DE69118178D1 - Verfahren zur verbesserung der empfindlichkeit von analysen - Google Patents
Verfahren zur verbesserung der empfindlichkeit von analysenInfo
- Publication number
- DE69118178D1 DE69118178D1 DE69118178T DE69118178T DE69118178D1 DE 69118178 D1 DE69118178 D1 DE 69118178D1 DE 69118178 T DE69118178 T DE 69118178T DE 69118178 T DE69118178 T DE 69118178T DE 69118178 D1 DE69118178 D1 DE 69118178D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- date oct
- sec
- optical
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6465—Angular discrimination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909008261A GB9008261D0 (en) | 1990-04-11 | 1990-04-11 | Method of improving assay sensitivity |
PCT/GB1991/000567 WO1991015751A1 (en) | 1990-04-11 | 1991-04-10 | Method of improving assay sensitivity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69118178D1 true DE69118178D1 (de) | 1996-04-25 |
DE69118178T2 DE69118178T2 (de) | 1996-09-12 |
Family
ID=10674305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69118178T Expired - Fee Related DE69118178T2 (de) | 1990-04-11 | 1991-04-10 | Verfahren zur verbesserung der empfindlichkeit von analysen |
Country Status (12)
Country | Link |
---|---|
US (1) | US5369717A (de) |
EP (1) | EP0524224B1 (de) |
JP (1) | JP3286314B2 (de) |
AT (1) | ATE135818T1 (de) |
AU (1) | AU642736B2 (de) |
CA (1) | CA2078568C (de) |
DE (1) | DE69118178T2 (de) |
DK (1) | DK0524224T3 (de) |
ES (1) | ES2084813T3 (de) |
GB (1) | GB9008261D0 (de) |
GR (1) | GR3019483T3 (de) |
WO (1) | WO1991015751A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192510A (en) * | 1991-01-30 | 1993-03-09 | E. I. Du Pont De Nemours And Company | Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence |
US5677196A (en) * | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
US5919712A (en) | 1993-05-18 | 1999-07-06 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
JP4026724B2 (ja) | 1995-01-27 | 2007-12-26 | ノースイースタン ユニバーシティー | 毛管電気泳動のためのポリビニルアルコール(pva)をベースとする共有結合の安定した親水性コーティング |
US5669997A (en) * | 1995-07-13 | 1997-09-23 | Hughes Danbury Optical Systems, Inc. | Method of bonding optical members together |
US6611634B2 (en) | 1996-03-19 | 2003-08-26 | University Of Utah Research Foundation | Lens and associatable flow cell |
US5568253A (en) * | 1996-03-20 | 1996-10-22 | Taiwan Semiconductor Manufacturing Company Ltd. | Sample holder for sample testing apparatus |
US6180288B1 (en) | 1997-03-21 | 2001-01-30 | Kimberly-Clark Worldwide, Inc. | Gel sensors and method of use thereof |
US6060256A (en) * | 1997-12-16 | 2000-05-09 | Kimberly-Clark Worldwide, Inc. | Optical diffraction biosensor |
GB9903283D0 (en) * | 1998-06-01 | 1999-04-07 | Farfield Sensors Ltd | Device |
US7640083B2 (en) | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
US6221579B1 (en) | 1998-12-11 | 2001-04-24 | Kimberly-Clark Worldwide, Inc. | Patterned binding of functionalized microspheres for optical diffraction-based biosensors |
US6579673B2 (en) | 1998-12-17 | 2003-06-17 | Kimberly-Clark Worldwide, Inc. | Patterned deposition of antibody binding protein for optical diffraction-based biosensors |
US6701032B1 (en) | 1999-05-27 | 2004-03-02 | Farfield Sensors Limited | Device for housing a planar optical component |
US6370837B1 (en) | 1999-08-04 | 2002-04-16 | Anthony B. Mcmahon | System for laying masonry blocks |
US7167615B1 (en) | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
US6399295B1 (en) | 1999-12-17 | 2002-06-04 | Kimberly-Clark Worldwide, Inc. | Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors |
EP1311824A4 (de) * | 2000-06-25 | 2010-12-08 | Affymetrix Inc | Optisch aktive substrate |
JP2004507786A (ja) | 2000-08-18 | 2004-03-11 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 光学部品及びその製造方法 |
US7098041B2 (en) | 2001-12-11 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Methods to view and analyze the results from diffraction-based diagnostics |
US7102752B2 (en) | 2001-12-11 | 2006-09-05 | Kimberly-Clark Worldwide, Inc. | Systems to view and analyze the results from diffraction-based diagnostics |
US20030119203A1 (en) | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
US8367013B2 (en) | 2001-12-24 | 2013-02-05 | Kimberly-Clark Worldwide, Inc. | Reading device, method, and system for conducting lateral flow assays |
US20030156819A1 (en) * | 2002-02-15 | 2003-08-21 | Mark Pruss | Optical waveguide |
US7118855B2 (en) * | 2002-05-03 | 2006-10-10 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7223534B2 (en) | 2002-05-03 | 2007-05-29 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7223368B2 (en) | 2002-05-03 | 2007-05-29 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7771922B2 (en) | 2002-05-03 | 2010-08-10 | Kimberly-Clark Worldwide, Inc. | Biomolecule diagnostic device |
US7485453B2 (en) * | 2002-05-03 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7214530B2 (en) | 2002-05-03 | 2007-05-08 | Kimberly-Clark Worldwide, Inc. | Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices |
US7091049B2 (en) | 2002-06-26 | 2006-08-15 | Kimberly-Clark Worldwide, Inc. | Enhanced diffraction-based biosensor devices |
US7285424B2 (en) | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
US7169550B2 (en) * | 2002-09-26 | 2007-01-30 | Kimberly-Clark Worldwide, Inc. | Diffraction-based diagnostic devices |
US7247500B2 (en) | 2002-12-19 | 2007-07-24 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
US8675276B2 (en) * | 2003-02-21 | 2014-03-18 | Kla-Tencor Corporation | Catadioptric imaging system for broad band microscopy |
US20040197819A1 (en) | 2003-04-03 | 2004-10-07 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
US20050112703A1 (en) | 2003-11-21 | 2005-05-26 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
US7713748B2 (en) | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
US7943395B2 (en) | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
US7943089B2 (en) | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
US20070196863A1 (en) * | 2006-02-17 | 2007-08-23 | Hanson Technologies, Inc. | Prion protein detection |
US20080026373A1 (en) * | 2006-07-26 | 2008-01-31 | Rodionova Natalia A | Assays Based On Light Emission From Analyte Complexes Within A Cassette |
US9357925B2 (en) * | 2013-08-02 | 2016-06-07 | John Adamovics | Method and apparatus for scanning 3D dosimeters |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4124364A (en) * | 1976-12-02 | 1978-11-07 | International Standard Electric Corporation | Method for making glass sleeve fiber splice |
US4469500A (en) * | 1981-01-26 | 1984-09-04 | Rca Corporation | Method of cleaving a crystal to produce a high optical quality corner |
EP0245206A1 (de) * | 1986-05-05 | 1987-11-11 | IntraCel Corporation | Analytisches Verfahren zum Nachweis und zur Messung einer spezifisch sequentierten Nukleinsäure |
GB8619823D0 (en) * | 1986-08-14 | 1986-09-24 | Buckley B M | Determining level of analyte |
US5152962A (en) * | 1988-07-22 | 1992-10-06 | Ord Corp. | Immunoassay apparatus |
EP0420960B1 (de) * | 1989-04-11 | 1994-11-02 | ARS Holding 89 N.V. | Multianalysenprobenträger |
GB8911462D0 (en) * | 1989-05-18 | 1989-07-05 | Ares Serono Res & Dev Ltd | Devices for use in chemical test procedures |
EP0429612B1 (de) * | 1989-06-22 | 1993-12-15 | ARS Holding 89 N.V. | Verfahren zur optischen analyse |
US5061857A (en) * | 1990-11-09 | 1991-10-29 | The United States Of America As Represented By The Secretary Of The Navy | Waveguide-binding sensor for use with assays |
US5192510A (en) * | 1991-01-30 | 1993-03-09 | E. I. Du Pont De Nemours And Company | Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence |
-
1990
- 1990-04-11 GB GB909008261A patent/GB9008261D0/en active Pending
-
1991
- 1991-04-10 WO PCT/GB1991/000567 patent/WO1991015751A1/en active IP Right Grant
- 1991-04-10 US US07/930,690 patent/US5369717A/en not_active Expired - Lifetime
- 1991-04-10 DE DE69118178T patent/DE69118178T2/de not_active Expired - Fee Related
- 1991-04-10 JP JP50699791A patent/JP3286314B2/ja not_active Expired - Fee Related
- 1991-04-10 AU AU76689/91A patent/AU642736B2/en not_active Ceased
- 1991-04-10 EP EP91907433A patent/EP0524224B1/de not_active Expired - Lifetime
- 1991-04-10 ES ES91907433T patent/ES2084813T3/es not_active Expired - Lifetime
- 1991-04-10 DK DK91907433.6T patent/DK0524224T3/da active
- 1991-04-10 CA CA002078568A patent/CA2078568C/en not_active Expired - Fee Related
- 1991-04-10 AT AT91907433T patent/ATE135818T1/de not_active IP Right Cessation
-
1996
- 1996-04-02 GR GR960400870T patent/GR3019483T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE135818T1 (de) | 1996-04-15 |
AU642736B2 (en) | 1993-10-28 |
GR3019483T3 (en) | 1996-07-31 |
AU7668991A (en) | 1991-10-30 |
JPH05505874A (ja) | 1993-08-26 |
US5369717A (en) | 1994-11-29 |
GB9008261D0 (en) | 1990-06-13 |
CA2078568A1 (en) | 1991-10-12 |
DK0524224T3 (da) | 1996-04-15 |
WO1991015751A1 (en) | 1991-10-17 |
CA2078568C (en) | 2002-06-11 |
EP0524224A1 (de) | 1993-01-27 |
JP3286314B2 (ja) | 2002-05-27 |
EP0524224B1 (de) | 1996-03-20 |
DE69118178T2 (de) | 1996-09-12 |
ES2084813T3 (es) | 1996-05-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69118178T2 (de) | Verfahren zur verbesserung der empfindlichkeit von analysen | |
DE69128516T2 (de) | Neue Mercaptoacetylamid-Derivate zur Verwendung als Enkephalinase- und ACE-Hemmer | |
CA2033168A1 (en) | Method of Optical Analysis | |
DE69505749T2 (de) | Dickenmessverfahren für transparentes material | |
ATE53256T1 (de) | Spektrokolorimetrische vorrichtung mit optischen fasern. | |
DE69025924T2 (de) | Optische vorrichtung zur erzeugung polarisierten lichtes | |
ATE40755T1 (de) | Lorgnettefassung. | |
DE69205814T2 (de) | Vorrichtung zur Bestimmung des effektiven Brechungsindexes von optischen Fasern. | |
DE3774376D1 (de) | Verfahren zur messung des refraktiven indexprofils von optischen fibern. | |
KR910013851A (ko) | 화상판독장치 | |
DE68910883D1 (de) | Vorrichtung zur Erzeugung optischer Oberwellen. | |
KR880011587A (ko) | 용액 모니터법 | |
DE69030617T2 (de) | Vorrichtung zur Zwei-Kanälenmessung der Fluoreszenz von Chlorophyl | |
ES2071798T3 (es) | Procedimiento y dispositivo de transmision de señal electromagnetica por una fibra optica. | |
DE3680460D1 (de) | Beleuchtung fuer eine fluessigkristallanzeige. | |
HUT69816A (en) | Apparatus for mesuring optical parameters | |
DE68918821T2 (de) | Verfahren zur Fluoreszenzverbesserung von Titandotierten Oxid-Kristallen für abstimmbaren Laser. | |
EA199800037A1 (ru) | Устройство и способ модуляции света | |
ATE237553T1 (de) | Vorrichtung und verfahren zur produktion von singulett-sauerstoff | |
FI872092A (fi) | Solglasoegonlinser. | |
ATE222645T1 (de) | Anordnung zum gleichmässigen be- bzw. ausleuchten einer fläche zum anzeigen von informationen | |
JPS5437767A (en) | Terminal processing part of optical fibers | |
JPS6418106A (en) | Surface lighting apparatus | |
DE59914028D1 (de) | Verfahren zur bestimmung von alkalischer phosphatase | |
DE3885312D1 (de) | Vorrichtung zur Bestimmung des Indexprofils einer optischen Faser. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH |
|
8339 | Ceased/non-payment of the annual fee |