DE69124129T2 - Hydroxyapatitbeschichtung von Substraten - Google Patents

Hydroxyapatitbeschichtung von Substraten

Info

Publication number
DE69124129T2
DE69124129T2 DE69124129T DE69124129T DE69124129T2 DE 69124129 T2 DE69124129 T2 DE 69124129T2 DE 69124129 T DE69124129 T DE 69124129T DE 69124129 T DE69124129 T DE 69124129T DE 69124129 T2 DE69124129 T2 DE 69124129T2
Authority
DE
Germany
Prior art keywords
coating
substrates
trough
substrate
hydroxyapatite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69124129T
Other languages
English (en)
Other versions
DE69124129D1 (de
Inventor
Brent R Constantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norian Corp
Original Assignee
Norian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norian Corp filed Critical Norian Corp
Publication of DE69124129D1 publication Critical patent/DE69124129D1/de
Application granted granted Critical
Publication of DE69124129T2 publication Critical patent/DE69124129T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901—Method of manufacturing prosthetic device
DE69124129T 1990-04-05 1991-04-03 Hydroxyapatitbeschichtung von Substraten Expired - Lifetime DE69124129T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/504,941 US5164187A (en) 1990-04-05 1990-04-05 Hydroxyapatite prosthesis coatings

Publications (2)

Publication Number Publication Date
DE69124129D1 DE69124129D1 (de) 1997-02-27
DE69124129T2 true DE69124129T2 (de) 1997-07-10

Family

ID=24008349

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69124129T Expired - Lifetime DE69124129T2 (de) 1990-04-05 1991-04-03 Hydroxyapatitbeschichtung von Substraten

Country Status (10)

Country Link
US (2) US5164187A (de)
EP (1) EP0450939B1 (de)
JP (1) JP3340447B2 (de)
AT (1) ATE147640T1 (de)
CA (1) CA2039815C (de)
DE (1) DE69124129T2 (de)
DK (1) DK0450939T3 (de)
ES (1) ES2097791T3 (de)
GR (1) GR3022845T3 (de)
IE (1) IE911123A1 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
SE469653B (sv) * 1992-01-13 1993-08-16 Lucocer Ab Poroest implantat
US5270351A (en) * 1992-06-15 1993-12-14 American Dental Association Health Foundation Adhesion-promoting agents incorporating polyvalent cations
JPH06105900A (ja) * 1992-09-22 1994-04-19 Mitsubishi Materials Corp 生体活性セラミックス被覆インプラント
HU212932B (en) * 1993-08-02 1996-12-30 Chinoin Gyogyszer Es Vegyeszet Parmaceutical composition containing ipriflavone, hydroxyapatit and tricalciumphosphate for treating lack of bones and process for producing the composition
NL9301941A (nl) * 1993-11-09 1995-06-01 Klaas De Groot Werkwijze voor het aanbrengen van een bekleding van een bioactief materiaal op implantaten.
EP0735895B1 (de) * 1993-11-19 2006-01-18 The University Of Sydney Verfahren zur prophylaxe oder kontrolle des katarakts
WO1995019796A1 (en) * 1994-01-21 1995-07-27 Brown University Research Foundation Biocompatible implants
ES2088767B1 (es) * 1994-05-31 1997-03-16 Consejo Superior Investigacion Procedimiento para el recubrimiento superficial con hidroxiapatito de implantes metalicos.
JP2754348B2 (ja) * 1994-10-20 1998-05-20 バイオマップ有限会社 アパタイト被覆基材とその製造法
ATE274861T1 (de) * 1994-11-30 2004-09-15 Implant Innovations Inc Preparierung einer implantatoberfläche
US5863201A (en) * 1994-11-30 1999-01-26 Implant Innovations, Inc. Infection-blocking dental implant
US6652765B1 (en) * 1994-11-30 2003-11-25 Implant Innovations, Inc. Implant surface preparation
US6065476A (en) * 1994-12-21 2000-05-23 Board Of Regents, University Of Texas System Method of enhancing surface porosity of biodegradable implants
US5782919A (en) 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
US6206922B1 (en) 1995-03-27 2001-03-27 Sdgi Holdings, Inc. Methods and instruments for interbody fusion
ATE286696T1 (de) 1995-03-27 2005-01-15 Sdgi Holdings Inc Wirbelsäulenfusionsimplantat und einführ- und überprüfungswerkzeuge
US6117456A (en) * 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US7150879B1 (en) 1995-05-19 2006-12-19 Etex Corporation Neutral self-setting calcium phosphate paste
US6541037B1 (en) 1995-05-19 2003-04-01 Etex Corporation Delivery vehicle
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6287341B1 (en) 1995-05-19 2001-09-11 Etex Corporation Orthopedic and dental ceramic implants
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6149688A (en) 1995-06-07 2000-11-21 Surgical Dynamics, Inc. Artificial bone graft implant
NZ315995A (en) * 1995-09-01 1999-09-29 Millenium Biologix Inc Artificial sintered composition comprising stabilised calcium phosphate phases capable of supporting bone cell activity
US5817326A (en) * 1995-12-01 1998-10-06 The Regents Of The University Of California Processing of hydroxylapatite coatings on titanium alloy bone prostheses
US6143948A (en) * 1996-05-10 2000-11-07 Isotis B.V. Device for incorporation and release of biologically active agents
DE69716505T2 (de) * 1996-05-10 2003-06-26 Isotis Nv Implantatwerkstoff und Verfahren zu seiner Herstellung
EP0806211B1 (de) * 1996-05-10 2002-10-23 IsoTis N.V. Implantatwerkstoff und Verfahren zu seiner Herstellung
EP0806212B1 (de) * 1996-05-10 2003-04-02 IsoTis N.V. Vorrichtung zur Aufnahme und Freigabe von biologisch aktiven Substanzen
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US7517539B1 (en) 1996-10-16 2009-04-14 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
ATE381314T1 (de) 1996-10-16 2008-01-15 Etex Corp Biokeramische zusammensetzung
US8728536B2 (en) 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
ES2113834B1 (es) * 1996-11-12 1999-01-01 Univ Vigo Metodo de mejora de la osteointegracion de implantes de fijacion osea.
SE9701647D0 (sv) * 1997-04-30 1997-04-30 Nobel Biocare Ab Calcium-phonsphate coated implant element
US6004353A (en) * 1997-07-30 1999-12-21 Medidea, Llc Modular acetabular reconstruction plate
FR2771102B1 (fr) * 1997-11-14 2000-12-15 Biocoral Inc Procede pour induire la differenciation osteoblastique de cellules de tissu adipeux extramedullaire humain
US6045683A (en) * 1997-12-01 2000-04-04 University Of Alabama In Huntsville Modified brushite surface coating, process therefor, and low temperature conversion to hydroxyapatite
US6139585A (en) * 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
US6736849B2 (en) 1998-03-11 2004-05-18 Depuy Products, Inc. Surface-mineralized spinal implants
DE59903490D1 (de) * 1998-09-11 2003-01-02 Schmidmaier Gerhard Biologisch aktive implantate
US6207218B1 (en) 1998-09-15 2001-03-27 Isotis B.V. Method for coating medical implants
WO2000050510A1 (fr) * 1999-02-22 2000-08-31 Maruo Calcium Company Limited Additif pour resine synthetique et composition de resine synthetique
US6799966B1 (en) 1999-03-04 2004-10-05 3M Innovative Properties Company Fluoropolymeric orthodontic article
SE514323C2 (sv) 1999-05-31 2001-02-12 Nobel Biocare Ab Implantat samt förfarande och användning vid implantat
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US6840995B2 (en) 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US6960249B2 (en) 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US7270705B2 (en) 1999-07-14 2007-09-18 Jiin-Huey Chern Lin Method of increasing working time of tetracalcium phosphate cement paste
WO2001054746A2 (en) 2000-01-31 2001-08-02 Advanced Research And Technology Institute, Inc. Composite biomaterial including anisometric calcium phosphate reinforcement particles
DE10006992B4 (de) * 2000-02-16 2006-10-12 Aesculap Ag & Co. Kg Verfahren zur Beschichtung eines Implantats und Implantat mit Beschichtung
DE10029520A1 (de) * 2000-06-21 2002-01-17 Merck Patent Gmbh Beschichtung für metallische Implantatmaterialien
US7160382B2 (en) * 2000-07-13 2007-01-09 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US7156915B2 (en) 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
SE519531C2 (sv) * 2001-07-04 2003-03-11 Nobel Biocare Ab Implantat innefattande porarrangemang belagt med kalciumfosfat
US6596338B2 (en) * 2001-10-24 2003-07-22 Howmedica Osteonics Corp. Antibiotic calcium phosphate coating
US20040131754A1 (en) * 2001-10-24 2004-07-08 Howmedica Osteonics Corp. Antibiotic calcium phosphate coating
US20040002766A1 (en) * 2002-06-27 2004-01-01 Gordon Hunter Prosthetic devices having diffusion-hardened surfaces and bioceramic coatings
US20060100716A1 (en) * 2002-06-27 2006-05-11 Reto Lerf Open-pored metal coating for joint replacement implants and method for production thereof
WO2004002543A1 (en) * 2002-06-27 2004-01-08 Smith & Nephew Inc. Prosthetic devices having diffusion-hardened surfaces and bioceramic coatings
GB2395713A (en) * 2002-11-13 2004-06-02 Univ Cambridge Tech A synthetic bone material
US8251700B2 (en) 2003-05-16 2012-08-28 Biomet 3I, Llc Surface treatment process for implants made of titanium alloy
US7067169B2 (en) * 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
US6994726B2 (en) 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US7118705B2 (en) 2003-08-05 2006-10-10 Calcitec, Inc. Method for making a molded calcium phosphate article
US7163651B2 (en) 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
WO2005027988A2 (en) * 2003-09-05 2005-03-31 Norian Corporation Bone cement compositions having fiber-reinforcement and/or increased flowability
BRPI0414843A (pt) * 2003-09-30 2006-11-21 John Arthur Disegi revestimentos de ácido hialurÈnico antimicrobiais para implantes ortopédicos
US7419680B2 (en) * 2003-10-01 2008-09-02 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US9199005B2 (en) * 2003-10-01 2015-12-01 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
CA2545185A1 (en) * 2003-11-07 2005-05-26 Calcitec, Inc. Spinal fusion procedure using an injectable bone substitute
US7785648B2 (en) * 2004-09-22 2010-08-31 New York University Adherent apatite coating on titanium substrate using chemical deposition
ATE369812T1 (de) * 2004-12-23 2007-09-15 Plus Orthopedics Ag Verfahren zum oberfläche-fertigbearbeiten von knochenimplantaten
WO2011053598A1 (en) 2009-10-26 2011-05-05 Rutgers, The State University Of New Jersey Hydroxyapatite with controllable size and morphology
US8071574B2 (en) * 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
US8814567B2 (en) 2005-05-26 2014-08-26 Zimmer Dental, Inc. Dental implant prosthetic device with improved osseointegration and esthetic features
US8562346B2 (en) 2005-08-30 2013-10-22 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
DE102005052354A1 (de) * 2005-11-02 2007-05-03 Plus Orthopedics Ag Offenporige biokompatible Oberflächenschicht für ein Implantat sowie Verfahren zur Herstellung und Verwendung
EP1962914B1 (de) 2005-11-14 2019-02-27 Biomet 3i, LLC Abscheidung von diskreten nanoteilchen auf einer implantatoberfläche
US8287914B2 (en) 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
EP2010104B1 (de) * 2006-04-25 2018-09-05 Teleflex Medical Incorporated Kalziumphosphatpolymerverbunddstoff und verfahren
WO2008059968A1 (fr) * 2006-11-17 2008-05-22 National Institute For Materials Science Dispositif médical à base de magnésium et son procédé de fabrication
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
DE602008005987D1 (de) * 2007-02-22 2011-05-19 Corning Inc Substrate für zellkultur und herstellungsverfahren dafür
KR100930279B1 (ko) * 2007-06-20 2009-12-09 재단법인서울대학교산학협력재단 인산칼슘 극초박막 및 그의 제조법
JP5806466B2 (ja) 2008-01-28 2015-11-10 バイオメット・３アイ・エルエルシー 親水性を向上させたインプラント表面
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
DE102008036955A1 (de) * 2008-08-08 2010-02-11 Borsig Gmbh Verbindungsstück zwischen einem Spaltrohr und einem Kühlrohr sowie ein Verfahren zum Verbinden eines Spaltrohres mit einem Kühlrohr
KR101026837B1 (ko) * 2009-02-12 2011-04-04 한국과학기술원 치아 임플란트 고정장치 및 그에 이용되는 픽스처
JP5506782B2 (ja) * 2009-03-19 2014-05-28 ブライトスマイルジャパン株式会社 歯面修復材
US20100262244A1 (en) * 2009-04-14 2010-10-14 Warsaw Orthopedic, Inc. Metal Coated Implant
DE102009041248A1 (de) * 2009-09-04 2011-05-05 Innotere Gmbh Bioaktiv beschichtete Metallimplantate und Verfahren zu deren Herstellung
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
CA3048850A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
EP2582407B1 (de) * 2010-06-15 2014-08-27 InnoTERE GmbH Knochenimplantat, enthaltend einen magnesiumhaltigen metallischen werkstoff mit verminderter korrosionsrate und verfahren und set zu dessen herstellung
US8613938B2 (en) 2010-11-15 2013-12-24 Zimmer Orthobiologics, Inc. Bone void fillers
KR101472745B1 (ko) * 2010-11-17 2014-12-15 경희대학교 산학협력단 표면개질된 하이드록시아파타이트를 함유하는 생체접착제 및 그의 용도
WO2012129234A1 (en) 2011-03-21 2012-09-27 Endo Pharmaceuticals Inc. Urethral anastomosis device and method
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
US9131995B2 (en) 2012-03-20 2015-09-15 Biomet 3I, Llc Surface treatment for an implant surface
WO2014047061A1 (en) 2012-09-18 2014-03-27 Endo Pharmaceuticals Inc. Urethral anastomosis device
US9889235B2 (en) 2013-02-05 2018-02-13 University Of Utah Research Foundation Implantable devices for bone or joint defects
US9480570B2 (en) * 2013-03-13 2016-11-01 Biomet Manufacturing, Llc Porous metal glenoid and associated method for molding the same
US20160074041A1 (en) 2013-03-14 2016-03-17 Endo Pharmaceuticals Inc. Urethral anastomosis device and method
ES2717678T3 (es) 2013-04-22 2019-06-24 Stryker European Holdings I Llc Procedimiento para la carga de fármacos sobre superficies de implantes recubiertos de hidroxiapatita
ES2753353T3 (es) 2013-06-21 2020-04-08 Stryker European Holdings I Llc Coprecipitación de Tobramicina en revestimientos de hidroxiapatita
EP2823780B1 (de) 2013-07-11 2021-05-19 Stryker European Holdings I, LLC Befestigungsvorrichtung mit mehreren Sektionen zur Sicherung von Teilen eines Sternums
WO2015028100A1 (en) 2013-09-02 2015-03-05 Stryker Trauma Gmbh Method of manufacturing an implant for use in a surgical procedure
WO2016057709A2 (en) 2014-10-09 2016-04-14 Blue Planet, Ltd. Continuous carbon sequestration material production methods and systems for practicing the same
EP3042622B1 (de) 2015-01-09 2018-05-09 Stryker European Holdings I, LLC Implantat zur Knochenfixierung
EP3320868B1 (de) 2016-11-11 2019-05-01 Stryker European Holdings I, LLC Implantat zur knochenfixierung
US10537658B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same
US10537661B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
KR20210123581A (ko) * 2020-04-03 2021-10-14 한국과학기술연구원 레이저를 이용한 아파타이트 분말 합성 방법
RU2745534C1 (ru) * 2020-08-07 2021-03-26 Общество с ограниченной ответственностью Научно-производственное объединение "Медицинские инструменты" (ООО НПО "Медицинские инструменты") Способ нанесения биоактивного покрытия на титановую пластину для остеосинтеза

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097935A (en) * 1976-07-21 1978-07-04 Sterling Drug Inc. Hydroxylapatite ceramic
FR2484246A1 (fr) * 1980-06-17 1981-12-18 Europ Propulsion Procede pour la realisation de revetements bioactifs sur des protheses osseuses, et protheses ainsi obtenues
US4542539A (en) * 1982-03-12 1985-09-24 Artech Corp. Surgical implant having a graded porous coating
FR2548011B2 (fr) * 1983-07-01 1985-12-13 Europ Propulsion Procede pour realiser des depots bioactifs de phosphates calciques et produits obtenus
EP0322250B1 (de) * 1987-12-23 1991-10-09 Sumitomo Chemical Company, Limited Hydroxyapatit enthaltende Beschichtungsflüssigkeit und Verfahren zur Herstellung eines Hydroxyapatitüberzugs unter Verwendung derselben
US4880610A (en) * 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5034059A (en) * 1989-02-17 1991-07-23 Norian Corporation Composition comprising octacalcium phosphate crystals and polypeptide

Also Published As

Publication number Publication date
EP0450939B1 (de) 1997-01-15
ES2097791T3 (es) 1997-04-16
US5279831A (en) 1994-01-18
EP0450939A3 (en) 1992-12-16
DE69124129D1 (de) 1997-02-27
EP0450939A2 (de) 1991-10-09
DK0450939T3 (da) 1997-07-14
ATE147640T1 (de) 1997-02-15
CA2039815A1 (en) 1991-10-06
GR3022845T3 (en) 1997-06-30
US5164187A (en) 1992-11-17
JP3340447B2 (ja) 2002-11-05
CA2039815C (en) 2003-06-17
IE911123A1 (en) 1991-10-09
JPH04224747A (ja) 1992-08-14

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