DE69107767D1 - Mikroeinkapselung für ein System zur kontrollierten oralen Wirkstoffabgabe. - Google Patents

Mikroeinkapselung für ein System zur kontrollierten oralen Wirkstoffabgabe.

Info

Publication number
DE69107767D1
DE69107767D1 DE69107767T DE69107767T DE69107767D1 DE 69107767 D1 DE69107767 D1 DE 69107767D1 DE 69107767 T DE69107767 T DE 69107767T DE 69107767 T DE69107767 T DE 69107767T DE 69107767 D1 DE69107767 D1 DE 69107767D1
Authority
DE
Germany
Prior art keywords
microencapsulation
delivery system
drug delivery
oral drug
controlled oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69107767T
Other languages
English (en)
Other versions
DE69107767T2 (de
Inventor
Haibang Lee
Soonhong Yuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
Original Assignee
Korea Research Institute of Chemical Technology KRICT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Research Institute of Chemical Technology KRICT filed Critical Korea Research Institute of Chemical Technology KRICT
Application granted granted Critical
Publication of DE69107767D1 publication Critical patent/DE69107767D1/de
Publication of DE69107767T2 publication Critical patent/DE69107767T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
DE69107767T 1990-10-11 1991-10-10 Mikroeinkapselung für ein System zur kontrollierten oralen Wirkstoffabgabe. Expired - Fee Related DE69107767T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR900016120 1990-10-11
KR1019910002092A KR930006431B1 (ko) 1990-10-11 1991-02-07 약물의 미세캡슐화 방법

Publications (2)

Publication Number Publication Date
DE69107767D1 true DE69107767D1 (de) 1995-04-06
DE69107767T2 DE69107767T2 (de) 1995-07-13

Family

ID=26628361

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69107767T Expired - Fee Related DE69107767T2 (de) 1990-10-11 1991-10-10 Mikroeinkapselung für ein System zur kontrollierten oralen Wirkstoffabgabe.

Country Status (5)

Country Link
US (2) US5362424A (de)
EP (1) EP0480729B1 (de)
JP (1) JP2523069B2 (de)
KR (1) KR930006431B1 (de)
DE (1) DE69107767T2 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
FR2694895B1 (fr) * 1992-08-20 1994-11-10 Coletica Procédé de fabrication de microparticules en émulsion par modification de la composition chimique de la phase dispersée après émulsification.
FR2694894B1 (fr) * 1992-08-20 1994-11-10 Coletica Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une substance polyaminée ou polyhydroxylée pour la fabrication de microparticules, procédé et composition.
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) * 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
DE69435137D1 (de) * 1993-05-13 2008-10-16 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
JPH11510479A (ja) 1995-06-07 1999-09-14 ネオルックス コーポレイション タモキシフェン類似体による心臓血管疾病の予防及び治療
US5776490A (en) * 1996-01-26 1998-07-07 The Center For Innovative Technology Complex protein-walled microcapsules containing lipid-walled microcapsules and method for producing same
US5941256A (en) * 1996-12-24 1999-08-24 Gillette Canada Inc. Dental hygiene article
EP0975340B2 (de) 1997-03-31 2009-10-28 Boston Scientific Limited Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose
US5937874A (en) * 1997-06-03 1999-08-17 Gillette Canada Inc. Dental floss having two components which react to form an active agent
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
DE19801811B4 (de) * 1998-01-19 2004-12-23 Stada Arzneimittel Ag Pharmazeutische Zubereitung zur oralen Verabreichung
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US7041313B1 (en) * 1998-08-12 2006-05-09 Altana Pharma Ag Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
JP3672008B2 (ja) * 1999-01-20 2005-07-13 シオノギクオリカプス株式会社 硬質カプセル及びその製造方法
US6391288B1 (en) * 1999-07-27 2002-05-21 Shiseido Co., Ltd. Microcapsule and method of making the same
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
EP1116515A3 (de) * 2000-01-11 2002-08-21 Givaudan SA Eingekapselte Flüssigkeit
AU7247000A (en) * 2000-01-11 2001-07-19 Givaudan Sa Composite materials
EP1280556A1 (de) * 2000-05-05 2003-02-05 Wisconsin Alumni Research Foundation Zusammensetzungen und verfahren zum schutz von zellen während der chemotherpie und strahlentherapie
PT1320356E (pt) * 2000-09-20 2008-01-03 Nycomed Pharma As Preparação de emulsões e concentrados destas
US6552004B1 (en) * 2000-10-30 2003-04-22 Universite De Montreal Delivery system for entrapping charged macromolecules and a method for preparing same
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US20050163846A1 (en) * 2001-11-21 2005-07-28 Eisai Co., Ltd. Preparation composition containing acid-unstable physiologically active compound, and process for producing same
US20030139582A1 (en) * 2002-01-17 2003-07-24 Wang Kai Hua Composition containing biologically active polypeptides suitable for the oral administration
US20030152484A1 (en) * 2002-02-08 2003-08-14 Heilman David L. Means and method of preserving legal rights by obtaining independent DUI test
NO20021592D0 (no) 2002-04-04 2002-04-04 Fmc Biopolymer As Polysakkaridkapsler og fremgangsmåte ved fremstilling derav
FR2843301B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
FR2843302B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
FR2843965A1 (fr) * 2002-08-28 2004-03-05 Rhodia Chimie Sa Particules sous forme de poudre et dispersions a base d'alginate modifie, et leurs procedes de preparation
US20040121010A1 (en) * 2002-10-25 2004-06-24 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
US20060003004A1 (en) * 2002-10-25 2006-01-05 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
AU2003294244A1 (en) * 2002-11-07 2004-06-03 Advanced Bionutrition Corp. Nutraceuticals and method of feeding aquatic animals
JP2006515008A (ja) * 2003-01-28 2006-05-18 コレギウム ファーマシューティカル, インコーポレイテッド 経口投与のためのミルナシプランの多粒子状組成物
JP2004290745A (ja) * 2003-03-25 2004-10-21 Ajinomoto Co Inc マイクロカプセルの製造法
ES2228243B1 (es) * 2003-03-28 2006-04-01 Universidad De Alcala Microgranulos reticulados biodegradables con un aceite farmaceutico para dirigir farmacos al colon.
US20050084519A1 (en) * 2003-10-17 2005-04-21 Japan Pet Drugs Co., Ltd. Feed for fish and shellfish, additive therefor, and method for producing additive
US8206622B2 (en) 2004-02-23 2012-06-26 Eyesense Ag Process for production of ionically crosslinked polysaccharide microspheres
MY139427A (en) * 2004-03-26 2009-09-30 Eisai R&D Man Co Ltd Controlled-release pharmaceutical composition and method for producing the same
TWI235834B (en) 2004-06-16 2005-07-11 Star Techn Inc Apparatus for probing multi-dies
US20060034927A1 (en) * 2004-08-04 2006-02-16 Gemma Casadevall Means of delivering drugs in an ascending zero order release pattern
CA2615939A1 (en) * 2005-08-02 2007-02-08 Miv Therapeutics Inc. Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same
WO2007037259A1 (ja) * 2005-09-29 2007-04-05 Eisai R & D Management Co., Ltd. 生体内での崩壊性を向上させたパルス製剤
AU2007206582B2 (en) 2006-01-23 2011-09-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Microspheres comprising nanocapsules containing a lipophilic drug
EP1991196B1 (de) 2006-03-03 2016-10-12 Fmc Corporation Verfahren und Vorrichtung zur Herstellung von Kapseln.
CA2654402A1 (en) * 2006-06-01 2007-12-06 Adel Penhasi Multiple unit pharmaceutical formulation
KR100809920B1 (ko) * 2006-09-22 2008-03-06 다윈이십일주식회사 장기 안정성이 우수한 인삼성분 미세캡슐의 제조방법
US20100105738A1 (en) * 2006-10-06 2010-04-29 Mitsuru Mizuno Extended release formulations of a proton pump inhibitor
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
US20090130160A1 (en) * 2007-11-21 2009-05-21 Fiber Innovation Technology, Inc. Fiber for wound dressing
US20100062057A1 (en) * 2008-09-10 2010-03-11 Pronova BioPharma Norge AS. Formulation
JP5696149B2 (ja) 2009-09-10 2015-04-08 エフ エム シー コーポレーションFmc Corporation シームレスなアルギン酸塩カプセル
US8691335B2 (en) 2012-02-08 2014-04-08 Empire Technology Development, Llc Coating a substance with graphene
US9724304B2 (en) 2012-06-14 2017-08-08 Temple University—Of the Commonwealth System of Higher Education Nanospheres for therapeutic agent delivery
JP6659075B2 (ja) * 2014-12-26 2020-03-04 ポーラ化成工業株式会社 カプセル体及びその製造方法
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
KR102272566B1 (ko) * 2019-01-18 2021-07-05 주식회사 대하맨텍 인체에 자극이 없어 안전하고 생분해가 가능한 캡슐 및 그의 제조방법
DE102019209475A1 (de) * 2019-06-28 2020-12-31 Beiersdorf Ag Calciumalginatpartikel
CN114652697B (zh) * 2022-04-20 2023-10-13 仲恺农业工程学院 一种天然多糖高分子螯合锌微胶囊及其制备方法与应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2766478A (en) * 1951-10-15 1956-10-16 Gasoline Res Ind And Commercia Encapsulating method and apparatus
BE530008A (de) * 1953-06-30
US3201353A (en) * 1960-06-14 1965-08-17 American Agricultural Chem Co Micro-inclusions and method of making same
DE1467864A1 (de) * 1964-10-03 1969-01-16 Akad Wissenschaften Ddr Verfahren zur Herstellung von kugelartigen Formkoerpern aus wirkstoffhaltigen waessrigen Emulsionen,Suspensionen oder Loesungen
US3396117A (en) * 1965-09-07 1968-08-06 Amp Inc Encapsulation technique
US3576758A (en) * 1966-10-17 1971-04-27 Ncr Co Treatment of polypeptide-containing hydrophilic polymeric capsule wall material with uranium and vanadium compounds
US3594327A (en) * 1969-03-28 1971-07-20 Ncr Co Process for making minute capsules and capsule product
US3819838A (en) * 1970-08-04 1974-06-25 Bush Boake Allen Ltd Encapsulated flavoring composition
US3749799A (en) * 1972-02-04 1973-07-31 Hoffmann La Roche Stable dry vitamin a preparations
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
JPS5176413A (ja) * 1974-12-25 1976-07-02 Toyo Jozo Kk Hifukuzainoseizoho
JPS52125615A (en) * 1976-04-09 1977-10-21 Kyowa Hakko Kogyo Co Ltd Method of making powdered products
US4389419A (en) * 1980-11-10 1983-06-21 Damon Corporation Vitamin encapsulation
EP0093757A1 (de) * 1981-11-12 1983-11-16 Ulf SCHRÖDER Verfahren zur herstellung von magnetisch beeinflussbaren nanopartikeln für intravaskulare anwendung
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4749620A (en) * 1984-02-15 1988-06-07 Massachusetts Institute Of Technology Encapsulated active material system
FR2561916B1 (fr) * 1984-03-30 1987-12-11 Lafon Labor Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
DE3509333A1 (de) * 1985-03-15 1986-09-18 Hoechst Ag, 6230 Frankfurt Substituierte benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
US4908233A (en) * 1985-05-08 1990-03-13 Lion Corporation Production of microcapsules by simple coacervation
KR950014441B1 (ko) * 1986-08-28 1995-11-28 코르텍스 리미티드 동물의 장에 생물학적 활성물질을 전달하는데 유용한 미세과립형 제제
FR2608456B1 (fr) * 1986-12-18 1993-06-18 Mero Rousselot Satia Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
IL88961A (en) * 1988-01-29 1992-07-15 Basf Ag Stable mixtures containing oxidation-sensitive compounds

Also Published As

Publication number Publication date
EP0480729B1 (de) 1995-03-01
DE69107767T2 (de) 1995-07-13
JPH07145045A (ja) 1995-06-06
US5508041A (en) 1996-04-16
EP0480729A1 (de) 1992-04-15
US5362424A (en) 1994-11-08
KR930006431B1 (ko) 1993-07-16
KR920007622A (ko) 1992-05-27
JP2523069B2 (ja) 1996-08-07

Similar Documents

Publication Publication Date Title
DE69107767T2 (de) Mikroeinkapselung für ein System zur kontrollierten oralen Wirkstoffabgabe.
NO890283L (no) Legemiddel-avgivelsessystem for forbedret opptak.
DE3787829T2 (de) System für die Periodontaltasche zur kontrollierten Drogenfreisetzung.
DE3771272D1 (de) Pulsierendes arzneistoffabgabesystem.
DE69133445D1 (de) Arzneistoffabgabesystem
DE69501780D1 (de) Schnellkupplung für ein medikamenteninfusionssystem
DE68908456T2 (de) Matrix zur Wirkstoffabgabe.
DE3879895D1 (de) Luftdetektor fuer ein medikamenteninfusionssystem.
DE69020832D1 (de) Mit Ultraschall arbeitender Luftmengendetektor für ein Medikamenten-Infusionssystem.
NO973630D0 (no) System for regulert avgivelse av medikament
DE69302933T2 (de) Arzneimittelabgabesystem
GB2140687B (en) Osmotic drug delivery system
DE3751314D1 (de) Ventil für ein medizinisches Infusionssystem.
DE69014513D1 (de) System des Typs "einmal täglich" zur gepulsten Minocyclinabgabe.
DE3750619D1 (de) System zur Abgabe von Arzneistoffen.
DE68916196D1 (de) Durch den Patienten kontrollierte Analgesie-Sicherheitsbefestigung für ein Medikamenteninfusionssystem.
DE3882670T2 (de) Optisches Kassettenerkennungsgerät für ein Medikamenteninfusionssystem.
NO882897L (no) Avleveringssystem for legemidler.
DK528988D0 (da) Laegemiddelafgivelsessystem
DE69012107T2 (de) Robotersystem für medizinabgabe.
NO903521D0 (no) Aromautleveringssystem for tyggegummi.
DE3850128D1 (de) Steuerungssystem zur Verbindung zwischen Einheiten.
DE69534973D1 (de) Trägerpfosten für ein zahnimplantatsystem
DE3784347T3 (de) Reinigungssystem für ein blutleitungsnetz.
DE69427251T2 (de) Verabreichungssystem für Arzneistoffe

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee