DE69305947T2 - Vorrichtung und Methode zur Affinitätstrennung - Google Patents

Vorrichtung und Methode zur Affinitätstrennung

Info

Publication number
DE69305947T2
DE69305947T2 DE69305947T DE69305947T DE69305947T2 DE 69305947 T2 DE69305947 T2 DE 69305947T2 DE 69305947 T DE69305947 T DE 69305947T DE 69305947 T DE69305947 T DE 69305947T DE 69305947 T2 DE69305947 T2 DE 69305947T2
Authority
DE
Germany
Prior art keywords
affinity separation
affinity
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69305947T
Other languages
English (en)
Other versions
DE69305947D1 (de
Inventor
Margaret Patricia Raybuck
Michael Kenneth Kenrick
David Alun Parry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Amersham International PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham International PLC filed Critical Amersham International PLC
Publication of DE69305947D1 publication Critical patent/DE69305947D1/de
Application granted granted Critical
Publication of DE69305947T2 publication Critical patent/DE69305947T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/64—In a syringe, pipette, e.g. tip or in a tube, e.g. test-tube or u-shape tube
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/524—Physical parameters structural properties
    • G01N2030/527—Physical parameters structural properties sorbent material in form of a membrane
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes
    • G01N2035/0434—Sample carriers adapted for special purposes in the form of a syringe or pipette tip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1053—General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1055—General features of the devices using the transfer device for another function for immobilising reagents, e.g. dried reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
DE69305947T 1992-09-18 1993-09-10 Vorrichtung und Methode zur Affinitätstrennung Expired - Fee Related DE69305947T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92308536 1992-09-18

Publications (2)

Publication Number Publication Date
DE69305947D1 DE69305947D1 (de) 1996-12-19
DE69305947T2 true DE69305947T2 (de) 1997-03-13

Family

ID=8211490

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69305947T Expired - Fee Related DE69305947T2 (de) 1992-09-18 1993-09-10 Vorrichtung und Methode zur Affinitätstrennung

Country Status (4)

Country Link
US (2) US5556598A (de)
JP (1) JPH06315603A (de)
CA (1) CA2105962A1 (de)
DE (1) DE69305947T2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006018332B4 (de) 2006-04-19 2023-07-13 Mykhaylo Ponizovskiy Verfahren und Vorrichtung zur Fraktionierung von Blutzellen

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2105962A1 (en) * 1992-09-18 1994-03-19 Margaret Patricia Raybuck Device and method for affinity separation
DE69634794T2 (de) * 1995-03-20 2006-04-27 PRECISION SYSTEM SCIENCE Co., Ltd., Matsudo Verfahren und gerät für die flüssigkeitsbehandlung mittels eines verteilers
WO1996037777A1 (en) * 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
US20030027216A1 (en) * 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
JP3522933B2 (ja) * 1995-11-24 2004-04-26 株式会社堀場製作所 油分濃度計用フィルタ装置
US5904846A (en) * 1996-01-16 1999-05-18 Corning Costar Corporation Filter cartridge having track etched membranes and methods of making same
US6117394A (en) * 1996-04-10 2000-09-12 Smith; James C. Membrane filtered pipette tip
US5846486A (en) * 1996-08-09 1998-12-08 Lifescan, Inc. Hollow frustum reagent test device
US6099802A (en) * 1996-08-09 2000-08-08 Lifescan, Inc. Hollow frustum reagent test device
US5798218A (en) * 1996-09-24 1998-08-25 University Of British Columbia Innovation And Development Corporation Compositions and methods for the specific detection of thy-1 antigen
US6998047B1 (en) 1997-02-26 2006-02-14 Millipore Corporation Cast membrane structures for sample preparation
US6048457A (en) 1997-02-26 2000-04-11 Millipore Corporation Cast membrane structures for sample preparation
EP0981647B1 (de) * 1997-05-16 2006-08-09 EXACT Sciences Corporation Elektrophoretische analyse von molekülen mit immobilisierten sonden
US6045757A (en) * 1997-06-30 2000-04-04 Rainin Instrument Co., Inc. Membrane filter pipette tip
JP4025399B2 (ja) 1997-10-28 2007-12-19 株式会社日立製作所 核酸の回収方法及び装置
US6270730B1 (en) * 1998-06-16 2001-08-07 Northwest Engineering Inc. Multi-well rotary synthesizer
AU762049B2 (en) * 1998-06-19 2003-06-19 Exact Sciences Corporation Detection of non-viral organisms with SRP RNA
FI107026B (fi) * 1998-08-26 2001-05-31 Biohit Oyj Imulaitteen kärki ja menetelmä nesteen annostelemiseksi imulaitteella
US6492162B1 (en) 1998-10-27 2002-12-10 Hitachi, Ltd. Apparatus for the recovery of nucleic acids
JP2000166556A (ja) * 1998-12-10 2000-06-20 Hitachi Ltd 核酸の回収方法及び装置
EP1411340A3 (de) * 1999-02-26 2004-05-19 EXACT Sciences Corporation Biochemische Reinigungsvorrichtungen mit immobilisierten Fang-Sonden und ihre Verwendungszwecke
WO2000050644A2 (en) * 1999-02-26 2000-08-31 Mosaic Technologies Methods for purifying dna using immobilized capture probes
US6579457B1 (en) * 1999-06-29 2003-06-17 The Procter & Gamble Company Liquid transport member for high flux rates between a port region and an opening
JP3425902B2 (ja) * 1999-08-31 2003-07-14 株式会社日立製作所 検体の前処理装置
JP4346754B2 (ja) * 1999-10-26 2009-10-21 日東電工株式会社 ピペット用フィルターの製作方法
EP1251935A1 (de) 2000-01-14 2002-10-30 Pall Corporation Gasanalysefilter
CA2398748C (en) 2000-01-31 2010-09-14 Emory University Immunological assay system and method
US20030133841A1 (en) * 2000-02-18 2003-07-17 Dagmar Weber End element for capillaries or chip channels
US20080260593A1 (en) * 2000-03-22 2008-10-23 Dewalch Norman Binz Method and apparatus for processing substances in a single container
US6471917B1 (en) * 2000-04-11 2002-10-29 Affymax, Inc. System and method for single or multiple bead distribution with an adjustable capillary
DE10024137A1 (de) * 2000-05-18 2001-11-22 Gert Schlueter Probenzylinder, insbesondere mit einer Filtriervorrichtung für die Wiedergewinnung von Zellmaterial aus Körperflüssigkeiten
US6458275B1 (en) 2000-06-05 2002-10-01 Harvard Apparatus, Inc. Multi-well equilibrium dialysis system
WO2002053256A1 (en) * 2001-01-05 2002-07-11 Pro-Chem, Inc. Devices and methods for purification
US6596240B2 (en) 2001-01-12 2003-07-22 Porex Corporation Pipette tip for easy mounting and ejecting from a pipette
WO2002082051A2 (en) * 2001-01-17 2002-10-17 Tubbs Kemmons A An integrated high throughput system for the analysis of biomolecules
EP1390466A4 (de) * 2001-04-26 2010-07-28 Pressure Biosciences Inc Mehrkammervorrichtung und ihre verwendung zur bearbeitung biologischer proben
MXPA03010209A (es) * 2001-05-09 2004-03-16 Axis Shield Asa Sistema de analisis.
US20030213740A1 (en) * 2001-06-05 2003-11-20 Andrew Creasey Multi-well equilibrium dialysis systems
US6623959B2 (en) * 2001-06-13 2003-09-23 Ethicon, Inc. Devices and methods for cell harvesting
CN1522170A (zh) * 2001-07-02 2004-08-18 健康活力研究所股份有限公司 液体试样的固体成分回收器具
JP3649160B2 (ja) * 2001-07-04 2005-05-18 ソニー株式会社 ステンシルマスク、その製造方法、該ステンシルマスクを使用した半導体デバイスの製造方法
US20030098271A1 (en) * 2001-11-26 2003-05-29 Ralph Somack Capsule and tray systems for combined sample collection, archiving, purification, and PCR
WO2003104814A2 (en) * 2002-01-01 2003-12-18 Phynexus, Inc. Biomolecule open channel solid phase extraction systems and methods
US8007745B2 (en) * 2002-05-24 2011-08-30 Millipore Corporation Anti-clogging device and method for in-gel digestion applications
US7879621B2 (en) * 2003-05-08 2011-02-01 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7122640B2 (en) * 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7151167B2 (en) * 2002-06-10 2006-12-19 Phynexus, Inc. Open channel solid phase extraction systems and methods
US20040142488A1 (en) * 2002-07-15 2004-07-22 Gierde Douglas T. Method and device for extracting an analyte
ATE529188T1 (de) 2002-07-15 2011-11-15 Phynexus Inc Extraktionskolonnenvorrichtung
WO2004037850A2 (en) * 2002-10-22 2004-05-06 Millipore Corporation Multi-sided immersion formation of composite structures and method
US7799526B2 (en) * 2002-11-21 2010-09-21 The University Of North Carolina At Chapel Hill Phosphoprotein detection reagent and methods of making and using the same
WO2004065543A2 (en) * 2003-01-16 2004-08-05 Exact Sciences Corporation Devices and method for recovery of a target molecule from a sample
US20040241721A1 (en) * 2003-05-08 2004-12-02 Gjerde Douglas T. Open channel solid phase extraction systems and methods
US7595026B2 (en) * 2003-05-29 2009-09-29 Varian, Inc. Solid phase extraction pipette
EP1631668A1 (de) * 2003-06-06 2006-03-08 Applera Corporation Gerät und methode zur reinigung von ribonukleinsäure in grossen volumen
US7722820B2 (en) * 2004-11-19 2010-05-25 Phynexus, Inc. Method and device for sample preparation
US7943393B2 (en) * 2003-07-14 2011-05-17 Phynexus, Inc. Method and device for extracting an analyte
US9114383B2 (en) 2003-07-14 2015-08-25 Phynexus, Inc. Method and device for extracting an analyte
US8377715B2 (en) * 2003-07-14 2013-02-19 Phynexus, Inc. Method and device for sample preparation
US20050019951A1 (en) * 2003-07-14 2005-01-27 Gjerde Douglas T. Method and device for extracting an analyte
US20050026175A1 (en) * 2003-07-31 2005-02-03 John Link Devices and methods for isolating RNA
US20070017870A1 (en) 2003-09-30 2007-01-25 Belov Yuri P Multicapillary device for sample preparation
WO2005054844A1 (ja) * 2003-12-04 2005-06-16 Olympus Corporation 反応容器およびそれを利用する反応装置および検出装置および反応容器の作製方法
US20050258097A1 (en) * 2004-01-08 2005-11-24 Gjerde Douglas T Method and device for extracting an analyte
AU2005211907A1 (en) * 2004-02-11 2005-08-25 Pamgene B.V. A device for analysing an interaction between target and probe molecules
US7378054B2 (en) * 2004-04-16 2008-05-27 Savvipharm Inc Specimen collecting, processing and analytical assembly
US7687032B2 (en) * 2004-05-06 2010-03-30 Cytyc Corporation Filter assembly for molecular testing
US20050254995A1 (en) * 2004-05-12 2005-11-17 Harvard Apparatus, Inc. Devices and methods to immobilize analytes of interest
CA2575077A1 (en) * 2004-07-23 2006-02-02 Biosystem Development, Llc Immunoassay assembly and methods of use
US20060099112A1 (en) * 2004-11-05 2006-05-11 Fitzco, Incorporated Biospecimen handling apparatus and method
US20060118491A1 (en) * 2004-12-03 2006-06-08 Gjerde Douglas T Method and device for desalting an analyte
JP4936901B2 (ja) * 2005-01-07 2012-05-23 ユニバーサル・バイオ・リサーチ株式会社 担体封入チップ、担体処理装置、および担体処理方法
US20060198765A1 (en) * 2005-03-03 2006-09-07 Gjerde Douglas T Method and device for sample preparation
US20060202922A1 (en) * 2005-03-10 2006-09-14 Hanna Christopher P Method for optimizing a purification procedure
US20060223073A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
US20060223072A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
US20070196833A1 (en) * 2005-04-21 2007-08-23 Gjerde Douglas T Open channel solid phase extraction systems and methods
JP3805352B1 (ja) * 2005-05-25 2006-08-02 株式会社エンプラス 流体取扱装置およびそれに用いる流体取扱ユニット
US20060270843A1 (en) * 2005-05-26 2006-11-30 Hall Gerald E Jr Methods for isolation of nucleic acids
US20070003449A1 (en) * 2005-06-10 2007-01-04 Mehdi Hatamian Valve for facilitating and maintaining fluid separation
GB0522193D0 (en) 2005-10-31 2005-12-07 Axis Shield Asa Method
US7794664B2 (en) * 2006-11-16 2010-09-14 Idexx Laboratories, Inc. Pipette tip
US8012349B2 (en) 2006-11-20 2011-09-06 Orbital Biosciences, Llc Small volume unitary molded filters and supports for adsorbent beds
EP2125224A4 (de) * 2007-02-21 2014-07-09 William Brewer Pipettenspitzen für extraktion, probenentnahe und probenreinigung sowie verfahren zu ihrer verwendung
US20080259722A1 (en) * 2007-04-23 2008-10-23 Sanford Samuel A Blender for production of scented materials
US7759112B2 (en) * 2007-10-31 2010-07-20 Akonni Biosystems, Inc. Apparatus, system, and method for purifying nucleic acids
US20090111193A1 (en) * 2007-10-31 2009-04-30 Cooney Christopher G Sample preparation device
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
US10125388B2 (en) 2007-10-31 2018-11-13 Akonni Biosystems, Inc. Integrated sample processing system
US8906700B2 (en) * 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
WO2009106760A2 (fr) * 2008-01-09 2009-09-03 Metagenex Dispositif et procédé pour isoler et cultiver des cellules vivantes sur filtre ou extraire leur matériel génétique
US20110107855A1 (en) * 2008-03-28 2011-05-12 Pelican Group Holdings, Inc. Sample preparation devices and methods for processing analytes
US8202495B1 (en) * 2008-06-23 2012-06-19 Smith James C Ergonomic pipette tip
US8011468B2 (en) * 2008-08-04 2011-09-06 Caterpillar Inc. Machine and pneumatic seat assembly having air container with integral air compressor housing
US8419939B2 (en) * 2008-08-25 2013-04-16 Ashok Kumar Shukla Micro dialyzer
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
JP4993632B2 (ja) * 2009-06-16 2012-08-08 朝日インテック株式会社 医療用ガイドワイヤ
JP5330144B2 (ja) * 2009-07-31 2013-10-30 花王株式会社 微量固体試料分析器具
CN102472692B (zh) * 2009-08-10 2015-01-07 株式会社日立高新技术 试样处理系统
US8999273B2 (en) * 2010-08-02 2015-04-07 Microscopy Innovations, Llc Methods and devices for preparing microscopy samples
KR101254675B1 (ko) 2010-10-25 2013-04-15 주식회사 싸이토젠 세포 채집 장치
WO2012083150A2 (en) * 2010-12-17 2012-06-21 Biomerieux, Inc. Methods for the isolation, accumulation characterization and/or identification of microorganisms using a filtration and sample transfer device
US11274292B2 (en) 2011-03-29 2022-03-15 Phynexus, Inc. Devices and methods for plasmid purification
EP3434759A1 (de) 2011-07-22 2019-01-30 bioMerieux, Inc. Verfahren und kit zur isolierung von mikroorganismen aus einer kultur
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
ITBO20110766A1 (it) * 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
JP5963159B2 (ja) * 2012-01-05 2016-08-03 日立化成株式会社 細胞捕捉デバイス
WO2013108292A1 (ja) * 2012-01-19 2013-07-25 ヤマハ発動機株式会社 吸引チップ
PT106204A (pt) * 2012-03-12 2013-09-12 Inst Politecnico De Leiria Ponta de pipetadora estanque para centrífuga
DE102012009088B4 (de) * 2012-05-09 2016-04-28 Forschungszentrum Jülich GmbH Vorrichtung und Verfahren zur Zellseparation
JP6207815B2 (ja) * 2012-06-29 2017-10-04 株式会社日立ハイテクノロジーズ フィルタリング部材及びフィルタリング方法
JP2014098661A (ja) * 2012-11-15 2014-05-29 Olympus Corp 標本作製デバイス
FR3005163A1 (fr) * 2013-04-24 2014-10-31 Biomerieux Sa Dispositif de filtration et concentration automatique de microorganismes.
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
WO2016112253A1 (en) * 2015-01-09 2016-07-14 Children's Medical Center Corporation Methods of membrane-based proteomic sample preparation
EP3261763B1 (de) 2015-02-24 2019-03-27 Porex Corporation Mit memmbran beschichtetes gesintertes und poröses medium für probenentnahme
SG11201707461YA (en) 2015-03-17 2017-10-30 Mbs Co Ltd Sample collection and separation device
US20160318014A1 (en) * 2015-05-01 2016-11-03 Molecular Bioproducts, Inc. Thin walled pipette tip
USD782693S1 (en) 2016-01-14 2017-03-28 DPX Technologies, LLC Dispersive insert for pipette tips
JP6562154B2 (ja) 2016-08-10 2019-08-21 株式会社村田製作所 濾過フィルタデバイス
US10329554B2 (en) * 2016-11-07 2019-06-25 Wavesense, Inc. System and method for sequestering substances in bulk liquids
CN107338184A (zh) * 2017-08-02 2017-11-10 苏州博福生物医药科技有限公司 一种用于捕获细胞或溶液中生物分子的捕获筛及装置
US20190134634A1 (en) * 2017-08-09 2019-05-09 Shazi Iqbal Reagent Storage Device for Storing a Target-Specific Reagent
US20210041473A1 (en) * 2018-03-30 2021-02-11 Porex Corporation Robotic Liquid Handling System with On-Site, On-Demand Porous Filter Functional Media Assembly Capability for Disposable Liquid Handling Devices
JP6878726B2 (ja) * 2018-10-16 2021-06-02 防衛装備庁長官 試料前処理器具及び該器具を用いた試料前処理方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014653A (en) * 1974-12-26 1977-03-29 Denver Chemical Manufacturing Company Micro-filter
US3985032A (en) * 1975-11-13 1976-10-12 Centaur Chemical Co. Micropipette filter tips
US4059020A (en) * 1976-09-09 1977-11-22 Centaur Chemical Co. Filter for micropipettes
US4267729A (en) * 1979-05-14 1981-05-19 Eddelman Roy T Volumetric pipettor
SE458643B (sv) * 1984-12-07 1989-04-17 Pharmacia Ab Anordning med kolonnelement uppdelat i provparti och referenspatri
FR2580074A1 (en) * 1985-04-04 1986-10-10 Probiotec Single-use device for immobilising molecules contained in particular in a liquid with a view to their metering
US4753775A (en) * 1985-04-12 1988-06-28 E. I. Du Pont De Nemours And Company Rapid assay processor
US4795562A (en) * 1985-09-13 1989-01-03 Walsh James W Membrane batch-processing apparatus
US4774058A (en) * 1985-09-26 1988-09-27 Mehl Ehrenfried L Apparatus for, and methods of, operating upon a fluid
DE3635598A1 (de) * 1986-10-20 1988-05-05 Eppendorf Geraetebau Netheler Pipettiervorrichtung mit einem aufsteckkonus fuer eine pipettenspitze sowie pipettenspitze fuer eine solche pipettiervorrichtung
US4787971A (en) * 1987-01-23 1988-11-29 Alan Donald Miniaturized column chromatography separation apparatus and method of assaying biomolecules employing the same
US4797260A (en) * 1987-01-27 1989-01-10 V-Tech, Inc. Antibody testing system
DE3717211A1 (de) * 1987-05-22 1988-12-01 Diagen Inst Molekularbio Vorrichtung und verfahren zur trennung und reinigung von molekuelen
US4886836A (en) * 1987-06-03 1989-12-12 Pall Corporation Activated medium with low non-specific protein adsorption
US5219529A (en) * 1987-07-07 1993-06-15 Unisyn Technologies, Inc. Cartridge assembly
AU2303588A (en) * 1987-08-27 1989-03-31 Polyfiltronics Limited Filter units for biological sample preparation
US4874691A (en) * 1987-10-16 1989-10-17 Quadra Logic Technologies Inc. Membrane-supported immunoassays
NL8800796A (nl) * 1988-03-29 1989-10-16 X Flow Bv Werkwijze voor de chemische analyse van bestanddelen van een lichaamsvloeistof, alsmede een testinrichting en testpakket voor een dergelijke analyse.
US4933148A (en) * 1988-08-04 1990-06-12 Brandeis University Pipetter barrel extension tube
US5108704A (en) * 1988-09-16 1992-04-28 W. R. Grace & Co.-Conn. Microfiltration apparatus with radially spaced nozzles
US5043082A (en) * 1988-12-15 1991-08-27 Hermann Jr William J Collection device and method of use thereof for the concentration, transport and processing of cellular components to determine the presence or absence of biomarkers
US5079170A (en) * 1989-05-18 1992-01-07 Quidel Corporation Method of sample transfer using a filter applicator
US5124041A (en) * 1989-07-28 1992-06-23 Applied Biosystems, Inc. Biomolecule sample immobilization
US5143627A (en) * 1990-07-09 1992-09-01 Cytyc Corporation Method and apparatus for preparing cells for examination
US5156811A (en) * 1990-11-07 1992-10-20 Continental Laboratory Products, Inc. Pipette device
US5171537A (en) * 1991-05-06 1992-12-15 Richard E. MacDonald Activated immunodiagnostic pipette tips
CA2105962A1 (en) * 1992-09-18 1994-03-19 Margaret Patricia Raybuck Device and method for affinity separation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006018332B4 (de) 2006-04-19 2023-07-13 Mykhaylo Ponizovskiy Verfahren und Vorrichtung zur Fraktionierung von Blutzellen

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US5833927A (en) 1998-11-10

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