DE69231614T2 - Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose - Google Patents

Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose

Info

Publication number
DE69231614T2
DE69231614T2 DE69231614T DE69231614T DE69231614T2 DE 69231614 T2 DE69231614 T2 DE 69231614T2 DE 69231614 T DE69231614 T DE 69231614T DE 69231614 T DE69231614 T DE 69231614T DE 69231614 T2 DE69231614 T2 DE 69231614T2
Authority
DE
Germany
Prior art keywords
devices
molecular spectroscopy
spectroscopy method
tissue diagnosis
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69231614T
Other languages
English (en)
Other versions
DE69231614D1 (de
Inventor
P Rava
J Baraga
S Feld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE69231614D1 publication Critical patent/DE69231614D1/de
Application granted granted Critical
Publication of DE69231614T2 publication Critical patent/DE69231614T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
DE69231614T 1991-02-26 1992-01-17 Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose Expired - Lifetime DE69231614T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66107791A 1991-02-26 1991-02-26
PCT/US1992/000420 WO1992015008A1 (en) 1991-02-26 1992-01-17 Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue

Publications (2)

Publication Number Publication Date
DE69231614D1 DE69231614D1 (de) 2001-02-01
DE69231614T2 true DE69231614T2 (de) 2001-05-03

Family

ID=24652118

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231614T Expired - Lifetime DE69231614T2 (de) 1991-02-26 1992-01-17 Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose

Country Status (7)

Country Link
US (3) US6690966B1 (de)
EP (1) EP0573535B1 (de)
JP (1) JPH06505183A (de)
AT (1) ATE198375T1 (de)
CA (1) CA2104960C (de)
DE (1) DE69231614T2 (de)
WO (1) WO1992015008A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005028268A1 (de) * 2005-06-14 2006-12-28 Forschungsverbund Berlin E.V. Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums
DE102008034008A1 (de) * 2008-07-21 2010-01-28 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE198375T1 (de) * 1991-02-26 2001-01-15 Massachusetts Inst Technology Molekularspektroskopieverfahren und - einrichtungen zur gewebediagnose
US5539207A (en) * 1994-07-19 1996-07-23 National Research Council Of Canada Method of identifying tissue
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5991653A (en) * 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
US5615673A (en) * 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
US5733739A (en) * 1995-06-07 1998-03-31 Inphocyte, Inc. System and method for diagnosis of disease by infrared analysis of human tissues and cells
US5873831A (en) * 1997-03-13 1999-02-23 The University Of Utah Technology Transfer Office Method and system for measurement of macular carotenoid levels
US20010048077A1 (en) * 1997-10-27 2001-12-06 Afanassieva Natalia I. Apparatus and method for spectroscopic analysis of human or animal tissue or body fluids
US6937885B1 (en) 1997-10-30 2005-08-30 Hypermed, Inc. Multispectral/hyperspectral medical instrument
AU751456B2 (en) * 1997-10-30 2002-08-15 Hypermed Imaging, Inc. Multispectral/hyperspectral medical instrument
US6044285A (en) * 1997-11-12 2000-03-28 Lightouch Medical, Inc. Method for non-invasive measurement of an analyte
US6364829B1 (en) 1999-01-26 2002-04-02 Newton Laboratories, Inc. Autofluorescence imaging system for endoscopy
AU752829B2 (en) 1998-01-26 2002-10-03 Brigham And Women's Hospital Fluorescence imaging endoscope
US7899518B2 (en) 1998-04-06 2011-03-01 Masimo Laboratories, Inc. Non-invasive tissue glucose level monitoring
US6721582B2 (en) 1999-04-06 2004-04-13 Argose, Inc. Non-invasive tissue glucose level monitoring
US6505059B1 (en) 1998-04-06 2003-01-07 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US6728560B2 (en) 1998-04-06 2004-04-27 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US7433035B2 (en) * 1998-06-29 2008-10-07 San Diego State University Research Foundation Detection of carbon halogen bonds
JP4486253B2 (ja) 1998-07-07 2010-06-23 ライタッチ メディカル インコーポレイテッド 検体濃度決定装置
DE19836496A1 (de) * 1998-08-12 2000-02-17 Karsten Hoeland Faseroptische Messung der Myokardkontraktion
US8024027B2 (en) 1998-09-03 2011-09-20 Hyperspectral Imaging, Inc. Infrared endoscopic balloon probes
US6741884B1 (en) 1998-09-03 2004-05-25 Hypermed, Inc. Infrared endoscopic balloon probes
US6503478B2 (en) 1999-01-13 2003-01-07 Lightouch Medical, Inc. Chemically specific imaging of tissue
EP1148810B1 (de) 1999-01-26 2005-11-16 Newton Laboratories, Inc. Vorrichtung zur autofluoreszensbildgebung für ein endoskop
US6205354B1 (en) 1999-06-18 2001-03-20 University Of Utah Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue
US6734962B2 (en) * 2000-10-13 2004-05-11 Chemimage Corporation Near infrared chemical imaging microscope
JP2003530544A (ja) * 2000-01-04 2003-10-14 アイメトリクス インコーポレイティッド 血管内画像処理検出器
CA2400305A1 (en) 2000-02-18 2001-08-23 Argose,Inc. Generation of spatially-averaged excitation-emission map in heterogeneous tissue
AU2001254566A1 (en) * 2000-04-13 2001-10-30 National Research Council Of Canada Ltd. Tissue viability/health monitor utilizing near infrared spectroscopy
DE10027100C2 (de) * 2000-05-31 2002-08-08 Klaus Mueller-Dethlefs Verfahren und Vorrichtung zum Nachweisen von Substanzen in Körperflüssigkeiten
AU2001273412A1 (en) * 2000-07-11 2002-01-21 Lightouch Medical, Inc. Method of tissue modulation for noninvasive measurement of an analyte
US6821245B2 (en) 2000-07-14 2004-11-23 Xillix Technologies Corporation Compact fluorescence endoscopy video system
US6841388B2 (en) * 2000-12-05 2005-01-11 Vysis, Inc. Method and system for diagnosing pathology in biological samples by detection of infrared spectral markers
US7039452B2 (en) 2002-12-19 2006-05-02 The University Of Utah Research Foundation Method and apparatus for Raman imaging of macular pigments
US20060241496A1 (en) 2002-01-15 2006-10-26 Xillix Technologies Corp. Filter for use with imaging endoscopes
US7647092B2 (en) 2002-04-05 2010-01-12 Massachusetts Institute Of Technology Systems and methods for spectroscopy of biological tissue
US20040068193A1 (en) * 2002-08-02 2004-04-08 Barnes Russell H. Optical devices for medical diagnostics
US7376456B2 (en) * 2002-08-05 2008-05-20 Infraredx, Inc. Near-infrared spectroscopic analysis of blood vessel walls
US7689268B2 (en) 2002-08-05 2010-03-30 Infraredx, Inc. Spectroscopic unwanted signal filters for discrimination of vulnerable plaque and method therefor
CA2404891C (en) * 2002-10-25 2003-11-18 Nir Technologies Inc. Method of in-vivo measurement of fat content of a body and apparatus therefor
DE10304221A1 (de) * 2003-01-30 2004-08-12 Carl Zeiss Vorrichtung zum Behandeln von Körpergewebe
US20040254479A1 (en) 2003-02-20 2004-12-16 John Fralick Bio-photonic feedback control software and database
EP1620001B1 (de) * 2003-04-24 2008-12-17 Koninklijke Philips Electronics N.V. Katheterkopf
US7181219B2 (en) 2003-05-22 2007-02-20 Lucent Technologies Inc. Wireless handover using anchor termination
JP2007524833A (ja) * 2003-07-01 2007-08-30 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 骨組織の状態を診断するための方法および装置
US20050119587A1 (en) * 2003-07-01 2005-06-02 University Of Michigan Method and apparatus for evaluating connective tissue conditions
WO2005057244A2 (en) * 2003-08-19 2005-06-23 Cornell Research Foundation, Inc. Optical fiber delivery and collection system for biological applications
US7803624B2 (en) 2003-09-30 2010-09-28 Cytyc Corporation Automated cytological sample classification
US8571640B2 (en) * 2003-12-11 2013-10-29 The Regents Of The University Of California Catheter based mid-infrared reflectance and reflectance generated absorption spectroscopy
JP2010286493A (ja) * 2004-01-23 2010-12-24 Horiba Ltd 基板検査装置
US20050278184A1 (en) 2004-06-10 2005-12-15 John Fralick Bio-photonic feedback control software and database
US7697576B2 (en) 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US20050250091A1 (en) * 2004-05-05 2005-11-10 Chemlmage Corporation Raman molecular imaging for detection of bladder cancer
US20060281068A1 (en) * 2005-06-09 2006-12-14 Chemimage Corp. Cytological methods for detecting a disease condition such as malignancy by Raman spectroscopic imaging
US7580126B2 (en) * 2004-06-30 2009-08-25 Chemimage Corp. Method and apparatus for producing a streaming Raman image of nucleation, aggregation, and chemical interaction
US7394542B2 (en) 2004-08-18 2008-07-01 Chemimage Corporation Method and apparatus for chemical imaging in a microfluidic circuit
US7046359B2 (en) * 2004-06-30 2006-05-16 Chemimage Corporation System and method for dynamic chemical imaging
US20060098194A1 (en) * 2004-11-08 2006-05-11 David Tuschel Method and apparatus for determining change in an attribute of a sample during nucleation, aggregation, or chemical interaction
US7218822B2 (en) 2004-09-03 2007-05-15 Chemimage Corporation Method and apparatus for fiberscope
US20060111622A1 (en) * 2004-10-07 2006-05-25 Sean Merritt Apparatus and method for monitoring deep tissue temperature using broadband diffuse optical spectroscopy
KR100700913B1 (ko) * 2004-10-20 2007-03-28 고려대학교 산학협력단 공초점 라만 분광법을 이용한 조직으로부터의 자기-형광신호 감소 방법
US7365839B2 (en) * 2004-11-03 2008-04-29 Nu Skin International, Inc. Process and compositions for synthetic calibration of bio-photonic scanners
US7417740B2 (en) * 2004-11-12 2008-08-26 Medeikon Corporation Single trace multi-channel low coherence interferometric sensor
GB0426993D0 (en) 2004-12-09 2005-01-12 Council Cent Lab Res Councils Apparatus for depth-selective raman spectroscopy
EP1838215B1 (de) * 2005-01-18 2012-08-01 Philips Electronics LTD Elektromagnetisch verfolgte k-draht-vorrichtung
US7524671B2 (en) * 2005-01-27 2009-04-28 Prescient Medical, Inc. Handheld raman blood analyzer
US7651851B2 (en) * 2005-01-27 2010-01-26 Prescient Medical, Inc. Handheld Raman body fluid analyzer
US7688440B2 (en) 2005-01-27 2010-03-30 Prescient Medical, Inc. Raman spectroscopic test strip systems
US7283241B2 (en) * 2005-01-31 2007-10-16 Chemimage Corp. Method and apparatus for a microscope image selector
US7060955B1 (en) * 2005-01-31 2006-06-13 Chemimage Corporation Apparatus and method for defining illumination parameters of a sample
WO2006085894A1 (en) * 2005-01-31 2006-08-17 Chemimage Corporation Apparatus and method for chemical imaging of a biological sample
US20060170916A1 (en) * 2005-01-31 2006-08-03 Voigt Thomas C Method and apparatus for variable-field illumination
DE202005003411U1 (de) * 2005-02-24 2006-07-06 Karl Storz Gmbh & Co. Kg Multifunktionales Fluoreszenzdiagnosesystem
US20060221335A1 (en) * 2005-04-04 2006-10-05 Bangalore Arjun S Method and apparatus for interactive hyperspectral image subtraction
US7956991B2 (en) 2005-04-04 2011-06-07 Chemimage Corporation Method and apparatus for interactive hyperspectral image subtraction
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
WO2006113476A2 (en) * 2005-04-15 2006-10-26 Bayer Healthcare Llc Non-invasive system for measuring glucose in the body
US8355767B2 (en) * 2005-04-27 2013-01-15 Massachusetts Institute Of Technology Raman spectroscopy for non-invasive glucose measurements
US8452365B2 (en) * 2005-05-25 2013-05-28 Bayer Healthcare Llc Methods of using Raman spectral information in determining analyte concentrations
US20070038123A1 (en) * 2005-06-02 2007-02-15 Newton Laboratories, Inc. Optical probe for Raman scattering from arterial tissue
US7330747B2 (en) * 2005-06-07 2008-02-12 Chemimage Corporation Invasive chemometry
US7330746B2 (en) * 2005-06-07 2008-02-12 Chem Image Corporation Non-invasive biochemical analysis
US8253936B2 (en) * 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
US7655003B2 (en) 2005-06-22 2010-02-02 Smith & Nephew, Inc. Electrosurgical power control
US7411188B2 (en) * 2005-07-11 2008-08-12 Revera Incorporated Method and system for non-destructive distribution profiling of an element in a film
WO2007014173A2 (en) * 2005-07-22 2007-02-01 Massachusetts Institute Of Technology Intrinsic raman spectroscopy
US20070027362A1 (en) * 2005-07-27 2007-02-01 Olympus Medical Systems Corp. Infrared observation system
US7729749B2 (en) * 2005-09-01 2010-06-01 The Regents Of The University Of Michigan Method and apparatus for evaluating connective tissue conditions
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
AT502855B1 (de) * 2005-11-30 2009-10-15 Oridis Biomed Forschungs Und E Verfahren und vorrichtung zur automatischen zerstörungsfreien analyse einer vielzahl von biologischen proben
US7233870B1 (en) * 2006-01-13 2007-06-19 Thermo Electron Scientific Instruments Llc Spectrometric data cleansing
US20070171433A1 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and processes for providing endogenous molecular imaging with mid-infrared light
US7787129B2 (en) * 2006-01-31 2010-08-31 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US20090303317A1 (en) * 2006-02-07 2009-12-10 Novadaq Technologies Inc. Near infrared imaging
US20070208257A1 (en) * 2006-03-03 2007-09-06 Furnish Simon M Lateral Viewing Optical Catheters
EP1991301A4 (de) * 2006-03-03 2010-08-18 Prescient Medical Inc Ballonkatheter für optische bildgebung
ES2357309T3 (es) * 2006-03-03 2011-04-25 Prescient Medical, Inc. Prótesis endoluminal para tratamiento de placa vulnerable.
US20070225795A1 (en) * 2006-03-24 2007-09-27 Juan Granada Composite vascular prosthesis
US20080140182A1 (en) * 2006-04-28 2008-06-12 Patricia Scheller Composite endoluminal prostheses for treating vulnerable plaque
US8187189B2 (en) * 2006-04-28 2012-05-29 The Invention Science Fund I, Llc Imaging via blood vessels
US20080002927A1 (en) * 2006-06-12 2008-01-03 Prescient Medical, Inc. Miniature fiber optic spectroscopy probes
EP2077748A2 (de) * 2006-08-22 2009-07-15 Bayer Healthcare, LLC Verfahren zur korrektur eines spektralbildes für optische aberrationen mit software
US7603151B2 (en) * 2006-08-22 2009-10-13 Bayer Healthcare Llc Non-invasive methods of using spectral information in determining analyte concentrations
WO2008064130A2 (en) * 2006-11-17 2008-05-29 Bloom Matthew B Mir spectroscopy of tissue
US7990532B2 (en) 2007-01-16 2011-08-02 Chemimage Corporation Method and apparatus for multimodal detection
US9566030B2 (en) 2007-02-01 2017-02-14 Ls Biopath, Inc. Optical system for detection and characterization of abnormal tissue and cells
EP2160217A1 (de) * 2007-06-08 2010-03-10 Prescient Medical, Inc. Optische katheterkonfigurationen mit einer kombination aus raman-spektroskopie und niederkohärenz-reflektometrie auf faseroptik-basis
EP2190389A1 (de) 2007-08-01 2010-06-02 Prescient Medical, Inc. Expandierbare prothesen zur behandlung von atherosklerotischen läsionen einschliesslich anfälliger plaques
US20090062662A1 (en) * 2007-08-27 2009-03-05 Remicalm, Llc Optical spectroscopic device for the identification of cervical cancer
US20090099460A1 (en) * 2007-10-16 2009-04-16 Remicalm Llc Method and device for the optical spectroscopic identification of cervical cancer
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US9672471B2 (en) 2007-12-18 2017-06-06 Gearbox Llc Systems, devices, and methods for detecting occlusions in a biological subject including spectral learning
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US8280484B2 (en) 2007-12-18 2012-10-02 The Invention Science Fund I, Llc System, devices, and methods for detecting occlusions in a biological subject
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US9560994B2 (en) 2008-03-26 2017-02-07 Covidien Lp Pulse oximeter with adaptive power conservation
CA2891990C (en) 2008-05-20 2022-07-26 Ralph Sebastian Dacosta Device and method for fluorescence-based imaging and monitoring
US8416405B2 (en) 2008-08-08 2013-04-09 Chemimage Corporation Raman chemical imaging of implantable drug delivery devices
US20100081915A1 (en) * 2008-09-29 2010-04-01 Searete Llc, Alimited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081924A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081916A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware. Histological facilitation systems and methods
US20100081926A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081927A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081928A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological Facilitation systems and methods
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US8968210B2 (en) * 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US20100113906A1 (en) * 2008-11-06 2010-05-06 Prescient Medical, Inc. Hybrid basket catheters
WO2010103661A1 (ja) * 2009-03-13 2010-09-16 京都府公立大学法人 ラマン散乱を用いた生体組織イメージング
EP2417435A4 (de) 2009-04-07 2014-09-10 Rare Light Inc Perikritische reflexionsspektroskope, systeme und verfahren
US8702321B2 (en) 2009-12-03 2014-04-22 Eric T. Marple Filtered fiber optic probe
US8971998B2 (en) 2009-12-31 2015-03-03 Integral Electromagnetronic Technologies Llc Systems and methods for multispectral scanning and detection for medical diagnosis
US8812084B1 (en) * 2009-12-31 2014-08-19 Albert Francis Messano, JR. Systems and methods for multispectral scanning and detection for medical diagnosis
US20130137134A1 (en) * 2010-03-29 2013-05-30 Ben Gurion University Of The Negev Research And Development Authority Method and system for detecting and monitoring hematological cancer
US9606057B2 (en) * 2010-06-01 2017-03-28 Todos Medical Ltd. Biochemical analysis of PBMC
JP5672058B2 (ja) * 2010-07-02 2015-02-18 ソニー株式会社 スペクトルデータ解析装置、生体内物質検出システム及び生体内物質検出方法
WO2012096689A1 (en) 2011-01-10 2012-07-19 Emvision Llc Fiber optic probes utilizing grin lenses for spatially precise optical spectroscopy
JP5466182B2 (ja) * 2011-01-11 2014-04-09 富士フイルム株式会社 内視鏡システムおよび内視鏡システムの作動方法
US8970838B2 (en) * 2011-04-29 2015-03-03 Avolonte Health LLC Method and apparatus for evaluating a sample through variable angle Raman spectroscopy
WO2012153326A1 (en) 2011-05-11 2012-11-15 Todos Medical Ltd. Diagnosis of cancer
JP6398093B2 (ja) * 2012-04-13 2018-10-03 ベイカー ハート アンド ダイアベーツ インスティテュート アテローム斑の検出
US9526426B1 (en) 2012-07-18 2016-12-27 Bernard Boon Chye Lim Apparatus and method for assessing tissue composition
US10881459B2 (en) 2012-07-18 2021-01-05 Bernard Boon Chye Lim Apparatus and method for assessing tissue treatment
US10499984B2 (en) 2012-07-18 2019-12-10 Bernard Boon Chye Lim Apparatus and method for assessing tissue treatment
US9804145B2 (en) 2013-05-28 2017-10-31 Todos Medical Ltd. Infrared analysis of benign tumors
US9645086B2 (en) * 2013-08-30 2017-05-09 Kabushiki Kaisha Toshiba Componential analysis method, componential analysis apparatus and non-transitory computer-readable recording medium
US10188330B1 (en) 2014-02-05 2019-01-29 Covidien Lp Methods and systems for determining a light drive parameter limit in a physiological monitor
US11187692B2 (en) 2014-06-18 2021-11-30 Texas Tech University System Enhanced chemical characterization of solid matrices using x-ray fluorescence and optical color reflectance
US10697953B2 (en) 2014-06-18 2020-06-30 Texas Tech University System Portable apparatus for liquid chemical characterization
DK3171765T3 (da) 2014-07-24 2021-11-01 Univ Health Network Indsamling og analyse af data til diagnostiske formål
WO2016201572A1 (en) * 2015-06-16 2016-12-22 Dalhousie University Methods of detection of steatosis
CN105520719A (zh) * 2016-01-25 2016-04-27 上海电力学院 一种基于红外光谱的早期癌细胞检测系统
US10293122B2 (en) 2016-03-17 2019-05-21 Novadaq Technologies ULC Endoluminal introducer with contamination avoidance
US11627895B2 (en) 2018-08-10 2023-04-18 Samsung Electronics Co., Ltd. Apparatus and method for estimating analyte concentration, and apparatus and method for generating analyte concentration estimation model
KR102574088B1 (ko) * 2018-08-10 2023-09-04 삼성전자주식회사 분석 물질의 농도 추정 장치 및 방법과, 농도 추정 모델 생성 장치 및 방법
US10588514B1 (en) * 2019-04-29 2020-03-17 Hua Shang Vivo photon analysis system and method
JP2022545646A (ja) 2019-08-12 2022-10-28 バード・アクセス・システムズ，インコーポレーテッド 医療機器用の形状センシングシステムおよび方法
KR20210057506A (ko) * 2019-11-12 2021-05-21 삼성전자주식회사 피부 장벽 기능 추정 장치 및 방법
CN214804697U (zh) 2019-11-25 2021-11-23 巴德阿克塞斯系统股份有限公司 光学尖端追踪系统
WO2021108688A1 (en) 2019-11-25 2021-06-03 Bard Access Systems, Inc. Shape-sensing systems with filters and methods thereof
EP4110175A1 (de) 2020-02-28 2023-01-04 Bard Access Systems, Inc. Optische verbindungssysteme und verfahren dafür
WO2021202589A1 (en) 2020-03-30 2021-10-07 Bard Access Systems, Inc. Optical and electrical diagnostic systems and methods thereof
CN216319408U (zh) 2020-06-26 2022-04-19 巴德阿克塞斯系统股份有限公司 错位检测系统
EP4171373A1 (de) 2020-06-29 2023-05-03 Bard Access Systems, Inc. Automatische dimensionale rahmenreferenz für faseroptische
CN113907705A (zh) 2020-07-10 2022-01-11 巴德阿克塞斯系统股份有限公司 连续光纤功能监测和自诊断报告系统
CN216675721U (zh) 2020-08-03 2022-06-07 巴德阿克塞斯系统股份有限公司 布拉格光栅光纤波动感测与监测系统
CN216985791U (zh) 2020-10-13 2022-07-19 巴德阿克塞斯系统股份有限公司 用于光纤连接器的消毒罩
CN112353378A (zh) * 2020-11-04 2021-02-12 上海交通大学医学院附属瑞金医院 一种基于平行结构探测体的微循环探测装置及系统

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3327117A (en) 1963-08-12 1967-06-20 Ibm Cancer cell detector using two wavelengths for comparison
US3327119A (en) 1964-03-26 1967-06-20 Ibm Method and apparatus for detecting cancer cells
US3461856A (en) 1965-10-23 1969-08-19 American Optical Corp Oximeters
US3647299A (en) 1970-04-20 1972-03-07 American Optical Corp Oximeter
JPS6043134B2 (ja) 1977-08-25 1985-09-26 信紘 佐藤 生体の臓器，組識の反射特性測定装置
US4290433A (en) 1979-08-20 1981-09-22 Alfano Robert R Method and apparatus for detecting the presence of caries in teeth using visible luminescence
DE2934190A1 (de) * 1979-08-23 1981-03-19 Müller, Gerhard, Prof. Dr.-Ing., 7080 Aalen Verfahren und vorrichtung zur molekuelspektroskopie, insbesondere zur bestimmung von stoffwechselprodukten
US4515165A (en) 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
SU922050A1 (ru) 1980-06-26 1982-04-23 Алтайский Филиал Всесоюзного Проектно-Конструкторского Технологического Института Атомного Машиностроения И Котлостроения Стрела грузоподъемного крана
FR2521727A2 (fr) 1981-03-25 1983-08-19 Cilas Dispositif pour mesurer l'etat d'oxydo-reduction d'un organe vivant in situ
US4479499A (en) 1982-01-29 1984-10-30 Alfano Robert R Method and apparatus for detecting the presence of caries in teeth using visible light
US4445892A (en) * 1982-05-06 1984-05-01 Laserscope, Inc. Dual balloon catheter device
JPS5940830A (ja) 1982-08-31 1984-03-06 浜松ホトニクス株式会社 レ−ザ光パルスを用いた癌の診断装置
US4541438A (en) * 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US4768516A (en) 1983-10-14 1988-09-06 Somanetics Corporation Method and apparatus for in vivo evaluation of tissue composition
US4620284A (en) * 1983-12-29 1986-10-28 Uop Inc. Qualitative and quantitative analysis using Raman scattering
US4737628A (en) 1984-02-07 1988-04-12 International Technical Associates Method and system for controlled and selective removal of material
US4641650A (en) 1985-03-11 1987-02-10 Mcm Laboratories, Inc. Probe-and-fire lasers
US4718417A (en) 1985-03-22 1988-01-12 Massachusetts Institute Of Technology Visible fluorescence spectral diagnostic for laser angiosurgery
US4758081A (en) 1985-07-18 1988-07-19 Bausch & Lomb Incorporated Control of laser photocoagulation using Raman radiation
US4930516B1 (en) 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US4810875A (en) * 1987-02-02 1989-03-07 Wyatt Technology Corporation Method and apparatus for examining the interior of semi-opaque objects
EP0292695B1 (de) * 1987-05-25 1993-02-17 Deutsche Aerospace AG Einrichtung zur zirkumferenziellen Bestrahlung von Objekten
ATE187315T1 (de) 1987-09-24 1999-12-15 Massachusetts Inst Technology Kathetersystem zur abbildung
US4894547A (en) 1987-09-28 1990-01-16 Yale University Optical method and apparatus for detecting and measuring aging, photoaging, dermal disease and pigmentation in skin
US4981138A (en) 1988-06-30 1991-01-01 Yale University Endoscopic fiberoptic fluorescence spectrometer
WO1990006718A1 (en) * 1988-12-21 1990-06-28 Massachusetts Institute Of Technology A method for laser induced fluorescence of tissue
SE8900612D0 (sv) * 1989-02-22 1989-02-22 Jonas Johansson Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium
US5042980A (en) * 1989-05-26 1991-08-27 C. R. Bard, Inc. Optical fiber diffusion tip for uniform illumination
US4975581A (en) * 1989-06-21 1990-12-04 University Of New Mexico Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids
US5261410A (en) * 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
ATE198375T1 (de) * 1991-02-26 2001-01-15 Massachusetts Inst Technology Molekularspektroskopieverfahren und - einrichtungen zur gewebediagnose
US5293872A (en) * 1991-04-03 1994-03-15 Alfano Robert R Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005028268A1 (de) * 2005-06-14 2006-12-28 Forschungsverbund Berlin E.V. Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums
US7864311B2 (en) 2005-06-14 2011-01-04 Forschungsverbund Berlin E.V. Method and device for producing and detecting a Raman spectrum
DE102005028268B4 (de) * 2005-06-14 2013-12-12 Forschungsverbund Berlin E.V. Verfahren und Vorrichtung zur Erzeugung und Detektion eines Raman-Spektrums
DE102008034008A1 (de) * 2008-07-21 2010-01-28 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe
DE102008034008B4 (de) * 2008-07-21 2010-07-01 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe

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