DE69219482T2 - Mit einer einfach ungesättigten omega-9 C18 or C20 Fettsäure O-acylierte Nukleoside - Google Patents

Mit einer einfach ungesättigten omega-9 C18 or C20 Fettsäure O-acylierte Nukleoside

Info

Publication number
DE69219482T2
DE69219482T2 DE69219482T DE69219482T DE69219482T2 DE 69219482 T2 DE69219482 T2 DE 69219482T2 DE 69219482 T DE69219482 T DE 69219482T DE 69219482 T DE69219482 T DE 69219482T DE 69219482 T2 DE69219482 T2 DE 69219482T2
Authority
DE
Germany
Prior art keywords
fatty acid
nucleosides
acid
monounsaturated omega
ara
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69219482T
Other languages
English (en)
Other versions
DE69219482D1 (de
Inventor
Are Dalen
Finn Myhren
Rretzen Bernt B
Kjell Stokke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Conpharma AS
Original Assignee
Norsk Hydro ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro ASA filed Critical Norsk Hydro ASA
Publication of DE69219482D1 publication Critical patent/DE69219482D1/de
Application granted granted Critical
Publication of DE69219482T2 publication Critical patent/DE69219482T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
DE69219482T 1991-10-07 1992-09-30 Mit einer einfach ungesättigten omega-9 C18 or C20 Fettsäure O-acylierte Nukleoside Expired - Lifetime DE69219482T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9121257A GB2260319B (en) 1991-10-07 1991-10-07 Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
PCT/NO1992/000162 WO1993007163A1 (en) 1991-10-07 1992-09-30 Chemical compounds

Publications (2)

Publication Number Publication Date
DE69219482D1 DE69219482D1 (de) 1997-06-05
DE69219482T2 true DE69219482T2 (de) 1997-10-23

Family

ID=10702531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69219482T Expired - Lifetime DE69219482T2 (de) 1991-10-07 1992-09-30 Mit einer einfach ungesättigten omega-9 C18 or C20 Fettsäure O-acylierte Nukleoside

Country Status (27)

Country Link
US (1) US6548486B1 (de)
EP (1) EP0642525B1 (de)
JP (1) JP2873313B2 (de)
KR (1) KR100272732B1 (de)
AT (1) ATE152454T1 (de)
CA (1) CA2120725C (de)
CH (1) CH0642525H1 (de)
CZ (1) CZ288153B6 (de)
DE (1) DE69219482T2 (de)
DK (1) DK0642525T3 (de)
FI (2) FI105035B (de)
GB (1) GB2260319B (de)
GR (1) GR3024149T3 (de)
HK (1) HK1007430A1 (de)
HU (1) HU219400B (de)
IL (1) IL103351A (de)
MX (1) MX9205715A (de)
NO (1) NO300014B1 (de)
NZ (1) NZ244535A (de)
PL (1) PL170846B1 (de)
RU (1) RU2126417C1 (de)
SG (1) SG47759A1 (de)
SK (1) SK281903B6 (de)
TW (1) TW347333B (de)
UA (1) UA41296C2 (de)
WO (1) WO1993007163A1 (de)
ZA (1) ZA927432B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
GB0201179D0 (en) * 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
US9029345B2 (en) * 2005-03-16 2015-05-12 Case Western Reserve University Selective inhibitors of translesion DNA replication
US8114847B2 (en) 2005-03-16 2012-02-14 Case Western Reserve University Selective inhibitors of translesion DNA replication
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en) 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
WO2008150438A1 (en) * 2007-06-01 2008-12-11 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
CA2717788A1 (en) 2007-07-09 2009-01-15 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
MX2010003261A (es) * 2007-09-26 2010-08-18 Sinai School Medicine Analogos de azacitidina y usos de los mismos.
EP2825546B1 (de) 2011-09-01 2017-07-12 Case Western Reserve University Nicht-natürliche nukleoside als theranostika
US9493500B2 (en) 2012-07-19 2016-11-15 Richard Daifuku Fluorinated pyrimidine analogs and methods of use thereof
US9821173B2 (en) 2013-02-08 2017-11-21 Case Western Reserve University Anti-cancer agents and methods of use
RU2621145C2 (ru) * 2015-11-03 2017-05-31 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ") Способ получения липосом

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920630A (en) 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
GB1325797A (en) 1970-09-24 1973-08-08 Upjohn Co Medicines comprising cytidine derivatives
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
US4355032B2 (en) 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4816447A (en) 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
NZ201662A (en) 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
JPH0655755B2 (ja) 1985-01-23 1994-07-27 富山化学工業株式会社 新規な5−フルオロ−2′−デオキシウリジン−3′−ホスフエ−ト誘導体およびその塩
US4684631A (en) 1984-10-09 1987-08-04 Toyama Chemical Co., Ltd. Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
JPS6483092A (en) 1987-09-24 1989-03-28 Arakawa Chotaro & Co Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component
ZA888083B (en) * 1987-10-28 1990-06-27 Pro Neuron Inc Acyl deoxyribonucleoside derivatives and uses thereof
JPH0278696A (ja) 1988-09-13 1990-03-19 Shoichiro Ozaki 5−フルオロウラシル誘導体
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
FI105556B (fi) * 1991-09-30 2000-09-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta

Also Published As

Publication number Publication date
HUT68008A (en) 1995-05-29
NZ244535A (en) 1995-08-28
EP0642525B1 (de) 1997-05-02
FI990270A (fi) 1999-02-10
PL170846B1 (en) 1997-01-31
DK0642525T3 (da) 1997-11-03
US6548486B1 (en) 2003-04-15
NO941269D0 (no) 1994-04-07
GB9121257D0 (en) 1991-11-20
FI941574A0 (fi) 1994-04-06
JP2873313B2 (ja) 1999-03-24
NO941269L (no) 1994-04-07
TW347333B (en) 1998-12-11
KR100272732B1 (ko) 2000-11-15
ATE152454T1 (de) 1997-05-15
SG47759A1 (en) 1998-04-17
ZA927432B (en) 1993-06-09
DE69219482D1 (de) 1997-06-05
SK281903B6 (sk) 2001-09-11
RU2126417C1 (ru) 1999-02-20
GR3024149T3 (en) 1997-10-31
EP0642525A1 (de) 1995-03-15
FI105035B (fi) 2000-05-31
HU9400988D0 (en) 1994-07-28
HU219400B (hu) 2001-04-28
WO1993007163A1 (en) 1993-04-15
FI941574A (fi) 1994-04-06
JPH06511249A (ja) 1994-12-15
CZ80594A3 (en) 1994-12-15
GB2260319B (en) 1995-12-06
UA41296C2 (uk) 2001-09-17
IL103351A (en) 2000-02-17
NO300014B1 (no) 1997-03-17
CH0642525H1 (en) 1999-06-30
AU672369B2 (en) 1996-10-03
AU2867392A (en) 1993-05-03
CA2120725C (en) 2000-04-11
CZ288153B6 (en) 2001-05-16
SK39794A3 (en) 1994-10-05
IL103351A0 (en) 1993-03-15
GB2260319A (en) 1993-04-14
CA2120725A1 (en) 1993-04-15
FI990270A0 (fi) 1999-02-10
HK1007430A1 (en) 1999-04-09
MX9205715A (es) 1993-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8315 Request for restriction filed
8318 Patent restricted
8327 Change in the person/name/address of the patent owner

Owner name: CONPHARMA AS, OSLO, NO

R071 Expiry of right

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