DE69230563T2 - Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung - Google Patents
Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkungInfo
- Publication number
- DE69230563T2 DE69230563T2 DE69230563T DE69230563T DE69230563T2 DE 69230563 T2 DE69230563 T2 DE 69230563T2 DE 69230563 T DE69230563 T DE 69230563T DE 69230563 T DE69230563 T DE 69230563T DE 69230563 T2 DE69230563 T2 DE 69230563T2
- Authority
- DE
- Germany
- Prior art keywords
- antiarrhythmic
- antifibrillational
- effect
- oxazolidinone derivatives
- unsaturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74486591A | 1991-08-14 | 1991-08-14 | |
PCT/US1992/006682 WO1993004064A1 (en) | 1991-08-14 | 1992-08-10 | Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69230563D1 DE69230563D1 (de) | 2000-02-17 |
DE69230563T2 true DE69230563T2 (de) | 2000-09-14 |
Family
ID=24994270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69230563T Expired - Fee Related DE69230563T2 (de) | 1991-08-14 | 1992-08-10 | Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung |
Country Status (23)
Country | Link |
---|---|
US (1) | US5994354A (de) |
EP (2) | EP0599968B1 (de) |
JP (1) | JPH06510285A (de) |
AT (1) | ATE188696T1 (de) |
AU (1) | AU665367B2 (de) |
BR (1) | BR9206353A (de) |
CA (1) | CA2115029C (de) |
CZ (1) | CZ283323B6 (de) |
DE (1) | DE69230563T2 (de) |
DK (1) | DK0599968T3 (de) |
ES (1) | ES2141725T3 (de) |
FI (1) | FI940658A0 (de) |
GR (1) | GR3032432T3 (de) |
HU (1) | HUT70144A (de) |
IL (1) | IL102791A (de) |
MX (1) | MX9204736A (de) |
NO (1) | NO300807B1 (de) |
NZ (1) | NZ243936A (de) |
PL (1) | PL171280B1 (de) |
PT (1) | PT100775B (de) |
RU (1) | RU2125568C1 (de) |
SK (1) | SK16994A3 (de) |
WO (1) | WO1993004064A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69232681T2 (de) * | 1991-08-14 | 2003-02-13 | Procter & Gamble Pharma | 4-oxozyklische harnstoffe mit antiarrhythmische und entfibrillatorische wirkung |
RU2125568C1 (ru) * | 1991-08-14 | 1999-01-27 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Соединения циклического уретана или их фармацевтически приемлемые соли, способ лечения людей и других млекопитающих, страдающих сердечной аритмией и/или сердечной фибрилляцией, фармацевтическая композиция для лечения аритмии и фибрилляции |
CA2115426C (en) * | 1991-08-14 | 2001-09-11 | Stanford Salvatore Pelosi Jr. | Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents |
DE69920003T2 (de) | 1998-04-29 | 2005-09-15 | The Procter & Gamble Company, Cincinnati | Verfahren zur herstellung von 1,3-disubstituierten-4-oxocyclischen harnstoffen |
SK15842000A3 (sk) | 1998-04-29 | 2001-06-11 | The Procter & Gamble Company | Spôsob prípravy 1,3-disubstituovaných-4-oxocyklických močovín |
KR20100072230A (ko) * | 2007-09-26 | 2010-06-30 | 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 | 아자시티딘 유사체 및 이의 용도 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE624402A (de) * | ||||
US2802002A (en) * | 1956-07-18 | 1957-08-06 | Norwich Pharma Co | Series of new nu-(5-nitro-2-furyl) alkylidene-3-amino-5-tertiaryamino-methyl-2-oxazolidones and the preparation thereof |
GB843834A (en) * | 1957-05-13 | 1960-08-10 | Norwich Pharma Co | N-(5-nitro-2-furyl)-alkylidene-3-amino-5-tertiaryaminomethyl-2-oxazolidones and chemotherapeutic compositions containing them |
FR1274399A (fr) * | 1958-01-23 | 1961-10-27 | Norwich Pharma Co | Procédé perfectionné de préparation de dérivés du 5-nitro-2-formyl-furan |
NL104211C (de) * | 1958-02-28 | |||
US3004888A (en) * | 1959-01-12 | 1961-10-17 | Pfizer & Co C | Mastitis treatment |
NL266216A (de) * | 1960-07-12 | |||
FR385M (fr) * | 1960-08-17 | 1961-03-24 | Norwich Pharma Co | Nouveau médicament pour le traitement des infections staphylococciques et analogues. |
CH398599A (fr) * | 1961-03-24 | 1966-03-15 | Om Lab Sa | Procédé de préparation d'hydrazones de l'a-bromo-B-(5-nitro-2-furyl)acroléine |
BE633841A (de) * | 1962-06-21 | |||
BE635608A (de) * | 1962-08-01 | |||
US3415821A (en) * | 1965-09-07 | 1968-12-10 | Norwich Pharma Co | 1-(5-substituted)furfurylideneamino hydantoins and imidazolidinones |
US3318878A (en) * | 1966-04-14 | 1967-05-09 | Smith Kline French Lab | Nitrothiophene compounds |
GB1279408A (en) * | 1968-09-12 | 1972-06-28 | Ciba Geigy Ag | 5-nitro-2-furfurylideneamino-oxazolidinones |
US3839567A (en) * | 1969-04-17 | 1974-10-01 | Schering Ag | Pharmaceutical compositions comprising 3-(5-nitro-2-imidazolyl-methylen-amino)-2-oxazolidinones and their use in trichomoniasia |
US3906101A (en) * | 1969-06-05 | 1975-09-16 | Ciba Geigy Corp | Pharmaceutical compositions containing substituted 5-nitrofurfurylideneamino-oxazolidinones |
US4775670A (en) * | 1980-09-29 | 1988-10-04 | E. R. Squibb & Sons, Inc. | 2-oxo-1-azetidinesulfonic acid salts |
US4393204A (en) * | 1982-05-21 | 1983-07-12 | Norwich Eaton Pharmaceuticals, Inc. | 3-[[5-(4-Chlorophenyl)furfurylidene]amino]-5-(substituted)-2-oxazolidinones |
US4543359A (en) * | 1982-10-01 | 1985-09-24 | Eaton Laboratories, Inc. | Treating cardiac arrhythmias with dantrolene sodium |
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
US4581370A (en) * | 1983-07-12 | 1986-04-08 | Schering A.G. | Antiarrhythmic imidazoliums |
US4720580A (en) * | 1984-09-21 | 1988-01-19 | American Home Products Corporation | N-(aminoalkylene)benzenesulfonamides |
US4707499A (en) * | 1985-12-02 | 1987-11-17 | G. D. Searle & Co. | 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia |
PH23283A (en) * | 1986-02-26 | 1989-06-30 | Eisai Co Ltd | Piperidine derivative, pharmaceutical composition containing the same and method of use thereof |
US4713832A (en) * | 1986-04-11 | 1987-12-15 | Ampex Corporation | Programmable divider up/down counter with anti-aliasing feature and asynchronous read/write |
IL79174A0 (en) * | 1986-06-05 | 1986-09-30 | Abic Ltd | Water soluble salt of furaltadone |
US4895867A (en) * | 1986-06-26 | 1990-01-23 | Norwich Eaton Pharmaceuticals, Inc. | 2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents |
US4886794A (en) * | 1987-05-07 | 1989-12-12 | A. H. Robins Company, Incorporated | 4-[(α,α-diaryl)-hydroxymethyl]-1-piperidinylalkyl-cyclic carbamate derivatives as allergic response inhibitors |
US4882354A (en) * | 1987-12-16 | 1989-11-21 | Norwich Eaton Pharmaceuticals, Inc. | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents |
US4870095A (en) * | 1988-06-13 | 1989-09-26 | Sterling Drug, Inc. | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use |
EP0347733A1 (de) * | 1988-06-20 | 1989-12-27 | Eisai Co., Ltd. | Optisch aktive Hydantoin-Derivate |
DE68929303T2 (de) * | 1988-09-15 | 2002-05-02 | Upjohn Co | 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one |
PH30434A (en) * | 1989-04-07 | 1997-05-09 | Janssen Pharmaceutica Nv | Hydroxyalkylfuranyl derivatives |
US5091426A (en) * | 1989-06-23 | 1992-02-25 | Norwich Eaton Pharmaceuticals, Inc. | 5-phenyl-2-furan ketones and use as antiepileptic agents |
US4966967A (en) * | 1989-09-15 | 1990-10-30 | Berlex Laboratories, Inc. | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents |
US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
US4963561A (en) * | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
US5066662A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Company | Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors |
US5086055A (en) * | 1990-12-24 | 1992-02-04 | A. H. Robins Company, Incorporated | Series of 5-[-(4-aryl-1-piperazinyl)alkyl]-2-oxazolidinone derivatives useful in the treatment of allergic conditions |
RU2125568C1 (ru) * | 1991-08-14 | 1999-01-27 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Соединения циклического уретана или их фармацевтически приемлемые соли, способ лечения людей и других млекопитающих, страдающих сердечной аритмией и/или сердечной фибрилляцией, фармацевтическая композиция для лечения аритмии и фибрилляции |
-
1992
- 1992-08-10 RU RU94016524A patent/RU2125568C1/ru active
- 1992-08-10 PL PL92302375A patent/PL171280B1/pl unknown
- 1992-08-10 AT AT92918216T patent/ATE188696T1/de not_active IP Right Cessation
- 1992-08-10 DK DK92918216T patent/DK0599968T3/da active
- 1992-08-10 AU AU24678/92A patent/AU665367B2/en not_active Ceased
- 1992-08-10 WO PCT/US1992/006682 patent/WO1993004064A1/en active IP Right Grant
- 1992-08-10 CA CA002115029A patent/CA2115029C/en not_active Expired - Fee Related
- 1992-08-10 CZ CZ94278A patent/CZ283323B6/cs not_active IP Right Cessation
- 1992-08-10 SK SK169-94A patent/SK16994A3/sk unknown
- 1992-08-10 JP JP5504374A patent/JPH06510285A/ja active Pending
- 1992-08-10 HU HU9400403A patent/HUT70144A/hu unknown
- 1992-08-10 EP EP92918216A patent/EP0599968B1/de not_active Expired - Lifetime
- 1992-08-10 BR BR9206353A patent/BR9206353A/pt not_active Application Discontinuation
- 1992-08-10 DE DE69230563T patent/DE69230563T2/de not_active Expired - Fee Related
- 1992-08-10 ES ES92918216T patent/ES2141725T3/es not_active Expired - Lifetime
- 1992-08-12 IL IL102791A patent/IL102791A/en not_active IP Right Cessation
- 1992-08-13 NZ NZ243936A patent/NZ243936A/en unknown
- 1992-08-14 PT PT100775A patent/PT100775B/pt not_active IP Right Cessation
- 1992-08-14 MX MX9204736A patent/MX9204736A/es not_active IP Right Cessation
-
1994
- 1994-02-11 FI FI940658A patent/FI940658A0/fi unknown
- 1994-02-14 NO NO940496A patent/NO300807B1/no unknown
-
1995
- 1995-06-07 US US08/479,254 patent/US5994354A/en not_active Expired - Fee Related
-
1999
- 1999-04-23 EP EP99107448A patent/EP0957103A1/de not_active Withdrawn
-
2000
- 2000-01-19 GR GR20000400129T patent/GR3032432T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0599968B1 (de) | 2000-01-12 |
EP0599968A1 (de) | 1994-06-08 |
IL102791A0 (en) | 1993-01-31 |
CA2115029A1 (en) | 1993-03-04 |
ES2141725T3 (es) | 2000-04-01 |
ATE188696T1 (de) | 2000-01-15 |
BR9206353A (pt) | 1995-11-07 |
NO300807B1 (no) | 1997-07-28 |
HUT70144A (en) | 1995-09-28 |
US5994354A (en) | 1999-11-30 |
NO940496D0 (no) | 1994-02-14 |
PT100775A (pt) | 1994-01-31 |
CA2115029C (en) | 2002-03-26 |
AU2467892A (en) | 1993-03-16 |
CZ283323B6 (cs) | 1998-02-18 |
NZ243936A (en) | 1996-10-28 |
HU9400403D0 (en) | 1994-05-30 |
IL102791A (en) | 1998-06-15 |
CZ27894A3 (en) | 1995-07-12 |
SK16994A3 (en) | 1995-03-08 |
NO940496L (no) | 1994-02-14 |
JPH06510285A (ja) | 1994-11-17 |
FI940658A (fi) | 1994-02-11 |
WO1993004064A1 (en) | 1993-03-04 |
FI940658A0 (fi) | 1994-02-11 |
MX9204736A (es) | 1993-11-01 |
GR3032432T3 (en) | 2000-05-31 |
PL171280B1 (pl) | 1997-03-28 |
DK0599968T3 (da) | 2000-04-17 |
PT100775B (pt) | 1999-09-30 |
DE69230563D1 (de) | 2000-02-17 |
RU2125568C1 (ru) | 1999-01-27 |
EP0957103A1 (de) | 1999-11-17 |
AU665367B2 (en) | 1996-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR24136A (tr) | Ikameli tiyazollar ve bunlarin fungisitler yerine kullanimi | |
ES456287A1 (es) | Procedimiento para la preparacion de derivados de ladano po-lioxigenados. | |
DE69211182T2 (de) | Pyranylcyanoguanidinderivate | |
ATE109763T1 (de) | Benzophenon-derivate. | |
DE69230563T2 (de) | Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung | |
DE68906965D1 (de) | Analgetische phenothiazinderivate. | |
ES468658A1 (es) | Un procedimiento para preparar 4-alcohiltio-2-trifluorome- tilalcanosulfonanilidas y sus derivados | |
ATE105565T1 (de) | Pradimicinderivate. | |
DE3882015T2 (de) | Photochromische zusammensetzung und diese zusammensetzung enthaltende gegenstaende. | |
ATE112682T1 (de) | Isocarbacyclinderivate enthaltende antidiabetika. | |
TH14336EX (th) | อนุพันธ์ต่าง ๆ ของพิเพอริดีน | |
KR920702364A (ko) | 신규 세팔로스포린계 화합물 | |
DE60316219D1 (de) | Farbphotographisches lichtempfindliches Silberhalogenidmaterial | |
ATE24887T1 (de) | Cycloaliphatische alkohole. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |