DE69130482T2 - Luciferase-zusammensetzungen und verfahren - Google Patents

Luciferase-zusammensetzungen und verfahren

Info

Publication number
DE69130482T2
DE69130482T2 DE69130482T DE69130482T DE69130482T2 DE 69130482 T2 DE69130482 T2 DE 69130482T2 DE 69130482 T DE69130482 T DE 69130482T DE 69130482 T DE69130482 T DE 69130482T DE 69130482 T2 DE69130482 T2 DE 69130482T2
Authority
DE
Germany
Prior art keywords
luciferase
methods
luciferin
coenzyme
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69130482T
Other languages
English (en)
Other versions
DE69130482D1 (de
DE69130482T3 (de
Inventor
Keith Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24320802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69130482(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Promega Corp filed Critical Promega Corp
Publication of DE69130482D1 publication Critical patent/DE69130482D1/de
Publication of DE69130482T2 publication Critical patent/DE69130482T2/de
Application granted granted Critical
Publication of DE69130482T3 publication Critical patent/DE69130482T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
    • C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
DE69130482T 1990-09-10 1991-09-09 Luciferase-zusammensetzungen und verfahren Expired - Lifetime DE69130482T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US580371 1990-09-10
US07/580,371 US5283179A (en) 1990-09-10 1990-09-10 Luciferase assay method
PCT/US1991/006474 WO1992004468A1 (en) 1990-09-10 1991-09-09 Luciferase compositions and methods

Publications (3)

Publication Number Publication Date
DE69130482D1 DE69130482D1 (de) 1998-12-17
DE69130482T2 true DE69130482T2 (de) 1999-05-27
DE69130482T3 DE69130482T3 (de) 2006-05-04

Family

ID=24320802

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130482T Expired - Lifetime DE69130482T3 (de) 1990-09-10 1991-09-09 Luciferase-zusammensetzungen und verfahren

Country Status (10)

Country Link
US (4) US5283179A (de)
EP (1) EP0553234B2 (de)
JP (2) JP3171595B2 (de)
AT (1) ATE173298T1 (de)
AU (1) AU649289B2 (de)
DE (1) DE69130482T3 (de)
DK (1) DK0553234T4 (de)
ES (1) ES2126576T5 (de)
GR (1) GR3029352T3 (de)
WO (1) WO1992004468A1 (de)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283179A (en) * 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method
GB9224058D0 (en) * 1992-11-17 1993-01-06 Celsis Ltd Bioluminescence reagent formulation
AT401526B (de) * 1993-02-10 1996-09-25 Scheirer Winfried Reagenzlösung zur stabilisierung der lumineszenz bei der luciferasemessung
JP2651651B2 (ja) * 1993-04-21 1997-09-10 チッソ株式会社 蛍酵素ルシフェラーゼ遺伝子
US5695928A (en) * 1993-12-10 1997-12-09 Novartis Corporation Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction
US6770446B1 (en) * 1994-06-14 2004-08-03 Wyeth Cell systems having specific interaction of peptide binding pairs
US6649143B1 (en) 1994-07-01 2003-11-18 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5679515A (en) * 1994-10-03 1997-10-21 Pathogenesis Corporation Mycobacterial reporter strains and uses thereof
US5744320A (en) * 1995-06-07 1998-04-28 Promega Corporation Quenching reagents and assays for enzyme-mediated luminescence
US5726041A (en) * 1995-08-30 1998-03-10 Gentest Corporation Method for detecting a receptor-ligand complex using a cytochrome P450 reporter gene
US8349602B1 (en) 1996-04-19 2013-01-08 Xenogen Corporation Biodetectors targeted to specific ligands
US5798263A (en) * 1996-09-05 1998-08-25 Promega Corporation Apparatus for quantifying dual-luminescent reporter assays
US6602677B1 (en) * 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
US6171809B1 (en) 1998-01-29 2001-01-09 Packard Instrument Company Method and compositions for detecting luciferase biological samples
CA2263784A1 (en) 1998-03-23 1999-09-23 Megabios Corporation Dual-tagged proteins and their uses
US6183978B1 (en) * 1998-09-04 2001-02-06 Tropix, Inc. Luciferase assay, compositions and kits for use in connection therewith
NL1010224C2 (nl) * 1998-09-30 2000-03-31 Packard Biosciene B V Werkwijze voor het detecteren van ATP.
WO2000040746A1 (en) * 1999-01-08 2000-07-13 Medical Analysis Systems, Inc. Compositions and methods for stabilizing thiol-containing biomolecules
US6410255B1 (en) 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
JP2001103972A (ja) * 1999-10-06 2001-04-17 Kikkoman Corp ルシフェリンを再生する能力を有するタンパク質をコードする遺伝子、新規な組み換え体ｄｎａ及びルシフェリンを再生する能力を有するタンパク質の製造法
US20040214227A1 (en) * 1999-12-22 2004-10-28 Erik Joly Bioluminescence resonance energy transfer (bret) fusion molecule and method of use
US6502774B1 (en) * 2000-03-08 2003-01-07 J + L Fiber Services, Inc. Refiner disk sensor and sensor refiner disk
US6927851B2 (en) * 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
US6667287B2 (en) * 2000-04-20 2003-12-23 Colgate-Palmolive Company Light duty cleaning composition comprising an amine oxide and polyacrylic acid homopolymer
WO2001081548A1 (en) * 2000-04-24 2001-11-01 Wyeth Novel cell systems having specific interaction of peptide binding pairs
AU2001275138A1 (en) * 2000-06-02 2001-12-17 The University Of Utah Research Foundation Active needle devices with integrated functionality
US7118878B1 (en) 2000-06-09 2006-10-10 Promega Corporation Method for increasing luminescence assay sensitivity
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US20030157643A1 (en) * 2000-08-24 2003-08-21 Almond Brian D Synthetic nucleic acids from aquatic species
US7879540B1 (en) 2000-08-24 2011-02-01 Promega Corporation Synthetic nucleic acid molecule compositions and methods of preparation
CA2427472A1 (en) 2000-10-27 2002-06-06 Tae Kook Kim Double and triple readout assay systems
US6660489B2 (en) 2000-12-01 2003-12-09 Becton, Dickinson And Company ATP extraction method
CA2328684A1 (en) * 2000-12-15 2002-06-15 Yahia Gawad Photon-triggered luminescent assay
ATE538380T1 (de) * 2001-01-23 2012-01-15 Harvard College Nukleinsäure-programmierbare protein-arrays
US7666615B2 (en) * 2001-01-29 2010-02-23 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
US7354730B2 (en) * 2002-01-29 2008-04-08 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
WO2003004995A2 (en) * 2001-01-29 2003-01-16 Rich Ivan N High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
US7989178B2 (en) * 2001-01-29 2011-08-02 Hemogenix, Inc. Colony assay miniaturization with enumeration output
US7083911B2 (en) 2001-02-16 2006-08-01 Promega Corporation Method for detection of ATP
US6858773B2 (en) * 2001-04-20 2005-02-22 Xenogen Corporation Transgenic mice comprising transcription control elements associated with mouse eosinophil peroxidase expression
WO2003016839A2 (en) * 2001-08-15 2003-02-27 Xenogen Corporation Modified railroad worm red luciferase coding sequences
US7268229B2 (en) * 2001-11-02 2007-09-11 Promega Corporation Compounds to co-localize luminophores with luminescent proteins
WO2003044223A2 (en) * 2001-11-16 2003-05-30 Pierce Biotechnology, Inc. Phosphine-containing formulations for chemiluminescent luciferase assays
US6696473B2 (en) * 2001-12-21 2004-02-24 X-Ceptor Therapeutics, Inc. Heterocyclic modulators of nuclear receptors
WO2003059884A1 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US20040044063A1 (en) * 2002-05-31 2004-03-04 Brent Stockwell SMA therapy and cell based assay for identifying therapies
AU2003258319B2 (en) * 2002-08-21 2009-09-17 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
JP2004089117A (ja) * 2002-09-03 2004-03-25 Toyo B-Net Co Ltd ルシフェラーゼ検出試薬キット及び当該キットを使用したルシフェラーゼ検出方法
JP5155515B2 (ja) 2002-09-06 2013-03-06 プロメガ コーポレイション トランスフェラーゼ酵素活性を検出する方法
ATE513838T1 (de) 2002-09-20 2011-07-15 Promega Corp Auf lumineszenz basierende verfahren und sonden zur messung der cytochrom-p450-aktivität
US7413874B2 (en) * 2002-12-09 2008-08-19 University Of Miami Nucleic acid encoding fluorescent proteins from aquatic species
AU2003300008B2 (en) 2002-12-23 2007-04-05 Promega Corporation Improved luciferase-based assays
WO2004067728A2 (en) * 2003-01-17 2004-08-12 Ptc Therapeutics Methods and systems for the identification of rna regulatory sequences and compounds that modulate their function
WO2004072299A1 (en) * 2003-02-12 2004-08-26 Promega Corporation Methods and kits for dual enzymatic assays whereby light is quenched from luminescent reactions
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
DE10315640A1 (de) 2003-04-04 2004-10-14 Ignatov, Konstantin Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
US7494781B1 (en) 2003-05-12 2009-02-24 Charm Sciences, Inc. Sensitive method for detecting low levels of ATP
US7132249B1 (en) 2003-05-12 2006-11-07 Charm Sciences, Inc. Method of determining allergenic food on surfaces
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7727752B2 (en) * 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
WO2005014796A2 (en) 2003-08-08 2005-02-17 Invitrogen Corporation Methods and compositions for seamless cloning of nucleic acid molecules
WO2005035719A2 (en) * 2003-10-03 2005-04-21 Board Of Control Of Michigan Technological University Modified luciferase
ATE469984T1 (de) 2003-12-01 2010-06-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
CA2572608A1 (en) * 2004-07-02 2006-08-17 Promega Corporation Microbial atp extraction and detection system
US7728118B2 (en) * 2004-09-17 2010-06-01 Promega Corporation Synthetic nucleic acid molecule compositions and methods of preparation
TWI290956B (en) * 2004-12-31 2007-12-11 Ind Tech Res Inst Luminescence-based recipe and device using the same
CA2600129A1 (en) * 2005-03-07 2006-09-14 Rampyari Raja Walia Enhancing a luminescent signal
US20060214141A1 (en) * 2005-03-23 2006-09-28 Yankielun Norbert E Luminescent illumination adjunct for night vision
US20060234323A1 (en) * 2005-04-18 2006-10-19 Cali James J Luminescent ATP detection with extended linearity
EP1724359A1 (de) * 2005-05-18 2006-11-22 PerkinElmer Life and Analytical Sciences B.V. Luciferase-Assaysystem
WO2006130551A2 (en) * 2005-05-31 2006-12-07 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
CA2613517A1 (en) 2005-06-27 2007-01-04 Exelixis, Inc. Pyrazole based lxr modulators
CA2658003A1 (en) * 2006-06-06 2007-12-21 University Of Tennessee Research Foundation Compositions enriched in neoplastic stem cells and methods comprising same
US8178316B2 (en) * 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
WO2008045121A1 (en) * 2006-10-13 2008-04-17 Charm Sciences, Inc. Method and apparatus for reducing luminescent test result interferences
JP2008113620A (ja) * 2006-11-07 2008-05-22 Toyobo Co Ltd ルシフェラーゼの発光方法
DE102006054562A1 (de) * 2006-11-20 2008-05-21 Bayer Healthcare Ag Verfahren zum Nachweis von Pyrophosphat mit Biolumineszenz Detektion
EP2845909B1 (de) 2006-12-21 2018-01-31 Gene Stream Pty Ltd. Biolumineszenz-Testverfahren mit Nutzung sezernierter Luciferasen
US8603950B2 (en) * 2007-02-20 2013-12-10 Anaptysbio, Inc. Methods of generating libraries and uses thereof
US7910087B2 (en) 2007-03-02 2011-03-22 University Of Massachusetts Luciferins
WO2008118445A1 (en) * 2007-03-26 2008-10-02 Promega Corporation Methods to quench light from optical reactions
US20090081715A1 (en) * 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
JP5332178B2 (ja) * 2007-11-02 2013-11-06 東洋紡株式会社 多色ルシフェラーゼの検出方法
WO2009061837A1 (en) * 2007-11-05 2009-05-14 Novostem Therapeutics Inc Neoplastic stem cell system and method
EP2268825A4 (de) 2008-04-09 2012-05-02 Cobalt Technologies Inc Immobilisierte produkttolerante mikroorganismen
WO2010021686A1 (en) * 2008-08-18 2010-02-25 Promega Corporation Luminogenic compounds and methods to detect cytochrome p450 3a enzymes
CN102482639B (zh) 2009-04-03 2016-01-06 医学研究会 活化诱导胞苷脱氨酶(aid)突变体及使用方法
WO2010151706A1 (en) * 2009-06-26 2010-12-29 Cobalt Technologies, Inc. Integrated system and process for bioproduct production
US8569002B2 (en) 2010-10-20 2013-10-29 The Board Of Regents Of The University Of Texas System Multiplexed luciferase reporter assay systems
JP5863338B2 (ja) * 2011-08-25 2016-02-16 株式会社東芝 プラスミド型ベクター、遺伝子プロモーター活性の検出方法、及びアッセイキット
WO2013037482A1 (en) 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
EP3099683B1 (de) 2014-01-29 2020-08-05 Promega Corporation Chinonmaskierte sonden als markierungsreagenzien für zellaufnahmemessungen
CN107922428B (zh) * 2015-06-25 2021-02-05 普洛麦格公司 噻吩并吡咯化合物及其作为刺虾源性荧光素酶的抑制剂的用途
JP7114460B2 (ja) 2015-06-26 2022-08-08 サノフィ・バイオテクノロジー モノクローナル抗ＩＬ－１ＲＡｃＰ抗体
WO2017155036A1 (ja) 2016-03-11 2017-09-14 国立研究開発法人産業技術総合研究所 発光酵素タンパク質
EP3241845A1 (de) 2016-05-06 2017-11-08 MAB Discovery GmbH Humanisierte anti-il-1r3-antikörper
JP7161475B2 (ja) 2016-12-28 2022-10-26 プロメガ コーポレイション 官能化ｎａｎｏｌｕｃ阻害剤
EP3401332A1 (de) 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antikörper zur verwendung bei entzündungskrankheiten
CN111089859A (zh) * 2018-10-23 2020-05-01 北京中医药大学 新型三磷酸腺苷生物发光测定方法及其用途
RU2744869C2 (ru) * 2019-08-08 2021-03-16 Общество с ограниченной ответственностью "ПЛАНТА" Метод и реактивы для детекции активности люциферазы
CN113030052B (zh) * 2021-03-18 2022-10-21 中国科学院华南植物园 一种香蕉采后果实eATP水平的检测方法
WO2022235929A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
CN114350626A (zh) * 2021-12-21 2022-04-15 合肥巅峰生物科技有限公司 一种荧光素酶冻干粉稀释反应液
CN114736949B (zh) * 2022-03-22 2024-03-01 药科元(上海)生物技术有限公司 一种萤火虫荧光素酶报告基因检测试剂盒

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE428379B (sv) * 1978-05-31 1983-06-27 Lkb Produkter Ab Bioluminiscens bestemning av atp och reagens herfor
DE2828658C3 (de) * 1978-06-29 1981-10-22 Lkb-Produkter Ab, Stockholm Verfahren zur photometrischen Bestimmung der Untereinheit B der Creatinkinase und Reagens hierfür
US4234681A (en) * 1978-07-21 1980-11-18 The Regents Of The University Of California Immobolized light emitting systems
US4614712A (en) * 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
US4665022A (en) * 1984-02-17 1987-05-12 The Regents Of The University Of California Bioluminescent assay reagent and method
FR2566798B1 (fr) * 1984-06-27 1986-12-12 Centre Nat Rech Scient Membrane porteuse de la luciferase pour le dosage de l'atp et son procede de production
JPS6163855A (ja) * 1984-09-05 1986-04-02 Fuji Photo Film Co Ltd 静電写真用液体現像剤
DK258787D0 (da) * 1987-05-21 1987-05-21 Foss Electric As N Fremgangsmaade til bestemmelse af bakteriekoncentration i en proeve
GB8722252D0 (en) * 1987-09-22 1987-10-28 Brewing Res Found Atp extraction
US5283179A (en) * 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method

Also Published As

Publication number Publication date
AU8858391A (en) 1992-03-30
US5641641A (en) 1997-06-24
DE69130482D1 (de) 1998-12-17
JP3171595B2 (ja) 2001-05-28
EP0553234A4 (de) 1995-08-02
ES2126576T5 (es) 2005-12-01
JPH06500921A (ja) 1994-01-27
GR3029352T3 (en) 1999-05-28
EP0553234B2 (de) 2005-07-13
ATE173298T1 (de) 1998-11-15
US5650289A (en) 1997-07-22
EP0553234B1 (de) 1998-11-11
ES2126576T3 (es) 1999-04-01
US5283179A (en) 1994-02-01
EP0553234A1 (de) 1993-08-04
WO1992004468A1 (en) 1992-03-19
DK0553234T3 (da) 1999-07-26
DE69130482T3 (de) 2006-05-04
AU649289B2 (en) 1994-05-19
DK0553234T4 (da) 2005-08-01
JP2001224398A (ja) 2001-08-21
US5814471A (en) 1998-09-29

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