DE69223980T2 - Bindungstest unter benutzung eines markierten reagens - Google Patents

Bindungstest unter benutzung eines markierten reagens

Info

Publication number
DE69223980T2
DE69223980T2 DE69223980T DE69223980T DE69223980T2 DE 69223980 T2 DE69223980 T2 DE 69223980T2 DE 69223980 T DE69223980 T DE 69223980T DE 69223980 T DE69223980 T DE 69223980T DE 69223980 T2 DE69223980 T2 DE 69223980T2
Authority
DE
Germany
Prior art keywords
analyte
binding
binding agent
pct
capture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69223980T
Other languages
English (en)
Other versions
DE69223980D1 (de
Inventor
Roger Ekins
Frederick Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Multilyte Ltd
Original Assignee
Multilyte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919121873A external-priority patent/GB9121873D0/en
Application filed by Multilyte Ltd filed Critical Multilyte Ltd
Publication of DE69223980D1 publication Critical patent/DE69223980D1/de
Application granted granted Critical
Publication of DE69223980T2 publication Critical patent/DE69223980T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
DE69223980T 1991-10-15 1992-10-15 Bindungstest unter benutzung eines markierten reagens Expired - Lifetime DE69223980T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919121873A GB9121873D0 (en) 1991-10-15 1991-10-15 Improved non-competitive sandwich immunoassay system
GB929221094A GB9221094D0 (en) 1991-10-15 1992-10-07 Binding assay employing labelled reagent
PCT/GB1992/001892 WO1993008472A1 (en) 1991-10-15 1992-10-15 Binding assay employing labelled reagent

Publications (2)

Publication Number Publication Date
DE69223980D1 DE69223980D1 (de) 1998-02-12
DE69223980T2 true DE69223980T2 (de) 1998-05-28

Family

ID=26299698

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69223980T Expired - Lifetime DE69223980T2 (de) 1991-10-15 1992-10-15 Bindungstest unter benutzung eines markierten reagens

Country Status (9)

Country Link
US (1) US5516635A (de)
EP (1) EP0608370B1 (de)
JP (1) JP3097866B2 (de)
AT (1) ATE161964T1 (de)
AU (1) AU2872092A (de)
DE (1) DE69223980T2 (de)
DK (1) DK0608370T3 (de)
ES (1) ES2112916T3 (de)
WO (1) WO1993008472A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005062003A1 (de) * 2005-12-22 2007-06-28 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung und Verfahren zur Detektion und/oder quantitativen Messung eines Zielmediums

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI96143C (fi) * 1993-03-16 1996-05-10 Wallac Oy Biospesifinen määritysmenetelmä
GB9326450D0 (en) * 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
US6416714B1 (en) * 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
GB9602323D0 (en) * 1996-02-06 1996-04-03 Boehringer Mannheim Gmbh Materials and methods relating to binding assays
FI100276B (fi) * 1996-02-06 1997-10-31 Orion Yhtymae Oy Menetelmä analyyttien ei-kilpailevaa määritystä varten
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
WO1997032212A1 (en) * 1996-03-01 1997-09-04 Beckman Instruments, Inc. System for simultaneously conducting multiple ligand binding assays
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
ES2288760T3 (es) * 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
EP0912761A4 (de) 1996-05-29 2004-06-09 Cornell Res Foundation Inc Bestimmung von unterschieden in der nukleisäuresequenz mittels einer kombination von ligasebestimmung und polymerase-kettenreaktion
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6280945B1 (en) * 1997-02-21 2001-08-28 Saigene Corporation Universal solid-phase hybridization apparatus
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
CA2792122C (en) * 1997-07-07 2015-09-08 Medical Research Council In vitro sorting method
DE19731465A1 (de) * 1997-07-22 1999-01-28 Boehringer Mannheim Gmbh Verwendung von Kontrollflächen zur Detektion von Störproben in einem Nachweisverfahren
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7157234B2 (en) * 1997-10-24 2007-01-02 Beckman Coulter, Inc. Detection of very low quantities of analyte bound to a solid phase
DE19748489A1 (de) 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
WO1999040434A1 (en) 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6395562B1 (en) 1998-04-22 2002-05-28 The Regents Of The University Of California Diagnostic microarray apparatus
US6342395B1 (en) 1998-04-22 2002-01-29 The Regents Of The University Of California Compact assay system with digital information
US8063190B2 (en) * 1998-06-02 2011-11-22 Tom Robin Caine Boyde Nucleic acid-linked conjugates and methods for making and using them
WO1999067643A1 (de) * 1998-06-22 1999-12-29 Roche Diagnostics Gmbh Verbesserung von bindeassays durch multiepitopanalyse und kombination von antigen- und antikörper-bestimmung
DE19838802A1 (de) * 1998-06-22 1999-12-23 Roche Diagnostics Gmbh Verbesserung von Bindeassays durch Multiepitopanalyse und Kombination von Antigen- und Antikörper-Bestimmung
EP1090293B2 (de) 1998-06-24 2019-01-23 Illumina, Inc. Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20060275782A1 (en) * 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
EP1190100B1 (de) 1999-05-20 2012-07-25 Illumina, Inc. Kombinatorische entschlüsselung von zufallsnukleinsäurearrays
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
DE19927783A1 (de) * 1999-06-18 2000-12-21 Roche Diagnostics Gmbh Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts
US6645733B1 (en) * 1999-06-25 2003-11-11 Ingeneus Corporation Fluorescent intensity method for assaying binding between proteins or peptides
DK1218545T3 (da) 1999-08-18 2012-02-20 Illumina Inc Fremgangsmåder til fremstilling af oligonukleotidopløsninger
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US7429466B2 (en) * 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US8143195B2 (en) * 2000-01-24 2012-03-27 Yingjian Wang Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US6913884B2 (en) * 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
EP1255865B1 (de) 2000-02-07 2007-04-18 Illumina, Inc. Nukleinsäure Nachweisverfahren mit universellem Priming
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
EP1990428B1 (de) 2000-02-07 2010-12-22 Illumina, Inc. Nukleinsäuredetektionsverfahren mit universellem Priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
DE10005301A1 (de) * 2000-02-07 2001-08-09 Trutnau Hans Heinrich Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
AU2001239760B2 (en) * 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
EP1257668B1 (de) 2000-02-16 2008-10-29 Illumina, Inc. Parallele genotypisierung mehrerer patientenproben
CA2405412A1 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
IL152634A0 (en) * 2000-05-04 2003-06-24 Univ Yale High density protein arrays for screening of protein activity
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (es) 2000-06-21 2006-10-16 Bioarray Solutions Ltd Analisis molecular de multiples analitos usando series de particulas aleatorias con especificidad de aplicacion.
AU2001288751A1 (en) * 2000-09-05 2002-03-22 Illumina, Inc. Cellular arrays comprising encoded cells
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7354721B2 (en) * 2000-09-22 2008-04-08 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods, and kits and systems for practicing the same
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US20040018491A1 (en) * 2000-10-26 2004-01-29 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
WO2002038812A2 (en) * 2000-11-07 2002-05-16 Denton Richard V Method in quantitative analysis of gene and protein expression
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003029490A1 (en) * 2001-10-01 2003-04-10 Yingjian Wang Methods and arrays for detecting biological molecules
EP2722395B1 (de) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Gemultiplexte Analyse polymorphischer Stellen durch gleichzeitige Abfrage und enzymvermittelte Detektion
GB0127564D0 (en) * 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US6837171B1 (en) 2002-04-29 2005-01-04 Palmer/Snyder Furniture Company Lightweight table with unitized table top
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US7499806B2 (en) * 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
US20030162178A1 (en) * 2002-02-25 2003-08-28 O'hagan David Variable microarray and methods of detecting one or more anlaytes in a sample
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
WO2004013290A2 (en) * 2002-08-05 2004-02-12 Invitrogen Corporation Compositions and methods for molecular biology
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) * 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
DE10245644A1 (de) * 2002-09-30 2004-04-08 Cibitest Gmbh & Co.Kg. Verfahren zum Nachweis von Analyten
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7781172B2 (en) * 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040106190A1 (en) * 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
US7887752B2 (en) * 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ES2375962T3 (es) 2003-09-22 2012-03-07 Bioarray Solutions Ltd Polielectrolito inmovilizado en superficie con múltiples grupos funcionales capaces de unirse covalentemente a biomoléculas.
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
US20050112703A1 (en) * 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7943089B2 (en) * 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US20050136550A1 (en) * 2003-12-19 2005-06-23 Kimberly-Clark Worldwide, Inc. Flow control of electrochemical-based assay devices
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
US20050147963A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
WO2005071401A2 (en) * 2004-01-15 2005-08-04 Chiron Corporation Homogeneous multiplex assay for nucleic acid targets
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
ATE487943T1 (de) * 2004-04-08 2010-11-15 Hoffmann La Roche Fluoreszenzpolypeptidkomplex einer grösse von 40 bis 500 nm
US7521226B2 (en) * 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
ES2303925T3 (es) * 2004-08-12 2008-09-01 F. Hoffmann-La Roche Ag Metodo para diagnosticar la fibrosis hepatica.
EP1626280B1 (de) * 2004-08-12 2007-02-14 Roche Diagnostics GmbH Verfahren zur Diagnose von Leberfibrose.
GB0421838D0 (en) 2004-09-30 2004-11-03 Congenia S R L Cancer markers
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE102004052729A1 (de) * 2004-10-30 2006-05-04 Roche Diagnostics Gmbh Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten
KR100601983B1 (ko) * 2005-01-20 2006-07-18 삼성전자주식회사 시료 내 핵산 증폭 저해 물질의 제거 방법
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US7439079B2 (en) * 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
EP2363205A3 (de) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen Und Verfahren Zur Verwendung Bei Der Bildung Und Kontrolle Von Nanoreaktoren
EP2530168B1 (de) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
EP3415235A1 (de) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation von mikrofluidiktröpfchen
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (de) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Digitale analyse von analyten
ES2555864T3 (es) 2010-08-19 2016-01-11 F. Hoffmann-La Roche Ag Ensayo para la medición de anticuerpos de unión a un anticuerpo monoclonal terapéutico
GB201016403D0 (en) 2010-09-29 2010-11-10 Bath Ventures Novel interaction between staphylococcus aureus Sbi and C3d protiens
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3709018A1 (de) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtung zum nachweis von komponenten einer chemischen reaktion
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
TWI476394B (zh) * 2012-04-02 2015-03-11 Univ Chang Gung And a method and method for determining whether a target biomolecule exists in a sample to be measured
EP4219750A3 (de) 2013-03-11 2023-12-13 Meso Scale Technologies, LLC. Verbesserte verfahren zur durchführung von multiplex-assays
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10252231B2 (en) 2014-10-31 2019-04-09 Massachusetts Institute Of Technology Compositions and methods for forming emulsions
WO2016070027A1 (en) 2014-10-31 2016-05-06 Massachusetts Institute Of Technology Compositions and methods for arranging colloid phases
US10060913B2 (en) * 2016-09-19 2018-08-28 Massachusetts Institute Of Technology Systems including janus droplets capable of binding an analyte and changing orientation to provide a detectable change
US11119098B2 (en) 2014-10-31 2021-09-14 Massachusetts Institute Of Technology Systems including Janus droplets
CN104714017A (zh) * 2015-02-06 2015-06-17 北京豪迈生物工程有限公司 一种定量检测降钙素原的方法
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11415551B2 (en) * 2016-04-26 2022-08-16 Qorvo Biotechnologies, Llc Resonator for detecting single molecule binding
US20220397528A1 (en) * 2019-11-15 2022-12-15 The Regents Of The University Of Michigan Systems and methods for rapid, sensitive multiplex immunoassays
CN111077316A (zh) * 2019-12-24 2020-04-28 北京博肽未名生物技术有限公司 一种荧光微球与抗体的偶联方法
CN113419059B (zh) * 2021-06-30 2023-09-01 迈克生物股份有限公司 用于化学发光免疫分析方法的封闭剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4372745A (en) * 1979-12-19 1983-02-08 Electro-Nucleonics, Inc. Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
US4732847A (en) * 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
WO1984001031A1 (en) * 1982-08-27 1984-03-15 Roger Philip Ekins Measurement of analyte concentration
US4663277A (en) * 1983-05-20 1987-05-05 Profile Diagnostic Sciences Inc. Virus detection method and materials
JP2690011B2 (ja) * 1986-08-06 1997-12-10 マルティライト リミテッド 二種の標識マーカーを使用するアナライト濃度の測定
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US5132242A (en) * 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
JPS6435373A (en) * 1987-07-31 1989-02-06 Fujirebio Kk Method and device for high-sensitivity immunoassay
GB8803000D0 (en) * 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US4978625A (en) * 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
JPH01214760A (ja) * 1988-02-23 1989-08-29 Teikoku Hormone Mfg Co Ltd 免疫学的簡易測定方法
FR2628530B1 (fr) * 1988-03-08 1994-01-28 Chemunex Sa Appareil et procede de detection et de numeration de particules fluorescentes, portees par un support solide
US5252459A (en) * 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005062003A1 (de) * 2005-12-22 2007-06-28 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung und Verfahren zur Detektion und/oder quantitativen Messung eines Zielmediums

Also Published As

Publication number Publication date
DE69223980D1 (de) 1998-02-12
EP0608370B1 (de) 1998-01-07
ES2112916T3 (es) 1998-04-16
DK0608370T3 (da) 1998-09-07
EP0608370A1 (de) 1994-08-03
JPH07500906A (ja) 1995-01-26
JP3097866B2 (ja) 2000-10-10
ATE161964T1 (de) 1998-01-15
WO1993008472A1 (en) 1993-04-29
AU2872092A (en) 1993-05-21
US5516635A (en) 1996-05-14

Similar Documents

Publication Publication Date Title
DE69223980T2 (de) Bindungstest unter benutzung eines markierten reagens
JP4997222B2 (ja) 多機能かつ構成可能なアッセイ
DE69022254D1 (de) Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes.
US6713271B1 (en) Systems and methods for performing magnetic chromatography assays
KR900702368A (ko) 전기화학 발광성 분석
US20070105237A1 (en) Lateral flow assay device with multiple equidistant capture zones
IL101233A (en) Receptor-based screening and identifying methods for amylin agonists and antagonists
DE60018537D1 (de) Teststreifen zur Bestimmung eines Analyts in eine flüssige Probe
WO1999064867A8 (en) Multiple assay method
ATE312199T1 (de) Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests
DE60006975D1 (de) Analytische testvorrichtung mit orientierte durchgehende kanäle besitzendem substrat und verbesserte verfahren und vorrichtung zum gebrauch derselben
JPH07503063A (ja) 生体分子検定施行法及び当該方法に使用する固相担体
ATE352786T1 (de) Reagens zur lumineszenz-optischen bestimmung eines analyten
JPH04500860A (ja) 分析的アッセイ方法
Eggen et al. The potential of mechanism-based bioanalytical tools in ecotoxicological exposure and effect assessment
US7371584B2 (en) Multi-functional and configurable assay
ATE360206T1 (de) Verfahren zur messung der gesamkonzentration eines analytes
CN101266245A (zh) 纳米金银染增强技术检测痕量二恶英的生物学方法
JP4460779B2 (ja) ホスファターゼ標的毒素のアッセイ
WO2002014869A3 (en) Assay method and device for detecting the presence and concentration of analytes
WO2002068697A3 (en) Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
Roffman et al. Field Screening for Organic Contaminants in Samples From Hazardous Waste Sites

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R071 Expiry of right

Ref document number: 608370

Country of ref document: EP