DE69232552D1 - Tetrapeptide Derivat - Google Patents

Tetrapeptide Derivat

Info

Publication number
DE69232552D1
DE69232552D1 DE69232552T DE69232552T DE69232552D1 DE 69232552 D1 DE69232552 D1 DE 69232552D1 DE 69232552 T DE69232552 T DE 69232552T DE 69232552 T DE69232552 T DE 69232552T DE 69232552 D1 DE69232552 D1 DE 69232552D1
Authority
DE
Germany
Prior art keywords
chem
tetrapeptide derivative
tetrapeptide
derivative
dolastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232552T
Other languages
English (en)
Other versions
DE69232552T2 (de
Inventor
Kyoichi Sakakibara
Masaaki Gondo
Koichi Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69232552(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Application granted granted Critical
Publication of DE69232552D1 publication Critical patent/DE69232552D1/de
Publication of DE69232552T2 publication Critical patent/DE69232552T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69232552T 1991-08-09 1992-08-06 Tetrapeptide Derivat Expired - Fee Related DE69232552T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22353491 1991-08-09
JP22539191 1991-08-12

Publications (2)

Publication Number Publication Date
DE69232552D1 true DE69232552D1 (de) 2002-05-16
DE69232552T2 DE69232552T2 (de) 2002-10-31

Family

ID=26525532

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69230824T Expired - Lifetime DE69230824T2 (de) 1991-08-09 1992-08-06 Neue tetrapeptidderivate
DE69232552T Expired - Fee Related DE69232552T2 (de) 1991-08-09 1992-08-06 Tetrapeptide Derivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69230824T Expired - Lifetime DE69230824T2 (de) 1991-08-09 1992-08-06 Neue tetrapeptidderivate

Country Status (13)

Country Link
US (2) US6004934A (de)
EP (2) EP0934950B1 (de)
JP (1) JP2618597B2 (de)
KR (2) KR0185440B1 (de)
AT (2) ATE190983T1 (de)
AU (2) AU662551B2 (de)
CA (1) CA2115355C (de)
DE (2) DE69230824T2 (de)
DK (2) DK0934950T3 (de)
ES (2) ES2144421T3 (de)
GR (1) GR3033397T3 (de)
SG (1) SG87056A1 (de)
WO (1) WO1993003054A1 (de)

Families Citing this family (55)

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US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
AU669710B2 (en) * 1992-05-20 1996-06-20 Abbott Gmbh & Co. Kg Derivatives of dolastatin
CA2151953A1 (en) * 1992-12-16 1994-06-23 Andreas Haupt "dolostatin analog" (novel peptides, the preparation and use thereof)
CA2173150C (en) * 1993-10-01 2004-11-30 Kyoichi Sakakibara Novel peptide derivatives
US5599902A (en) * 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
KR100408909B1 (ko) * 1995-04-21 2004-04-29 데이꼬꾸 조끼 세이야꾸 가부시키가이샤 신규펩티드유도체
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686445B1 (en) 1997-09-24 2004-02-03 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
DE69829881T2 (de) * 1997-09-24 2006-03-09 Arizona Board Of Regents, Tempe Synthetische antineoplastische wirkstoffe abgeleitet von dolastatin 15 sowie verfahren zu ihrer herstellung
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6323315B1 (en) * 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AU1730701A (en) * 1999-12-07 2001-06-18 Santen Pharmaceutical Co. Ltd. Rheumatism remedy containing tetrapeptide derivative as active ingredient
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
KR20010079252A (ko) * 2001-06-27 2001-08-22 홍진의 주름형 드럼을 갖는 드럼 필터
CN1309413C (zh) * 2001-09-20 2007-04-11 Aska制药株式会社 四肽衍生物的晶体
CA2494105C (en) 2002-07-31 2013-04-02 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
ZA200603619B (en) * 2003-11-06 2008-10-29 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
EP1817336B1 (de) * 2004-11-12 2019-01-09 Seattle Genetics, Inc. Auristatine mit einer aminobenzoesäureeinheit am n-ende
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
AU2006269422B2 (en) 2005-07-07 2012-12-06 Seagen Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
SG10201407457UA (en) 2006-05-16 2014-12-30 Pharmascience Inc Iap bir domain binding compounds
AR067543A1 (es) 2007-07-16 2009-10-14 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso
JP5469600B2 (ja) 2007-07-16 2014-04-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法
US20090035848A1 (en) * 2007-08-03 2009-02-05 Robert Hickey Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
PE20091318A1 (es) 2008-01-31 2009-09-16 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados y metodos de uso de los mismos
EP2842575B1 (de) * 2008-03-18 2017-09-27 Seattle Genetics, Inc. Auristatin mit einem Heilmittel bindenden Konjugat
CN102985439B9 (zh) 2010-02-12 2016-08-03 制药科学股份有限公司 Iap bir结构域结合化合物
DK3327027T3 (da) 2011-11-17 2021-01-18 Pfizer Cytotoksiske peptider og antistof-medikamentkonjugater deraf
WO2014046441A1 (ko) * 2012-09-20 2014-03-27 (주)셀트리온 돌라스타틴 10 유도체, 그의 제조방법 및 그를 포함하는 항암제 조성물
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
EA201691251A1 (ru) 2013-12-17 2016-11-30 Новартис Аг Цитотоксические пептиды и их конъюгаты
AU2014384434B2 (en) 2014-02-28 2016-11-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
RU2747989C2 (ru) * 2014-05-28 2021-05-18 Эдженсис, Инк. Производные пептидов долапроин-долаизолейина
CA2951368A1 (en) 2014-06-13 2015-12-17 Novartis Ag Auristatin derivatives and conjugates thereof
ES2796903T3 (es) 2014-09-23 2020-11-30 Hoffmann La Roche Procedimiento de uso de inmunoconjugados anti-CD79b
CN108449940B (zh) 2015-07-12 2021-06-08 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016297786A1 (en) 2015-07-24 2018-02-08 Noeleen Melody Quinstatin compounds
WO2017058808A1 (en) * 2015-10-02 2017-04-06 Sirenas Llc Anti-cancer compounds and conjugates thereof
HUE062120T2 (hu) * 2016-03-29 2023-09-28 Toray Industries Peptid-származék és alkalmazása
KR20220147721A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
US20230000995A1 (en) * 2019-10-28 2023-01-05 Ariel Scientific Innovations Ltd. Dolastatin 10 analog
AU2022338463A1 (en) 2021-09-03 2024-03-21 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US5635483A (en) * 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US6034065A (en) * 1992-12-03 2000-03-07 Arizona Board Of Regents Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10

Also Published As

Publication number Publication date
DE69230824D1 (de) 2000-04-27
AU673487B2 (en) 1996-11-07
EP0598129B1 (de) 2000-03-22
EP0934950A1 (de) 1999-08-11
CA2115355C (en) 2007-09-11
WO1993003054A1 (en) 1993-02-18
GR3033397T3 (en) 2000-09-29
US5654399A (en) 1997-08-05
ATE190983T1 (de) 2000-04-15
KR0185440B1 (ko) 1999-04-01
DE69232552T2 (de) 2002-10-31
AU2415292A (en) 1993-03-02
AU662551B2 (en) 1995-09-07
US6004934A (en) 1999-12-21
CA2115355A1 (en) 1993-02-18
DK0934950T3 (da) 2002-07-29
ES2144421T3 (es) 2000-06-16
ES2172069T3 (es) 2002-09-16
DK0598129T3 (da) 2000-07-03
EP0934950B1 (de) 2002-04-10
AU2001095A (en) 1995-07-20
DE69230824T2 (de) 2000-07-27
KR100202474B1 (en) 1999-06-15
JP2618597B2 (ja) 1997-06-11
ATE215962T1 (de) 2002-04-15
EP0598129A4 (en) 1995-10-25
EP0598129A1 (de) 1994-05-25
SG87056A1 (en) 2002-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee