DE69316660T2 - Terfanadin Metaboliten und deren optisch reine Isomere zur Behandlung von allergischen Krankheiten - Google Patents

Terfanadin Metaboliten und deren optisch reine Isomere zur Behandlung von allergischen Krankheiten

Info

Publication number: DE69316660T2
Authority: DE; Germany
Prior art keywords: treatment; terfanadine; metabolites; optically pure; allergic diseases
Prior art date: 1992-08-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69316660T

Other languages

English (en)

Other versions

DE69316660T3 (de

DE69316660D1 (de

Inventor

James Young

Nancy Gray

Raymond Woosley

Yiwang Chen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sunovion Pharmaceuticals Inc

Original Assignee

Georgetown University

Sepracor Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-03

Filing date

1993-08-03

Publication date

1998-05-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27129882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69316660(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-08-03 Application filed by Georgetown University, Sepracor Inc filed Critical Georgetown University

1998-02-26 Publication of DE69316660D1 publication Critical patent/DE69316660D1/de

1998-05-07 Application granted granted Critical

1998-05-07 Publication of DE69316660T2 publication Critical patent/DE69316660T2/de

2001-04-05 Publication of DE69316660T3 publication Critical patent/DE69316660T3/de

2013-08-04 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

DE69316660T 1992-08-03 1993-08-03 Terfanadin Metaboliten und deren optisch reine Isomere zur Behandlung von allergischen Krankheiten Expired - Lifetime DE69316660T3 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US92418292A	1992-08-03	1992-08-03
US92415692A	1992-08-03	1992-08-03
PCT/US1993/007260 WO1994003170A1 (en)	1992-08-03	1993-08-03	Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Publications (3)

Publication Number	Publication Date
DE69316660D1 DE69316660D1 (de)	1998-02-26
DE69316660T2 true DE69316660T2 (de)	1998-05-07
DE69316660T3 DE69316660T3 (de)	2001-04-05

Family

ID=27129882

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
DE69334008T Expired - Lifetime DE69334008T2 (de)	1992-08-03	1993-08-03	Terfenadin-Carboxylat und die Behandlung von allergischen Erkrankungen
DE0701443T Pending DE701443T1 (de)	1992-08-03	1993-08-03	Terfanadin Metaboliten und deren optische reine Isomeren zur Behandlung vonallegischen Krankheiten
DE69316660T Expired - Lifetime DE69316660T3 (de)	1992-08-03	1993-08-03	Terfanadin Metaboliten und deren optisch reine Isomere zur Behandlung von allergischen Krankheiten
DE9320925U Expired - Lifetime DE9320925U1 (de)	1992-08-03	1993-08-03	Terfenadin-Metabolite und deren optisch reine Isomere für die Behandlung von allergischen Störungen
DE69334145T Expired - Lifetime DE69334145T2 (de)	1992-08-03	1993-08-03	Terfenadincarboxylat und die Behandlung von Hautreizung

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DE69334008T Expired - Lifetime DE69334008T2 (de)	1992-08-03	1993-08-03	Terfenadin-Carboxylat und die Behandlung von allergischen Erkrankungen
DE0701443T Pending DE701443T1 (de)	1992-08-03	1993-08-03	Terfanadin Metaboliten und deren optische reine Isomeren zur Behandlung vonallegischen Krankheiten

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DE9320925U Expired - Lifetime DE9320925U1 (de)	1992-08-03	1993-08-03	Terfenadin-Metabolite und deren optisch reine Isomere für die Behandlung von allergischen Störungen
DE69334145T Expired - Lifetime DE69334145T2 (de)	1992-08-03	1993-08-03	Terfenadincarboxylat und die Behandlung von Hautreizung

Country Status (24)

Country	Link
US (1)	US5375693A (de)
EP (4)	EP0701443B2 (de)
JP (6)	JP3041954B2 (de)
KR (1)	KR950702420A (de)
AT (3)	ATE363283T1 (de)
AU (3)	AU675240B2 (de)
BR (1)	BR9306841A (de)
CA (1)	CA2141572C (de)
CZ (1)	CZ27495A3 (de)
DE (5)	DE69334008T2 (de)
DK (3)	DK1214937T3 (de)
ES (3)	ES2257757T3 (de)
FI (1)	FI950467A (de)
GB (1)	GB2284351B (de)
GR (3)	GR960300024T1 (de)
HK (1)	HK1045806B (de)
HU (1)	HU226242B1 (de)
NO (1)	NO310644B1 (de)
PL (1)	PL174373B1 (de)
PT (2)	PT815860E (de)
RO (1)	RO116043B1 (de)
RU (1)	RU2167657C2 (de)
SK (1)	SK12495A3 (de)
WO (1)	WO1994003170A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19913862A1 (de) *	1999-03-26	2000-10-05	Forschungszentrum Juelich Gmbh	Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen

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DE69320952T2 (de) *	1992-05-11	1999-05-27	Merrell Pharma Inc	Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
ATE363283T1 (de) *	1992-08-03	2007-06-15	Sepracor Inc	Terfenadin-carboxylat und die behandlung von hautreizung
US20020007068A1 (en)	1999-07-16	2002-01-17	D'ambra Thomas E.	Piperidine derivatives and process for their production
KR100387348B1 (ko) *	1993-06-24	2003-06-12	알바니 몰레큘라 리써치, 인크.	피페리딘 유도체의 제조 방법
WO1995010278A1 (en) *	1993-10-15	1995-04-20	Hoechst Marion Roussel, Inc.	Treatment of allergic disorders with terfenadine carboxylate
EP2354125A1 (de)	1994-05-18	2011-08-10	Aventisub II Inc.	Wasserfreien und Hydrat-Polymorphen von antihistaminische Piperidinderivate
US20030045722A1 (en) *	1994-05-18	2003-03-06	Henton Daniel R.	Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US5455049A (en) *	1995-01-04	1995-10-03	Ascent Pharmaceuticals, Inc.	Terfenadine oral powder
PT812195E (pt) *	1995-02-28	2003-03-31	Aventis Pharma Inc	Composicao farmaceutica para compostos de piperidinoalcanol
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US5906747A (en) *	1995-11-13	1999-05-25	Biosepra Inc.	Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6486177B2 (en)	1995-12-04	2002-11-26	Celgene Corporation	Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en)	1995-12-04	1998-11-17	Mehta; Atul M.	Delivery of multiple doses of medications
US5908850A (en) *	1995-12-04	1999-06-01	Celgene Corporation	Method of treating attention deficit disorders with d-threo methylphenidate
US6355656B1 (en)	1995-12-04	2002-03-12	Celgene Corporation	Phenidate drug formulations having diminished abuse potential
US5733756A (en) *	1996-01-05	1998-03-31	Celgene Corporation	Lactams and processes for stereoselective enrichment of lactams, amides, and esters
US5922736A (en) *	1995-12-04	1999-07-13	Celegene Corporation	Chronic, bolus administration of D-threo methylphenidate
US6201124B1 (en)	1995-12-21	2001-03-13	Albany Molecular Research, Inc.	Process for production of piperidine derivatives
US6153754A (en)	1995-12-21	2000-11-28	Albany Molecular Research, Inc.	Process for production of piperidine derivatives
ES2124167B1 (es) *	1996-06-04	1999-09-16	Espanola Prod Quimicos	Nuevos derivados del bencimidazol con actividad antihistaminica.
US5925761A (en) *	1997-02-04	1999-07-20	Sepracor Inc.	Synthesis of terfenadine and derivatives
US6962997B1 (en) *	1997-05-22	2005-11-08	Celgene Corporation	Process and intermediates for resolving piperidyl acetamide steroisomers
IL133420A (en) *	1997-08-26	2004-07-25	Aventis Pharma Inc	Tablet-shaped pharmaceutical preparation containing a combination of piperidinoalkanol and antihistamines and reduces symptomatic congestion
US6194431B1 (en)	1998-04-14	2001-02-27	Paul D. Rubin	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
DE10007203A1 (de) *	2000-02-17	2001-08-23	Asta Medica Ag	Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
US6613907B2 (en)	2000-11-08	2003-09-02	Amr Technology, Inc.	Process for the production of piperidine derivatives with microorganisms
US20030021849A1 (en) *	2001-04-09	2003-01-30	Ben-Zion Dolitzky	Polymorphs of fexofenadine hydrochloride
CA2444456A1 (en) *	2001-04-09	2002-10-17	Teva Pharmaceutical Industries Ltd.	Polymorphs of fexofenadine hydrochloride
WO2003020274A1 (en) *	2001-08-30	2003-03-13	Aventis Pharmaceuticals Inc.	Treatment of atopic dermatitis
JP2005532356A (ja) *	2002-06-10	2005-10-27	テバファーマシューティカルインダストリーズリミティド	塩酸フェキソフェナジンの多型体ｘｖｉ
US20050026890A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
TW200517114A (en)	2003-10-15	2005-06-01	Combinatorx Inc	Methods and reagents for the treatment of immunoinflammatory disorders
JP4515121B2 (ja)	2004-03-15	2010-07-28	東芝テック株式会社	ワイヤドットプリンタヘッド及びワイヤドットプリンタ
JP4473021B2 (ja)	2004-03-22	2010-06-02	東芝テック株式会社	窒化層形成方法、磁気回路形成部材、アーマチュア、ワイヤドットプリンタヘッド及びワイヤドットプリンタ
US20050239830A1 (en) *	2004-04-26	2005-10-27	Vikram Khetani	Methods of diminishing co-abuse potential
CA2560882A1 (en) *	2004-04-26	2005-11-03	Teva Pharmaceutical Industries Ltd.	Crystalline forms of fexofenadine hydrochloride and processes for their preparation
US7498345B2 (en)	2004-09-17	2009-03-03	Albany Molecular Research, Inc.	Process for production of piperidine derivatives
US7498443B2 (en)	2004-09-17	2009-03-03	Albany Molecular Research, Inc.	Process for production of carebastine
JP2008514641A (ja) *	2004-09-28	2008-05-08	テバファーマシューティカルインダストリーズリミティド	結晶形フェキソフェナジン、およびその調製方法
JP2008523097A (ja) *	2004-12-09	2008-07-03	セルジーン・コーポレーション	Ｄ−トレオメチルフェニデートを用いた治療
NZ568694A (en)	2005-11-09	2011-09-30	Zalicus Inc	Method, compositions, and kits for the treatment of medical conditions
EP2139325B1 (de) *	2007-04-13	2015-01-14	Southern Research Institute	Bithionol als Anti-Angiogenese-Mittel
US20090076080A1 (en) *	2007-09-19	2009-03-19	Protia, Llc	Deuterium-enriched fexofenadine
WO2014052836A2 (en)	2012-09-27	2014-04-03	Dunman Paul M	Methods and compositions for treating infection
EP3273952B1 (de)	2015-03-26	2022-06-15	Sen-Jam Pharmaceutical LLC	Kombination von naproxen und fexofenadine zur hemmung von symptomen im zusammenhang mit veisalgia
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ATE363283T1 (de)	1992-08-03	2007-06-15	Sepracor Inc	Terfenadin-carboxylat und die behandlung von hautreizung
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1993
- 1993-08-03 AT AT02006356T patent/ATE363283T1/de active
- 1993-08-03 DE DE69334008T patent/DE69334008T2/de not_active Expired - Lifetime
- 1993-08-03 EP EP93918584A patent/EP0701443B2/de not_active Expired - Lifetime
- 1993-08-03 AT AT93918584T patent/ATE162399T1/de active
- 1993-08-03 SK SK124-95A patent/SK12495A3/sk unknown
- 1993-08-03 AU AU47986/93A patent/AU675240B2/en not_active Expired
- 1993-08-03 DK DK02006356T patent/DK1214937T3/da active
- 1993-08-03 WO PCT/US1993/007260 patent/WO1994003170A1/en active IP Right Grant
- 1993-08-03 EP EP06114048A patent/EP1688142A1/de not_active Withdrawn
- 1993-08-03 RU RU95107881/14A patent/RU2167657C2/ru active
- 1993-08-03 RO RO95-00160A patent/RO116043B1/ro unknown
- 1993-08-03 BR BR9306841A patent/BR9306841A/pt not_active Application Discontinuation
- 1993-08-03 ES ES97104837T patent/ES2257757T3/es not_active Expired - Lifetime
- 1993-08-03 HU HU9500313A patent/HU226242B1/hu unknown
- 1993-08-03 DE DE0701443T patent/DE701443T1/de active Pending
- 1993-08-03 AT AT97104837T patent/ATE322899T1/de active
- 1993-08-03 DE DE69316660T patent/DE69316660T3/de not_active Expired - Lifetime
- 1993-08-03 EP EP02006356A patent/EP1214937B1/de not_active Revoked
- 1993-08-03 EP EP97104837A patent/EP0815860B1/de not_active Revoked
- 1993-08-03 DE DE9320925U patent/DE9320925U1/de not_active Expired - Lifetime
- 1993-08-03 CA CA002141572A patent/CA2141572C/en not_active Expired - Lifetime
- 1993-08-03 PL PL93307339A patent/PL174373B1/pl unknown
- 1993-08-03 JP JP6505499A patent/JP3041954B2/ja not_active Expired - Lifetime
- 1993-08-03 PT PT97104837T patent/PT815860E/pt unknown
- 1993-08-03 GB GB9502183A patent/GB2284351B/en not_active Revoked
- 1993-08-03 PT PT02006356T patent/PT1214937E/pt unknown
- 1993-08-03 KR KR1019950700382A patent/KR950702420A/ko not_active Application Discontinuation
- 1993-08-03 DK DK93918584T patent/DK0701443T4/da active
- 1993-08-03 ES ES02006356T patent/ES2284740T3/es not_active Expired - Lifetime
- 1993-08-03 DE DE69334145T patent/DE69334145T2/de not_active Expired - Lifetime
- 1993-08-03 ES ES93918584T patent/ES2086270T5/es not_active Expired - Lifetime
- 1993-08-03 DK DK97104837T patent/DK0815860T3/da active
1994
- 1994-02-02 US US08/191,061 patent/US5375693A/en not_active Expired - Lifetime
1995
- 1995-02-01 NO NO19950374A patent/NO310644B1/no not_active IP Right Cessation
- 1995-02-02 FI FI950467A patent/FI950467A/fi unknown
- 1995-02-03 CZ CZ95274A patent/CZ27495A3/cs unknown
1996
- 1996-05-31 GR GR960300024T patent/GR960300024T1/el unknown
- 1996-11-19 AU AU71822/96A patent/AU7182296A/en not_active Abandoned
1998
- 1998-04-03 GR GR980400714T patent/GR3026530T3/el unknown
1999
- 1999-02-25 AU AU18429/99A patent/AU1842999A/en not_active Abandoned
- 1999-10-13 JP JP29122399A patent/JP3288661B2/ja not_active Expired - Lifetime
- 1999-10-13 JP JP29122099A patent/JP3288660B2/ja not_active Expired - Lifetime
- 1999-10-13 JP JP29122899A patent/JP3288662B2/ja not_active Expired - Lifetime
- 1999-10-13 JP JP11291230A patent/JP3037697B2/ja not_active Expired - Lifetime
- 1999-10-13 JP JP11291216A patent/JP2000086512A/ja active Pending
2001
- 2001-02-14 GR GR20010400247T patent/GR3035417T3/el unknown
2002
- 2002-08-17 HK HK02106014.7A patent/HK1045806B/zh not_active IP Right Cessation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19913862A1 (de) *	1999-03-26	2000-10-05	Forschungszentrum Juelich Gmbh	Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen
DE19913862C2 (de) *	1999-03-26	2003-04-10	Forschungszentrum Juelich Gmbh	Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen

Also Published As

Publication number	Publication date
DE69316660T3 (de)	2001-04-05
EP1214937B1 (de)	2007-05-30
DE701443T1 (de)	1997-01-30
JP3041954B2 (ja)	2000-05-15
GR3035417T3 (en)	2001-05-31
US5375693A (en)	1994-12-27
RU95107881A (ru)	1996-11-27
ATE363283T1 (de)	2007-06-15
EP0701443B1 (de)	1998-01-21
JP3288660B2 (ja)	2002-06-04
DK0701443T4 (da)	2000-12-18
JP2000086516A (ja)	2000-03-28
JP2000086513A (ja)	2000-03-28
HK1045806B (zh)	2008-03-14
CZ27495A3 (en)	1996-09-11
EP1214937A3 (de)	2002-10-30
EP0701443B2 (de)	2000-11-22
JP3288661B2 (ja)	2002-06-04
DK0815860T3 (da)	2006-08-14
FI950467A (fi)	1995-03-31
CA2141572A1 (en)	1994-02-17
EP1214937A2 (de)	2002-06-19
GR3026530T3 (en)	1998-07-31
GB9502183D0 (en)	1995-03-22
EP0815860A2 (de)	1998-01-07
GB2284351B (en)	1996-11-27
ES2086270T5 (es)	2001-02-01
ATE322899T1 (de)	2006-04-15
SK12495A3 (en)	1997-01-08
KR950702420A (ko)	1995-07-29
HK1045806A1 (en)	2002-12-13
AU7182296A (en)	1997-01-30
BR9306841A (pt)	1998-12-08
NO310644B1 (no)	2001-08-06
ATE162399T1 (de)	1998-02-15
WO1994003170A1 (en)	1994-02-17
ES2086270T1 (es)	1996-07-01
DE9320925U1 (de)	1995-08-31
PT815860E (pt)	2006-08-31
EP0815860A3 (de)	1998-01-14
RO116043B1 (ro)	2000-10-30
JPH08500348A (ja)	1996-01-16
HU9500313D0 (en)	1995-03-28
JP2000086515A (ja)	2000-03-28
HUT71889A (en)	1996-02-28
DE69334008D1 (de)	2006-05-24
JP2000086514A (ja)	2000-03-28
ES2284740T3 (es)	2007-11-16
DE69316660D1 (de)	1998-02-26
JP3037697B2 (ja)	2000-04-24
DE69334145D1 (de)	2007-07-12
GR960300024T1 (en)	1996-05-31
DE69334008T2 (de)	2006-10-19
FI950467A0 (fi)	1995-02-02
PT1214937E (pt)	2007-07-25
NO950374D0 (no)	1995-02-01
RU2167657C2 (ru)	2001-05-27
DK0701443T3 (da)	1998-02-09
AU675240B2 (en)	1997-01-30
ES2257757T3 (es)	2006-08-01
HU226242B1 (en)	2008-07-28
CA2141572C (en)	2001-02-06
JP3288662B2 (ja)	2002-06-04
EP1688142A1 (de)	2006-08-09
DK1214937T3 (da)	2007-09-17
DE69334145T2 (de)	2008-01-24
JP2000086512A (ja)	2000-03-28
ES2086270T3 (es)	1998-03-01
AU4798693A (en)	1994-03-03
NO950374L (no)	1995-03-29
PL307339A1 (en)	1995-05-15
AU1842999A (en)	1999-04-29
EP0701443A1 (de)	1996-03-20
PL174373B1 (pl)	1998-07-31
EP0815860B1 (de)	2006-04-12
GB2284351A (en)	1995-06-07

Legal Events

Date	Code	Title	Description
1998-08-06	8363	Opposition against the patent
2001-01-18	8327	Change in the person/name/address of the patent owner	Owner name: SEPRACOR INC., MARLBOROUGH, MASS., US
2001-01-25	8366	Restricted maintained after opposition proceedings