A (en) * 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5433896A (en) * 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US6159686A (en) * 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6399397B1 (en) 1992-09-14 2002-06-04 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
DE4322884A1 (de) * 1992-10-09 1994-04-14 Bayer Ag Biologisch aktive Polymere
JP3099853B2 (ja) * 1993-02-19 2000-10-16 株式会社日立製作所 核酸の測定試薬及び測定方法
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
JP3598123B2 (ja) * 1993-07-15 2004-12-08 浜松ホトニクス株式会社 核酸の変性検出装置
US6576419B1 (en) 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
US7322927B2 (en) 1993-09-24 2008-01-29 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US6238931B1 (en) * 1993-09-24 2001-05-29 Biosite Diagnostics, Inc. Fluorescence energy transfer in particles
US6251687B1 (en) 1993-09-24 2001-06-26 Biosite Diagnostics, Inc. Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds
US5824799A (en) * 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US7083984B2 (en) * 1993-09-24 2006-08-01 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US6028190A (en) * 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US5869255A (en) 1994-02-01 1999-02-09 The Regents Of The University Of California Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis
US5650872A (en) * 1994-12-08 1997-07-22 Research Frontiers Incorporated Light valve containing ultrafine particles
AUPN214095A0 (en) 1995-04-03 1995-04-27 Australian Water Technologies Pty Ltd Method for detecting microorganisms using flow cytometry
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US5994063A (en) * 1995-06-23 1999-11-30 Metzker; Michael L. Substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene compounds for homogenous amplification/detection assays
US5728528A (en) * 1995-09-20 1998-03-17 The Regents Of The University Of California Universal spacer/energy transfer dyes
US6127188A (en) * 1995-10-06 2000-10-03 Mj Research, Inc. Method and apparatus for controlling evaporation in histological procedures
AU7398996A (en) 1995-10-11 1997-04-30 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5869689A (en) * 1995-10-17 1999-02-09 Molecular Probes, Inc Stains for acidic organelles
US5683823A (en) * 1996-01-26 1997-11-04 Eastman Kodak Company White light-emitting organic electroluminescent devices
DE19612356B4 (de) * 1996-03-28 2007-04-26 Clondiag Chip Technologies Gmbh Optischer Nachweis von Hybridisierungs-Signalen
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7825237B2 (en) * 1996-05-03 2010-11-02 Applied Biosystems, Llc Oligonucleotides and analogs labeled with energy transfer dyes
US7388092B2 (en) * 1996-05-03 2008-06-17 Applera Corporation Oligonucleotides and analogs labeled with energy transfer dyes
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US6005113A (en) * 1996-05-15 1999-12-21 Molecular Probes, Inc. Long wavelength dyes for infrared tracing
KR100479000B1 (ko) 1996-05-15 2005-08-01 세이코 엡슨 가부시키가이샤 박막디바이스,액정패널및전자기기및박막디바이스의제조방법
CA2205099A1 (en) * 1996-05-24 1997-11-24 Patricia Marie Lesko Fluorescent polymers and coating compositions
DE19621312A1 (de) 1996-05-28 1997-12-04 Bayer Ag Maskierung der Hintergrundfluoreszenz und Signalverstärkung bei der optischen Analyse biologisch medizinischer Assays
US6280967B1 (en) 1996-08-02 2001-08-28 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time of cellular responses
US6558916B2 (en) * 1996-08-02 2003-05-06 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time measurements of patient cellular responses
US5804436A (en) * 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
US5719031A (en) * 1996-08-14 1998-02-17 Molecular Probes, Inc. Dye labeled polymers as reagents for measuring polymer degradation
CN1173315C (zh) 1996-09-19 2004-10-27 精工爱普生株式会社 矩阵式显示元件及其制造方法
WO1998013524A1 (fr) * 1996-09-27 1998-04-02 Laboratory Of Molecular Biophotonics Sondes de detection de polynucleotides et procede de detection
US5853992A (en) * 1996-10-04 1998-12-29 The Regents Of The University Of California Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels
FI963989A (fi) * 1996-10-04 1998-04-05 Wallac Oy Homogeenisiä määritysmenetelmiä, jotka perustuvat luminesenssienergiasiirtoon
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US6204002B1 (en) 1996-10-22 2001-03-20 Daikin Industries, Ltd. Gangliosides having fluorescent-tagged ceramide moieties
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
JP3899566B2 (ja) 1996-11-25 2007-03-28 セイコーエプソン株式会社 有機ｅｌ表示装置の製造方法
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US5804386A (en) * 1997-01-15 1998-09-08 Incyte Pharmaceuticals, Inc. Sets of labeled energy transfer fluorescent primers and their use in multi component analysis
KR20000070747A (ko) * 1997-02-03 2000-11-25 에프. 아. 프라저, 에른스트 알테르 (에. 알테르), 한스 페터 비틀린 (하. 페. 비틀린), 피. 랍 보프, 브이. 스펜글러, 페. 아에글러 형광 조성물의 제조방법, 형광 조성물 및 이의 용도
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
ES2563643T3 (es) * 1997-04-01 2016-03-15 Illumina Cambridge Limited Método de secuenciación de ácido nucleico
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
DE69838067T2 (de) * 1997-05-23 2008-03-13 Bioarray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
US6843937B1 (en) 1997-07-16 2005-01-18 Seiko Epson Corporation Composition for an organic EL element and method of manufacturing the organic EL element
US6106999A (en) * 1997-08-12 2000-08-22 Mitsui Chemicals Photosensitizer, visible light curable resin composition using the same, and use of the composition
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
JP2001518624A (ja) 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン 同時の粒子分離および化学反応
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
KR20010031140A (ko) * 1997-10-14 2001-04-16 루미넥스 코포레이션 정밀 형광염료 입자 및 그의 제조방법 그리고 그의 사용
CA2306138A1 (en) * 1997-10-31 1999-05-14 Peter John Zanzucchi Method for enhancing fluorescence
US6165796A (en) * 1997-11-26 2000-12-26 Beckman Coulter, Inc. Pipettable ion detector and method
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
DE69907630T2 (de) * 1998-01-22 2004-02-26 Luminex Corp., Austin Mikropartikel mit multiplen fluoreszenz-signalen
US6713256B1 (en) * 1998-02-14 2004-03-30 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Fluorescent energy transfer mediated chemical activation (fetma) for the elucidation of the three-dimensional structure of biomacromolecules
EP1078265A1 (de) 1998-02-18 2001-02-28 Dade Behring Inc. Chemilumineszente verbindungen zur detektion einer mehrzahl von analyten
US7951989B2 (en) * 1998-02-23 2011-05-31 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
ATE295899T1 (de) 1998-02-23 2005-06-15 Phylonix Pharmaceuticals Inc Screeningverfahren für die aktivität von agenzien unter verwendung von teleosten
US6656449B1 (en) * 1998-02-23 2003-12-02 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
WO1999052708A1 (en) * 1998-04-13 1999-10-21 Luminex Corporation Liquid labeling with fluorescent microparticles
EP1072006A1 (de) * 1998-04-16 2001-01-31 Northeastern University Expert-system zur analyse von dna-sequenzierten elektropherogrammen
US5952131A (en) * 1998-04-27 1999-09-14 Xerox Corporation Core and shell matrix compositions and processes
ATE423314T1 (de) 1998-06-24 2009-03-15 Illumina Inc Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel
JP2000014223A (ja) * 1998-07-01 2000-01-18 Mitsubishi Agricult Mach Co Ltd コンバインにおける前処理部のスライド保持装置
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
JP4486256B2 (ja) 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
EP1135531B1 (de) * 1998-12-01 2007-05-02 Phylonix Pharmaceuticals Inc. Methoden zur introduktion heterologer zellen in fische
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US7612020B2 (en) 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6846460B1 (en) * 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US6395534B1 (en) * 1999-03-31 2002-05-28 Council Of Scientific And Industrial Research White rot-lignin-modifying fungus Flavodon flavus and a process for removing dye from dye containing water or soil using the fungus
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
WO2000075373A2 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
DE19933104A1 (de) * 1999-07-15 2001-01-18 Ingo Klimant Phosphoreszierende Mikro- und Nanopartikel als Referenzstandard und Phosphoreszenzmarker
AU6779700A (en) * 1999-08-17 2001-03-13 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
AU6779200A (en) * 1999-08-17 2001-03-13 Luminex Corporation Encapsulation of fluorescent particles
ATE542916T1 (de) 1999-08-18 2012-02-15 Illumina Inc Methoden zur erzeugung von oligonukleotidlösungen
EP1248853A2 (de) * 1999-08-20 2002-10-16 Luminex Corporation Flüssigarray-technologie
US6358684B1 (en) 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
CA2382436C (en) 1999-08-30 2011-05-17 Illumina, Inc. Methods for improving signal detection from an array
US7098042B2 (en) * 1999-09-02 2006-08-29 Btf Pty Ltd. Internal quality control
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
CA2642066C (en) 1999-10-18 2010-01-26 Prince Henry's Institute Of Medical Research Immuno-interactive fragments of the .alpha.c subunit of inhibin
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6361916B1 (en) 1999-12-14 2002-03-26 Eastman Kodak Company Loaded latex compositions with dye and stabilizer
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
DE10001188A1 (de) * 2000-01-14 2001-07-19 Philips Corp Intellectual Pty Flüssigkristallfarbbildschirm mit Leuchtstoffschicht
US20010051348A1 (en) * 2000-01-28 2001-12-13 Lee Chee Wee Novel ligands and methods for preparing same
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6913884B2 (en) * 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
AU3806701A (en) 2000-02-07 2001-08-14 Illumina Inc Nucleic acid detection methods using universal priming
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1257805B1 (de) * 2000-02-10 2015-10-14 Illumina, Inc. Element mit einem substrat mit mehreren immunoassay-stellen zur simultanen analyse mehrerer proben mit hilfe von mikrokugeln, das element enthaltende vorrichtung, und herstellungsverfahren für das element
EP1257668B1 (de) 2000-02-16 2008-10-29 Illumina, Inc. Parallele genotypisierung mehrerer patientenproben
US6528318B1 (en) * 2000-03-06 2003-03-04 The Johns Hopkins University Scatter controlled emission for optical taggants and chemical sensors
EP1259808A2 (de) 2000-03-10 2002-11-27 Washington University Verfahren zur markierung von einzelzellen
KR20010095437A (ko) * 2000-03-30 2001-11-07 윤덕용 발광물질/점토 나노복합소재를 이용한 유기 전기 발광 소자
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US20040224421A1 (en) * 2000-06-15 2004-11-11 Deweerd Herman Bi-directional scanning method
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001288751A1 (en) * 2000-09-05 2002-03-22 Illumina, Inc. Cellular arrays comprising encoded cells
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
DE10047528A1 (de) * 2000-09-22 2002-05-02 Roche Diagnostics Gmbh Konjugate aus Silikatpartikeln und Biomolekülen und deren Anwendung in der medizinisch-technischen Diagnostik
US6777198B2 (en) * 2000-10-11 2004-08-17 Pharmacia Diagnostics Ab Assay method and kit therefor
US6803196B1 (en) * 2000-10-13 2004-10-12 Affymetrix, Inc. Methods and compositions for detecting signals in binding assays using microparticles
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US20040018491A1 (en) * 2000-10-26 2004-01-29 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US6515314B1 (en) * 2000-11-16 2003-02-04 General Electric Company Light-emitting device with organic layer doped with photoluminescent material
FI20002623A (fi) * 2000-11-30 2002-05-31 Inno Trac Diagnostics Oy Bioanalyyttinen määritysmenetelmä
US20040096515A1 (en) * 2001-12-07 2004-05-20 Bausch Andreas R. Methods and compositions for encapsulating active agents
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
US6538725B2 (en) 2001-01-22 2003-03-25 General Electric Company Method for determination of structural defects of coatings
DE10108808A1 (de) * 2001-02-16 2002-09-05 Joerg Enderlein Fluoreszierende Mikroteilchen
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US6514617B1 (en) 2001-07-11 2003-02-04 General Electric Company Tagging materials for polymers, methods, and articles made thereby
WO2003009804A2 (en) * 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
DE10137530A1 (de) * 2001-08-01 2003-02-13 Presens Prec Sensing Gmbh Anordnung und Verfahren zur Mehrfach-Fluoreszenzmessung
US20030059850A1 (en) * 2001-09-26 2003-03-27 Psychiatric Genomics, Inc. Fluorescence proximity assay
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
EP1456657A4 (de) * 2001-11-09 2008-03-12 Aclara Biosciences Inc Mikropartikelzusammensetzungen mit tag und verfahren
US6838289B2 (en) * 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
US20050118589A1 (en) 2001-11-21 2005-06-02 Vann Charles S. Digital array
US6927071B2 (en) * 2001-12-07 2005-08-09 Beckman Coulter, Inc. Method for reducing non-specific aggregation of latex microparticles in the presence of serum or plasma
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US6837171B1 (en) 2002-04-29 2005-01-04 Palmer/Snyder Furniture Company Lightweight table with unitized table top
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
PT1471054E (pt) 2002-01-11 2009-09-23 Daiichi Sankyo Co Ltd Derivado de aminoálcool ou derivado de ácido fosfónico e composição medicinal que os contém
US7499806B2 (en) 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
ATE400663T1 (de) 2002-02-21 2008-07-15 Asm Scient Inc Rekombinase-polymerase-amplifikation
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US6792019B2 (en) * 2002-02-28 2004-09-14 Texas Instruments Incorporated Driver with tail currents in discrete subranges
AU2003224000A1 (en) * 2002-03-22 2003-10-08 University College Dublin, National University Of Ireland, Dublin Compounds useful as photodynamic therapeutic agents
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
CA2490261A1 (en) 2002-06-27 2004-01-08 The University Of Queensland Differentiation modulating agents and uses therefor
FR2841794B1 (fr) * 2002-07-03 2004-10-01 Centre Nat Rech Scient Controle de la distribution spatiale de cristaux microscopiques dans des evidements realises sur un substrat
AU2003245127B2 (en) 2002-07-26 2007-11-29 The Walter And Eliza Hall Institute Of Medical Research Immunogenic compositions and diagnostic and therapeutic uses thereof
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
AU2003263106A1 (en) * 2002-09-07 2004-03-29 Arizona Board Of Regents Nanoengineered biophotonic hybrid device
US8173407B2 (en) * 2002-09-07 2012-05-08 Labelle Jeffrey T Nanoengineered biophotonic hybrid device
US9034623B2 (en) 2002-09-07 2015-05-19 Jeffrey T. LaBelle Nanoengineered biophotonic hybrid device
US6774758B2 (en) * 2002-09-11 2004-08-10 Kalyan P. Gokhale Low harmonic rectifier circuit
AU2003266932B2 (en) * 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
JP2006504937A (ja) * 2002-10-31 2006-02-09 シェモメテック・アクティーゼルスカブ 粒子の評価方法
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US6767677B2 (en) 2002-11-20 2004-07-27 Eastman Kodak Company Display element with a backprint comprising a squarine dye
US6706460B1 (en) 2002-11-20 2004-03-16 Eastman Kodak Company Stable IR dye composition for invisible marking
US6689518B1 (en) 2002-11-20 2004-02-10 Eastman Kodak Company Photographic display elements comprising stable IR dye compositions for invisible marking
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US6964747B2 (en) * 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
US7255895B2 (en) * 2003-01-21 2007-08-14 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles
US7312257B2 (en) * 2003-01-23 2007-12-25 General Electric Company Polymer encapsulation of high aspect ratio materials and methods of making same
US7488764B2 (en) * 2003-01-23 2009-02-10 Sabic Innovative Plastics Ip B.V. Polymer encapsulation of high aspect ratio materials and methods of making same
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
EP2201960A1 (de) * 2003-03-19 2010-06-30 The General Hospital Corporation Konformationseingeschränkte Parathormone mit Alpha-Helix-Stabilisatoren
AU2003901325A0 (en) 2003-03-21 2003-04-03 Stephen Locarnini Therapeutic, prophylactic and diagnostic agents
WO2004084890A1 (en) * 2003-03-26 2004-10-07 Crc For Asthma Limited Therapeutic and prophylactic compositions and uses therefor
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
WO2005017181A2 (en) * 2003-05-20 2005-02-24 Investigen, Inc. System for detecting polynucleotides
NZ543897A (en) * 2003-05-30 2009-04-30 Gemin X Pharmaceuticals Canada Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
WO2005009358A2 (en) 2003-07-17 2005-02-03 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
WO2005043117A2 (en) * 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US20050095715A1 (en) * 2003-10-31 2005-05-05 General Electric Company Tagging Material for Polymers, Methods, and Articles Made Thereby
JP2005139371A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency イオン感応性色素およびそれを用いたイオンセンサー。
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7496938B2 (en) * 2003-11-24 2009-02-24 Sabic Innovative Plastics Ip B.V. Media drive with a luminescence detector and methods of detecting an authentic article
US7175086B2 (en) * 2004-04-21 2007-02-13 General Electric Company Authentication system, data device, and methods for using the same
US20090266991A1 (en) * 2003-11-26 2009-10-29 Sabic Innovative Plastics Ip B.V. Method of authenticating tagged polymers
US7094364B2 (en) * 2003-11-26 2006-08-22 General Electric Company Method of authenticating polymers, authenticatable polymers, methods of making authenticatable polymers and authenticatable articles, and articles made there from
US20050110978A1 (en) * 2003-11-26 2005-05-26 Radislav Potyrailo Method of authenticating articles, authenticatable polymers, and authenticatable articles
US7169615B2 (en) * 2003-11-26 2007-01-30 General Electric Company Method of authenticating polymers, authenticatable polymers, methods of making authenticatable polymers and authenticatable articles, and articles made there from
US20050112768A1 (en) * 2003-11-26 2005-05-26 Thomas Evans Method of authenticating tagged polymers
EP1720944B1 (de) 2003-12-05 2013-07-17 Life Technologies Corporation Cyanin farbstoffverbindungen
US7776529B2 (en) * 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
WO2005061094A1 (en) * 2003-12-22 2005-07-07 Versamatrix A/S Identification of encoded beads
WO2005062018A2 (en) * 2003-12-22 2005-07-07 Versamatrix A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
US7323696B2 (en) 2004-01-09 2008-01-29 Applera Corporation Phosphor particle coded beads
EP1769247A1 (de) * 2004-02-13 2007-04-04 Molecular Probes, Inc. Biotin anerkenung sensoren und hoch durchfluss tests
US7910617B2 (en) 2004-02-24 2011-03-22 Sankyo Company, Limited Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound
US7334330B2 (en) * 2004-04-28 2008-02-26 Siemens Power Generation, Inc. Thermally insulating layer incorporating a distinguishing agent and method for inspecting the same
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7407816B2 (en) * 2004-05-07 2008-08-05 Gentius, Inc Isoelectric particles and uses thereof
US20060216723A1 (en) * 2004-05-21 2006-09-28 University Of Miami High through-put detection of pathogenic yeasts in the genus trichosporon
WO2005117908A2 (en) * 2004-05-28 2005-12-15 Gemin X Biotechnologies, Inc. Triheterocyclic compounds compositions, and methods for treating cancer or viral diseases
WO2005118810A1 (en) 2004-06-03 2005-12-15 Athlomics Pty Ltd Agents and methods for diagnosing stress
US20050277710A1 (en) * 2004-06-14 2005-12-15 Joyce Richard P Tagged resin, method of making a tagged resin, and articles made therefrom
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US7906276B2 (en) * 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7597961B2 (en) * 2004-07-13 2009-10-06 Sabic Innovative Plastics Ip B.V. Authenticatable article and method of authenticating
WO2006007664A1 (en) * 2004-07-22 2006-01-26 Genomics Research Partners Pty Ltd Agents and methods for diagnosing osteoarthritis
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
WO2006020605A2 (en) * 2004-08-10 2006-02-23 The Regents Of The University Of California Device and method for the delivery and/or elimination of compounds in tissue
EP1627921B1 (de) * 2004-08-18 2008-08-27 Roche Diagnostics GmbH Verfahren zur Messung einer Nukleinsäureamplifikation in Real Time beinhaltend die Positionierung eines Reaktionsgefässes relativ zu einer Detektionseinheit
US20060045814A1 (en) * 2004-09-01 2006-03-02 Zhang Yu-Zhong Microplates containing microsphere fluorescence standards, microsphere standards, and methods for their use
US7682696B2 (en) * 2004-09-13 2010-03-23 Sabic Innovative Plastics Ip B.V. Medical article and method of making and using the same
US7355944B2 (en) * 2004-11-12 2008-04-08 General Electric Company Authenticatable media and method of authenticating
US8871272B2 (en) 2005-02-14 2014-10-28 Australian Nuclear Science & Technology Organisation Layered nanoparticles
AU2006214762B2 (en) * 2005-02-18 2010-07-08 American Dye Source Inc. Method for encoding materials with a luminescent tag and apparatus for reading same
WO2006089397A1 (en) * 2005-02-22 2006-08-31 Gemin X Biotechnologies Inc. Methods for treating arthritis using triheterocyclic compounds
US9039273B2 (en) 2005-03-04 2015-05-26 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
JP2008538609A (ja) * 2005-04-20 2008-10-30 ベクトン・ディキンソン・アンド・カンパニー マルチプレックスマイクロ粒子システム
US7439079B2 (en) * 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US7803319B2 (en) 2005-04-29 2010-09-28 Kimberly-Clark Worldwide, Inc. Metering technique for lateral flow assay devices
US7858384B2 (en) 2005-04-29 2010-12-28 Kimberly-Clark Worldwide, Inc. Flow control technique for assay devices
EP1885718B1 (de) 2005-05-11 2017-03-15 Life Technologies Corporation Chemische fluoreszente verbindungen mit hoher selektivität für doppelstrang-dna sowie verfahren zu ihrer verwendung
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20100034748A1 (en) * 2008-08-07 2010-02-11 Guizhi Li Molecular imaging probes based on loaded reactive nano-scale latex
EP2476761A3 (de) 2005-07-07 2012-10-17 Athlomics Pty Ltd Polynukleotidmarkergene und ihre Expression zur Diagnose von Endotoxämie
NO20053373D0 (no) * 2005-07-11 2005-07-11 Rikshospitalet Radiumhospitale Multicolored Particles.
EP2385140B1 (de) 2005-07-25 2014-07-16 Alere San Diego, Inc. Verfahren zur Multiplexierung einer Rekombinase-Polymerase-Verstärkung
US7829347B2 (en) * 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US20080181965A1 (en) * 2006-04-10 2008-07-31 Leon Jeffrey W Loaded latex optical molecular imaging probes
US7250612B2 (en) * 2005-09-28 2007-07-31 General Electric Company Devices and methods capable of authenticating batteries
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0524069D0 (en) * 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
US7279136B2 (en) 2005-12-13 2007-10-09 Takeuchi James M Metering technique for lateral flow assay devices
US7745158B2 (en) * 2005-12-14 2010-06-29 Kimberly-Clark Worldwide, Inc. Detection of secreted aspartyl proteases from Candida species
US7645583B2 (en) * 2005-12-14 2010-01-12 Kimberly-Clark Worldwide, Inc. Identification of compounds for inhibiting complexation of C-reactive protein with fibronectin
US7618810B2 (en) 2005-12-14 2009-11-17 Kimberly-Clark Worldwide, Inc. Metering strip and method for lateral flow assay devices
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
WO2012158207A2 (en) * 2011-05-13 2012-11-22 E.I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
ATE551067T1 (de) 2006-02-03 2012-04-15 Crc For Asthma And Airways Ltd Tumstatin zur behandlung von erkrankungen die mit der neumodellierung von atemwegsgewebe zusammenhängen
DE102006029032A1 (de) * 2006-02-17 2007-08-23 Poly-An Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Vorrichtung, Verfahren und Kit zum Nachweis von Analyten in einer Probe
EP2010677A4 (de) * 2006-02-24 2010-04-14 Investigen Inc Verfahren und zusammensetzungen zum nachweis von polynukleotiden
EP2021503A1 (de) * 2006-03-17 2009-02-11 Solexa Ltd. Isothermische methoden zur entstehung von arrays von einzelnen molekülen
US8758989B2 (en) * 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US8841134B2 (en) * 2006-04-10 2014-09-23 Bruker Biospin Corporation Fluorescence resonance energy transfer detection with nanoparticles for in vitro and in vivo applications
JP2009535053A (ja) 2006-05-04 2009-10-01 エーエスエム サイエンティフィック， インコーポレイテッド レコンビナーゼポリメラーゼ増幅
FR2901067A1 (fr) * 2006-05-09 2007-11-16 Centre Nat Rech Scient Dispositif anti-lasage transverse pour un cristal laser
US20080051400A1 (en) * 2006-07-06 2008-02-28 Gemin X Biotechnologies Inc. Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound
US20100311186A1 (en) * 2006-07-28 2010-12-09 Biosite Incorporated Devices and methods for performing receptor binding assays using magnetic particles
EP2054077A4 (de) * 2006-08-04 2010-10-13 Gen Hospital Corp Polypeptidderivate des parathyroidhormons (pth)
US20080081210A1 (en) * 2006-09-29 2008-04-03 General Electric Company Authenticatable articles and methods therefor
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
US8114515B2 (en) * 2007-02-05 2012-02-14 Sabic Innovative Plastics Ip B.V. Crosslinked polyester compositions, method of manufacture, and uses thereof
WO2008103702A2 (en) * 2007-02-23 2008-08-28 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
US8017104B2 (en) * 2007-02-28 2011-09-13 Carestream Health, Inc. Large stoke shift dye used for optical imaging
US8568737B2 (en) * 2007-08-01 2013-10-29 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
US8277775B2 (en) * 2007-08-17 2012-10-02 The Research Foundation Of The City University Of New York Boron dipyrromethene difluoro (BODIPY) conjugates
US8535617B2 (en) * 2007-11-30 2013-09-17 Kimberly-Clark Worldwide, Inc. Blood cell barrier for a lateral flow device
US20090155770A1 (en) * 2007-12-12 2009-06-18 Kimberly-Clark Worldwide, Inc. Implantable devices for fiber optic based detection of nosocomial infection
EP2223087B1 (de) * 2007-12-17 2013-06-12 Life Technologies Corporation Verfahren zum nachweisen von defekten bei anorganisch-beschichteten polymeroberflächen und substrat
US20130020507A1 (en) 2010-06-17 2013-01-24 Life Technologies Corporation Methods for Detecting Defects in Inorganic-Coated Polymer Surfaces
US20090191276A1 (en) * 2008-01-24 2009-07-30 Fellows And President Of Harvard University Colloidosomes having tunable properties and methods for making colloidosomes having tunable properties
WO2010033200A2 (en) 2008-09-19 2010-03-25 President And Fellows Of Harvard College Creation of libraries of droplets and related species
US20100075298A1 (en) * 2008-09-23 2010-03-25 The Regents Of The University Of California Method for rapid identification and quantification of microorganisms
WO2010038042A1 (en) 2008-10-02 2010-04-08 Illumina Cambridge Ltd. Nucleic acid sample enrichment for sequencing applications
US8415161B2 (en) 2008-11-13 2013-04-09 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
JP5458301B2 (ja) * 2009-02-10 2014-04-02 三菱化学株式会社 ジベンゾピロメテンホウ素キレート化合物及びその製造方法、並びにこれを用いた太陽電池、光重合性組成物、光記憶媒体、発光素子、光学フィルター、及び医療診断用蛍光色素
WO2010135310A1 (en) 2009-05-20 2010-11-25 Biosite Incorporated Dna glycosylase/lyase and ap endonuclease substrates
EP3360974A1 (de) 2009-06-05 2018-08-15 Alere San Diego, Inc. Reagentien zur rekombinase polymerase amplifikation
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
US20120211084A1 (en) 2009-09-02 2012-08-23 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
JP5317899B2 (ja) * 2009-09-11 2013-10-16 富士フイルム株式会社 ラテックス粒子を用いた免疫アッセイ方法
US8182994B2 (en) 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
GB2475226A (en) * 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
AR080405A1 (es) * 2010-03-17 2012-04-04 Basf Se Emulsificacion para fundir
JP5985140B2 (ja) * 2010-04-28 2016-09-06 ソニー株式会社 蛍光強度補正方法、蛍光強度算出方法及び蛍光強度算出装置
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
CA2802762A1 (en) * 2010-06-18 2011-12-22 Pathogen Detection Systems, Inc. An optical pathogen detection system and quality control materials for use in same
WO2012016290A1 (en) 2010-08-04 2012-02-09 The Macfarlane Burnet Institute For Medical Research And Public Health Ltd Modified hepatitis c virus proteins
US10809167B2 (en) 2010-08-30 2020-10-20 Konica Minolta, Inc. Tissue staining method with staining agent containing particle holding plural phosphors
US20120065092A1 (en) 2010-09-14 2012-03-15 Wai Hobert Fusion analyte cytometric bead assay, and systems and kits for performing the same
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
EP3978620A1 (de) 2011-04-07 2022-04-06 Abbott Diagnostics Scarborough, Inc. Überwachung von rekombinase-polymerase-verstärkungsmischungen
CN102286213A (zh) * 2011-05-12 2011-12-21 河南大学 近红外氮杂-bodipy染料及其制备方法和应用
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
CN103764265A (zh) 2011-07-06 2014-04-30 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
EP2755026B1 (de) 2011-09-09 2021-10-27 Konica Minolta, Inc. Verfahren zum färben von geweben
WO2013036543A2 (en) 2011-09-10 2013-03-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Molecular imaging of cancer cells in vivo
US8835000B2 (en) * 2011-12-23 2014-09-16 General Electric Company High-density fluorescent dye clusters
US8715529B1 (en) 2012-01-23 2014-05-06 Arrowhead Center, Inc. Synthesis and applications of triazaborolopyridinium compounds and substituted triazaborolopyridinium compounds and methods of use
DE102012003519A1 (de) * 2012-02-24 2013-08-29 Polysecure Gmbh Werkstück mit Markierung
US9632081B2 (en) 2012-03-28 2017-04-25 Konica Minolta, Inc. Detection method for biological substance
US9483684B2 (en) 2012-03-30 2016-11-01 Konica Minolta, Inc. Medical image processor and storage medium
WO2013146741A1 (ja) 2012-03-30 2013-10-03 コニカミノルタ株式会社 組織染色方法
US9189678B2 (en) 2012-03-30 2015-11-17 Konica Minolta, Inc. Medical image processor and storage medium
WO2013153911A1 (ja) * 2012-04-12 2013-10-17 国立大学法人東京大学 核酸の定量方法、検出プローブ、検出プローブセット、及び核酸の検出方法
TWI557187B (zh) * 2012-05-03 2016-11-11 拜耳材料科學股份有限公司 用於光聚合物之新穎光起始劑
JP6148033B2 (ja) * 2013-02-22 2017-06-14 旭化成株式会社 蛍光色素化合物を含むセルロース微粒子
US9903797B2 (en) 2013-03-08 2018-02-27 Konica Minolta, Inc. Staining agent for staining tissue, production method for staining agent for staining tissue and tissue staining kit including staining agent for staining tissue
CN105324667B (zh) 2013-06-19 2018-08-24 柯尼卡美能达株式会社 生物体分子染色用的荧光纳米粒子及其制造方法
WO2015069634A1 (en) 2013-11-08 2015-05-14 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
JP6187170B2 (ja) * 2013-11-08 2017-08-30 コニカミノルタ株式会社 蛍光色素内包樹脂粒子、該蛍光色素内包樹脂粒子を含む組織多重染色用蛍光色素内包樹脂粒子セット、及び該蛍光色素内包樹脂粒子を用いた組織多重染色法
EP3086110A4 (de) 2013-12-18 2017-06-21 Konica Minolta, Inc. Bildverarbeitungsvorrichtung, system zur unterstützung einer pathologischen diagnose, bildverarbeitungsprogramm und bildverarbeitungsverfahren
CN103911144B (zh) * 2014-02-24 2015-11-18 苏州大学 掺杂铕离子的高分子荧光编码微球及其制备方法
EP3124956B1 (de) 2014-03-27 2018-12-26 Konica Minolta, Inc. Bildverarbeitungsvorrichtung und bildverarbeitungsprogramm
EP3136098B1 (de) 2014-04-23 2020-12-09 Konica Minolta, Inc. Medium für harzteilchen mit fluoreszierendem farbstoff
US20170247751A1 (en) * 2014-07-25 2017-08-31 Microscale Devices Llc Apparatus and methods for detecting multiple labelled biopolymers
US10962705B2 (en) * 2015-01-31 2021-03-30 Lg Chem, Ltd. Color conversion film and back light unit and display apparatus comprising the same
US9867250B1 (en) 2015-04-20 2018-01-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence
EP3312605A4 (de) 2015-06-16 2018-05-30 Konica Minolta, Inc. Bildverarbeitungsvorrichtung, bildverarbeitungsverfahren und bildverarbeitungsprogramm
WO2017066231A1 (en) 2015-10-13 2017-04-20 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
CN105238092B (zh) * 2015-10-30 2017-06-23 东莞理工学院 一种2,6‑位取代的bodipy类有机染料敏化剂及其制备方法
CN105295441B (zh) * 2015-11-20 2018-05-08 三诺生物传感股份有限公司 一种显色剂的稳定剂及其应用
FR3046610B1 (fr) 2016-01-08 2020-02-21 Crime Science Technology Utilisation de 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes pour la securisation
JP6763407B2 (ja) 2016-01-19 2020-09-30 コニカミノルタ株式会社 画像処理装置及びプログラム
JP2019503203A (ja) 2016-01-29 2019-02-07 アカオジェン インコーポレイテッド 細胞表面エピトープと結合する抗体を同定するためのスクリーニング方法
WO2017136892A1 (en) 2016-02-11 2017-08-17 La Trobe University Method of diagnosis
KR102438354B1 (ko) 2016-04-15 2022-08-31 베크만 컬터, 인코포레이티드 광활성 거대분자 및 그의 용도
CN109922834B (zh) 2016-06-16 2022-09-23 良药治疗公司 用于治疗癌症的卟啉化合物和组合物
JP6679726B2 (ja) * 2016-07-26 2020-04-15 富士フイルム株式会社 発光性粒子
JP6756838B2 (ja) * 2016-08-23 2020-09-16 富士フイルム株式会社 発光性粒子
WO2018038138A1 (ja) * 2016-08-23 2018-03-01 富士フイルム株式会社 発光性粒子及び化合物
JP6432697B2 (ja) 2016-11-30 2018-12-05 東レ株式会社 ピロメテンホウ素錯体、色変換組成物、色変換フィルム、光源ユニット、ディスプレイおよび照明装置
EP3564655A4 (de) 2016-12-27 2019-12-18 Konica Minolta, Inc. Bildverarbeitungsverfahren und bildverarbeitungssystem
WO2018140827A1 (en) 2017-01-27 2018-08-02 Achaogen, Inc. Reporter microorganisms and uses thereof
WO2018151071A1 (ja) * 2017-02-14 2018-08-23 コニカミノルタ株式会社 蛍光標識法
JP7151489B2 (ja) * 2017-02-14 2022-10-12 コニカミノルタ株式会社 アミノクマリン化合物およびアミノクマリン化合物内包樹脂粒子
WO2018150450A1 (ja) * 2017-02-14 2018-08-23 コニカミノルタ株式会社 アミノクマリン化合物およびアミノクマリン化合物内包樹脂粒子
WO2018181795A1 (ja) 2017-03-30 2018-10-04 富士フイルム株式会社 生体試料中の測定対象物質を測定するためのキット及び方法
KR20190120328A (ko) * 2017-03-30 2019-10-23 후지필름 가부시키가이샤 측정 대상 물질을 측정하기 위한 키트, 방법 및 시약
CN110476062A (zh) * 2017-03-30 2019-11-19 富士胶片株式会社 用于测定活体样品中的测定对象物质的试剂盒及方法
EP3605098A4 (de) * 2017-03-30 2020-03-11 FUJIFILM Corporation Kit und verfahren zur messung der messzielsubstanz in einer biologischen probe
KR20190120330A (ko) 2017-03-30 2019-10-23 후지필름 가부시키가이샤 측정 대상 물질을 측정하기 위한 키트, 방법 및 시약
WO2018181796A1 (ja) 2017-03-30 2018-10-04 富士フイルム株式会社 生体試料中の測定対象物質を測定するためのキット及び方法
JP6447679B2 (ja) * 2017-08-02 2019-01-09 コニカミノルタ株式会社 蛍光色素内包樹脂粒子および該蛍光色素内包樹脂粒子を含む組織多重染色用蛍光色素内包樹脂粒子セット
US20210192721A1 (en) 2017-10-26 2021-06-24 Konica Minolta, Inc. Image Processing Device, In-Focus Position Specifying Method, and In-Focus Position Specifying Program
RU2688744C1 (ru) * 2017-12-29 2019-05-22 Общество с ограниченной ответственностью "Биотех-Инновации" Фотостабильный и яркий флуоресцентный бордипиррометеновый краситель
EP3757569A4 (de) * 2018-02-22 2021-04-21 FUJIFILM Corporation Kit zur progesteronmessung, progesteronmessverfahren und progesteronmessreagenz
JP6867962B2 (ja) * 2018-02-22 2021-05-12 富士フイルム株式会社 測定対象物質を測定するためのキット、蛍光標識剤および蛍光標識抗体
EP3764096A4 (de) 2018-03-07 2021-04-28 Konica Minolta, Inc. Bildverarbeitungsverfahren, bildverarbeitungsvorrichtung und programm
US20210005818A1 (en) * 2018-03-26 2021-01-07 Toray Industries, Inc. Color conversion composition, color conversion sheet, and light source unit, display and lighting device each comprising same
BR102019025989A2 (pt) 2018-12-14 2020-06-23 Beckman Coulter, Inc. Modificação de corantes poliméricos e aplicações
WO2020162474A1 (ja) * 2019-02-06 2020-08-13 富士フイルム株式会社 測定対象物質を測定するためのキットおよび測定対象物質を測定する方法
CN111333670B (zh) * 2019-12-12 2023-05-16 安徽师范大学 异吲哚氟硼三吡咯荧光染料及其制备方法
GB2597797A (en) 2020-08-07 2022-02-09 Sumitomo Chemical Co Light-emitting marker
AU2022216619A1 (en) 2021-02-05 2023-09-07 Beckman Coulter, Inc. Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates
WO2023056460A1 (en) 2021-09-30 2023-04-06 Beckman Coulter, Inc. Water-soluble tetrahydropyrene based fluorescent polymers
WO2023086103A1 (en) 2021-11-12 2023-05-19 Beckman Coulter, Inc. Novel formulation for drying of polymer dye conjugated antibodies
WO2024007016A2 (en) 2022-07-01 2024-01-04 Beckman Coulter, Inc. Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2994697A (en) * 1957-04-20 1961-08-01 Hoechst Ag New dyestuffs of the 1, 8-naphthalene dicarboxylic acid series
US3096333A (en) * 1960-11-21 1963-07-02 Gen Aniline & Film Corp Reaction of 4-amino-1, 8-naphthalimides and aromatic dhsocyanates, and resulting products
DE2238378C3 (de) 1972-08-04 1975-01-09 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Perlnonfarbstoffe und Verfahren zu Ihrer Herstellung
US4326008A (en) * 1976-08-27 1982-04-20 California Institute Of Technology Protein specific fluorescent microspheres for labelling a protein
CA1186621A (en) * 1981-08-10 1985-05-07 John L. Hendrix Fluoro immuno assay system
US4707454A (en) * 1981-08-10 1987-11-17 Bio-Diagnostics, Inc. Fluorescent chlorophyll labeled assay reagents
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
US4542104A (en) * 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4666862A (en) * 1984-08-14 1987-05-19 Ortho Diagnostic Systems Inc. Fluorescent energy transfer with phycobiliproteins
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US4808524A (en) * 1987-09-18 1989-02-28 Eastman Kodak Company Test kit and method for the determination of Streptococcus A antigen
US4774339A (en) * 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US4916711A (en) * 1988-09-29 1990-04-10 Boyer Joseph H Lasing compositions and methods for using the same
US4997597A (en) * 1989-11-13 1991-03-05 The United States Of America As Represented By The United States Department Of Energy Solid-state radioluminescent compositions
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5248782A (en) * 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5187288A (en) * 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis

Also Published As

Publication number Publication date
JPH07508309A (ja) 1995-09-14
US5326692B1 (en) 1996-04-30
JP3442777B2 (ja) 2003-09-02
JP3689412B2 (ja) 2005-08-31
CA2113106C (en) 2000-10-24
US5573909A (en) 1996-11-12
DE69319205D1 (de) 1998-07-23
ATE167511T1 (de) 1998-07-15
EP0596098B1 (de) 1998-06-17
US5326692A (en) 1994-07-05
WO1993023492A1 (en) 1993-11-25
CA2113106A1 (en) 1993-11-25
JP2004002851A (ja) 2004-01-08
EP0596098A1 (de) 1994-05-11

Similar Documents

Publication Publication Date Title
US5326692B1 (en) Fluorescent microparticles with controllable enhanced stokes shift
WO1999024797A8 (en) Single molecule identification using selected fluorescence characteristics
DK0804457T3 (da) Modificerede grønt fluorescerende proteiner
ATE236996T1 (de) Sätze von, mit fluoreszierenden energieübertragungsverbindungen, markierten primern und deren verwendung in mehrkomponentenanalyse
DE69530286D1 (de) Mit energieübertragungsvermittelnden verbindungen markierte proben
CO4230033A1 (es) Uso de compuestos absorbentes y/o fluorescentes en la region infrarroja como marcadores para liquidos
DE69907630D1 (de) Mikropartikel mit multiplen fluoreszenz-signalen
EP0257559A3 (de) Mehrfarbige Fluoreszenzanalyse mit Anregung einzelner Wellenlänge
ATE293252T1 (de) Differenzgelelektrophorese mit mehreren übereinstmmungsfarbstoffen
DE69837839D1 (de) Fluorometrischer Nachweis mit sichtbarem Light
ATE302412T1 (de) Fluoreszierende markierungskomplexe mit grossem stokes-shift die durch verbindung von cyaninen und anderen resonanzenergieübertragungsfähigen fluorochromen zusammengestellt sind
WO2000046839A3 (en) LUMINESCENCE SPECTRAL PROPERTIES OF CdS NANOPARTICLES
ATE133257T1 (de) Ermittlung und quantifizierung mehrerer analyten unter verwendung von markierungstechniken
ES2104881T3 (es) Procedimiento para teñir papel con colorantes diazoicos.
NO173096C (no) Ny benzotiazoliumforbindelse som kan anvendes som fluorescent farvestoff for merking av nucleinsyrer
ES2164043T3 (es) Marcador detectablemente marcado, que comprende un grupo fluoroforo, una sonda fluorescente que comprende el marcador y aplicaciones de los mismos.
DE59710585D1 (de) Vorrichtung und verfahren zur detektion von fluoreszentem und phosphoreszentem licht
EP0354847A3 (de) Mehrfache Fluoreszenzmarkierung mit Europiumchelatoren
EP0294105A3 (de) Nichtfluoreszierendes, nichtreflektierendes Polyamid zur Verwendung in diagnostische Prüfungsverfahren
DE69009561T2 (de) Halbleiterlaser zur selektiven Ausstrahlung von Licht mit verschiedenen Wellenlängen.
WO1998055873A3 (fr) Utilisation d'une proteine fluorescente pour la detection d'interactions entre une proteine cible et son ligand
NO173409C (no) Fremgangsm}te for in vitro bestemmelse av malignans
SE8702462L (sv) Termokaensligt registreringsmaterial med registreringsskikt innehaallande fluorescensfaergaemneskomposition
DE68925973D1 (de) Zellenaussortierungstechnik und ihre anwendungen
DE60014365D1 (de) Fluoreszenzpolarizationsbestimmungen unter verwendung von polyionen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KRAMER - BARSKE - SCHMIDTCHEN, 81245 MUENCHEN

8380 Miscellaneous part iii

Free format text: PFANDRECHT

8380 Miscellaneous part iii

Free format text: PFANDRECHT AUFGEHOBEN