DE69130165T2 - Cyclodextrinderivate mit erhöhter wasserlöslichkeit sowie deren verwendung - Google Patents

Cyclodextrinderivate mit erhöhter wasserlöslichkeit sowie deren verwendung

Info

Publication number
DE69130165T2
DE69130165T2 DE69130165T DE69130165T DE69130165T2 DE 69130165 T2 DE69130165 T2 DE 69130165T2 DE 69130165 T DE69130165 T DE 69130165T DE 69130165 T DE69130165 T DE 69130165T DE 69130165 T2 DE69130165 T2 DE 69130165T2
Authority
DE
Germany
Prior art keywords
cyclodextrin derivatives
solubility
increased water
intranasal
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69130165T
Other languages
English (en)
Other versions
DE69130165D1 (de
Inventor
Valentino Stella
Roger Rajewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Original Assignee
University of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kansas filed Critical University of Kansas
Publication of DE69130165D1 publication Critical patent/DE69130165D1/de
Application granted granted Critical
Publication of DE69130165T2 publication Critical patent/DE69130165T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16Cyclodextrin; Derivatives thereof
DE69130165T 1990-01-23 1991-01-22 Cyclodextrinderivate mit erhöhter wasserlöslichkeit sowie deren verwendung Expired - Lifetime DE69130165T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/469,087 US5134127A (en) 1990-01-23 1990-01-23 Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
PCT/US1991/000326 WO1991011172A1 (en) 1990-01-23 1991-01-22 Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof

Publications (2)

Publication Number Publication Date
DE69130165D1 DE69130165D1 (de) 1998-10-15
DE69130165T2 true DE69130165T2 (de) 1999-04-29

Family

ID=23862363

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130165T Expired - Lifetime DE69130165T2 (de) 1990-01-23 1991-01-22 Cyclodextrinderivate mit erhöhter wasserlöslichkeit sowie deren verwendung

Country Status (10)

Country Link
US (1) US5134127A (de)
EP (1) EP0512050B1 (de)
JP (1) JP2722277B2 (de)
KR (1) KR0166088B1 (de)
AT (1) ATE170742T1 (de)
AU (1) AU646020B2 (de)
CA (1) CA2074186C (de)
DE (1) DE69130165T2 (de)
RU (1) RU2099354C1 (de)
WO (1) WO1991011172A1 (de)

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US4596795A (en) * 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
JPH0651725B2 (ja) * 1985-02-28 1994-07-06 メルシャン株式会社 部分メチル化シクロデキストリン及びその製造方法
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
JPS6327440A (ja) * 1986-07-18 1988-02-05 Sanraku Inc グルコシル化分岐シクロデキストリン含有組成物
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JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
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EP0512050A1 (de) 1992-11-11
DE69130165D1 (de) 1998-10-15
JPH05504783A (ja) 1993-07-22
JP2722277B2 (ja) 1998-03-04
EP0512050B1 (de) 1998-09-09
AU7236491A (en) 1991-08-21
RU2099354C1 (ru) 1997-12-20
US5134127A (en) 1992-07-28
WO1991011172A1 (en) 1991-08-08
CA2074186A1 (en) 1991-07-24
AU646020B2 (en) 1994-02-03
KR920703008A (ko) 1992-12-17
CA2074186C (en) 2001-04-03
EP0512050A4 (en) 1993-04-21
KR0166088B1 (ko) 1999-01-15
ATE170742T1 (de) 1998-09-15

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