US20030194807A1
(en)
*
|
1992-11-02 |
2003-10-16 |
Roberto Crea |
Walk-through mutagenesis
|
EP0695353B1
(de)
*
|
1993-04-09 |
2001-12-12 |
Catalytic Antibodies, Inc. |
Selektion von genen katalytischer antikörper
|
US6309883B1
(en)
|
1994-02-17 |
2001-10-30 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
US6117679A
(en)
|
1994-02-17 |
2000-09-12 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
US6995017B1
(en)
|
1994-02-17 |
2006-02-07 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
US20060257890A1
(en)
|
1996-05-20 |
2006-11-16 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
US6335160B1
(en)
|
1995-02-17 |
2002-01-01 |
Maxygen, Inc. |
Methods and compositions for polypeptide engineering
|
US6165793A
(en)
|
1996-03-25 |
2000-12-26 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
US5605793A
(en)
*
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
US5683987A
(en)
*
|
1994-07-12 |
1997-11-04 |
The Board Of Regents Of The University Of Nebraska |
Therapeutic oligonucleotides targeting the human MDR1 and MRP genes
|
US6063562A
(en)
*
|
1994-09-16 |
2000-05-16 |
Sepracor, Inc. |
In vitro method for predicting the evolutionary response of HIV protease to a drug targeted thereagainst
|
US5602021A
(en)
*
|
1994-12-29 |
1997-02-11 |
Catalytic Antibodies, Inc. |
Method for generating proteolytic enzymes specific against a selected peptide sequence
|
US6238884B1
(en)
|
1995-12-07 |
2001-05-29 |
Diversa Corporation |
End selection in directed evolution
|
US6358709B1
(en)
|
1995-12-07 |
2002-03-19 |
Diversa Corporation |
End selection in directed evolution
|
US6537776B1
(en)
*
|
1999-06-14 |
2003-03-25 |
Diversa Corporation |
Synthetic ligation reassembly in directed evolution
|
US5830696A
(en)
|
1996-12-05 |
1998-11-03 |
Diversa Corporation |
Directed evolution of thermophilic enzymes
|
US20030219752A1
(en)
*
|
1995-12-07 |
2003-11-27 |
Diversa Corporation |
Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
|
US6740506B2
(en)
|
1995-12-07 |
2004-05-25 |
Diversa Corporation |
End selection in directed evolution
|
US6713279B1
(en)
|
1995-12-07 |
2004-03-30 |
Diversa Corporation |
Non-stochastic generation of genetic vaccines and enzymes
|
US6939689B2
(en)
|
1995-12-07 |
2005-09-06 |
Diversa Corporation |
Exonuclease-mediated nucleic acid reassembly in directed evolution
|
AU5760698A
(en)
*
|
1996-12-20 |
1998-07-17 |
Unilever Plc |
Enzymatic bleach composition
|
US6153410A
(en)
*
|
1997-03-25 |
2000-11-28 |
California Institute Of Technology |
Recombination of polynucleotide sequences using random or defined primers
|
DE19731990A1
(de)
*
|
1997-07-25 |
1999-01-28 |
Studiengesellschaft Kohle Mbh |
Verfahren zur Herstellung und Identifizierung von neuen Hydrolasen mit verbesserten Eigenschaften
|
US6670127B2
(en)
*
|
1997-09-16 |
2003-12-30 |
Egea Biosciences, Inc. |
Method for assembly of a polynucleotide encoding a target polypeptide
|
CA2319114A1
(en)
*
|
1998-01-30 |
1999-08-05 |
Donald L. Heefner |
Gene regulator fusion proteins and methods of using the same for determining resistance of a protein to a drug targeted thereagainst
|
US7153655B2
(en)
*
|
1998-06-16 |
2006-12-26 |
Alligator Bioscience Ab |
Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
|
US20090130718A1
(en)
*
|
1999-02-04 |
2009-05-21 |
Diversa Corporation |
Gene site saturation mutagenesis
|
MXPA00009723A
(es)
*
|
1999-02-04 |
2003-09-22 |
Diversa Corp |
Generacion no estocastica de vacunas y enzimas geneticas.
|
JP3399518B2
(ja)
*
|
1999-03-03 |
2003-04-21 |
インターナショナル・ビジネス・マシーンズ・コーポレーション |
半導体構造およびその製造方法
|
EP1161529A2
(de)
*
|
1999-03-09 |
2001-12-12 |
Diversa Corporation |
Selektion am ende in gezielter evolution
|
US6251604B1
(en)
|
1999-08-13 |
2001-06-26 |
Genopsys, Inc. |
Random mutagenesis and amplification of nucleic acid
|
US7115712B1
(en)
|
1999-12-02 |
2006-10-03 |
Maxygen, Inc. |
Cytokine polypeptides
|
AU2001241939A1
(en)
*
|
2000-02-28 |
2001-09-12 |
Maxygen, Inc. |
Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
|
EP1276861A2
(de)
*
|
2000-03-24 |
2003-01-22 |
Maxygen, Inc. |
Methoden zur modulation zellulärer und organismenspezifischer phenotypen
|
DK2199393T3
(da)
*
|
2000-04-17 |
2012-11-26 |
Dyax Corp |
Hidtil ukendte fremgangsmåder til opbygning af biblioteker over genetiske pakker, der kollektivt viser medlemmerne af en forskelligartet familie af peptider, polypeptider eller proteiner
|
US8288322B2
(en)
|
2000-04-17 |
2012-10-16 |
Dyax Corp. |
Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
|
CA2411139A1
(en)
*
|
2000-06-08 |
2001-12-13 |
James T. Willerson |
Inhibitors of c-reactive protein induced inflammation
|
FR2813314B1
(fr)
*
|
2000-08-25 |
2004-05-07 |
Biomethodes |
Procede de mutagenese dirigee massive
|
WO2005012515A2
(en)
|
2003-04-29 |
2005-02-10 |
Pioneer Hi-Bred International, Inc. |
Novel glyphosate-n-acetyltransferase (gat) genes
|
US6958213B2
(en)
|
2000-12-12 |
2005-10-25 |
Alligator Bioscience Ab |
Method for in vitro molecular evolution of protein function
|
PT2316940E
(pt)
|
2000-12-18 |
2013-10-16 |
Dyax Corp |
Bibliotecas orientadas de pacotes genéticos
|
US20020086292A1
(en)
|
2000-12-22 |
2002-07-04 |
Shigeaki Harayama |
Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
|
WO2002092780A2
(en)
*
|
2001-05-17 |
2002-11-21 |
Diversa Corporation |
Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
|
SE0102327D0
(sv)
|
2001-06-28 |
2001-06-28 |
Active Biotech Ab |
A novel engineered superantigen for human therapy
|
US7647184B2
(en)
*
|
2001-08-27 |
2010-01-12 |
Hanall Pharmaceuticals, Co. Ltd |
High throughput directed evolution by rational mutagenesis
|
US20040096826A1
(en)
*
|
2002-01-30 |
2004-05-20 |
Evans Glen A. |
Methods for creating recombination products between nucleotide sequences
|
US20030224404A1
(en)
*
|
2002-02-25 |
2003-12-04 |
Manuel Vega |
High throughput directed evolution of nucleic acids by rational mutagenesis
|
US20030171543A1
(en)
*
|
2002-03-05 |
2003-09-11 |
Bott Richard R. |
High throughput mutagenesis screening method
|
US20030199068A1
(en)
*
|
2002-03-05 |
2003-10-23 |
Bott Richard R. |
High throughput mutagenesis screening method
|
WO2003089671A1
(en)
*
|
2002-04-17 |
2003-10-30 |
Roberto Crea |
'doping' in walk-through mutagenesis
|
DE60328674D1
(de)
*
|
2002-04-17 |
2009-09-17 |
Bioren Inc |
Universelle banken für immunoglobuline
|
ES2285118T5
(es)
*
|
2002-05-17 |
2012-09-21 |
Alligator Bioscience Ab |
Un método para el desarrollo molecular in vitro de una función proteica.
|
EP2275536A1
(de)
|
2002-08-06 |
2011-01-19 |
Verdia, Inc. |
AP1-Aminoxidase-Varianten
|
EP2269618A1
(de)
|
2002-08-12 |
2011-01-05 |
Jennerex Biotherapeutics ULC |
Ein onkolytisches Vaccinia-Virus zur Verwendung in Kombination mit Chemotherapie zur Behandlung von Krebs
|
US20040067532A1
(en)
*
|
2002-08-12 |
2004-04-08 |
Genetastix Corporation |
High throughput generation and affinity maturation of humanized antibody
|
US7785799B2
(en)
*
|
2002-08-16 |
2010-08-31 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods related to flavivirus envelope protein domain III antigens
|
US7611700B2
(en)
*
|
2002-09-09 |
2009-11-03 |
Hanall Pharmaceuticals, Co., Ltd. |
Protease resistant modified interferon alpha polypeptides
|
US20050118154A1
(en)
|
2003-04-02 |
2005-06-02 |
Mien-Chie Hung |
Antitumor effect of mutant Bik
|
WO2005003345A2
(en)
*
|
2003-06-27 |
2005-01-13 |
R. Crea & Co. |
Look-through mutagenesis
|
EP2325339A3
(de)
|
2003-09-09 |
2011-11-02 |
Integrigen, Inc. |
Verfahren und zusammensetzungen zur Erzeugung menschlicher keimlinien-Antikörpergene
|
MX2007000103A
(es)
|
2004-07-06 |
2007-05-11 |
Bioren Inc |
Bibliotecas de anticuerpos universales.
|
WO2006023144A2
(en)
|
2004-07-06 |
2006-03-02 |
Bioren Inc. |
Look-through mutagenesis for developing altered polypeptides with enhanced properties
|
CA2573259A1
(en)
*
|
2004-07-06 |
2006-02-09 |
Bioren Inc. |
High affinity anti-tnf-alpha antibodies and method
|
EP1877441A2
(de)
*
|
2005-04-26 |
2008-01-16 |
Bioren, Inc. |
Verfahren zur herstellung von antikörpern gegen humanes igg mit verbesserten effektorfunktionen
|
US20070026012A1
(en)
|
2005-08-01 |
2007-02-01 |
Cornell Research Foundation, Inc. |
Compositions and methods for monitoring and altering protein folding and solubility
|
KR20090004839A
(ko)
*
|
2005-09-07 |
2009-01-12 |
제네렉스, 인코포레이티드 |
Gm-csf를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법
|
US8980246B2
(en)
|
2005-09-07 |
2015-03-17 |
Sillajen Biotherapeutics, Inc. |
Oncolytic vaccinia virus cancer therapy
|
CA2627075A1
(en)
|
2005-11-14 |
2007-05-18 |
Bioren, Inc. |
Antibody ultrahumanization by predicted mature cdr blasting and cohort library generation and screening
|
GB2432366B
(en)
*
|
2005-11-19 |
2007-11-21 |
Alligator Bioscience Ab |
A method for in vitro molecular evolution of protein function
|
AU2007249160B2
(en)
|
2006-05-15 |
2013-09-12 |
I2 Pharmaceuticals, Inc. |
Neutralizing antibodies to influenza viruses
|
US20080108513A1
(en)
*
|
2006-06-01 |
2008-05-08 |
Northwestern University |
Cellular Arrays
|
WO2008020079A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
EP2064229B1
(de)
|
2006-09-15 |
2015-08-12 |
Ottawa Hospital Research Institute |
Onkolytisches rhabdovirus
|
MX2009004221A
(es)
|
2006-10-20 |
2009-09-10 |
Univ Arizona State |
Cianobacterias modificadas.
|
US20090118130A1
(en)
*
|
2007-02-12 |
2009-05-07 |
Codexis, Inc. |
Structure-activity relationships
|
US20100106585A1
(en)
*
|
2007-04-17 |
2010-04-29 |
American Express Travel Related Services Company, Inc. |
System and method for evaluating positive behavior and offering incentives based upon limited use identifier transactions
|
US8470966B2
(en)
|
2007-08-10 |
2013-06-25 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
US8680019B2
(en)
*
|
2007-08-10 |
2014-03-25 |
Protelica, Inc. |
Universal fibronectin Type III binding-domain libraries
|
US20090176654A1
(en)
*
|
2007-08-10 |
2009-07-09 |
Protelix, Inc. |
Universal fibronectin type III binding-domain libraries
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
BRPI0816785A2
(pt)
*
|
2007-09-14 |
2017-05-02 |
Adimab Inc |
bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmas
|
JP2011504740A
(ja)
|
2007-11-27 |
2011-02-17 |
アブリンクス エン.ヴェー. |
ヘテロ二量体サイトカイン及び/又はこれらの受容体に指向性を有するアミノ酸配列、並びにこれを含むポリペプチド
|
US9873957B2
(en)
|
2008-03-13 |
2018-01-23 |
Dyax Corp. |
Libraries of genetic packages comprising novel HC CDR3 designs
|
CA2722409C
(en)
|
2008-04-24 |
2017-12-12 |
Dyax Corp. |
Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
|
ES2620285T3
(es)
|
2008-05-02 |
2017-06-28 |
Novartis Ag |
Moléculas de unión con base en fibronectina mejorada y usos de las mismas
|
ES2752025T3
(es)
|
2008-07-25 |
2020-04-02 |
Wagner Richard W |
Métodos de cribado de proteínas
|
JP5230397B2
(ja)
*
|
2008-12-18 |
2013-07-10 |
独立行政法人科学技術振興機構 |
抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
|
US8987433B2
(en)
|
2009-03-27 |
2015-03-24 |
Sapphire Energy, Inc. |
Variant isoprenoid producing enzymes and uses thereof
|
JP5647222B2
(ja)
|
2009-04-10 |
2014-12-24 |
アブリンクス エン.ヴェー. |
Il−6r関連疾患及び障害の治療のためのil−6rに指向性を有する改善されたアミノ酸配列及びこれを含むポリペプチド
|
WO2010115995A2
(en)
|
2009-04-10 |
2010-10-14 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
US8945567B2
(en)
|
2009-06-05 |
2015-02-03 |
Ablynx N.V. |
Monovalent, bivalent and trivalent anti human respiratory syncytial virus (HRSV) nanobody constructs for the prevention and/or treatment of respiratory tract infections
|
CN107303302A
(zh)
|
2009-09-14 |
2017-10-31 |
希拉金股份有限公司 |
溶瘤牛痘病毒组合癌症疗法
|
AU2010291902A1
(en)
*
|
2009-09-14 |
2012-04-05 |
Dyax Corp. |
Libraries of genetic packages comprising novel HC CDR3 designs
|
EP3434769B1
(de)
|
2009-10-30 |
2020-11-25 |
Novartis AG |
Unterseitig bindende universelle fibronectin-typ-iii-domänenbibliotheken
|
WO2011051327A2
(en)
|
2009-10-30 |
2011-05-05 |
Novartis Ag |
Small antibody-like single chain proteins
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
EP2507262A1
(de)
|
2009-11-30 |
2012-10-10 |
Ablynx N.V. |
Verbesserte gegen hrsv gerichtete aminosäuresequenzen und polypeptide damit zur prävention und/oder behandlung von atemwegsinfektionen
|
MX337062B
(es)
|
2009-12-10 |
2016-02-11 |
Ottawa Hospital Res Inst |
Rabdovirus oncolítico.
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
EP3741883B1
(de)
|
2010-07-16 |
2022-12-14 |
Adimab, LLC |
Antikörperbibliotheken
|
EP2598529A2
(de)
|
2010-07-30 |
2013-06-05 |
Novartis AG |
Fibronectin-cradle-moleküle und bibiotheken
|
CA2805941A1
(en)
|
2010-08-13 |
2012-02-16 |
Pioneer Hi-Bred International, Inc. |
Methods and compositions for targeting sequences of interest to the chloroplast
|
KR101942237B1
(ko)
|
2011-01-04 |
2019-01-25 |
신라젠(주) |
종양 항원에 대한 항체의 생산 및 종양용해 우두 바이러스의 투여에 의한 종양 특이적 보체 의존적 세포독성의 생산
|
EP2718427B1
(de)
|
2011-06-08 |
2017-01-11 |
Children's Hospital of Eastern Ontario Research Institute Inc. |
Zusammensetzungen zur behandlung von glioblastomen
|
WO2013041722A1
(en)
|
2011-09-23 |
2013-03-28 |
Ablynx Nv |
Prolonged inhibition of interleukin-6 mediated signaling
|
RU2019133467A
(ru)
|
2011-10-11 |
2020-07-06 |
МЕДИММЬЮН, ЭлЭлСи |
Cd40l-специфичные каркасные структуры, происходящие из tn3, и способы их применения
|
MX2014010495A
(es)
|
2012-03-02 |
2014-11-14 |
Ablynx Nv |
Polipeptidos que enlazan a pcrv.
|
CA2872096A1
(en)
|
2012-05-04 |
2013-11-07 |
E. I. Du Pont De Nemours And Company |
Compositions and methods comprising sequences having meganuclease activity
|
WO2014087010A1
(en)
|
2012-12-07 |
2014-06-12 |
Ablynx N.V. |
IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
|
CA2901501C
(en)
|
2013-02-21 |
2023-03-07 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Vaccine composition
|
WO2014153242A1
(en)
|
2013-03-14 |
2014-09-25 |
Pioneer Hi-Bred International, Inc. |
Compositions having dicamba decarboxylase activity and methods of use
|
WO2014153234A1
(en)
|
2013-03-14 |
2014-09-25 |
Pioneer Hi-Bred International, Inc. |
Compositions having dicamba decarboxylase activity and methods of use
|
WO2016062766A1
(en)
|
2014-10-21 |
2016-04-28 |
Ablynx Nv |
Treatment of il-6r related diseases
|
EP3268389B1
(de)
|
2015-03-12 |
2020-09-30 |
Medimmune, LLC |
Verfahren zur aufreinigung von albuminfusionsproteinen
|
JP6962819B2
(ja)
|
2015-04-10 |
2021-11-05 |
アディマブ, エルエルシー |
親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法
|
WO2016187101A2
(en)
|
2015-05-21 |
2016-11-24 |
Full Spectrum Genetics, Inc. |
Method of improving characteristics of proteins
|
CA3028002A1
(en)
|
2016-06-27 |
2018-01-04 |
Juno Therapeutics, Inc. |
Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
|
MA45491A
(fr)
|
2016-06-27 |
2019-05-01 |
Juno Therapeutics Inc |
Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
|
WO2018237323A1
(en)
|
2017-06-23 |
2018-12-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
DOMAINS OF DETABILIZATION OF PDE5A
|
MA51154A
(fr)
|
2017-12-15 |
2020-10-21 |
Aleta Biotherapeutics Inc |
Variants de cd19
|