DE69123090D1 - Kondensierte Thiophenverbindungen und deren Verwendung - Google Patents

Kondensierte Thiophenverbindungen und deren Verwendung

Info

Publication number
DE69123090D1
DE69123090D1 DE69123090T DE69123090T DE69123090D1 DE 69123090 D1 DE69123090 D1 DE 69123090D1 DE 69123090 T DE69123090 T DE 69123090T DE 69123090 T DE69123090 T DE 69123090T DE 69123090 D1 DE69123090 D1 DE 69123090D1
Authority
DE
Germany
Prior art keywords
thiocarbonyl
carbonyl
amino
substituted
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69123090T
Other languages
English (en)
Inventor
Tohru Nakao
Hiroshi Tanaka
Hirotake Yamato
Takeshi Akagi
Shuzo Takehara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Application granted granted Critical
Publication of DE69123090D1 publication Critical patent/DE69123090D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DE69123090T 1990-07-06 1991-07-04 Kondensierte Thiophenverbindungen und deren Verwendung Expired - Lifetime DE69123090D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP17995390 1990-07-06
JP23224490 1990-08-31
JP32664490 1990-11-27
JP1368491 1991-01-11
JP7565791 1991-03-14

Publications (1)

Publication Number Publication Date
DE69123090D1 true DE69123090D1 (de) 1996-12-19

Family

ID=27519538

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123090T Expired - Lifetime DE69123090D1 (de) 1990-07-06 1991-07-04 Kondensierte Thiophenverbindungen und deren Verwendung

Country Status (5)

Country Link
US (1) US5141930A (de)
EP (1) EP0465254B1 (de)
AT (1) ATE145208T1 (de)
CA (1) CA2046368A1 (de)
DE (1) DE69123090D1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
WO1993013105A1 (fr) * 1991-12-26 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Compose de thiophene condense et utilisation pharmaceutique de ce compose
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
US5952351A (en) * 1995-02-23 1999-09-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
ZA979781B (en) * 1996-11-14 1998-06-08 Akzo Nobel Nv Piperidine derivatives.
JP5127096B2 (ja) * 1999-04-30 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アポトーシスにより誘導される自己免疫疾患を処置するためのベンゾジアゼピンの使用
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
CN100384836C (zh) * 2000-02-29 2008-04-30 三菱制药株式会社 新型环状酰胺衍生物
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JP2004513915A (ja) * 2000-11-14 2004-05-13 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 複合的な選択的ドーパミンｄ２レセプターアンタゴニストおよび５−ｈｔ１ａレセプターアゴニストの新規な使用
US7872030B2 (en) 2001-07-26 2011-01-18 Merck Patent Gmbh Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
AU2006203946B2 (en) * 2005-01-03 2009-07-23 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
EP1893218A4 (de) 2005-06-01 2011-01-12 Univ Michigan Ungelöste benzodiazepin-zusammensetzungen und verfahren
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
EP1948191B1 (de) 2005-11-01 2013-01-16 The Regents of the University of Michigan Neuartige 1,4-benzodiazepin-2,5-dione mit therapeutischen eigenschaften
US8349850B2 (en) 2006-03-28 2013-01-08 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
NZ573452A (en) 2006-06-09 2011-09-30 Univ Michigan Compositions and methods relating to novel compounds and targets thereof
NZ579507A (en) 2007-03-09 2011-11-25 Univ Michigan Compositions and methods relating to novel compounds and targets thereof
EP2896624B1 (de) * 2007-03-28 2016-07-13 Atir Holding S.A. Heterotricyclische Verbindungen als Serotonerge und/oder Dopaminerge Mittel und Anwendungen davon
CN101855203B (zh) 2007-09-14 2014-03-19 密执安州立大学董事会 F1f0-atp合成酶抑制剂以及相关的方法
UA99839C2 (ru) 2007-11-06 2012-10-10 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Бензодиазепиноновые соединения, применяемые при лечении кожных состояний
EP2352724B1 (de) 2008-09-11 2015-04-22 The Regents of the University of Michigan Arylguanidine-f1f0-aptase inhibitoren und deren therapeutischen verwendung
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
WO2011035124A1 (en) 2009-09-18 2011-03-24 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
WO2011062766A2 (en) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
CA2780333C (en) 2009-11-17 2016-05-24 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
EP2697206B1 (de) 2011-04-10 2019-04-03 Atir Holding S.A. Heterocyclische verbindungen und ihre verwendung bei der behandlung von sexuellen funktionsstörungen
JP7015092B2 (ja) 2016-07-28 2022-02-02 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
WO2019146740A1 (ja) 2018-01-26 2019-08-01 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物
TW201938537A (zh) 2018-01-26 2019-10-01 日商鹽野義製藥股份有限公司 具有多巴胺ｄ３受體拮抗作用的稠環化合物
US10745401B2 (en) 2018-07-23 2020-08-18 Sumitomo Dainippon Pharma Co., Ltd. Condensed lactam derivative
JP7387605B2 (ja) 2018-07-23 2023-11-28 住友ファーマ株式会社 縮環ラクタム誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ209876A (en) * 1983-10-17 1988-03-30 Duphar Int Res Piperazines and pharmaceutical compositions
ZW17385A1 (en) * 1984-11-06 1986-02-19 Hoffmann La Roche Tricyclic pyridine derivatives
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
GB8800891D0 (en) * 1988-01-15 1988-02-17 Lilly Industries Ltd Pharmaceutical compounds
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
DE68918832T2 (de) * 1988-12-28 1995-02-09 Suntory Ltd Benzoxazepinderivate.
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds

Also Published As

Publication number Publication date
CA2046368A1 (en) 1992-01-07
EP0465254A1 (de) 1992-01-08
EP0465254B1 (de) 1996-11-13
ATE145208T1 (de) 1996-11-15
US5141930A (en) 1992-08-25

Similar Documents

Publication Publication Date Title
DE69123090D1 (de) Kondensierte Thiophenverbindungen und deren Verwendung
KR850002483A (ko) 1-헤테로아릴-4-[(2,5-피롤리딘디온-1-일]피페라진 유도체의 제조방법
KR920021514A (ko) 피리딘 유도체, 이의 제법 및 용도
IE41539L (en) Chroman derivatives.
DE69027235D1 (de) Xanthinderivate
KR920002555A (ko) 앤지오텐신 ii 수용체 길항질인 신규한 피리미딘 유도체, 그 제조방법 및 그를 포함하는 제약학적 조성물
YU47555B (sh) Derivati tetrahidrobenzimidazola i postupak za njihovo dobijanje
DE69839753D1 (de) 2-(Arylphenyl)amino-imidazolin-Derivate
ATE261445T1 (de) Neue 1,8-naphtyridin-2(1h)-on-derivate
NZ221699A (en) Pyridazinone derivatives; pharmaceutical compositions and intermediates
ATE247104T1 (de) Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren
ES2159618T3 (es) Derivados de propenona.
PT74199B (de) Neue trisubstituierte pyrimido<5,4-d>pyrimidine ihre herstel- lung und ihre verwendung als arzneimittel
ZA831477B (en) Substituted pyridines,processes for preparing these and pharmaceutical composition thereof
EP1496059A4 (de) Kondensierte bicyclische pyrimidinderivate
GB1397060A (en) 1,4-dighiino 2,3-c pyrrole derivatives
ATE197952T1 (de) Neue 1-phenylmethyl-benzimidazol- piperazinderivate
GB1466829A (en) 1,4-oxathiino 2,3-c- pyrrole derivatives
DE69116302T2 (de) 4-[4- oder 6-(Trifluormethyl-2-pyridinyl)]-1-piperazinyl-alkyl substituierte Laktame
YU38498A (sh) Derivati 2-(arilfenil)amino-imidazolina

Legal Events

Date Code Title Description
8332 No legal effect for de