DE69230563D1 - Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung - Google Patents

Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung

Info

Publication number
DE69230563D1
DE69230563D1 DE69230563T DE69230563T DE69230563D1 DE 69230563 D1 DE69230563 D1 DE 69230563D1 DE 69230563 T DE69230563 T DE 69230563T DE 69230563 T DE69230563 T DE 69230563T DE 69230563 D1 DE69230563 D1 DE 69230563D1
Authority
DE
Germany
Prior art keywords
antiarrhythmic
antifibrillational
effect
oxazolidinone derivatives
unsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230563T
Other languages
English (en)
Other versions
DE69230563T2 (de
Inventor
Salvatore Pelosi
Chia-Nien Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Procter and Gamble Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Pharmaceuticals Inc filed Critical Procter and Gamble Pharmaceuticals Inc
Publication of DE69230563D1 publication Critical patent/DE69230563D1/de
Application granted granted Critical
Publication of DE69230563T2 publication Critical patent/DE69230563T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
DE69230563T 1991-08-14 1992-08-10 Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung Expired - Fee Related DE69230563T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74486591A 1991-08-14 1991-08-14
PCT/US1992/006682 WO1993004064A1 (en) 1991-08-14 1992-08-10 Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents

Publications (2)

Publication Number Publication Date
DE69230563D1 true DE69230563D1 (de) 2000-02-17
DE69230563T2 DE69230563T2 (de) 2000-09-14

Family

ID=24994270

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230563T Expired - Fee Related DE69230563T2 (de) 1991-08-14 1992-08-10 Oxazolidinon-derivate mit antiarrhythmischer und antifibrillatorische wirkung

Country Status (23)

Country Link
US (1) US5994354A (de)
EP (2) EP0599968B1 (de)
JP (1) JPH06510285A (de)
AT (1) ATE188696T1 (de)
AU (1) AU665367B2 (de)
BR (1) BR9206353A (de)
CA (1) CA2115029C (de)
CZ (1) CZ283323B6 (de)
DE (1) DE69230563T2 (de)
DK (1) DK0599968T3 (de)
ES (1) ES2141725T3 (de)
FI (1) FI940658A0 (de)
GR (1) GR3032432T3 (de)
HU (1) HUT70144A (de)
IL (1) IL102791A (de)
MX (1) MX9204736A (de)
NO (1) NO300807B1 (de)
NZ (1) NZ243936A (de)
PL (1) PL171280B1 (de)
PT (1) PT100775B (de)
RU (1) RU2125568C1 (de)
SK (1) SK16994A3 (de)
WO (1) WO1993004064A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9206369A (pt) * 1991-08-14 1995-05-30 Procter & Gamble Pharma Novas uréias 4-oxocíclicas utilizáveis como agentes antiarrítmicos e antifibrilatórios
AU665367B2 (en) * 1991-08-14 1996-01-04 Procter & Gamble Pharmaceuticals, Inc. Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents
CZ286265B6 (cs) * 1991-08-14 2000-03-15 Procter And Gamble Pharmaceuticals Cyklické sloučeniny močoviny a farmaceutický prostředek, který je obsahuje
SK15842000A3 (sk) 1998-04-29 2001-06-11 The Procter & Gamble Company Spôsob prípravy 1,3-disubstituovaných-4-oxocyklických močovín
AU747237B2 (en) 1998-04-29 2002-05-09 Procter & Gamble Company, The Process for making 1,3-disubstituted-4-oxocyclic ureas
BRPI0817234A2 (pt) * 2007-09-26 2014-09-30 Sinai School Medicine Análogos de azacitidina e seus usos

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE624402A (de) *
US2802002A (en) * 1956-07-18 1957-08-06 Norwich Pharma Co Series of new nu-(5-nitro-2-furyl) alkylidene-3-amino-5-tertiaryamino-methyl-2-oxazolidones and the preparation thereof
GB843834A (en) * 1957-05-13 1960-08-10 Norwich Pharma Co N-(5-nitro-2-furyl)-alkylidene-3-amino-5-tertiaryaminomethyl-2-oxazolidones and chemotherapeutic compositions containing them
FR1274399A (fr) * 1958-01-23 1961-10-27 Norwich Pharma Co Procédé perfectionné de préparation de dérivés du 5-nitro-2-formyl-furan
NL104211C (de) * 1958-02-28
US3004888A (en) * 1959-01-12 1961-10-17 Pfizer & Co C Mastitis treatment
NL266216A (de) * 1960-07-12
FR385M (fr) * 1960-08-17 1961-03-24 Norwich Pharma Co Nouveau médicament pour le traitement des infections staphylococciques et analogues.
CH398599A (fr) * 1961-03-24 1966-03-15 Om Lab Sa Procédé de préparation d'hydrazones de l'a-bromo-B-(5-nitro-2-furyl)acroléine
BE633841A (de) * 1962-06-21
BE635608A (de) * 1962-08-01
US3415821A (en) * 1965-09-07 1968-12-10 Norwich Pharma Co 1-(5-substituted)furfurylideneamino hydantoins and imidazolidinones
US3318878A (en) * 1966-04-14 1967-05-09 Smith Kline French Lab Nitrothiophene compounds
GB1279408A (en) * 1968-09-12 1972-06-28 Ciba Geigy Ag 5-nitro-2-furfurylideneamino-oxazolidinones
US3839567A (en) * 1969-04-17 1974-10-01 Schering Ag Pharmaceutical compositions comprising 3-(5-nitro-2-imidazolyl-methylen-amino)-2-oxazolidinones and their use in trichomoniasia
US3906101A (en) * 1969-06-05 1975-09-16 Ciba Geigy Corp Pharmaceutical compositions containing substituted 5-nitrofurfurylideneamino-oxazolidinones
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
US4393204A (en) * 1982-05-21 1983-07-12 Norwich Eaton Pharmaceuticals, Inc. 3-[[5-(4-Chlorophenyl)furfurylidene]amino]-5-(substituted)-2-oxazolidinones
US4543359A (en) * 1982-10-01 1985-09-24 Eaton Laboratories, Inc. Treating cardiac arrhythmias with dantrolene sodium
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US4581370A (en) * 1983-07-12 1986-04-08 Schering A.G. Antiarrhythmic imidazoliums
US4720580A (en) * 1984-09-21 1988-01-19 American Home Products Corporation N-(aminoalkylene)benzenesulfonamides
US4707499A (en) * 1985-12-02 1987-11-17 G. D. Searle & Co. 3-alkyl-5-(substituted amino)methyl)dihydro-3-phenyl-2(3H)-furanones and imino analogs thereof used for treatment of arrhythmia
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
US4713832A (en) * 1986-04-11 1987-12-15 Ampex Corporation Programmable divider up/down counter with anti-aliasing feature and asynchronous read/write
IL79174A0 (en) * 1986-06-05 1986-09-30 Abic Ltd Water soluble salt of furaltadone
US4895867A (en) * 1986-06-26 1990-01-23 Norwich Eaton Pharmaceuticals, Inc. 2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents
US4886794A (en) * 1987-05-07 1989-12-12 A. H. Robins Company, Incorporated 4-[(α,α-diaryl)-hydroxymethyl]-1-piperidinylalkyl-cyclic carbamate derivatives as allergic response inhibitors
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
US4870095A (en) * 1988-06-13 1989-09-26 Sterling Drug, Inc. 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use
EP0347733A1 (de) * 1988-06-20 1989-12-27 Eisai Co., Ltd. Optisch aktive Hydantoin-Derivate
DE68929303T2 (de) * 1988-09-15 2002-05-02 Upjohn Co 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
US5091426A (en) * 1989-06-23 1992-02-25 Norwich Eaton Pharmaceuticals, Inc. 5-phenyl-2-furan ketones and use as antiepileptic agents
US4966967A (en) * 1989-09-15 1990-10-30 Berlex Laboratories, Inc. 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US4963561A (en) * 1990-02-28 1990-10-16 Sterling Drug Inc. Imidazopyridines, their preparation and use
US5066662A (en) * 1990-05-21 1991-11-19 Warner-Lambert Company Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors
US5086055A (en) * 1990-12-24 1992-02-04 A. H. Robins Company, Incorporated Series of 5-[-(4-aryl-1-piperazinyl)alkyl]-2-oxazolidinone derivatives useful in the treatment of allergic conditions
AU665367B2 (en) * 1991-08-14 1996-01-04 Procter & Gamble Pharmaceuticals, Inc. Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents

Also Published As

Publication number Publication date
US5994354A (en) 1999-11-30
EP0599968B1 (de) 2000-01-12
PL171280B1 (pl) 1997-03-28
NZ243936A (en) 1996-10-28
DK0599968T3 (da) 2000-04-17
HUT70144A (en) 1995-09-28
EP0957103A1 (de) 1999-11-17
CA2115029C (en) 2002-03-26
FI940658A (fi) 1994-02-11
GR3032432T3 (en) 2000-05-31
NO300807B1 (no) 1997-07-28
PT100775A (pt) 1994-01-31
CZ27894A3 (en) 1995-07-12
SK16994A3 (en) 1995-03-08
FI940658A0 (fi) 1994-02-11
IL102791A0 (en) 1993-01-31
ES2141725T3 (es) 2000-04-01
AU2467892A (en) 1993-03-16
CZ283323B6 (cs) 1998-02-18
RU2125568C1 (ru) 1999-01-27
BR9206353A (pt) 1995-11-07
NO940496L (no) 1994-02-14
ATE188696T1 (de) 2000-01-15
PT100775B (pt) 1999-09-30
EP0599968A1 (de) 1994-06-08
NO940496D0 (no) 1994-02-14
DE69230563T2 (de) 2000-09-14
JPH06510285A (ja) 1994-11-17
AU665367B2 (en) 1996-01-04
IL102791A (en) 1998-06-15
HU9400403D0 (en) 1994-05-30
WO1993004064A1 (en) 1993-03-04
CA2115029A1 (en) 1993-03-04
MX9204736A (es) 1993-11-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee