DE69304065T2 - Herstellung und verwendung von, auf basis von cyclodextrin dispergierbaren kolloidal-systemen, in form von nanokugeln - Google Patents

Herstellung und verwendung von, auf basis von cyclodextrin dispergierbaren kolloidal-systemen, in form von nanokugeln

Info

Publication number
DE69304065T2
DE69304065T2 DE69304065T DE69304065T DE69304065T2 DE 69304065 T2 DE69304065 T2 DE 69304065T2 DE 69304065 T DE69304065 T DE 69304065T DE 69304065 T DE69304065 T DE 69304065T DE 69304065 T2 DE69304065 T2 DE 69304065T2
Authority
DE
Germany
Prior art keywords
pct
cyclodextrin
dispersable
production
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69304065T
Other languages
English (en)
Other versions
DE69304065D1 (de
Inventor
Mohamed Skiba
Denis Wouessidjewe
Antony Coleman
Hatem Fessi
Jean-Philippe Devissaguet
Dominique Duchene
Francis Puisieux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE69304065D1 publication Critical patent/DE69304065D1/de
Application granted granted Critical
Publication of DE69304065T2 publication Critical patent/DE69304065T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/14—Layer or component removable to expose adhesive
    • Y10T428/1405—Capsule or particulate matter containing [e.g., sphere, flake, microballoon, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
DE69304065T 1992-06-16 1993-06-16 Herstellung und verwendung von, auf basis von cyclodextrin dispergierbaren kolloidal-systemen, in form von nanokugeln Expired - Lifetime DE69304065T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9207287A FR2692168B1 (fr) 1992-06-16 1992-06-16 Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
PCT/FR1993/000594 WO1993025195A1 (fr) 1992-06-16 1993-06-16 Preparation et utilisation de nouveaux systemes colloidaux dispersibles a base de cyclodextrine, sous forme de nanospheres

Publications (2)

Publication Number Publication Date
DE69304065D1 DE69304065D1 (de) 1996-09-19
DE69304065T2 true DE69304065T2 (de) 1997-03-20

Family

ID=9430801

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69304065T Expired - Lifetime DE69304065T2 (de) 1992-06-16 1993-06-16 Herstellung und verwendung von, auf basis von cyclodextrin dispergierbaren kolloidal-systemen, in form von nanokugeln

Country Status (8)

Country Link
US (1) US5718905A (de)
EP (1) EP0646003B1 (de)
JP (1) JPH07507784A (de)
AT (1) ATE141161T1 (de)
DE (1) DE69304065T2 (de)
ES (1) ES2091012T3 (de)
FR (1) FR2692168B1 (de)
WO (1) WO1993025195A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10033990B4 (de) * 2000-05-12 2007-12-27 Engelhard Lyon S.A. Nanopartikel aus einem substituierten Cyclodextrin, dessen Verwendung und diese enthaltenden Zubereitungen

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070117862A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5576311A (en) * 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
AU695207B2 (en) * 1995-03-28 1998-08-06 Fidia Farmaceutici S.P.A. Nanospheres comprising a biocompatible polysaccharide
FR2742677B1 (fr) 1995-12-21 1998-01-16 Oreal Nanoparticules enrobees d'une phase lamellaire a base de tensioactif silicone et compositions les contenant
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
KR100789008B1 (ko) * 1997-06-27 2007-12-26 아브락시스 바이오사이언스 인크. 신규 약물 제제
SG165156A1 (en) * 1997-06-27 2010-10-28 Abraxis Bioscience Llc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
FR2775435B1 (fr) * 1998-02-27 2000-05-26 Bioalliance Pharma Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs
GB9805417D0 (en) * 1998-03-14 1998-05-06 Core Technologies Limited Production of microparticles
US6344218B1 (en) 1998-11-23 2002-02-05 The Procter & Gamble Company Skin deodorizing and santizing compositions
US6177088B1 (en) 1999-01-07 2001-01-23 Fayette Environmental Services, Inc. Surface-functionalized, probe-containing nanospheres
US6653524B2 (en) 1999-12-23 2003-11-25 Kimberly-Clark Worldwide, Inc. Nonwoven materials with time release additives
EP1287039A1 (de) * 2000-04-28 2003-03-05 University College Dublin Ampiphile makrozyklische derivate und ihre analoge
AU2001255709A1 (en) * 2000-05-11 2001-11-20 Eastman Chemical Company Acylated cyclodextrin guest inclusion complexes
DE60133550T2 (de) * 2001-09-17 2009-04-02 Nanopart-C S.A. Neue dispergierbare kolloidale Calixarene-Systeme in Form von Nanoteilchen
US7879820B2 (en) * 2002-04-22 2011-02-01 L'oreal S.A. Use of a cyclodextrin as pearlescent agent and pearlescent compositions
US20040258757A1 (en) * 2002-07-16 2004-12-23 Elan Pharma International, Ltd. Liquid dosage compositions of stable nanoparticulate active agents
WO2005044224A2 (en) * 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
SE0303179D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
WO2005102248A2 (en) * 2004-04-20 2005-11-03 Dow Corning Corporation Silicone vesicles containing actives
WO2006038552A1 (ja) * 2004-10-01 2006-04-13 Eisai R & D Management Co., Ltd. 微粒子含有組成物およびその製造方法
FR2895257A1 (fr) * 2005-12-22 2007-06-29 Oreal Actif pour le traitement du contour des yeux.
FR2898817B1 (fr) * 2006-03-23 2008-08-08 Univ Rouen Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines
US20100143373A1 (en) 2006-12-06 2010-06-10 Medimmune, Llc Methods of treating systemic lupus erythematosus
FR2910345A1 (fr) 2006-12-20 2008-06-27 Oreal Particules coeur/ecorce a base de composes silicones
EP2076590A4 (de) 2007-05-03 2011-06-01 Medimmune Llc Auto-antikörper-marker für autoimmunerkrankungen
ITMI20081056A1 (it) * 2008-06-10 2009-12-11 Sea Marconi Technologies Sas Nanospugne a base di ciclodestrine come supporto per catalizzatori biologici e nella veicolazione e rilascio di enzimi, proteine, vaccini ed anticorpi
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
US20100311838A1 (en) 2009-05-29 2010-12-09 Pipkin James D Injectable Melphalan Compositions Comprising a Cyclodextrin Derivative and Methods of Making and Using the Same
ITTO20110884A1 (it) * 2011-10-04 2013-04-05 Univ Degli Studi Torino Membrana per nanocapsula, nanocapsula comprendente la stessa e suo uso
US9598503B2 (en) 2012-04-18 2017-03-21 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US11406595B2 (en) * 2012-05-21 2022-08-09 University Of Maryland, College Park Highly stable colloid from aqueous solutions of small organic molecules
CA2879139C (en) 2012-07-18 2021-05-11 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204244L (sv) * 1982-07-09 1984-01-10 Ulf Schroder Kristalliserad kolhydratsmatris for biologiskt aktiva substanser
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10033990B4 (de) * 2000-05-12 2007-12-27 Engelhard Lyon S.A. Nanopartikel aus einem substituierten Cyclodextrin, dessen Verwendung und diese enthaltenden Zubereitungen

Also Published As

Publication number Publication date
EP0646003B1 (de) 1996-08-14
FR2692168A1 (fr) 1993-12-17
ES2091012T3 (es) 1996-10-16
DE69304065D1 (de) 1996-09-19
JPH07507784A (ja) 1995-08-31
US5718905A (en) 1998-02-17
FR2692168B1 (fr) 1995-03-24
WO1993025195A1 (fr) 1993-12-23
ATE141161T1 (de) 1996-08-15
EP0646003A1 (de) 1995-04-05

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