DE69230824D1 - Neue tetrapeptidderivate - Google Patents

Neue tetrapeptidderivate

Info

Publication number
DE69230824D1
DE69230824D1 DE69230824T DE69230824T DE69230824D1 DE 69230824 D1 DE69230824 D1 DE 69230824D1 DE 69230824 T DE69230824 T DE 69230824T DE 69230824 T DE69230824 T DE 69230824T DE 69230824 D1 DE69230824 D1 DE 69230824D1
Authority
DE
Germany
Prior art keywords
chem
tetrapeptide derivatives
new tetrapeptide
new
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69230824T
Other languages
English (en)
Other versions
DE69230824T2 (de
Inventor
Kyoichi Sakakibara
Masaaki Gondo
Koichi Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69230824(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Publication of DE69230824D1 publication Critical patent/DE69230824D1/de
Application granted granted Critical
Publication of DE69230824T2 publication Critical patent/DE69230824T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69230824T 1991-08-09 1992-08-06 Neue tetrapeptidderivate Expired - Lifetime DE69230824T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22353491 1991-08-09
JP22539191 1991-08-12
PCT/JP1992/001005 WO1993003054A1 (en) 1991-08-09 1992-08-06 Novel tetrapeptide derivative

Publications (2)

Publication Number Publication Date
DE69230824D1 true DE69230824D1 (de) 2000-04-27
DE69230824T2 DE69230824T2 (de) 2000-07-27

Family

ID=26525532

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69230824T Expired - Lifetime DE69230824T2 (de) 1991-08-09 1992-08-06 Neue tetrapeptidderivate
DE69232552T Expired - Fee Related DE69232552T2 (de) 1991-08-09 1992-08-06 Tetrapeptide Derivat

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69232552T Expired - Fee Related DE69232552T2 (de) 1991-08-09 1992-08-06 Tetrapeptide Derivat

Country Status (13)

Country Link
US (2) US6004934A (de)
EP (2) EP0598129B1 (de)
JP (1) JP2618597B2 (de)
KR (2) KR0185440B1 (de)
AT (2) ATE215962T1 (de)
AU (2) AU662551B2 (de)
CA (1) CA2115355C (de)
DE (2) DE69230824T2 (de)
DK (2) DK0934950T3 (de)
ES (2) ES2144421T3 (de)
GR (1) GR3033397T3 (de)
SG (1) SG87056A1 (de)
WO (1) WO1993003054A1 (de)

Families Citing this family (55)

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US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
CA2136339C (en) * 1992-05-20 2008-02-05 Andreas Haupt Derivatives of dolastatin
NZ258882A (en) * 1992-12-16 1997-06-24 Basf Ag Antineoplastic peptides and compositions thereof
DE69434136T2 (de) * 1993-10-01 2005-12-01 Teikoku Hormone Mfg. Co., Ltd. Dolastatin-derivate
US5599902A (en) * 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
DK0831100T3 (da) * 1995-04-21 2001-01-02 Teikoku Hormone Mfg Co Ltd Nye peptidderivater
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
CA2298639C (en) * 1997-09-24 2005-07-05 Erik J. Flahive Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
US6686445B1 (en) 1997-09-24 2004-02-03 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2001041789A1 (fr) * 1999-12-07 2001-06-14 Santen Pharmaceutical Co., Ltd. Medicament contre les rhumatismes contenant un derive tetrapeptidique en tant qu'ingredient actif
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
KR20010079252A (ko) * 2001-06-27 2001-08-22 홍진의 주름형 드럼을 갖는 드럼 필터
JP4060794B2 (ja) * 2001-09-20 2008-03-12 あすか製薬株式会社 テトラペプチド誘導体の結晶
EP1545613B9 (de) 2002-07-31 2012-01-25 Seattle Genetics, Inc. Auristatin-konjugate und ihre verwendung zur behandlung von krebs, einer autoimmunkranheit oder einer infektionskrankheit
KR101520209B1 (ko) * 2003-11-06 2015-05-13 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
US8288352B2 (en) * 2004-11-12 2012-10-16 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the N terminus
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
CA2614436C (en) 2005-07-07 2016-05-17 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
WO2007008848A2 (en) * 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
US8163792B2 (en) 2006-05-16 2012-04-24 Pharmascience Inc. IAP BIR domain binding compounds
TW200918089A (en) 2007-07-16 2009-05-01 Genentech Inc Humanized anti-CD79b antibodies and immunoconjugates and methods of use
JP5469600B2 (ja) 2007-07-16 2014-04-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法
US20090035848A1 (en) * 2007-08-03 2009-02-05 Robert Hickey Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
SI2657253T1 (sl) 2008-01-31 2017-10-30 Genentech, Inc. Protitelesa proti CD79b in imunokonjugati in postopki za uporabo
NO2842575T3 (de) 2008-03-18 2018-02-24
ES2625637T3 (es) 2010-02-12 2017-07-20 Pharmascience Inc. Compuestos de unión al dominio BIR IAP
SI2780039T1 (en) 2011-11-17 2018-06-29 Pfizer Inc. Cytotoxic peptides and their conjugates between the antibody and the drug
AU2013318779B2 (en) * 2012-09-20 2016-07-28 Celltrion, Inc. Dolastatin-10 derivative, method of producing the same and anticancer drug composition containing the same
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
AU2014364812B2 (en) 2013-12-17 2017-05-25 Novartis Ag Cytotoxic peptides and conjugates thereof
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
JP2017519740A (ja) * 2014-05-28 2017-07-20 アジェンシス，インコーポレイテッド ドラプロイン‐ドライソロイインペプチド誘導体
CA2951368A1 (en) 2014-06-13 2015-12-17 Novartis Ag Auristatin derivatives and conjugates thereof
PL3262071T3 (pl) 2014-09-23 2020-08-10 F. Hoffmann-La Roche Ag Sposób stosowania immunokoniugatów anty-CD79b
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10435435B2 (en) 2015-07-24 2019-10-08 The Arizona Board Of Regents On Behalf Of Arizona State University Quinstatin compounds
US10722593B2 (en) 2015-10-02 2020-07-28 Sirenas Llc Anti-cancer compounds and conjugates thereof
US10792365B2 (en) 2016-03-29 2020-10-06 Toray Industries, Inc. Peptide derivative and use thereof
NZ752394A (en) 2016-11-14 2021-07-30 Hangzhou Dac Biotech Co Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
WO2021084532A1 (en) * 2019-10-28 2021-05-06 Ariel Scientific Innovations Ltd. Dolastatin 10 analog
CA3230737A1 (en) 2021-09-03 2023-03-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US6034065A (en) * 1992-12-03 2000-03-07 Arizona Board Of Regents Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
US5635483A (en) * 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides

Also Published As

Publication number Publication date
ES2144421T3 (es) 2000-06-16
DE69232552D1 (de) 2002-05-16
ATE190983T1 (de) 2000-04-15
SG87056A1 (en) 2002-03-19
AU673487B2 (en) 1996-11-07
EP0934950A1 (de) 1999-08-11
US6004934A (en) 1999-12-21
EP0598129B1 (de) 2000-03-22
ATE215962T1 (de) 2002-04-15
AU2415292A (en) 1993-03-02
JP2618597B2 (ja) 1997-06-11
KR100202474B1 (en) 1999-06-15
DK0934950T3 (da) 2002-07-29
KR0185440B1 (ko) 1999-04-01
CA2115355C (en) 2007-09-11
WO1993003054A1 (en) 1993-02-18
EP0598129A4 (en) 1995-10-25
CA2115355A1 (en) 1993-02-18
EP0934950B1 (de) 2002-04-10
AU2001095A (en) 1995-07-20
DK0598129T3 (da) 2000-07-03
AU662551B2 (en) 1995-09-07
US5654399A (en) 1997-08-05
DE69230824T2 (de) 2000-07-27
DE69232552T2 (de) 2002-10-31
EP0598129A1 (de) 1994-05-25
GR3033397T3 (en) 2000-09-29
ES2172069T3 (es) 2002-09-16

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings