DE69233022D1 - Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung - Google Patents

Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung

Info

Publication number
DE69233022D1
DE69233022D1 DE69233022T DE69233022T DE69233022D1 DE 69233022 D1 DE69233022 D1 DE 69233022D1 DE 69233022 T DE69233022 T DE 69233022T DE 69233022 T DE69233022 T DE 69233022T DE 69233022 D1 DE69233022 D1 DE 69233022D1
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DE
Germany
Prior art keywords
methods
compositions
bone morphogenetic
morphogenetic protein
recombinant bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233022T
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English (en)
Other versions
DE69233022T2 (de
Inventor
David Israel
M Wolfman
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Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of DE69233022D1 publication Critical patent/DE69233022D1/de
Application granted granted Critical
Publication of DE69233022T2 publication Critical patent/DE69233022T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69233022T 1991-11-04 1992-11-02 Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung Expired - Lifetime DE69233022T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78749691A 1991-11-04 1991-11-04
US787496 1991-11-04
US86469292A 1992-04-07 1992-04-07
US864692 1992-04-07
PCT/US1992/009430 WO1993009229A1 (en) 1991-11-04 1992-11-02 Recombinant bone morphogenetic protein heterodimers, compositions and methods of use

Publications (2)

Publication Number Publication Date
DE69233022D1 true DE69233022D1 (de) 2003-05-28
DE69233022T2 DE69233022T2 (de) 2004-02-12

Family

ID=27120657

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69233022T Expired - Lifetime DE69233022T2 (de) 1991-11-04 1992-11-02 Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung

Country Status (9)

Country Link
US (5) US5866364A (de)
EP (1) EP0612348B1 (de)
JP (2) JP3504263B2 (de)
KR (1) KR100259827B1 (de)
AT (1) ATE238417T1 (de)
AU (1) AU674500B2 (de)
DE (1) DE69233022T2 (de)
MX (1) MX9206315A (de)
WO (1) WO1993009229A1 (de)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US20080070842A1 (en) * 1991-11-04 2008-03-20 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
DK0653942T3 (da) * 1992-07-31 2003-10-20 Curis Inc Morphogen-induceret nerve-regenerering og -reparation
JP3431153B2 (ja) * 1992-09-03 2003-07-28 リジエネロン・フアーマシユーテイカルズ・インコーポレーテツド 背側組織作用因子及び組成物
KR100227406B1 (ko) * 1993-05-12 1999-12-01 브루스 엠. 에이센 Bmp-11 조성물
EP0626451A3 (de) * 1993-05-27 1997-11-05 Takeda Chemical Industries, Ltd. Heterodimere einer TGF-Beta Superfamilie
AU7605394A (en) * 1993-09-03 1995-03-22 Regents Of The University Of California, The Neural tissue affecting factor and compositions
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
PT733109E (pt) * 1993-12-07 2006-07-31 Genetics Inst Llc Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
AU1734895A (en) 1994-03-08 1995-09-25 Genetics Institute Inc. Methods and compositions for treatment of periodontal disease and repair of periodontal lesions
US5906827A (en) † 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
EP0691349A3 (de) * 1994-07-04 1997-09-10 Hoechst Japan Dimere Knochenmorphogeneseproteine und ihre Fragmente und Analoge und sie enthaltende pharmazeutische Zubereitungen
US5679783A (en) * 1994-11-22 1997-10-21 The Regents Of The University Of California DNA encoding a tissue differentiation affecting factor
DK0955313T3 (da) 1995-04-19 2006-08-21 Bioph Biotech Entw Pharm Gmbh Nyt protein og fremgangsmåde til fremstilling af samme
US6638912B2 (en) 1995-05-01 2003-10-28 The Regents Of The University Of California Peptide compositions mimicking TGF-β activity
US5661127A (en) * 1995-05-01 1997-08-26 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US5780436A (en) * 1995-05-01 1998-07-14 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
ES2440441T3 (es) 1995-06-05 2014-01-29 Genetics Institute, Llc Uso de proteínas morfogenéticas óseas para cicatrización y reparación de uniones de tejido conjuntivo
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
WO1997025443A1 (en) * 1996-01-10 1997-07-17 The University Of Liverpool Metastasis inducing dna's
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
EP0883410B1 (de) * 1996-02-29 2004-08-18 Bioactive Bone Substitute OY, AB Osteogene vorrichtungen und methode zur herstellung derselben
EP1364655B1 (de) 1996-03-22 2010-12-29 Stryker Corporation Verfahren zur verbesserten funktionellen Erholung der motorischen Koordiination, der Sprache oder der Sinneswahrnehmung nach Trauma oder Ischämie des ZNS
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
EP1988395A1 (de) 1997-05-30 2008-11-05 Curis, Inc. Verfahren zur Beurteilung von Gewebemorphogenese und- aktivität
US20030036629A1 (en) * 1997-12-12 2003-02-20 Barry Foster Novel tgf-beta protein purification methods
US6211157B1 (en) 1998-05-01 2001-04-03 Sulzer Biologics, Inc. Protein mixtures to induce therapeutic angiogenesis
JP4768125B2 (ja) 1998-10-06 2011-09-07 ラッシュ プレスバイテリアン セントルークス メディカルセンター 化学的髄核分解の治療方法
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
EP1117805A2 (de) * 1998-10-07 2001-07-25 STRYKER CORPORATION (a Michigan corporation) Modifizierte proteine der tgf-beta superfamilie
US6992066B2 (en) 1998-10-16 2006-01-31 Zimmer Orthobiologics, Inc. Povidone-containing carriers for polypeptide growth factors
US7087577B2 (en) * 1998-10-16 2006-08-08 Zimmer Orthobiologies, Inc. Method of promoting natural bypass
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
DE60012557T2 (de) 1999-10-15 2005-08-04 Genetics Institute, LLC, Cambridge Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
ATE447969T1 (de) 1999-12-16 2009-11-15 Biogen Idec Inc Verfahren zur behandlung der schädigung des zentralnervensystems durch ischämie oder durch hämorrhagie mit antagonisten von alpha4 integrin
US6500205B1 (en) * 2000-04-19 2002-12-31 Gary K. Michelson Expandable threaded arcuate interbody spinal fusion implant with cylindrical configuration during insertion
US6709458B2 (en) * 2000-02-04 2004-03-23 Gary Karlin Michelson Expandable push-in arcuate interbody spinal fusion implant with tapered configuration during insertion
US6716247B2 (en) 2000-02-04 2004-04-06 Gary K. Michelson Expandable push-in interbody spinal fusion implant
EP1645248B8 (de) * 2000-02-04 2010-06-16 Warsaw Orthopedic, Inc. Ausdehnbares interspinales Fusionsimplantat mit schwenkbarem Blocker
US6814756B1 (en) 2000-02-04 2004-11-09 Gary K. Michelson Expandable threaded arcuate interbody spinal fusion implant with lordotic configuration during insertion
US20030104977A1 (en) * 2000-03-31 2003-06-05 Ugo Ripamonti Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors
US6808537B2 (en) * 2000-07-07 2004-10-26 Gary Karlin Michelson Expandable implant with interlocking walls
US6902881B2 (en) 2000-10-13 2005-06-07 President And Fellows Of Harvard College Compounds and methods for regulating cell differentiation
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
DE60201945T2 (de) 2001-02-04 2005-12-01 Michelson, Gary Karlin, Los Angeles Instrument zum Einführen und Spreiten eines Zwischenwirbelfusionsimplantats
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
DK1399023T3 (da) * 2001-06-01 2008-08-18 Wyeth Corp Sammensætninger til systemisk indgivelse af sekvenser, der koder for knoglemorfogenese-proteiner
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
FI117667B (fi) 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
US7232802B2 (en) 2001-12-21 2007-06-19 Zimmer Orthobiologics, Inc. Compositions and methods for promoting myocardial and peripheral angiogenesis
US7897174B2 (en) * 2002-02-08 2011-03-01 University Of Erlangen-Nurnberg Formulation comprising bioactive agents and method of using same
EA008354B1 (ru) * 2002-05-17 2007-04-27 Уайз Инъецируемые твердые переносчики гиалуроновой кислоты для доставки остеогенных протеинов
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
ES2282904T3 (es) * 2003-09-12 2007-10-16 Wyeth Barras solidas de fosfato calcico inyectables para el suministro de proteinas osteogenicas.
BRPI0514253A (pt) * 2004-08-12 2008-06-03 Wyeth Corp terapia de combinação para diabetes, obesidade e doenças cardiovasculares usando composições contendo inibidores de gdf-8
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7799754B2 (en) 2004-10-14 2010-09-21 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
WO2006047728A2 (en) * 2004-10-27 2006-05-04 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Bmp gene and fusion protein
US7517870B2 (en) 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
US20060166251A1 (en) * 2005-01-26 2006-07-27 Archambault Joanne M Use of sFRPs as markers of BMP activity
KR100775958B1 (ko) * 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
WO2006104306A1 (en) * 2005-03-30 2006-10-05 Jung Moon Kim Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
EP1863518A2 (de) * 2005-03-30 2007-12-12 Wyeth VERFAHREN ZUR STIMULATION DES WAARWACHSTUMS MITTELS VERABREICHUNG VON BMPs
WO2007052096A2 (en) * 2005-06-29 2007-05-10 Cameron Malcolm Lang Clokie Production of bone morphogenic proteins (bmps) in transgenic mammals
US7771995B2 (en) * 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
AU2007269712B2 (en) 2006-06-30 2013-02-07 Biomimetic Therapeutics, Llc PDGF-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US20100184659A1 (en) 2006-12-21 2010-07-22 Warren Jaworowicz Sustained-Release Formulations Comprising Crystals, Macromolecular Gels, and Particulate Suspensions of Biologic Agents
LT3345607T (lt) 2006-12-29 2023-01-10 Ossifi-Mab Llc Kaulų augimo keitimo būdai, skiriant sost arba wise antagonistą ar agonistą
WO2008144900A1 (en) * 2007-05-25 2008-12-04 Peel Sean A A method of enhancing recombinant protein production
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2019117A1 (de) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein
CA2695697A1 (en) 2007-08-07 2009-02-12 Advanced Technologies And Regenerative Medicine, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
US20090061002A1 (en) * 2007-09-05 2009-03-05 Venbrocks Rudolf A Calcium phospate based delivery of growth and differentiation factors to compromised bone
US9700584B2 (en) 2007-12-21 2017-07-11 Rti Surgical, Inc. Osteoinductive putties and methods of making and using such putties
EP2268302B1 (de) 2008-02-13 2014-04-09 Keith Hruska Bmp-7 zur behandlung von neointimaler hyperplasie
US7947649B2 (en) 2008-04-14 2011-05-24 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
CA2653866A1 (en) * 2008-07-03 2010-01-03 Induce Biologics Inc. Use of immobilized antagonists for enhancing growth factor containing bioimplant effectiveness
EP2341951A2 (de) 2008-09-09 2011-07-13 BioMimetic Therapeutics, Inc. Aus thrombozyten stammende wachstumsfaktor-zusammensetzungen und verfahren zur behandlung von sehnen- und bänderverletzungen
SG2014010680A (en) 2009-02-12 2014-04-28 Stryker Corp Peripheral administration of proteins including tgf-beta superfamily members for treatment of systemic disorders and disease
WO2010093941A2 (en) 2009-02-12 2010-08-19 Stryker Corporation COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
AU2010295509A1 (en) 2009-09-17 2012-04-19 Stryker Corporation Buffers for controlling the pH of bone morphogenetic proteins
EP2516456A1 (de) 2009-12-22 2012-10-31 Stryker Corporation Bmp-7-varianten mit reduzierter immunogenität
JP6144049B2 (ja) 2010-02-22 2017-06-07 バイオミメティック セラピューティクス，リミテッド ライアビリティ カンパニー 腱障害を処置するための血小板由来成長因子組成物及び方法
US9856305B2 (en) * 2010-08-20 2018-01-02 Wyeth Llc Designer osteogenic proteins
RU2017134806A (ru) 2011-04-11 2019-02-07 Индьюс Байолоджикс Инк. Система и способ многофазного высвобождения факторов роста
RU2014145234A (ru) 2012-04-11 2016-05-27 Индьюс Байолоджикс Инк. Система и способ для многофазного высвобождения факторов роста
WO2014012101A1 (en) 2012-07-13 2014-01-16 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
CN113416187A (zh) 2013-03-14 2021-09-21 奥斯特克有限公司 促进骨生长的烷基胺骆驼蓬碱衍生物
KR20150129717A (ko) * 2013-03-14 2015-11-20 젠자임 코포레이션 열-감수성 골 성장 조성물
CN104163865A (zh) * 2014-07-01 2014-11-26 杭州瑞固生物技术有限公司 优化的重组人骨形态发生蛋白质-2的dna序列及其编码蛋白质
KR101744763B1 (ko) * 2014-12-19 2017-06-09 (주)케어젠 Bmp 유래 펩타이드 및 이의 용도
AU2015374114B2 (en) 2014-12-29 2018-07-26 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
US10780171B2 (en) 2015-10-26 2020-09-22 President And Fellows Of Harvard College Reduced and oxidized polysaccharides and methods of use thereof
US10919948B2 (en) 2016-12-30 2021-02-16 Biogend Therapeutics Co., Ltd. Recombinant polypeptides, compositions, and methods thereof
US11596712B2 (en) 2017-10-19 2023-03-07 Genera Istrazivanja D.O.O. Autologous bone graft substitute composition
KR20210075971A (ko) 2018-08-14 2021-06-23 오스테오큐씨 인코포레이티드 플루오로 β-카볼린 화합물
KR20210075071A (ko) 2018-08-14 2021-06-22 오스테오큐씨 인코포레이티드 피롤로-디피리딘 화합물

Family Cites Families (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465357A (en) 1944-08-14 1949-03-29 Upjohn Co Therapeutic sponge and method of making
CH563767A5 (de) 1973-01-30 1975-07-15 Pheulpin Jean
US4468464A (en) 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
DE2657370C2 (de) 1976-12-17 1982-11-11 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten
DE2732848A1 (de) 1977-07-18 1979-02-08 Schering Ag Diurethane, herbizide mittel enthaltend diese verbindungen sowie verfahren zu ihrer herstellung
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4619989A (en) 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4761471A (en) * 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
PH19942A (en) 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4727028A (en) 1981-06-22 1988-02-23 Eli Lilly And Company Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4474181A (en) 1982-02-18 1984-10-02 Schenck Robert R Method and apparatus for anastomosing small blood vessels
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
EP0128041A3 (de) 1983-06-06 1986-12-03 David Jeston Baylink Polypeptide mit einer Skelettwachstumsfaktor-Wirksamkeit
US4795804A (en) 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
NZ210699A (en) 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
US4804744A (en) * 1984-01-04 1989-02-14 International Genetic Engineering, Inc. Osteogenic factors
DK518384A (da) 1984-01-31 1985-07-01 Idaho Res Found Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US4662884A (en) 1984-04-25 1987-05-05 University Of Utah Research Foundation Prostheses and methods for promoting nerve regeneration
US4596574A (en) 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
CA1341617C (en) 1984-06-08 2011-06-28 Henry George Burger Inhibin isolated from ovarian follicular fluid
US4868161A (en) 1984-06-29 1989-09-19 City Of Hope Method for promoting nerve regeneration
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
DE3588058T3 (de) * 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4843063A (en) * 1984-07-16 1989-06-27 Collagen Corporation Polypeptide cartilage-inducing factors found in bone
ATE78515T1 (de) 1984-10-05 1992-08-15 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US4769328A (en) * 1984-10-12 1988-09-06 Zymogenetics Inc. Expression of biologically active PDGF analogs in yeast
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
KR930007429B1 (ko) 1984-12-27 1993-08-10 산도리 가부시기가이샤 인터페론의 정제방법
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US4766067A (en) 1985-05-31 1988-08-23 President And Fellows Of Harvard College Gene amplification
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
NZ231899A (en) 1985-10-03 1991-07-26 Genentech Inc Human or porcine inhibin peptide compositions and dna encoding them
US4798885A (en) * 1986-02-07 1989-01-17 Genentech, Inc. Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain
US5215893A (en) 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5089396A (en) 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US4737578A (en) * 1986-02-10 1988-04-12 The Salk Institute For Biological Studies Human inhibin
DE3764144D1 (de) 1986-04-16 1990-09-13 Asta Pharma Ag Synergistische kombination von amantadin und selegilin.
US4758233A (en) 1986-04-22 1988-07-19 N.J. Phillips TPY. Limited Cream applicator
NL8601328A (nl) 1986-05-23 1987-12-16 Langen Research Inrichting voor het met een massa, in het bijzonder pasteuze massa, injekteren van vlees.
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5366875A (en) 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5108922A (en) 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5939388A (en) 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US4877864A (en) 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5543394A (en) 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5631142A (en) 1986-07-01 1997-05-20 Genetics Institute, Inc. Compositions comprising bone morphogenetic protein-2 (BMP-2)
US5459047A (en) 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5019087A (en) 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
US5124316A (en) 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
US5457092A (en) 1987-07-30 1995-10-10 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Methods of promoting bone growth in mammals comprising administration of modified parathyroid hormone
US5041538A (en) 1987-08-28 1991-08-20 The Salk Institute For Biological Studies Mammalian follistatin
US5202120A (en) 1987-09-11 1993-04-13 Case Western Reserve University Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes
US5147399A (en) 1988-02-01 1992-09-15 Dellon Arnold L Method of treating nerve defects through use of a bioabsorbable surgical device
IT1215881B (it) 1988-02-16 1990-02-22 Giancarlo Foresti Sussidio chirurgico ad azione osteotropa.
IL89869A0 (en) * 1988-04-06 1989-12-15 Collagen Corp Bone-inducing protein
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
DE68929472T2 (de) * 1988-04-08 2004-05-13 Stryker Corp., Kalamazoo Biosynthetische knochenbildende Proteine, und sie enthaltende knochenbildende Vorrichtungen
EP0408649A4 (en) * 1988-04-08 1991-11-27 Genetics Institute, Inc. Bone and cartilage inductive compositions
US5024841A (en) 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5071834A (en) 1988-09-16 1991-12-10 Genentech, Inc. Purified activin B composition
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US4955892A (en) 1988-10-24 1990-09-11 Louisiana State University Neural cell adhesion protein nerve prosthesis
US5457038A (en) 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
US5011486A (en) 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4920962A (en) 1988-11-23 1990-05-01 Claude Proulx Splint-like element for use in end-to-end nerve suture
US5217867A (en) 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
WO1990010067A1 (de) 1989-02-23 1990-09-07 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Pth-varianten kodierende dna-sequenzen, pth-varianten, expressionsvektor, bakterieller wirt, verwendung und therapeutische zusammensetzung
ATE162223T1 (de) * 1989-03-28 1998-01-15 Genetics Inst Osteoinduktive zusammensetzungen
US5026381A (en) 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
JPH03151877A (ja) 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
CA2017466A1 (en) * 1989-06-02 1990-12-02 Michael C. Kiefer Bone calcification factor
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
AU5958090A (en) 1989-06-29 1991-01-17 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
AU632160B2 (en) * 1989-08-21 1992-12-17 Celtrix Pharmaceuticals, Inc. Bone-specific protein
US5422340A (en) 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
JP3045398B2 (ja) * 1989-09-06 2000-05-29 武田薬品工業株式会社 蛋白質、ｄｎａおよびその用途
JP2845346B2 (ja) * 1989-10-17 1999-01-13 ストライカー・コーポレーション 骨形成具
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5215895A (en) 1989-11-22 1993-06-01 Genetics Institute, Inc. Dna encoding a mammalian cytokine, interleukin-11
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5166190A (en) 1990-01-08 1992-11-24 Genentech, Inc. Method for increasing fertility in males
US5256418A (en) 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5290271A (en) 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
DE69132823T2 (de) * 1990-05-16 2002-07-18 Genetics Inst Knochen- und knorpel-bildung hervorrufende proteine
US5688678A (en) 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US5168050A (en) 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5218090A (en) 1990-06-12 1993-06-08 Warner-Lambert Company EGF receptor truncates
US5364839A (en) 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
US5206028A (en) 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5208219A (en) 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US6395883B1 (en) * 1991-03-11 2002-05-28 Curis, Inc. Soluble morphogenic protein complex compositions of matter
US5318898A (en) 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
CA2102808A1 (en) 1991-05-10 1992-11-11 Hanne Bentz Targeted delivery of bone growth factors
US5229495A (en) 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5216126A (en) 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
AU652472B2 (en) 1991-06-25 1994-08-25 Genetics Institute, Llc BMP-9 compositions
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5306307A (en) 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5171579A (en) 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
SE469653B (sv) 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
JPH07504106A (ja) 1992-02-28 1995-05-11 コラーゲン　コーポレイション 注射可能なセラミック組成物及びそれらの製造及び使用のための方法
WO1993019177A1 (en) 1992-03-18 1993-09-30 The General Hospital Corporation FOUR NOVEL RECEPTORS OF THE TGF-β RECEPTOR FAMILY
IT1259100B (it) 1992-05-20 1996-03-11 Lanfranco Callegaro Uso di idrogeli per il bloccaggio di sistemi protesici
US5420243A (en) 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
EP0690873B1 (de) 1993-03-19 2003-06-11 The Johns Hopkins University School Of Medicine Wachstumsfaktor-8
GB9308060D0 (en) 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
US5637480A (en) 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
KR100227406B1 (ko) 1993-05-12 1999-12-01 브루스 엠. 에이센 Bmp-11 조성물
EP0626451A3 (de) * 1993-05-27 1997-11-05 Takeda Chemical Industries, Ltd. Heterodimere einer TGF-Beta Superfamilie
US5447725A (en) 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
EP0717633A4 (de) 1993-07-09 1998-05-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-7
KR100329409B1 (ko) 1993-08-26 2002-03-20 브루스 엠. 에이센, 토마스 제이 데스로저 인간 골 형태발생 단백질을 사용한 신경 재생법
US5455041A (en) 1993-09-13 1995-10-03 Research Foundation Of State University Of New York At Buffalo Method for inducing periodontal tissue regeneration
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
CA2175049A1 (en) 1993-10-28 1995-05-04 Timothy Ringeisen Improved process and device for treating and healing a bone void
US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
PT733109E (pt) 1993-12-07 2006-07-31 Genetics Inst Llc Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao
US5556767A (en) 1993-12-22 1996-09-17 Human Genome Sciences, Inc. Polynucleotide encoding macrophage inflammatory protein γ
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5520923A (en) 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US5545616A (en) 1994-09-22 1996-08-13 Genentech, Inc. Method for predicting and/or preventing preterm labor
US5693779A (en) 1994-11-08 1997-12-02 The United States Of America As Represented By The Department Of Health And Human Services Production and use of anti-dorsalizing morphogenetic protein
ES2093593T1 (es) 1995-05-05 1997-01-01 Hoffmann La Roche Proteinas obesas (ob) recombinantes.
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
ES2440441T3 (es) 1995-06-05 2014-01-29 Genetics Institute, Llc Uso de proteínas morfogenéticas óseas para cicatrización y reparación de uniones de tejido conjuntivo
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
WO1997022308A1 (de) 1995-12-18 1997-06-26 Degussa Aktiengesellschaft Medizinisches implantat
US5700774A (en) 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
EP0907721A1 (de) 1996-05-28 1999-04-14 Brown University Research Foundation Biologisch abbaubarer träger auf basis von hyaluronan für die gewebewiederherstellung
US5813411A (en) 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
US6034062A (en) 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per

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US6190880B1 (en) 2001-02-20
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EP0612348A1 (de) 1994-08-31
US7678885B2 (en) 2010-03-16
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US6593109B1 (en) 2003-07-15
AU674500B2 (en) 1997-01-02
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