DE69309047D1 - Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren - Google Patents

Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren

Info

Publication number
DE69309047D1
DE69309047D1 DE69309047T DE69309047T DE69309047D1 DE 69309047 D1 DE69309047 D1 DE 69309047D1 DE 69309047 T DE69309047 T DE 69309047T DE 69309047 T DE69309047 T DE 69309047T DE 69309047 D1 DE69309047 D1 DE 69309047D1
Authority
DE
Germany
Prior art keywords
alkyl
phenyl
inhibitors
group
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69309047T
Other languages
English (en)
Other versions
DE69309047T2 (de
Inventor
Michael Crimmin
William Galloway
Andrew Gearing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929207759A external-priority patent/GB9207759D0/en
Priority claimed from GB929226337A external-priority patent/GB9226337D0/en
Priority claimed from GB939300701A external-priority patent/GB9300701D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of DE69309047D1 publication Critical patent/DE69309047D1/de
Application granted granted Critical
Publication of DE69309047T2 publication Critical patent/DE69309047T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
DE69309047T 1992-04-07 1993-04-05 Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren Expired - Fee Related DE69309047T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929207759A GB9207759D0 (en) 1992-04-07 1992-04-07 Compounds
GB929226337A GB9226337D0 (en) 1992-12-17 1992-12-17 Inhibition of cytokine production
GB939300701A GB9300701D0 (en) 1993-01-15 1993-01-15 Inhibition of cytokine production
PCT/GB1993/000706 WO1993020047A1 (en) 1992-04-07 1993-04-05 Hydroxamic acid based collagenase and cytokine inhibitors

Publications (2)

Publication Number Publication Date
DE69309047D1 true DE69309047D1 (de) 1997-04-24
DE69309047T2 DE69309047T2 (de) 1997-09-11

Family

ID=27266136

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69309047T Expired - Fee Related DE69309047T2 (de) 1992-04-07 1993-04-05 Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren

Country Status (7)

Country Link
US (1) US5525629A (de)
EP (1) EP0634998B1 (de)
JP (1) JP3348725B2 (de)
AT (1) ATE150452T1 (de)
AU (1) AU3899193A (de)
DE (1) DE69309047T2 (de)
WO (1) WO1993020047A1 (de)

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US5665777A (en) * 1995-11-14 1997-09-09 Abbott Laboratories Biphenyl hydroxamate inhibitors of matrix metalloproteinases
KR19990067687A (ko) * 1995-11-22 1999-08-25 마르크 젠너 이미다졸 치환체를 갖는 메캅토알킬펩티딜 화합물 및 매트릭스금속단백질 가수분해 효소의 억제제 및/또는 종양 괴사 인자로서의 용도
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GB9715962D0 (en) * 1996-08-23 1997-10-01 Zeneca Ltd Sulfonamides
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DE69716619T2 (de) * 1996-08-28 2003-06-26 Procter & Gamble Phosphinsäureamide als matrix metalloprotease inhibitoren
RU2203274C2 (ru) * 1996-08-28 2003-04-27 Дзе Проктер Энд Гэмбл Компани Спироциклические ингибиторы металлопротеаз
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US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
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US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
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Also Published As

Publication number Publication date
JP3348725B2 (ja) 2002-11-20
JPH07505387A (ja) 1995-06-15
AU3899193A (en) 1993-11-08
WO1993020047A1 (en) 1993-10-14
EP0634998A1 (de) 1995-01-25
ATE150452T1 (de) 1997-04-15
US5525629A (en) 1996-06-11
DE69309047T2 (de) 1997-09-11
EP0634998B1 (de) 1997-03-19

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