DE69316620T2 - Verbesserung für optische analyse - Google Patents

Verbesserung für optische analyse

Info

Publication number
DE69316620T2
DE69316620T2 DE69316620T DE69316620T DE69316620T2 DE 69316620 T2 DE69316620 T2 DE 69316620T2 DE 69316620 T DE69316620 T DE 69316620T DE 69316620 T DE69316620 T DE 69316620T DE 69316620 T2 DE69316620 T2 DE 69316620T2
Authority
DE
Germany
Prior art keywords
refractive index
pct
analyte
wavelength
variation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316620T
Other languages
English (en)
Other versions
DE69316620D1 (de
Inventor
Anders Hanning
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biacore AB
Original Assignee
Biacore AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore AB filed Critical Biacore AB
Application granted granted Critical
Publication of DE69316620D1 publication Critical patent/DE69316620D1/de
Publication of DE69316620T2 publication Critical patent/DE69316620T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
DE69316620T 1992-06-29 1993-06-29 Verbesserung für optische analyse Expired - Fee Related DE69316620T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9201984A SE9201984D0 (sv) 1992-06-29 1992-06-29 Improvement in optical assays
PCT/SE1993/000589 WO1994000751A1 (en) 1992-06-29 1993-06-29 Improvement in optical assays

Publications (2)

Publication Number Publication Date
DE69316620D1 DE69316620D1 (de) 1998-02-26
DE69316620T2 true DE69316620T2 (de) 1998-07-23

Family

ID=20386627

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316620T Expired - Fee Related DE69316620T2 (de) 1992-06-29 1993-06-29 Verbesserung für optische analyse

Country Status (8)

Country Link
US (1) US5641640A (de)
EP (1) EP0648328B1 (de)
JP (1) JPH07508346A (de)
AT (1) ATE162627T1 (de)
AU (1) AU4520093A (de)
DE (1) DE69316620T2 (de)
SE (1) SE9201984D0 (de)
WO (1) WO1994000751A1 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521185B1 (en) * 1995-10-23 2003-02-18 American Research Corporation Of Virginia Fluorescent probes based on the affinity of a polymer matrix for an analyte of interest
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
US6232124B1 (en) 1996-05-06 2001-05-15 Verification Technologies, Inc. Automated fingerprint methods and chemistry for product authentication and monitoring
WO1997044664A1 (en) * 1996-05-23 1997-11-27 Unilever Plc Improvements in or relating to specific binding assays
SE9602788L (sv) * 1996-07-16 1998-01-17 Anders Hanning Förbättrad refraktometrisk metod
US6165798A (en) * 1996-10-10 2000-12-26 University Of British Columbia Optical quantification of analytes in membranes
RU2198221C2 (ru) 1997-07-28 2003-02-10 Медикал Биосистемз Лтд. Способ секвенирования полинуклеотида и устройство для его осуществления
DE19741335C1 (de) * 1997-09-19 1999-06-10 Bosch Gmbh Robert Sensormembran einer Optode sowie Verfahren, Vorrichtung und deren Verwendung zur Bestimmung von Gasen in Gasgemischen
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
US6432364B1 (en) * 1998-07-06 2002-08-13 Suzuki Motor Corporation SPR sensor cell and immunoassay apparatus using the same
CN1237338C (zh) 1998-11-13 2006-01-18 莱卡微系统公司 折射计和用于定性及定量测量的方法
US6490030B1 (en) 1999-01-18 2002-12-03 Verification Technologies, Inc. Portable product authentication device
PT1192448E (pt) 1999-07-05 2007-01-31 Novartis Ag Processo para a utilização de uma plataforma de sensor
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US6512580B1 (en) 1999-10-27 2003-01-28 Verification Technologies, Inc. Method and apparatus for portable product authentication
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US20040000787A1 (en) * 2000-04-24 2004-01-01 Rakesh Vig Authentication mark for a product or product package
AU2001259033A1 (en) 2000-06-30 2002-01-14 Verification Technologies, Inc. Copy-protected optical media and method of manufacture thereof
US6638593B2 (en) 2000-06-30 2003-10-28 Verification Technologies, Inc. Copy-protected optical media and method of manufacture thereof
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US6833920B2 (en) 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7660415B2 (en) 2000-08-03 2010-02-09 Selinfreund Richard H Method and apparatus for controlling access to storage media
US6576430B1 (en) * 2000-11-20 2003-06-10 Becton, Dickinson And Company Detection of ligands by refractive surface methods
JP4173628B2 (ja) * 2000-12-14 2008-10-29 富士フイルム株式会社 表面プラズモン共鳴測定装置
WO2002078947A1 (en) * 2001-04-02 2002-10-10 Prolinx Incorporated Sensor surfaces for detecting analytes
WO2002079761A1 (en) * 2001-04-02 2002-10-10 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
US6858148B2 (en) * 2003-07-16 2005-02-22 The Regents Of The University Of California Method and apparatus for detecting chemical binding
AU2002351164A1 (en) * 2001-11-26 2003-06-10 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
US7288368B2 (en) * 2002-06-17 2007-10-30 Stephen Eliot Zweig Membrane receptor reagent and assay
US6790632B2 (en) 2002-06-17 2004-09-14 Stephen Eliot Zweig Membrane receptor reagent and assay
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
ES2368733T3 (es) * 2002-07-18 2011-11-21 Merus B.V. Producción recombinante de mezclas de anticuerpos.
US7015471B2 (en) * 2002-09-25 2006-03-21 North Carolina State University Surface plasmon resonance systems and methods having a variable charge density layer
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1639009B1 (de) 2003-05-30 2013-02-27 Merus B.V. Fab-bibliothek zur herstellung von einer mischung von antikörpern
JP4593573B2 (ja) * 2004-01-08 2010-12-08 オスモペン， リミテッド ライアビリティ カンパニー 表面プラズモン共鳴型ナノリットル浸透圧計
JP5912211B2 (ja) * 2004-01-20 2016-04-27 メルス ビー．ヴィー． 結合タンパク質の混合物
US7470549B2 (en) * 2004-05-26 2008-12-30 Fujifilm Corporation Measurement method using biosensor
DE102004033869B3 (de) * 2004-07-13 2006-03-30 Gesellschaft zur Förderung der Spektrochemie und angewandten Spektroskopie e.V. Verfahren zur Bestimmung von Oberflächenplasmonenresonanzen an zweidimensionalen Messflächen
US8249682B2 (en) * 2005-01-07 2012-08-21 Lacrisciences, Llc Device for measuring concentrations of constituents of tear sample
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
LT2460831T (lt) 2005-05-27 2016-12-12 Biogen Ma Inc. Tweak rišantys antikūnai
US20070003559A1 (en) * 2005-07-01 2007-01-04 Wyeth Methods of determining pharmacokinetics of targeted therapies
ES2336832T3 (es) 2005-07-22 2010-04-16 Five Prime Therapeutics, Inc. Composiciones y procedimientos para tratar enfermedades con proteinas de fusion de fgfr.
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
WO2007056411A2 (en) * 2005-11-08 2007-05-18 Genentech, Inc. Method of producing pan-specific antibodies
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7751052B2 (en) * 2006-12-04 2010-07-06 Electronics And Telecommunications Research Institute Surface plasmon resonance sensor capable of performing absolute calibration
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
GB2447696A (en) 2007-03-23 2008-09-24 Univ Exeter Photonic biosensor arrays
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
WO2009033056A1 (en) * 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
US8797028B2 (en) * 2007-10-25 2014-08-05 Koninklijke Philips N.V. Sensor device for target particles in a sample
WO2009081406A2 (en) * 2007-12-26 2009-07-02 Yissum, Research Development Company Of The Hebrew University Of Jerusalem Method and apparatus for monitoring processes in living cells
US20090227043A1 (en) * 2008-02-19 2009-09-10 Wei Huang Fluorescence Resonance Energy Transfer Assay Based on Modified Solid Surface
US9873957B2 (en) 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
WO2009132287A2 (en) 2008-04-24 2009-10-29 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
MX2010011679A (es) 2008-04-25 2011-05-23 Dyax Corp Anticuerpos contra el receptor fc neonatal y uso de los mismos.
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US9682372B2 (en) 2008-06-19 2017-06-20 Carterra, Inc. Tip overlay for continuous flow spotting apparatus
US8530152B2 (en) 2008-07-10 2013-09-10 Abaxis, Inc. Methods of reducing non-specific interaction in metal nanoparticle assays
US20100143349A1 (en) * 2008-08-12 2010-06-10 Wyeth Humanized anti-rage antibody
EP2349329A4 (de) 2008-10-14 2012-10-31 Dyax Corp Verwendung von igf-ii/igf-iie-bindung zur behandlung und prävention von systemischer sklerose im zusammenhang mit lungenfibrose
KR20100072528A (ko) * 2008-12-22 2010-07-01 한국전자통신연구원 바이오 칩 및 바이오 물질 검출 장치
JP2013504602A (ja) 2009-09-14 2013-02-07 ダイアックス コーポレーション 新しく設計したｈｃｃｄｒ３を含む遺伝子パッケージライブラリー
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
EP2521568B1 (de) 2010-01-06 2018-07-25 Dyax Corp. Plasmakallikreinbindende proteine
EP2577269A1 (de) 2010-05-27 2013-04-10 Episentec AB Verbessertes verfahren für sensorenmessung
CN108314733A (zh) 2010-07-16 2018-07-24 埃博灵克斯股份有限公司 修饰的单结构域抗原结合分子及其应用
WO2012141605A1 (en) 2011-02-16 2012-10-18 Centrul International De Biodinamica Systems and method for detection and quantitation of analytes using impedance analysis
MX343659B (es) 2011-06-02 2016-11-16 Dyax Corp Proteínas de unión receptoras fc.
EP2783201A1 (de) 2011-11-22 2014-10-01 Episentec AB Verfahren zur sensorkalibrierung
KR102076354B1 (ko) * 2012-02-15 2020-02-10 바이오콘 리미티드 분석물의 검출 및 선택적인 정량화를 위한 공정
EA202090591A3 (ru) 2012-04-20 2020-12-30 Мерюс Н.В. СПОСОБЫ И СРЕДСТВА ДЛЯ ПОЛУЧЕНИЯ Ig-ПОДОБНЫХ МОЛЕКУЛ
US10300450B2 (en) 2012-09-14 2019-05-28 Carterra, Inc. Method and device for depositing a substance on a submerged surface
LT2928923T (lt) 2012-12-10 2020-02-25 Biogen Ma Inc. Anti-kraujo dendritinių ląstelių antigeno 2 antikūnai ir jų panaudojimas
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
AU2014236986A1 (en) 2013-03-15 2015-09-03 Biogen Ma Inc. Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies
WO2015028571A1 (en) 2013-08-29 2015-03-05 Episentec Ab Improved method of sensor measurement
EP2863332A1 (de) 2013-10-15 2015-04-22 One Drop Diagnostics Sàrl System und Verfahren zur Steuerung des Zugriffs auf analytische Ergebnisse eines diagnostischen Test-Assays
WO2015057939A1 (en) 2013-10-18 2015-04-23 Biogen Idec Ma Inc. Anti-s1p4 antibodies and uses thereof
EP3071946B1 (de) 2013-11-19 2022-04-06 Cytiva Sweden AB Verfahren zur bestimmung von wechselwirkungskinetiken mit schneller dissoziation
EP3083052B1 (de) 2013-12-19 2019-09-25 GE Healthcare Bio-Sciences AB Laminierte mikrofluidische vorrichtung mit membranventilen
US9682396B2 (en) 2014-03-24 2017-06-20 Carterra, Inc. Dual flow cell fluid delivery systems
WO2015197500A1 (en) 2014-06-24 2015-12-30 Ge Healthcare Bio-Sciences Ab Normalization of mass transport properties on optical sensor surfaces
JP6789595B2 (ja) 2014-10-30 2020-11-25 サイティバ・スウェーデン・アクチボラグ 溶媒補正曲線を測定する方法
WO2017117218A1 (en) 2015-12-30 2017-07-06 Momenta Pharmaceuticals, Inc. Methods related to biologics
WO2017189483A1 (en) 2016-04-25 2017-11-02 The Johns Hopkins University Znt8 assays for drug development and pharmaceutical compositions
WO2018022479A1 (en) 2016-07-25 2018-02-01 Biogen Ma Inc. Anti-hspa5 (grp78) antibodies and uses thereof
CN106199803B (zh) * 2016-07-25 2018-11-06 镇江爱豪科思电子科技有限公司 一种温度探测用宽带红外滤光片及其制备方法
WO2018049219A1 (en) 2016-09-08 2018-03-15 Regenerative Research Foundation Bi-functional anti-tau polypeptides and use thereof
US20200095301A1 (en) 2016-12-14 2020-03-26 The Board Of Trustees Of The Leland Stanford Junior University Il-13 superkine: immune cell targeting constructs and methods of use thereof
TWI659750B (zh) 2017-01-13 2019-05-21 中央研究院 用以治療心肌梗塞之可重複裝載之改良水膠系統
WO2018130661A1 (en) 2017-01-13 2018-07-19 Academia Sinica Reloadable hydrogel system for treating brain conditions
EP3652540A4 (de) 2017-07-12 2021-04-07 The Johns Hopkins University Auf proteoliposom basierendes znt-8-selbstantigen zur diagnose von typ-1-diabetes
CN112533943B (zh) 2018-06-01 2024-03-05 利兰斯坦福初级大学董事会 Il-13/il-4超级因子：免疫细胞靶向性构建体及其使用方法
EP3837286A4 (de) 2018-08-16 2022-08-10 The Johns Hopkins University Antikörper gegen humanen znt8
US11474109B2 (en) 2018-11-16 2022-10-18 Scintimetrics, Inc. Compositions and methods for controllably merging emulsion droplets and sample analysis
AU2020272766A1 (en) 2019-04-08 2021-11-18 Biogen Ma Inc. Anti-integrin antibodies and uses thereof
CN115605229A (zh) 2020-04-24 2023-01-13 米伦纽姆医药公司（Us） 抗cd19抗体及其用途
AU2021340793A1 (en) 2020-09-14 2023-05-11 Vor Biopharma Inc. Single domain antibodies against cd33
JP2024505790A (ja) 2020-12-18 2024-02-08 モメンタ ファーマシューティカルズ インコーポレイテッド インテグリンアルファ１１ベータ１に対する抗体
WO2022215054A1 (en) 2021-04-09 2022-10-13 Takeda Pharmaceutical Company Limited Antibodies targeting complement factor d and uses therof
WO2022232035A1 (en) 2021-04-26 2022-11-03 Millennium Pharmaceuticals, Inc. Anti-adgre2 antibodies and uses thereof
IL307939A (en) 2021-04-26 2023-12-01 Millennium Pharm Inc Anti-CLEC12A antibodies and uses thereof
GB202107754D0 (en) 2021-05-31 2021-07-14 Univ Newcastle Screening for the effects of complement protein changes
TW202330612A (zh) 2021-10-20 2023-08-01 日商武田藥品工業股份有限公司 靶向ｂｃｍａ之組合物及其使用方法
WO2023201238A1 (en) 2022-04-11 2023-10-19 Vor Biopharma Inc. Binding agents and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954435A (en) * 1987-01-12 1990-09-04 Becton, Dickinson And Company Indirect colorimetric detection of an analyte in a sample using ratio of light signals
IL85137A (en) * 1987-01-21 1992-02-16 Ares Serono Res & Dev Ltd Method of assaying for a ligand using surface plasmon resonance effect
GB8801807D0 (en) * 1988-01-27 1988-02-24 Amersham Int Plc Biological sensors
DE68907519T2 (de) * 1988-05-10 1993-10-21 Amersham Int Plc Biosensoren.
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
GB8906776D0 (en) * 1989-03-23 1989-05-10 Amersham Int Plc Assay method using surface plasmon resonance spectrometry
SE9200917D0 (sv) * 1991-08-20 1992-03-25 Pharmacia Biosensor Ab Assay method

Also Published As

Publication number Publication date
EP0648328A1 (de) 1995-04-19
EP0648328B1 (de) 1998-01-21
AU4520093A (en) 1994-01-24
ATE162627T1 (de) 1998-02-15
WO1994000751A1 (en) 1994-01-06
SE9201984D0 (sv) 1992-06-29
DE69316620D1 (de) 1998-02-26
US5641640A (en) 1997-06-24
JPH07508346A (ja) 1995-09-14

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