DE69213844D1 - Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür - Google Patents
Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafürInfo
- Publication number
- DE69213844D1 DE69213844D1 DE69213844T DE69213844T DE69213844D1 DE 69213844 D1 DE69213844 D1 DE 69213844D1 DE 69213844 T DE69213844 T DE 69213844T DE 69213844 T DE69213844 T DE 69213844T DE 69213844 D1 DE69213844 D1 DE 69213844D1
- Authority
- DE
- Germany
- Prior art keywords
- vitamin
- group
- derivative
- production
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000543 intermediate Substances 0.000 title 1
- 150000003710 vitamin D derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 3
- 235000019166 vitamin D Nutrition 0.000 abstract 3
- 239000011710 vitamin D Substances 0.000 abstract 3
- -1 vitamin D compound Chemical class 0.000 abstract 3
- 229940046008 vitamin d Drugs 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- BNRNAKTVFSZAFA-UHFFFAOYSA-N hydrindane Chemical compound C1CCCC2CCCC21 BNRNAKTVFSZAFA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/532—Cycloaliphatic phosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91201746 | 1991-07-05 | ||
EP92200154 | 1992-01-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69213844D1 true DE69213844D1 (de) | 1996-10-24 |
DE69213844T2 DE69213844T2 (de) | 1997-04-10 |
Family
ID=26129316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69213844T Expired - Fee Related DE69213844T2 (de) | 1991-07-05 | 1992-06-24 | Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür |
Country Status (12)
Country | Link |
---|---|
US (3) | US5403940A (de) |
EP (1) | EP0521550B1 (de) |
JP (1) | JP3342047B2 (de) |
AT (1) | ATE143007T1 (de) |
AU (1) | AU650148B2 (de) |
CA (1) | CA2072915C (de) |
DE (1) | DE69213844T2 (de) |
DK (1) | DK0521550T3 (de) |
ES (1) | ES2093180T3 (de) |
GR (1) | GR3022053T3 (de) |
IL (1) | IL102385A (de) |
NZ (1) | NZ243409A (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US5830885A (en) * | 1992-03-12 | 1998-11-03 | The Johns Hopkins University | Antiproliferative vitamin D3 hybrids |
DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
GB9220272D0 (en) * | 1992-09-25 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
GB9220439D0 (en) * | 1992-09-28 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
TW267161B (de) * | 1992-11-20 | 1996-01-01 | Hoffmann La Roche | |
US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
US6121469A (en) * | 1993-12-23 | 2000-09-19 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs |
DK0717034T3 (da) * | 1994-12-14 | 1999-10-18 | Duphar Int Res | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser |
US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
CA2175881A1 (en) * | 1995-05-09 | 1996-11-10 | Andrzej Kutner | Vitamin d compounds and methods of preparing these compounds |
GB9607034D0 (en) * | 1996-04-03 | 1996-06-05 | Leo Pharm Prod Ltd | Chemical compounds |
US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
JP2001511811A (ja) * | 1997-02-13 | 2001-08-14 | ボーン ケア インターナショナル インコーポレイテッド | ビタミンd化合物の標的治療放出 |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
US5939406A (en) * | 1997-07-21 | 1999-08-17 | Wisconsin Alumni Research Foundation | 18-substituted-19-nor-vitamin D compounds |
US6359152B2 (en) | 1997-07-21 | 2002-03-19 | Wisconsin Alumni Research Foundation | 18-substituted-19-nor-vitamin D compounds |
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
JP4219553B2 (ja) | 1997-09-08 | 2009-02-04 | エフ.ホフマン−ラ ロシュ アーゲー | 1,3−ジヒドロキシ−20,20−ジアルキル−ビタミンd3類似体 |
WO1999049870A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
CA2414407A1 (en) * | 2000-07-18 | 2002-01-24 | Bone Care International, Inc. | Stabilized 1.alpha.-hydroxy vitamin d |
DE10129108A1 (de) * | 2001-06-16 | 2003-01-02 | Harman Becker Automotive Sys | Verfahren und Schaltungsanordnung zur Datenübertragung |
WO2003026445A1 (en) * | 2001-09-27 | 2003-04-03 | The Coca-Cola Company | Vitamin fortification of foodstuffs |
US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
DK1879595T3 (en) * | 2005-05-10 | 2015-01-05 | Dermipsor Ltd | Preparations and Methods for the Treatment of Hyperproliferative Epidermal Diseases |
US8034788B2 (en) * | 2005-05-10 | 2011-10-11 | Dermipsor Ltd. | Composition and methods for skin care |
WO2007070853A2 (en) * | 2005-12-14 | 2007-06-21 | Digital Signal Corporation | System and method for tracking eyeball motion |
EA026334B1 (ru) * | 2009-01-27 | 2017-03-31 | БЕРГ ЭлЭлСи | Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении |
CA2770683C (en) | 2009-08-14 | 2018-09-04 | Berg Biosystems, Llc | Vitamin d3 and analogs thereof for treating alopecia |
CN112156097A (zh) | 2013-05-29 | 2021-01-01 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
US20190183908A1 (en) | 2016-05-13 | 2019-06-20 | Case Western Reserve University | Autophagy activators for treating or preventing skin injury |
US9989699B2 (en) | 2016-10-27 | 2018-06-05 | Corning Incorporated | Low bend loss single mode optical fiber |
CN113056473A (zh) | 2018-09-07 | 2021-06-29 | 达特茅斯学院托管理事会 | C19支架和甾体及其使用和制造方法 |
US11512107B2 (en) | 2018-09-07 | 2022-11-29 | Trustees Of Dartmouth College | Methods for assembly of tetracyclic compounds by stereoselective C9-C10 bond formation |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4617297A (en) * | 1982-02-12 | 1986-10-14 | Hoffmann-La Roche Inc. | Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol |
US4508651A (en) * | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
US4613594A (en) * | 1984-11-16 | 1986-09-23 | Hoffmann-La Roche Inc. | Fluorinated vitamin D3 compounds |
US4612308A (en) * | 1984-11-29 | 1986-09-16 | Hoffmann-La Roche Inc. | 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers |
EP0205025A1 (de) * | 1985-05-27 | 1986-12-17 | Sumitomo Pharmaceuticals Company, Limited | Fluorin enthaltende Vitamin-D3-Derivate und Zelldifferenzierung induzierende Mittel, die sie als aktiven Wirkstoff enthalten |
US4755329A (en) * | 1985-06-10 | 1988-07-05 | Wisconsin Alumni Research Foundation | Process and intermediates for preparing 1α-hydroxyvitamin D compounds |
DE3666587D1 (en) * | 1985-08-02 | 1989-11-30 | Leo Pharm Prod Ltd | Novel vitamin d analogues |
IL77668A (en) * | 1986-01-21 | 1989-03-31 | Teva Pharma | Production of cholecalciferol derivatives and novel intermediates used therefor |
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
NZ232734A (en) * | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
US5617297A (en) * | 1995-09-25 | 1997-04-01 | National Semiconductor Corporation | Encapsulation filler technology for molding active electronics components such as IC cards or PCMCIA cards |
-
1992
- 1992-06-24 DK DK92201851.0T patent/DK0521550T3/da active
- 1992-06-24 ES ES92201851T patent/ES2093180T3/es not_active Expired - Lifetime
- 1992-06-24 EP EP92201851A patent/EP0521550B1/de not_active Expired - Lifetime
- 1992-06-24 DE DE69213844T patent/DE69213844T2/de not_active Expired - Fee Related
- 1992-06-24 AT AT92201851T patent/ATE143007T1/de not_active IP Right Cessation
- 1992-06-29 AU AU18649/92A patent/AU650148B2/en not_active Ceased
- 1992-07-01 NZ NZ243409A patent/NZ243409A/en not_active IP Right Cessation
- 1992-07-02 JP JP19928792A patent/JP3342047B2/ja not_active Expired - Fee Related
- 1992-07-02 IL IL10238592A patent/IL102385A/xx not_active IP Right Cessation
- 1992-07-02 CA CA002072915A patent/CA2072915C/en not_active Expired - Fee Related
-
1994
- 1994-01-12 US US08/180,463 patent/US5403940A/en not_active Expired - Lifetime
- 1994-11-01 US US08/333,305 patent/US5637742A/en not_active Expired - Fee Related
-
1996
- 1996-12-17 GR GR960403487T patent/GR3022053T3/el unknown
-
1997
- 1997-02-13 US US08/799,346 patent/US6072062A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK0521550T3 (da) | 1996-11-04 |
JPH05221961A (ja) | 1993-08-31 |
US6072062A (en) | 2000-06-06 |
US5637742A (en) | 1997-06-10 |
IL102385A0 (en) | 1993-01-14 |
EP0521550A3 (en) | 1993-06-16 |
IL102385A (en) | 1996-09-12 |
CA2072915A1 (en) | 1993-01-06 |
JP3342047B2 (ja) | 2002-11-05 |
DE69213844T2 (de) | 1997-04-10 |
CA2072915C (en) | 2005-11-01 |
GR3022053T3 (en) | 1997-03-31 |
ATE143007T1 (de) | 1996-10-15 |
AU650148B2 (en) | 1994-06-09 |
EP0521550B1 (de) | 1996-09-18 |
NZ243409A (en) | 1995-02-24 |
AU1864992A (en) | 1993-01-07 |
EP0521550A2 (de) | 1993-01-07 |
US5403940A (en) | 1995-04-04 |
ES2093180T3 (es) | 1996-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |